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Abstract The aim of this study is to investigate the effect of a continuous stream of pulses of monochromatic blue pulsed (BP) and a combination of blue and green pulsed (BGP) light-emitting diode (LED) light conditions on physiological responses. This study is an approach to clarify the most suitable LED combination and flickering frequency to evoke alertness when a continuous stream of pulsed LED light is delivered and may suggest applications of continuous pulsed light as support for task illumination for shift workers, hospital nurses, school students or office employees. Combinations were delivered by exposures of BPLED and BGPLED pulses at 100, 200, and 400 Hertz over two background light colors (BLC). Participants were exposed to 12 different light conditions in a counterbalanced procedure. By integrating measures of electroencephalogram (EEG) and pupil constriction; results suggested significant changes in responses during the interaction of BLC, LED, and EEG. Beta waves exhibited a statistically significance (p < 0.05) in arousal levels when exposed to BG light, although no active task was involved during exposure. Furthermore, pupil reacted with larger constriction towards BGPLED exposure than towards monochromatic BPLED exposure, thus demonstrating that a continuous stream of pulses can deliver the same irradiance as if delivered in a continuous flow and without affecting perception as no flickering was perceived in any of the conditions by a qualitative evaluation.
Resumen Este estudio tiene por objetivo determinar cuál es la combinación de luz LED más adecuada y la frecuencia de parpadeo que esta deba tener, para evocar un estado de alerta cuando se emite un flujo continuo de la misma al combinarla con una iluminación de ambiente; y poder sugerir aplicaciones como soporte para la iluminación de tareas para trabajadores por turnos, enfermeras, médicos, estudiantes; o en oficinas y hospitales. Es de original importancia resaltar que en el mercado no existe un producto comercial que se pueda ajustar para apoyar en el trabajo al estado de alerta, se tiene la limitante que estas son pruebas a nivel laboratorio y que posteriores pruebas serán necesarias para validar el producto final. El método usado se basó en las combinaciones que se administraron mediante exposiciones de luz azul pulsada (BPLED) y luz azul y verde combinadas (BGPLED) a frecuencias de 100, 200 y 400 Hz adicionadas a la iluminación ambiental (BLC). Los participantes fueron expuestos a 12 condiciones de luz diferentes en un experimento balanceado y contrapesado. Mediante la integración de medidas electroencefalográficas (EEG) y de constricción pupilar; los resultados sugirieron cambios significativos en las respuestas durante la interacción de BLC, LED y EEG. Las ondas beta mostraron una significancia estadística (p <0.05) en los niveles de activación cuando se expusieron a la luz BGPLED, además, la pupila reaccionó con una mayor constricción hacia la exposición a BGPLED que hacia la exposición BPLED monocromática, adicionalmente se demostró que un flujo continuo de pulsos puede proporcionar una irradiación igual a la que se emite en flujo continuo; se concluyó e identificó además la frecuencia (100 Hz) que mejor evoca estado de alerta encefalográfíca y sin afectar la percepción de los usuarios en cuanto a su percepción del ambiente de acuerdo a la evaluación cualitativa.
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Introducción. Pese a las estrategias de vigilancia se cree que existe subregistro de dengue, lo que puede ser secundario a la no detección de casos ya sea por no consulta del paciente, por falla en el diagnóstico o diligenciamiento de fichas de notificación. Objetivo. Estimar el subregistro de los casos de dengue en el municipio de Tocaima durante el periodo de enero a septiembre de 2019 y establecer los conocimientos, actitudes y prácticas respecto al dengue de los habitantes del municipio. Metodología. Se realizó un estudio transversal de prevalencia durante el período de enero a septiembre de 2019 en la población urbana de Tocaima, mediante encuestas a dos viviendas de las 262 manzanas seleccionadas por muestreo aleatorio simple en la búsqueda activa comunitaria y en el 100% de los registros individuales de prestación de servicios y del sistema de vigilancia nacional en salud pública SIVIGILA mediante Búsqueda Activa Institucional BAI. Resultados. Se encuestaron 440 personas de las cuales 19 manifestaron haber presentado síntomas y signos de dengue en el periodo de estudio, de estos, seis personas no asistieron a consulta médica. El Subregistro Comunitario por falta de asistencia a consulta médica fue de 31,5%. Se identificaron en SIVIGILA 125 casos de dengue notificados en el periodo y 156 en el Registro Individual de Prestación de Servicios (RIPS), aplicando el método de Chandra-Sekar Deming se estimaron un total de 257 casos, para un Subregistro Institucional de SIVIGILA de 48,5%. Conclusiones. Son diversas las razones por las cuales no se notificaron todos los casos de la enfermedad al sistema de vigilancia, la primera es que solo se notifican los casos de las personas que consultan a los servicios de salud y que además viven en Tocaima, la segunda es que algunos casos detectados no se notificaron al sistema de vigilancia por errores de procedimiento, o por desconocimiento del diagnóstico por el personal de salud.
Introduction. Despite the surveillance strategies, it is believed that there is an underreporting of dengue, which may be secondary to the non-detection of cases, either due to non-consultation of the patient, due to failure in the diagnosis or filling in of notification sheets. Objective. Estimate the under-registration of dengue cases in the municipality of Tocaima during the period from January to September 2019 and to establish the knowledge, attitudes and practices regarding dengue of the inhabitants of the municipality. Methodology and materials. A cross-sectional study of prevalence was carried out during the period from January to September 2019, in the urban population of Tocaima, through surveys of 2 dwellings of the 262 blocks selected by simple random sampling in the active community search, and in 100% of individual records of service provision and Sivigila through institutional active search. Results. 440 people were surveyed, 19 of whom reported having symptoms and signs of dengue in the study period, of these, six people did not attend a medical consultation. The Community Under-registration for lack of attendance at medical consultation was 31.5%. 125 cases of dengue reported in the period were identified in SIVIGILA and 156 in the Individual Service Provision Registry (RIPS), applying the Chandra-Sekar Deming method, a total of 257 cases were estimated, for a SIVIGILA Institutional Sub-registry of 48,5%. Conclusions. There are several reasons why not all cases of the disease were notified to the surveillance system, the first is that only the cases of people who consult the health services and who also live in Tocaima, the second, some cases detected were not notified to the surveillance system due to procedural errors, or due to lack of knowledge of the diagnosis by health personne.
Subject(s)
Medical Records , Dengue , Registries , Public Health/methods , Epidemiological Monitoring , Medical Record Administrators/educationABSTRACT
Background: Alertness and ability to perform vary as functions of homeostatic factors such as sleep duration, sleep quality, and time awake. As far as medical students are concerned, alertness during the lectures is important due to their vast curriculum, and their alertness aids in the development of better doctors in their future. Though the importance of sleep is known, there is scarcity of studies on how adequate sleep among medical students affects their alertness during lecture classes. The aim was to study effect of sleep duration on alertness among medical students from a tertiary care hospital in Thrissur district, Kerala.Methods: A cross-sectional study was conducted among undergraduate medical students and alertness was assessed following afternoon lecture classes, using a Stanford sleepiness scale questionnaire. The sample size was calculated with a formula 4PQ/d2 and total 202 undergraduate students were included. The data regarding overnight sleep duration and post lunch nap was also collected using a semi-structured questionnaire.Results: Based on stanford sleepiness scale 66.3% of students were alert and responsive, 29.2% were not alert and only 4.5% of students were sleepy following afternoon lecture classes. Out of total 202 undergraduate students 43.6% of them had poor overnight sleep and only 32.7% had taken post lunch nap. There was a statistically significant association between alertness and post lunch nap (p=0.01).Conclusions: Those students who had good overnight sleep and post lunch nap had better alertness during lecture classes.
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OBJECTIVES: Night shift workers suffer from sleep and daytime disturbances due to circadian misalignment. To investigate the role of environmental light in daytime sleep following 12 h-night shift work. METHODS: We enrolled 12 h-shift female nurses working at one university-affiliated hospital (n=10, mean age 26.6 years, shift work duration 3.8 years). This is a cross-over study to compare sleep between under light exposure (30 lux) and in the dark (<5 lux) following 12 h-night duty. Two sessions of experiments were underwent and the interval between sessions was about a month. Psychomotor vigilance test (PVT) had performed on awakening from sleep at each session and sleep-wake pattern had been monitored by actigraphy throughout the study period. Daytime sleep was also compared with night sleep of age-and gender matched daytime workers (n=10). RESULTS: Sleep parameters and PVT scores were not different between two light conditions. Activities during sleep seemed to be more abundant under 30 lux condition than in the dark, which was not significant. Compared to night sleep, daytime sleep of shift workers was different in terms of rapid eye movement (REM) sleep. Three shift workers showed sleep onset REM sleep and first REM sleep period was the longest during daytime sleep. CONCLUSIONS: Unexpectedly, daytime sleep of 12 h night shift workers was well-maintained regardless of light exposure. Early occurrence of REM sleep and shorter sleep latency during daytime sleep suggest that shift workers meet with misalignment of circadian rhythm as well as increased homeostatic sleep pressure drive.
Subject(s)
Female , Humans , Actigraphy , Circadian Rhythm , Cross-Over Studies , Polysomnography , Sleep, REMABSTRACT
Abstract Purpose: An experiment was conducted to investigate the physiological effects of a continuous blue pulsed light emitting diode (BP-LED) added to a task lamp in an actual indoor lighting environment and its influence in alertness having as a final purpose to develop a commercial product that could be applied in situations similar to those depicted in the present work. Design methodology: Previous research studies have stated that the addition of pulsed light evokes physiological changes that may induce alertness. The participants were exposed to four different lighting conditions. Electroencephalograms (EEG), pupil sizes, heart rates (HR), performance tests, and subjective reactions were measured. Findings: Low colour temperature light and the BP-LED revealed an improved alertness according to the data from the EEG recordings. The intervention of the BP-LED in a high colour temperature ambiance was beneficial in maintaining high levels of alertness compared to the conditions where the BP-LED was not used. It was tested that the use of a BP-LED in a task lamp may be beneficial in improving or maintaining alertness levels in an indoor workplace ambiance. Originality and Value: Designing of an adequate workplace task lamp light that improves alertness for in-house, office, or classroom situations in which it is essential.
Resumen Propósito: Un experimento fue llevado a cabo para investigar los efectos fisiológicos que una luz azul LED pulsada de manera intermitente (BP-LED), adicionada a una lámpara de escritorio, y en un ambiente interior; pueda influir en el estado de alerta de una persona con la finalidad de desarrollar un producto comercial que pueda ser aplicado para los casos desarrollados y otros posibles escenarios. Metodología de Diseño: En estudios anteriores se establece que la adición de luz en pulsaciones evoca cambios fisiológicos que pueden inducir al estado de alerta. Los participantes experimentaron cuatro escenarios de iluminación. Se registraron mediciones con respecto a encefalografía (EEG), tamaño pupilar, ritmo cardiaco, prueba de performance, así como evaluación subjetiva. Hallazgos: Los datos de EEG revelaron un mayor estado de alerta durante la exposición a iluminación cálida aunado a luz BP-LED. La intervención de luz fría y BP-LED denotó ser benéfica en el nivel de estado de alerta en comparación con las condiciones donde el BP-LED no intervino. Se logró evaluar que el uso de BP-LED en una lámpara de escritorio puede ser benéfico para mejorar o mantener el estado de alerta cuando sea usado en un espacio interior. Originalidad y Valor: Propuesta para diseñar una luminaria de escritorio; para uso casero, laboral o de estudio; que mejore el estado de alerta de las personas.
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<p><b>BACKGROUND</b>Rhythmical massage therapy (RMT) is a massage technique used in anthroposophic medicine.</p><p><b>OBJECTIVE</b>The authors aimed to investigate the physiological action of RMT on the cardiovascular system by analysing heart rate variability (HRV).</p><p><b>DESIGN, SETTING, PARTICIPANTS AND INTERVENTION</b>This study was a randomised, controlled and single-blinded trial, involving 44 healthy women (mean age: (26.20 ± 4.71) years). The subjects were randomised to one of three arms: RMT with aromatic oil (RA), RMT without aromatic oil (RM) or standardised sham massage (SM). In the study the subjects were exposed to a standardised stress situation followed by one of the study techniques and Holter electrocardiograms (ECGs) were recorded for 24 h.</p><p><b>MAIN OUTCOME MEASURES</b>HRV parameters were calculated from linear (time and frequency domain) and nonlinear dynamics (symbolic dynamics, Poincare plot analysis) of the 24-h Holter ECG records.</p><p><b>RESULTS</b>Short- and long-term effects of massage on autonomic regulation differed significantly among the three groups. Immediately after an RMT session, stimulation of HRV was found in the groups RA and RM. The use of an aromatic oil produced greater short-term measurable changes in HRV compared with rhythmic massage alone, but after 24 h the effect was no longer distinguishable from the RM group. The lowest stimulation of HRV parameters was measured in the SM group.</p><p><b>CONCLUSION</b>RMT causes specific and marked stimulation of the autonomic nervous system. Use of a medicinal aromatic oil had only a temporary effect on HRV, indicating that the RM causes the most relevant long-term effect. The effect is relatively specific, as the physiological effects seen in the group of subjects who received only SM were considerably less pronounced.</p><p><b>TRIAL REGISTRATION</b>Registration trial DRKS00004164 on DRKS.</p>
Subject(s)
Adult , Female , Humans , Male , Young Adult , Autonomic Nervous System , Physiology , Heart , Physiology , Heart Rate , Massage , Single-Blind MethodABSTRACT
Resumo Objetivo: verificar o efeito do esforço físico sobre as funções cognitivas de trabalhadores eletricistas utilizando equipamento de proteção individual (EPI). Métodos: participaram 28 eletricistas que trabalhavam na construção, manutenção e operação de redes de distribuição de energia. Todos do sexo masculino, sadios e aptos para a prática de exercícios físicos. As funções cognitivas foram representadas pelo teste de reação simples (TRS) e pelo nível de vigilância mental (NVM). O TRS e o NVM foram mensurados pré e pós-teste máximo progressivo, em esteira rolante, a 27 °C de temperatura seca e umidade relativa do ar de 64%. O teste consistiu em aumentos progressivos na velocidade e na inclinação da esteira até a fadiga, com utilização de EPI. Resultados: a média (desvio padrão) do TRS não foi significativamente diferente antes, 227,8 (35,1) ms, e após o exercício, 220,6 (24,6) ms. O NVM foi significativamente maior após o exercício em todas as situações: frequência crescente - 36,5 (5,1) Hz vs 39,5 (2,7) Hz, frequência decrescente - 36,0 (5,2) vs 39,0 (3,88) Hz, e frequência geral - 36,2 (4,9) vs 39,2 (3,1) Hz. Conclusão: o exercício progressivo máximo realizado com EPI não modificou o tempo de reação simples e aumentou o nível de vigilância mental de eletricistas.
Abstract Objective: to verify the effects of physical effort on the cognitive functions of electricians wearing personal protective equipment (PPE). Methods: 28 electricians participated. They worked on the construction, maintenance and operation of electrical power distribution networks. All were male, healthy and able to practice physical exercises. The cognitive functions were checked by measuring simple reaction time (SRT) and mental alertness level (MAL). SRT and MAL were measured before and after progressive maximal exercise, on a treadmill, at 27 °C dry temperature and 64% relative humidity, wearing PPE. The test consisted of progressive increases in treadmill speed and incline, until fatigue. Results: SRT mean difference was not significantly different before - 227.8 (35.1) ms - and after exercising -220.6 (24.6) ms. MAL was significantly higher after exercise in all situations: increasing frequency - 36.5 (5.1) Hz vs. 39.5 (2.7) Hz; decreasing frequency-36.0 (5.2) Hz vs. 39.0 (3.88) Hz; and general frequency 36.2 (4.9) Hz vs. 39.2 (3.1) Hz. Conclusion: progressive maximal exercise performed while wearing PPE caused no change in simple reaction time, and increased electricians' mental alertness level.
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Objective To assess the accuracy of bispectral index (BIS) in monitoring the sedation level with dexmedetomidine combined with small-dose of sufentanil.And, to analyze the BIS value of the best opportunity for invasive manipulation with this sedation method.MethodsEighty elective operation patients, ASA Ⅰ~Ⅱ, were randomLy selected for the study.Before the start of anesthesia, small-dose of sufentanil 0.1μg/kg and dexmedetomidine were injected in vein in sequence.The loading dose of dexmedetomidine was 1.0μg/kg for 15 min and the maintenance dose was 0.3μg/kg for 5 min.The time-pint before the start of injection was recorded as T0.And, T1, T2, T3, and T4 respectively presented the infusion time of dexmedetomidine for 5min, 10min, 15min and 20min.According to these four time-points, 80 patients were randomLy divided into four groups: group T1, group T2, group T3,and group T4.The relevant HR, MAP, SpO2, BIS value, and OAA/S score were separately recorded.Analyze the correlation of BIS and OAA/S score, and the cutoff value of BIS for OAA/S score=1 was obtained by analyzing receiver operating characteristic (ROC) curve.ResultsThe compound use of dexmedetomidine and sufentanil significantly decreased HR.With this sedation method, BIS value was positively correlated with OAA/S score (r=0.95), and the best cutoff value of BIS values for OAA/S score=1 was 44.5.ConclusionThere was a good correlation between BIS and OAA/S score in monitoring sedation with dexmedetomidine combined with small-dose of sufentanil.BIS=44.5 could be regarded as a good monitoring index of invasive manipulation with this sedation method.
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PURPOSE: The purpose of this study was to identify sleep patterns, alertness, and fatigue of shift nurses according to circadian types. METHODS: The researchers' enrolled 17 nurses doing shift work in a tertiary hospital. To evaluate circadian types, a morningness-eveningness questionnaire (MEQ) was administered. Sleep patterns were examined using an actigraph for 14 days. To assess alertness and fatigue, Visual Analogue Scale (VAS) was used. The data were analyzed using ANOVA and Kruskal-Wallis test with a SPSS 21.0 program. RESULTS: The researchers found that 17.6% of participants reported morning type, 47.1% neither type, and 35.3% evening type. Mean total sleep time (TST) was 6.8 h, mean sleep efficacy was 82%, level of alertness was 6.54, and level of fatigue was 5.49, regardless of the type of shift work. Evening type nurses had higher variation in TST and alertness, according to the shift patterns than other circadian type nurses. Evening type nurses also had higher fatigue levels than other circadian type nurses. CONCLUSION: Sleep, alertness, and fatigue were related with circadian types. These results suggest that circadian rhythm management in shift work nurses, particularly in evening type nurses is urgently needed to improve sleep patterns, alertness, and to decrease the level of fatigue.
Subject(s)
Asthenopia , Circadian Rhythm , Fatigue , Tertiary Care CentersABSTRACT
It was suggested by most researchers that train drivers’ workload and alertness levels attribute to train accidents. The main objective of this study is to determine the significant patterns of mental workload and alertness levels of train drivers with respect to the conditions. The data are collected from simulation experiments on 15 professional train drivers. The simulation experiments are performed under three driving conditions (i.e. daytime, rainy daytime and rainy night) using a train driving simulator set. Electroencephalogram (EEG) signals are collected from six significant points on the body of the subjects. It is found that the mental workload of the train drivers tends to be high during rainy night driving condition and sleepiness occurs which is indicative of low vigilance. The beta amplitude increases under rainy night driving condition which may be attributed to viewing difficulties while driving in the dark. The results reveal that there is a significant different between each session (p = 0.042) especially with the pattern for rainy night driving. It is also observed that there is lower mental workload among the train drivers, which indicates that the train drivers are detached from their work.
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Introduction:-Reaction is purposeful voluntary response to different stimuli as visual or auditory stimuli. The present study was conducted to measure visual reaction time in 100 subjects, 50 basketball players and 50 healthy controls. Material & Method: - The visual reaction time was measured by the reaction time instrument in healthy controls and basketball players. Simple reaction time and choice reaction time measured. During the reaction time testing, visual stimuli were given for three times and minimum reaction time was taken as the final reaction time for that sensory modality of that subject. The results were statastically analyzed and were recorded as mean+ standard deviation and student’s unpaired t-test was applied to check the level of significance. Result:- The study shows that basketball players shows faster reaction time than healthy controls. Conclusion: - As reaction time gives the information how fast a person gives a response to sensory stimuli, it is a good indicator of performance in reactive sports like basketball.
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OBJECTIVES: Modafinil is a waking drug prescribed to narcolepsy patients, but its usage among healthy individuals is increasing to enhance their alertness or to mitigate fatigue. This study was conducted to investigate practical use and toxic effects on neuro-immune interaction of modafinil. METHODS: This study reviewed the significance of psychoactive drugs, and discussed the benefits and risks of the application of modafinil, which seems to be ideal as an anti-psychotic or anti-fatigue agent. RESULTS: Modafinil is known to have less or no adverse effects than those found in traditional psychostimulants such as amphetamine, methylphenidate or cocaine. It can be applied as an anti-psychotic or anti-fatigue agent. However, the waking mechanism of modafinil is yet to be fully revealed. Recent studies reported that modafinil may be subject to abuse and addiction. In addition prolonged sleeplessness induces stress responses and impairs immune function. CONCLUSIONS: Modafinil can be used by anyone, who wishes to work late, stay awake, enhance their cognitive reactions, or brighten their moods. Users may already be under a great level of stress, i.e. cancer patients or soldiers in a battle field. A psychoneuroimmunological approach is thus needed to investigate the multi-functional effects of modafinil.
Subject(s)
Humans , Amphetamine , Benzhydryl Compounds , Central Nervous System Stimulants , Cocaine , Fatigue , Methylphenidate , Military Personnel , Narcolepsy , Psychotropic Drugs , Risk Assessment , Sleep Initiation and Maintenance DisordersABSTRACT
The aim of the present study was to evaluate the effects of partial sleep deprivation on the cognitive status and alertness of medical students using auditory event related potential (ERP) and auditory reaction time (RT) using sleep questionnaire, Stanford Sleepiness Scale (SSS), auditory ERP (P300) and RT. Sleep time was significantly shorter in the test condition as compared to the baseline values (p<0.001). Significantly higher values on the SSS (p<0.05) were found after sleep restriction. The P300 latency and amplitude significantly decreased (p<0.01 and p<0.001 respectively) when the test values were compared to the baseline. RT also showed a significant decrease (p<0.001) in the test condition as compared to the baseline values. However, no significant correlation could be ascertained between SSS and P300 amplitude and latency as well as RT. This study demonstrates that partial sleep deprivation produces variable effects on the cognitive status of medical students as reflected by the decrease in P300 amplitude and latency. Alertness of medical students seemed to show an improvement as reflected by the decrease in RT.
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Objective: To study caffeine and/or placebo implication as countermeasures during sleep deprivation (SD). Methods: A double-blind, within-subjects and counterbalanced design was employed and five trials were conducted. Subjects were exposed to 30h SD in each trial. No medicine was administrated in control trial while placebo 200mg, caffeine 200mg, caffeine 400mg and the combination of caffeine (200mg) and placebo (200mg) were administered, respectively in the other trials. Letter Cancellation Test was used to assess the alertness. Result: The correct concealing numbers per minute (CCNM) of the combination of caffeine and placebo (62.36?7.31/min), caffeine 400mg(55.88?6.54/min) and caffeine 200mg (59.48?6.52/min) were more than that of control(46.80?5.35 /min), P0.05). Conclusion: Caffeine and the combination of caffeine and placebo expectation can increase alertness.
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BACKGROUND: Propofol has been frequently used for sedation or hypnosis in anesthesia and is relatively accurate in the dose-response relationship for hypnosis. The aim of this study was to define the bispectral index and modified observer's assessment of alertness/sedation (OAA/S) scale at various effect site concentrations (Ce) of propofol in Koreans. METHODS: Fifty premedicated (atropine 0.5 mg, I.M.) adult patients (ASA class I or II, 20 55 yrs) scheduled for elective orthopedic surgery were studied. Propofol was infused until 2 min after the target concentration equilibrated with the effect site concentration (Ce) of propofol using Master TCI. The target concentration of propofol was stepwise increased at intervals of 0.5 microgram/ml until BIS reached 40, BIS and OAA/S at each Ce of propofol were checked. If SpO2 decreased below 90%, oxygen (4 l/min) was given via nasal cannula. RESULTS: BIS was 97.9 +/- 0.2 and OAA/S 5 +/- 0.0 at a Ce of propofol of 0 microgram/ml; the Ce of propofol was 3.5 microgram/ml and OAA/S 0.1 +/- 0.3 at a BIS of 41.1 +/- 2.5. Also, systolic BP at a Ce of propofol above 1.0 microgram/ml and diasolic BP at a Ce of propofol above 1.5 microgram/ml significantly decreased compared to the control (P < 0.05). However, heart rate did not show any difference compared to the control value. Above a 1.0 microgram/ml Ce, fifty-eight percent of patients showed SpO2 < 90%, but there was no incidence of apnea. There were significant correlations between Ce of propofol, BIS and OAA/S. CONCLUSIONS: BIS showed a significant correlation with Ce of propofol (Spearman's r = 1.0) (P < 0.0001). The Ce of propofol was above 3.0 microgram/ml for BIS50.
Subject(s)
Adult , Humans , Anesthesia , Apnea , Catheters , Heart Rate , Hypnosis , Incidence , Orthopedics , Oxygen , PropofolABSTRACT
The results of rotation chair test were known to variable by many parameters such as eye opening and alertness, etc. The situational change in rotation chair test must be considered to interpretation of its result. But in Korea, there were no reports or articles about parameters which influence the result of rotation chair test. So, we assumed that eye opening and alertness were main parameters and took rotation chair test in neurotologically normal subjects. For evaluation of the effect of eye-open or eye-closure and alertness on the rotational vestibular stimulation, we have taken sinusoidal harmonic acceleration test in 30 otoneurologically normal subjects. The maximal slow phase eye velocity, gain and asymmetry were obtained and compared with each other in four different conditions with properly fixed conditions such as in darkness and 0.05Hz frequency. At least five minutes interval was given between the tests and recalibrations were done before each tests. The results of this test were as follows. 1) Vestibular-ocular reflex(VOR) changes according to eye open or closure. In cases of examinees which were given alerting tasks, larger gain was obtained with eyes opened than with eyes closed, and that was statistically significant(p0.05). 2) VOR changes according to alertness. In cases of examinees which opened their eyes, larger gain was obtained with alerting tasks than without alerting tasks, and that was statistically significant(p<0.05). In cases of examinees which closed their eyes, larger gain was obtained with alerting tasks than without alerting tasks, and that was statistically significant(p<0.05). 3) There was no significant changes of asymmetry according to the conditions. Therefore, from above results, we recommend the condition in which examinees open their eyes and be given alerting tasks as one of the optimal condition in sinusoidal harmonic acceleration test.
Subject(s)
Acceleration , Darkness , Korea , Plastics , Reflex, Vestibulo-OcularABSTRACT
PURPOSE: The aim of this study is to evaluate the influence of the feeding (fasting-postprandial) and the state of alertness (awake-asleep) on the amount of gastroesophageal reflux by using 24hour esophageal pH metry. METHODS: From July 1994 to June 1995, 32 cases of 24 hour esophageal pH metry had been done at the Asan Medical Center. Twenty three children with normal pH monitoring and 9 children with abnormal pH monitoring were included in this study. The children ranged in age from 13 days to 8 years old. Indications of the study were vomiting in 6, chronic respiratory symptoms in 22, chest pain in 2 and abdominal pain in 2 children. The parameters studied in this study were reflux index, the number of reflux episodes, the duration of the longest reflux episodes and the number of the reflux episodes lasting over 5 minutes. The former 4 parameters were analyzed according to feeding and the state of alertness between normal group and patient group respectively. RESULTS: 1) All four parameters were different between normal and patient group except No. of reflux episode longer than 5minutes per hour. 2) With regard to feeding in n normal group, reflux index and number of reflux episodes during fasting period were significantly higher than postprandial period. But duration of longest reflux episode and number of episodes lasting longer than 5 minutes were not. 3) With regard to alertness in normal group, reflux index and number of reflux episodes during alert period were significantly higher. Duration of longest reflux episode and number of episodes lasting longer than 5minutes were lower but was not statistically significant. 4) With regard to feeding in patient group, reflux index and number of reflux episodes during fasting period were significantly higher than postprandial period. But duration of longest reflux episode and number of episodes lasting longer than 5 minutes were not. 5) With regard to alertness in patient group, number of reflux episodes during awake period was significantly higher, but reflux index was not. Duration of longest reflux episode and number of episodes lasting longer than 5minutes were lower but was not statistically significant. CONCLUSIONS: The reflux index was significantly higher during postprandial and alert period both in normal and patient group except that in patient group between sleep and alert period. It is suggested that the esophageal clearance of children in our country is excellent than other country.