ABSTRACT
Objective: To study the chemical constituents of Acanthopanax senticosus. Methods: The compounds were separated and purified by column chromatography and their structures were identified by spectroscopic methods. Results: Twelve compounds were isolated from the chloroform and n-butanol extract of A. senticosus, and their structures were determined as ciwujiatone (1), eleutheroside B1 (2), tachioside (3), alimoxide (4), erythro-1-(4-hydroxy-3-methoxy-phenyl)-2-{4-[(E)-3-hydroxy-1-propenyl] -2-methoxy-phenoxy}-1,3-propanediol (5), erythro-1,2-bis(4-hydroxy-3- methoxyphenyl)-1,3-propanediol (6), tortoside A (7), episyringaresinol 4′-O-β-D-glucopyranoside (8), (+)-lyoniresinol (9), benzyl-O-α-L-rhamno-pyranosyl (1→6)-β-D-glucopyranoside (10), 2,6-dimethoxy-4-(3-hydroxy-propen-1-yl) phenyl-4-O-α-L-rhamno-pyranosyl- (1→6)-β-D-glucopyranoside (11), and nicotinamide (12). Conclusion: Compounds 3-5 and 10-12 are isolated from A. senticosus for the first time.