Progress on the allergic march and prevention / 国际儿科学杂志

While the term atopic march has been used to imply a natural progression of a cascade of symptoms from eczema to asthma and rhinitis through childhood, this developmental profiles at an individual level are not accurate.Only a small proportion of children(7％) follow this profile.There are increasing evidences from longitudinal studies suggesting that there exist other allergic phenotypes.Through the development of internal and external mechanism of allergic disease, we could do something to help earlier diagnosis and facilitate novel approaches to disease prevention, such as human breast milk, solid food, environmental control, pharmacotherapy, etc.This review aims to summarize recently published articles in order to highlight novel research findings,clinical trial results and guidelines to assist in identifying prevention strategies to arrest the atopic march.

Progress of the relationship between vitamin D and allergy diseases / 国际儿科学杂志

The prevalence of allergy diseases is increasing globally. Epidemiological surveies showed that the increased allergy prevalence rates followed the time trend of rickets prophylaxis in western countries. and vitamin D supplement increased the risk of allergy in early stage.Currently,most of investigators think that vltamin D deficiency may be one of the risk factors for allergy diseases.Laboratory investigations showed that vitamin D inhibited Th1、dendritic cell(DC)and Th2 cell proliferating,and keeped on epithelial suIfaces barrier tunction.However,no study has found generating of allergy disease is associated with vitamin D deftciency or excess.