ABSTRACT
Objective To determine the content of polysaccharide in Aloe barbadensis Miller and Aloe vera L. Var. Chinensis(Haw.)Berger. Methods Carubinose was used as reference substance, measured and compared polysaccharide content with the method of UV spectrophotometry at 610 nm absorbance of growth years for 1, 2, 3, 4 and 5 years of Aloe barbadensis Miller and Aloe vera L. Var. Chinensis(Haw.)Berger. Results The mannose and the absorbance was linear (r=0.998 5) in the range of 0.05 - 0.60 g/L, and the content of Aloe barbadensis Miller polysaccharide in the measured growth period was respectively 1.201, 1.485, 1.665, 2.355 and 5.040 mg/g. The content of polysaccharide in Aloe vera L. Var. Chinensis(Haw.)Berger was 0.780, 0.900, 1.035, 1.650 and 2.355 mg/g. Conclusions The content of polysaccharide in Aloe barbadensis Miller and Aloe vera L. Var. Chinensis(Haw.)Berger differed in growth years, which increased with aging and polysaccharide content in the same age of Aloe barbadensis Miller was significantly higher than that of the Aloe vera L. Var. Chinensis(Haw.)Berger.
ABSTRACT
The present research work was aimed to develop matrix tablets of Glimepiride with Aloe barbadensis miller leaves mucilage and Povidone and to study its functionality as a matrix forming agent for sustained release tablet formulations. Physicochemical properties of dried powdered mucilage of Aloe barbadensis miller mucilage and Povidone tablet blend were studied. Various formulations of Glimepiride Aloe barbadensis miller mucilage and Povidone were prepared. They found to have better satisfactory physicochemical properties with low SD values. The swelling behavior and release rate characteristics were studied. The dissolution study proved that the dried Aloe barbadensis miller mucilage and Povidone combination can be used as a matrix forming material for making Sustained release matrix tablets.