ABSTRACT
Objective To investigate the relationship between the expression of endostatin, VEGFR and chronic altiplano cardiopathy,and the mechanism of the curative effect of rhodiola.on treat altiplano cardiopathy. Methods The rat model with chronic altiplano cardiopathy was created.The experimental rats were divided into four groups: control group;smoking and running stimulated group;altiplano cardiopathy group and rhodiola treated group.The expression levels of endostatin and VEGFR were determined by the methods of immunohistochemistry and semi-quantitative RT-PCR. Results The expression levels of VEGFR in hearts and lungs of the stimulated groups were found higher than that of the control group,while endostatin level was contrary.The expression level of VEGFR in hearts and lungs of the rhodiola treated group was lower than that of the altiplano cardiopathy group,while endostatin was higher.Conclusion The pathogenesis of chronic altiplano cardiopathy seems to be closely associated with epithelial lesion.The curative effect of rhodila to this disease may be exerted by reducing the damage of epithelial cells.