ABSTRACT
Objective To explore the comparison of efficacy of Salmeterol assigned powder inhaler and Aminophylline Tablets treating female COPD with remission.Methods Selected in remission of COPD in female patients of 114 cases.With digital method were divided into observation group and control group with 57 cases in each group.The observation group inhaled salmeterol and fluticasone propionate powder,while the control group oral amin-ophylline tablets for treatment.Effect and Lung function index,such as IC,FEV1 ,FVC,FEV1 % etc.were compared between the two groups after the treatment.Results The observation group treatment effects achieved significantly accounted for 47.37% (27 /57),which was significantly higher than 26.32% (15 /57)in control group,and the total effective rate of the observation group was higher(χ2 =4.150,P =0.042).In addition,the IC,FEV1 ,FVC,FEV1 %index increased significantly in the observation group after treatment,and the TDI,6MWD was also higher.The difference was statistically significant (t =5.077,4.746,P =0.000,0.000).Conclusion Salmeterol and fluticasone propionate inhalation and aminophylline tablets in the treatment of female remission of COPD showed a high efficient results,but the relative effect of salmeterol and fluticasone propionate inhalation therapy effect is better,the degree of dyspnea alleviated better.
ABSTRACT
The effect of high fat diet on the pharmacokinetics of theophylline from controlled release aminophylline tablets has been observed in six healthy volunteers. The drug was administrated in single oral doses (400mg)after an overnight fast or immediately after the consumption of a high fat breakfast in an autocontrol study. Serum theophylline levels were measured by fluorescence polarization immunoassay. The absorption of theophylline was markedly delayed by high fat diet with significant difference in I_(max) (3.53?0.44h vs 6.54?2.08h, p