Deterioro cognitivo leve de tipo amnésico en ancianos de un área de salud / Amnestic mild cognitive impairment in elderly of a health area i: en

Introducción: La edad es el factor de riesgo más importante asociado al deterioro cognitivo. Al respecto, la pérdida de la memoria resulta un motivo frecuente y creciente de atención en las consultas médicas del nivel primario. Sin embargo, la disfunción cognitiva en los ancianos suele ser una de las afecciones que transcurren usualmente sin un diagnóstico oportuno. Objetivo: Determinar la prevalencia del deterioro cognitivo leve de tipo amnésico en ancianos de un área de salud. Métodos: Se realizó un estudio observacional, descriptivo y transversal de 203 ancianos pertenecientes al área de salud del Policlínico Docente Ramón López Peña de Santiago de Cuba, desde junio hasta diciembre de 2022. Para diagnosticar a los pacientes con disfunción cognitiva leve se utilizaron los criterios de Petersen. Resultados: Se halló que 36,9 % de los ancianos presentaron deterioro cognitivo leve de tipo amnésico, con predominio del sexo masculino (43,6 %) y del nivel de escolaridad primario (50,0 %), seguido del medio (40,3 %). Conclusiones: El deterioro cognitivo leve de tipo amnésico prevaleció en más de un tercio de la muestra estudiada; frecuencia que aumentó según la edad. Asimismo, se detectó una mayor incidencia del sexo masculino y de los ancianos con escolaridad primaria y media finalizadas.

Introduction: Age is the most important risk factor associated with cognitive deterioration. In this regard, loss of memory is a frequent and growing reason for attention in medical consultations of primary care. However, cognitive dysfunction in the elderly is one of the affections that usually go without an opportune diagnosis. Objective: To determine the prevalence of the amnestic mild cognitive impairment in elderly of a health area. Methods: An observational, descriptive and cross-sectional study of 203 elderly, belonging to the health area of Ramón López Peña Teaching Polyclinic was carried out in Santiago de Cuba, from June to December, 2022. To diagnose the patients with light cognitive dysfunction the Petersen approaches were used. Results: It was found that 36.9% of the elderly presented amnestic mild cognitive impairment, with a prevalence of male sex (43.6%) and the primary school level (50.0%), followed by the middle level (40.3%). Conclusions: Amnestic mild cognitive impairment prevailed in more than a third of the studied sample; frequency that increased according to the age. Likewise, a higher incidence of male sex and the elderly with concluded primary and middle schooling was detected.

Trauma y amnesia disociativa: la visión de Pierre Janet / Trauma and dissociative amnesia: Pierre Janet's vision

RESUMEN Se señala la importancia de reconsiderar el trabajo de Pierre Janet en trauma y amnesia disociativa, como elementos importantes en el estudio actual del trastorno de estrés postraumático (TEPT). Los objetivos de esta revisión histórica no sistemática y comparativa son: a) explicar, desde la perspectiva de Janet: el concepto de Idea Fija, que hoy denominamos trauma b) describir los diferentes tipos de amnesia en las cuales se basa el DSM para su clasificación actual y c) a través de un caso clínico descrito por Janet, mostrar su concordancia con lo que actualmente diagnosticamos como TEPT complejo, que denominó en su época: "una de las formas que puede tomar la histeria después de un accidente emocional". Esta revisión se basa principalmente en algunos capítulos originales de Janet publicados en Francés.

The present article gives emphasis in reconsidering the work of Pierre Janet in trauma and dissociative amnesia, as important aspects for the contemporary study of posttraumatic stress disorder (PTSD). The purpose of this non systematic historical review is to explain the following ideas under Janet´s perspective: a) the concept of fixed idea, denominated in our contemporary nomenclature as trauma, b) to describe the different types of amnesia described by Janet and its relation with DSM clasiffication for this penomenon, and c) to show through the analysis of a clinical case described by Janet, how a concordance exists between the current denomination of complex PTSD and what Janet nominated "one of the forms in which hysteria can presents after an emotional accident". This article is mainly based in some original chapters from Janet´s work published in French.

Random number generation and the ability of mentally reconstructing context in patients with organic amnesia / Geração aleatória de números e a capacidade de reconstruir mentalmente o contexto em pacientes com amnésia orgânica

ABSTRACT. Studies investigating amnesic patients have shown the involvement of the medial temporal lobe during working memory (WM) tasks, especially when multiple items or features have to be associated. However, so far, no study has examined the relationship between episodic memory and WM components in patients with amnesia for comprehensive neuropsychological evaluation. Objective: The objective of this study was to investigate whether the null retention relates to deficits in the episodic buffer (EB) or the central executive (CE) components of WM. Methods: This study included 15 amnesic patients with mixed etiologies and 13 matched healthy controls. These 15 amnesic patients with mixed etiologies were divided into two subgroups: NUL subgroup (n=7) patients whose raw score was 0 (zero) on the Logical Memory delayed recall test and MOR subgroup (n=8) patients who recalled at least 1 item. The EB was assessed by complex span tasks, and the CE was assessed by random number generation (RNG) test. Results: EB tasks were impaired in both subgroups compared with controls. RNG was impaired in NUL (p=0.03), but not in MOR (p=0.99), subgroup. Conclusions: CE impairment hampers the retrieval mode action, preventing it from initiating the mental reconstruction of the context in which the to-be-remembered information was presented minutes ago.

RESUMO. Estudos que investigaram pacientes amnésicos demonstraram envolvimento do lobo temporal medial durante tarefas de memória de trabalho, especialmente quando vários itens ou características devem ser associados. No entanto, até o momento, não há estudos que tenham examinado a relação entre memória episódica e os subcomponentes da memória de trabalho em pacientes com amnésia por meio de avaliação neuropsicológica ampla. Objetivo: Investigar se a retenção nula está relacionada a déficits no buffer episódico ou nos componentes do executivo central da memória operacional. Métodos: Quinze pacientes amnésicos com etiologias mistas foram divididos em dois subgrupos: subgrupo NUL (n=7), de pacientes cuja pontuação bruta foi 0 (zero) na memória lógica tardia, e subgrupo MOR (n=8), de pacientes que recordaram pelo menos um item; além de 13 controles saudáveis pareados. O retentor episódico foi avaliado por tarefas de spam complexo e o executivo central com geração aleatória de números. Resultados: As tarefas do retentor episódico estavam prejudicadas em ambos os subgrupos em comparação com os controles. O teste de geração aleatória de números foi prejudicado em NUL (p=0,03), mas não no subgrupo MOR (p=0,99). Conclusões: O comprometimento do executivo central dificulta a ação do modo de recuperação, impedindo-o de iniciar a reconstrução mental do contexto em que a informação a ser lembrada foi apresentada, minutos antes.

The relationship between executive function and gait in mildly mentally-impaired persons / 中华物理医学与康复杂志

Objective:To explore the relationship between executive function and gait in cases of mild amnestic cognitive impairment (aMCI).Methods:Twenty aMCI hospital patients formed an observation group, while 20 healthy counterparts were the control group. Both groups underwent the Tinetti test, followed by the " normal walking" single-task test and the " normal walking + Go/No-go" dual-task test. The pace, step width, stride length, Go/No-go task response time and accuracy rate were recorded.Results:In the single-task test, there was no significant difference in pace or stride width between the two groups, but the average stride length of the observation group (1.11±0.04)cm was significantly shorter than that of the control group. However, in the dual-task test, the average pace time (0.96±0.08)sec and stride length (1.02±0.06)cm of the observation group were significantly smaller than the control group′s averages, while their step width (0.11±0.02)cm was significantly wider. There was no significant difference between the two groups in the response time in a single (Go/No-go) task, but in the dual-task test, the observation group′s average time was significantly longer than the control group′s and the accuracy was significantly poorer. Both the error rate and the non-response rate were significantly higher than among the control group.Conclusions:Mild amnestic cognitive impairment reduces stride length and pace when walking and impairs executive function.

Right fornix column infarction: a case report / 中华神经科杂志

Isolated fornix infarction is very rare in cerebral infarction. A case of right column fornix infarction with acute anterograde amnesia as the only manifestation who was diagnosed in the Fifth Affiliated Hospital of Sun Yat-Sen University in March 2020 was presented. The clinical symptoms were the inability to recall recent events, repeated speech. Head magnetic resonance suggested right fornix column infarction and diffusion tensor imaging showed reduction of right fornix fiber bundles. The symptoms improved significantly after conventional treatment of cerebral infarction and improving intelligence treatment.

Ceguera cortical y amnesia global transitoria luego de arteriografía con iopamidol en miembro superior / Transient cortex blindness and global amnesia after performing left arm arteriography using iopamidol

RESUMEN Los medios de contraste iodados pueden presentar diferentes efectos adversos, siendo los más frecuentes daño renal y reacciones de hipersensibilidad. La ceguera cortical y amnesia global transitoria son complicaciones neurológicas raras descritas tras la administración de medios de contraste. Reportamos el caso de un paciente de 63 años, hipertenso que acude por cianosis, frialdad del segundo y tercer dedo de mano izquierda. Es sometido a arteriografía de miembro superior, usando 50 mL de iopamidol e inmediatamente desarrolla cefalea occipital asociada a visión borrosa bilateral que progresa rápidamente a ceguera; la tomografía cerebral reveló hiperdensidades subaracnoideas occipitales, sin efecto de masa. A las dieciocho horas del evento, el paciente presenta amnesia anterógrada con persistencia de amaurosis. Su tomografía cerebral de control no muestra trastornos focales. El paciente cursa con evolución favorable, la amaurosis bilateral y la cefalea ceden a las treinta horas del evento y es dado de alta sin mayores eventualidades a los diez días.

ABSTRACT Iodinated contrast substances may cause different adverse events, most frequently renal involvement and hypersensitivity reactions. Transient cortical blindness and global amnesia are rarely described neurological complications after the administration of contrast substances. We report the case of a 63-year old patient with high blood pressure who presented with cyanosis and cold sensation affecting the second and third digits of his left hand. The patient underwent an arteriography of the left arm, where 50-mL of iopamidol was used as a contrast substance, and he immediately developed occipital headache associated to bilateral blurred vision that rapidly progressed to blindness. A cerebral computed tomography (CT) scan showed occipital subarachnoid hypodense areas, with no mass effect. Eighteen hours after the event, the patient showed retrograde amnesia with persistent amaurosis. His control cerebral CT scan did now show any focal disorder. The patient had a good progression, both bilateral amaurosis and headache subsided thirty hours after the event, and the patient was uneventfully discharged after ten days.

Alleged amnesia in sexual crime / Alegação de amnésia em crime sexual

ABSTRACT The current article describes the case of a man who claimed amnesia in relation to a sexual crime he had allegedly committed. Psychiatric examination concluded that the individual was feigning amnesia. Claimed amnesia of a criminal offense is one of the most commonly feigned symptoms in the forensic medical setting. It is thus necessary to rule out organic or psychogenic causes of amnesia and always consider feigned amnesia in the presence of psychopathological alterations that do not reflect classically known syndromes.

RESUMO O presente artigo descreve o caso de um homem que alegou amnésia ao fato da denúncia de crime sexual que lhe foi imputada. A perícia psiquiátrica concluiu tratar-se de simulação. A alegação de amnésia da ofensa criminosa é um dos sintomas mais comumente simulados no ambiente pericial. Portanto, devem-se excluir as causas de amnésia orgânica ou psicogênica e sempre considerar a amnésia simulada na presença de alterações psicopatológicas que não configuram quadros sindrômicos classicamente conhecidos.

Dor psicopatológica antes do desenvolvimento da doença de Alzheimer / Psychopathological pain before the development of Alzheimer's disease / Dolor psicopatológico antes del desarrollo de la enfermedad de Alzheimer

Objetivo: identificar a causa da dor psicopatológica antes do desenvolvimento da doença de Alzheimer. Método: estudo observacional e descritivo, do tipo relato de experiência, realizado no Hospital Escola Portugal Ramalho, entre 2016 e 2019. Agrupou-se os pacientes conforme as causas dos tipos de esquecimento, com construção de gráficos, de acordo com as principais teorias acerca da gênese da doença de Alzheimer. Resultados: os grupos de pacientes foram submetidos à anamnese e ao teste de Folstein. Percebeu-se que os tratamentos dependem se a amnésia é relacionada ao humor; se ocorre por sequelas vasculares e endocrinológicas; ou pacientes com demência de Alzheimer diagnosticada. Conclusão: a causa da dor psicopatológica se baseia no esquecimento involuntário que gera a não aceitação ou no medo de relembrar situações traumáticas. Embora essas causas variam de acordo com as hipóteses que levam ao dano cognitivo e mnêmico.

Objective: to identify the cause of psychopathological pain before the development of Alzheimer's disease. Method: observational and descriptive study, experience report type, carried out at the Portugal Ramalho Teaching Hospital, between 2016 and 2019. The patients were grouped according to the causes of the types of forgetfulness, with construction of graphs, according to the main theories about the genesis of Alzheimer's disease. Results: the groups of patients were submitted to anamnesis and Folstein's test. It was noticed that the treatments depend on whether the amnesia is related to mood; if it occurs due to vascular and endocrinological sequelae; or patients with diagnosed Alzheimer's dementia. Conclusion: the cause of psychopathological pain is based on involuntary forgetfulness that generates non-acceptance or on the fear of remembering traumatic situations. However these causes vary according to the hypotheses that lead to cognitive and mnemic damage.

Comparisonof early joint amnesia degree after posterior cruciate-retaining and posterior stabilized total knee arthroplasty / 中国组织工程研究

BACKGROUND: Clinical long-term follow-up showed that there is no obvious difference in knee range of motion, 10-15 year prosthesis survival rate, and main clinical manifestations after replacement of posterior cruciate-retaining and posterior stabilized prostheses. However, the debate over the superiority and inferiority of the two knee prostheses remains. OBJECTIVE: To compare the differences of early functional recovery of patients with unilateral knee osteoarthritis after posterior cruciate-retaining and posterior stabilized prosthesis replacement. METHODS: A total of 60 patients with knee osteoarthritis admitted to the First Affiliated Hospital of Anhui Medical University from July 2018 to September 2019 were selected, including 13 males and 47 females, aged 46-83 years old. Of them, 30 patients received posterior cruciate-retaining prosthesis replacement, and 30 patients received posterior stabilized prosthesis replacement. At 3 months after operation and at the last follow-up, joint amnesia score, knee function HSS score, visual analogue scale score, and knee motion range were assessed. The study was approved by the Ethics Committee of the First Affiliated Hospital of Anhui Medical University. RESULTS AND CONCLUSION: (1) Sixty patients were followed up for 5-16 months, and no complications such as periprosthetic infection, loosening, dislocation, or stiffness occurred during the follow-up. (2) At 3 months after surgery and at the last follow-up, joint amnesia score, HSS scores, visual analogue scores, and knee motion range were not significantly different between the two groups (P > 0.05). (3) The results showed that joint amnesia score was not significantly different in early stage after the posterior cruciate-retaining and posterior stabilized prosthesis replacement for unilateral knee osthoarthritis.

The association between post traumatic amnesia and visual photosensitivity in mild traumatic brain injury

Background: Visual symptoms are a common occurrence following mTBI. Among visual symptoms, Visual photosensitivity is a frequent manifestation post mTBI, which can disrupt the normal lifestyle of any individual resulting in social and professional distress. Post traumatic amnesia is one of the markers of severity in mTBI. Authors have studied the association between visual photosensitivity and post traumatic amnesia following mTBI. The aim of this study is to find out the association between Visual Photosensitivity and post traumatic amnesia in patients with mild traumatic brain injury.Methods: Hospital based prospective, analytical, observational study. A total of 300 patients with the diagnosis of mTBI were studied. Diagnosis of mTBI was based on the WHO Operational criteria for clinical identification of mTBI.VLSQ-8 Questionnaire was used in this study to diagnose and monitor the progress of visual photosensitivity in patients with mTBI. The Galveston Orientation and Amnesia Test (GOAT) was applied to assess post traumatic amnesia. The study period was from July 2017 to March 2019. Each patient with mTBI who developed visual photosensitivity was followed up for 1 year after the appearance of their symptoms.Results: Thus the main observations of this study were (i) There is a strong possibility of developing visual photosensitivity among the group of patients who presented with the history of post traumatic amnesia following mild traumatic brain injury (p=0.0008)(ii) if a patient with mild traumatic brain injury suffers from visual photosensitivity, possibility of his/her symptoms persisting beyond 6 months increases significantly if there is history of post traumatic amnesia (p=0.0001).Conclusions: This result will help in providing information regarding prognosis of visual photosensitivity following mild traumatic brain injury.

Modafinil and Learning and Memory- Is there a Connection? Evaluation of the Effect of Modafinil on Learning and Memory in Wistar Rats

Background: Modafinil, a drug approved for use innarcolepsy, has shown conflicting effects on cognition.This study was conducted to observe the effects ofModafinil on learning and memory following acute andchronic administration in Wistar rats. Aim andObjectives: To observe the effects of Modafinil onlearning and memory following acute and chronicadministration. Material and Methods: The studyconducted in 42 male Wistar rats, had seven groups:Group I: Control, Group II: Negative Control(Vehicle), Group III: Standard Control (Donepezil),Group IV: Chronic Modafinil 10 mg/kg, Group V:Chronic Modafinil 20 mg/kg, Group VI: AcuteModafinil 10 mg/kg, Group VII: Acute Modafinil 10mg/kg. All drugs were administered for 15 days.th Scopolamine was used to induce amnesia on the 15day in all groups except Group I. Using the HebbWilliam maze, baseline learning score was recorded onday 1, and post-treatment learning scores wererecorded on days 15 and 16. Results: On days 15 and16, the learning scores significantly decreased in GroupI, while it significantly increased in group II, comparedto baseline, indicating induction of amnesia byscopolamine. In Group III the learning scores on days15 and 16 (8.66 ± 2.63, 9.66 ± 2.75, in seconds) weredecreased significantly compared to baseline (18.83 ±2.65), indicating a reversal of scopolamine-inducedamnesia. All doses of Modafinil (Acute 10 mg and 20mg/kg, Chronic 10 mg and 20 mg/kg) showed astatistically significant increase in learning scores ondays 15 and 16, compared to baseline, indicating noreversal of scopolamine-induced amnesia. Conclusion:Modafinil in doses of 10 mg/kg and 20 mg/kg, giveneither as a single dose or over a period of time, does notreverse amnesia induced by scopolamine in rats.

Optimization of magnetic resonance imaging protocol for the diagnosis of transient global amnesia / Otimização do protocolo de ressonância magnética para o diagnóstico por imagem da amnésia global transitória

Abstract Objective: To emphasize the most appropriate magnetic resonance imaging (MRI) diffusion protocol for the detection of lesions that cause transient global amnesia, in order to perform an accurate examination, as well as to determine the ideal time point after the onset of symptoms to perform the examination. Materials and Methods: We evaluated five patients with a diagnosis of transient global amnesia treated between 2012 and 2015. We analyzed demographic characteristics, clinical data, symptom onset, diffusion techniques, and radiological findings. Examination techniques included a standard diffusion sequence (b value = 1000 s/mm2; slice thickness = 5 mm) and a optimized diffusion sequence (b value = 2000 s/mm2; slice thickness = 3 mm). Results: Brain MRI was performed at 24 h or 36 h after symptom onset, except in one patient, in whom it was performed at 12 h after (at which point no changes were seen) and repeated at 36 h after symptom onset (at which point it showed alterations in the right hippocampus). The standard and optimized diffusion sequences were both able to demonstrate focal changes in the hippocampi in all of the patients but one, in whom the changes were demonstrated only in the optimized sequence. Conclusion: MRI can confirm a clinical hypothesis of transient global amnesia. Knowledge of the optimal diffusion parameters and the ideal timing of diffusion-weighted imaging (> 24 h after symptom onset) are essential to improving diagnostic efficiency.

Resumo Objetivo: Enfatizar o protocolo de difusão mais adequado para detecção de lesões da amnésia global transitória, a fim de realizar um exame preciso, em tempo ideal, após o início dos sintomas. Materiais e Métodos: Foram analisados cinco pacientes com diagnóstico de amnésia global transitória atendidos entre 2012 e 2015, considerando-se dados demográficos, clínicos, tempo do início dos sintomas, técnicas de difusão e achados radiológicos. As técnicas incluíram uma sequência de difusão padrão (b = 1000 s/mm2; espessura do corte = 5 mm) e uma sequência de difusão otimizada (b = 2000 s/mm2; espessura de corte = 3 mm). Resultados: A ressonância magnética de encéfalo foi realizada após 24 ou 36 horas do início dos sintomas, exceto em um paciente, em que foi realizada após 12 horas (sem alterações) e repetida após 36 horas (mostrando alterações hipocampais). Em todos os pacientes foram demonstradas alterações focais na difusão no hipocampo em ambas as técnicas, exceto em um paciente, em que as alterações foram demonstradas apenas na sequência otimizada. Conclusão: A ressonância magnética é capaz de confirmar a hipótese clínica de amnésia global transitória. O conhecimento dos parâmetros ótimos da técnica de difusão e o melhor tempo para a detecção das alterações (> 24 horas) são essenciais para aprimorar a eficiência diagnóstica.

Benzodiazepine premedication in general anaesthesia: a clinical comparative study

Background:The main aims of pre-anaesthetic medication are anxiolysis, analgesia, anti-emesis and reducing perioperative patient risk. Producing a state of amnesia for pre and post-operative events is desired by all. This study has been undertaken to evaluate the role of three of the benzodiazepines i.e. diazepam, lorazepam and midazolam during general anaesthesia, in providing anxiolysis, sedation and amnesia.Methods:The study included patients with ASA grade I and ASA grade II physical status of both sexes, age ranging between 18-60 years. Patients were divided into three groups of thirty patients each, every group receiving intramuscular injections of diazepam 0.1 mg/kg body weight, lorazepam 0.07 mg/kg body weight and midazolam0.08 mg/kg body weight respectively; 45 minutes prior to induction of general anaesthesia. Anxiety assessment before premedication along with assessment of sedation after premedication was done.Results:Before premedication the mean values of pulse rate, blood pressure and respiratory rate were not significantly different among the three groups (p>0.05). Maximum changes in these parameters were observed with Midazolam followed by lorazepam and diazepam. The dose of thiopentone used as inducing agent was also lowered significantly in case of midazolam (p<0.05). One patient in midazolam group showed respiratory depression whereas four patients receiving lorazepam and diazepam showed delayed recovery and prolonged sedation, but the effects were self-limiting. Conclusions: Midazolam offers the maximum advantage in allaying anxiety and providing excellent sedation and amnesia during general anaesthesia and proves to be the most suitable premedicant before general anaesthesia.

Transient global amnesia associated with sildenafil use: report of one case / Amnesia global transitoria asociada al uso de sildenafil: informe de un caso

ABSTRACT A 69 years old male with erectile dysfunction lasting 2 years, took 50 mg of sildenafil for having sex with his wife at about 6 o'clock in the morning. One hour later his wife detected that he had an anterograde memory impairment: this was interpreted as a confusional state. The neurological examination suggested a transient global amnesia (TGA). EEG and cerebral magnetic resonance imaging were non-informative and memory deficits resolved within 24 h. Therefore, a TGA was diagnosed. Since no other trigger was detectable, sildenafil was deemed responsible for its occurrence,

Se reporta el caso de un individuo de sexo masculino de 69 años con disfunción eréctil, que ingiere 50 mg de sildenafil con objetivo de facilitar el mantener relaciones sexuales con su esposa. Una hora después, su esposa nota que su marido presenta una alteración de su memoria anterógrada, lo que fue interpretado como un estado confusional. Evaluado clínicamente su examen neurológico es sugerente de una amnesia transitoria anterógrada. El EEG y las imágenes por resonancia magnética no muestran hallazgos significativos y el déficit de memoria remite dentro de 24 h. en vista de su evolución, se diagnostica una amnesia global transitoria. Como no se identifica otro gatillante, se consideró que el cuadro fue causado por sildenafil..

Amnesia en el embarazo / Amnesia in Pregnancy

La memoria es la capacidad para aprender, organizar y fijar eventos de nuestro pasado y se encuentra íntimamente ligado a la función de la atención. Es capaz de guardar datos a través de mecanismos ultra complejos que se desarrollan en tres etapas: codificación, almacenamiento y evocación. La presencia de la amnesia impide que esta capacidad se desarrolle adecuadamente. La amnesia ocurre cuando se comprueba que alguien ha perdido o tiene debilitada la memoria. Hay varias causas de pérdida de la memoria, como ha sido señalado, por ejemplo, en la etapa del climaterio y la menopausia donde este aspecto es considerado para clasificar la intensidad del síndrome climatérico que se presenta con frecuencia en esta etapa. La persona que sufre este trastorno no es capaz de almacenar ni de recuperar información recibida con anticipación, ya sea por motivos orgánicos o funcionales. La amnesia (del griego ἀμνησία amnesia, olvido) es la pérdida parcial o completa de la memoria. Sus causas son orgánicas o funcionales. Muchas mujeres, cuando se encuentran embarazadas experimentan una pérdida parcial de memoria a corto plazo conocida como amnesia del embarazo, mumnecia, o lo que los anglosajones suelen llamar placenta's brain (cerebro de placenta). Durante el embarazo, las fluctuaciones hormonales que experimenta la mujer producen cambios en la actividad cerebral, provocando una pérdida parcial de memoria a corto plazo. Sobre este aspecto abordaremos el estado actual que hay sobre este tema(AU)

Memory is the capacity to learn, organize and fix events of our past and is intimately linked to the function of attention. It is capable of saving data through ultra-complex mechanisms that are developed in three stages: coding, storage and evocation. The presence of amnesia prevents this ability from developing properly. Amnesia occurs when it is proven that someone has lost or has weakened memory. There are several causes of memory loss, as has been pointed out, for example, in the climacteric stage and menopause where this aspect is considered to classify the intensity of the climacteric syndrome that frequently occurs in this stage. The person suffering from this disorder is not able to store or retrieve information received in advance, for organic or functional reasons. Amnesia (from Greek ἀμνησία amnesia, forgetfulness) is the partial or complete loss of memory. Many pregnant women experience a partial loss of short-term memory known as pregnancy amnesia, mumnecia, or placenta's brain as the Anglo-Saxons usually call it. During pregnancy, the hormonal fluctuations experienced by women produce changes in brain activity, causing partial loss of short-term memory. On this aspect, we will address the status on this topic(AU)

Transient global amnesia: clinical features and prognostic factors suggesting recurrence / Amnesia global transitoria: características clínicas y factores pronósticos sugestivos de recurrencia

ABSTRACT The risk of recurrence of new amnesia events in patients having previously experienced transient global amnesia (TGA) ranges between 2.9-23.8%. Objective: Our objective was to search for recurrence predictors in TGA patients. Methods: Retrospective analysis to identify recurrence predictors in a cohort of 203 TGA patients from a single center in Buenos Aires, Argentina, diagnosed between January 2011 and March 2017 Clinical features and complementary studies (laboratory results, jugular vein Doppler ultrasound and brain MRI) were analyzed. Comparison between patients with recurrent versus single episode TGA was performed, applying a multivariate logistic regression model. Results: Mean age at presentation was 65 years (20-84); 52% were female. Median time elapsed between symptom onset and ER visit was two hours, with the average episode duration lasting four hours. Mean follow-up was 22 months. Sixty-six percent of patients referred to an identifiable trigger. Jugular reflux was present in 66% of patients; and 22% showed images with hippocampus restriction on diffusion-weighted MRI. Eight percent of patients had TGA recurrence. Patients with recurrent TGA had a more frequent history of migraine than patients without recurrence (37.5% vs. 14%; p = 0.03). None of the other clinical characteristics and complementary studies were predictors of increased risk of recurrence. Conclusions: Patients with migraine may have a higher risk of recurrent TGA. None of the other clinical characteristics evaluated allowed us to predict an increased risk of recurrence. Although the complementary studies allowed us to guide the diagnosis, they did not appear to have a significant impact on the prediction of recurrence risk.

RESUMEN El riesgo de recurrencia de nuevos eventos de amnesia en pacientes que han experimentado previamente Amnesia Global Transitoria (AGT) oscila entre el 2.9-23.8%. Objetivo: Nuestro objetivo fue buscar predictores de recurrencia en pacientes con AGT. Métodos: Análisis retrospectivo de una cohorte de 203 pacientes con AGT de un único centro en Buenos Aires, Argentina, diagnosticados entre enero-2011 y marzo-2017 Se analizaron las características clínicas y los estudios complementarios (laboratorio, Doppler de vena yugular y RM encéfalo). Se comparó el grupo de AGT recurrente versus episodio único, aplicando un modelo de regresión logística multivariada. Resultados: la edad promedio de presentación fue de 65 años (20-84); 52% mujeres. La mediana del tiempo transcurrido entre el inicio de los síntomas y la visita a la sala de emergencia fue de 2 horas, con una duración promedio del episodio de 4 horas. El seguimiento medio fue de 22 meses. 66% de los pacientes tuvieron un desencadenante identificable. El reflujo yugular estuvo presente en el 66% de los pacientes y el 22% mostró imágenes restrictivas en DWI a nivel hipocampal. 8% de los pacientes presentaron recurrencia. Los pacientes con AGT recurrente tuvieron un historial de migraña más frecuente (37.5% vs. 14%; p=0.03). Ninguna de las otras características clínicas y estudios complementarios fueron predictores de mayor riesgo de recurrencia. Conclusiones: los pacientes con migraña pueden tener un mayor riesgo de recurrencia de AGT. Ninguna de las otras características clínicas evaluadas nos permitió predecir un mayor riesgo de recurrencia. Aunque los estudios complementarios nos permitieron orientar el diagnóstico, no pareció tener un impacto significativo en la predicción del riesgo de recurrencia.

Impaired Smooth Pursuit During Transient Global Amnesia

BACKGROUND AND PURPOSE: During transient global amnesia (TGA), selective impairment of episodic memory is assumed to occur due to alteration in the neuronal network between the hippocampus and parietooccipital cortices that also include a hub for smooth pursuit (SP) eye movements. This study aimed to determine whether SP is impaired during TGA, and to identify any anatomical and functional linkage present between the oculomotor and memory systems. METHODS: Within a median of 1.0 day of TGA, horizontal SP was evaluated in 145 patients with a target moving at peak velocities of 10°/s and 20°/s. The average SP gains of patients were compared with those of the age-matched controls. RESULTS: The patients with TGA showed lower SP gains in both directions for both peak target velocities. While the normal controls showed symmetric SP in the rightward and leftward directions, in the TGA patients the SP gain was lower during rightward than leftward SP regardless of bilaterality or the side of the lesions. CONCLUSIONS: The cortical regions processing information about visual motion appeared to be affected during or soon after an amnestic episode of TGA, and more so in the right hemisphere. This means that disturbed processing of dynamic visual information may be related to the impaired spatial orientation observed during TGA.

Difference in Cognitive Function by First Onset Age of Alcohol Induced Blackout and Its Duration

OBJECTIVE: Alcohol-induced blackout (blackout) is a typical early symptom of cognitive impairment caused by drinking. However, the first onset age of blackout or the duration after onset of blackout has not been directly compared in previous studies. The purpose of this study was to investigate the differences in cognitive function to the first start age of blackouts and their duration. METHODS: Thirty-one male subjects were included in this study. Their age at the first blackout and the duration after the onset of blackout were investigated. Neuropsychological tests were conducted to determine their attention, memory, and executive function. Subjects were divided into three groups according to their age of the first onset blackout (group O1, 40 years). Subjects were also divided into three groups by duration after the onset of blackout (P1, 30 years). We then examined differences in neurocognitive function among these groups. RESULTS: O1 tended to have a lower memory score than O2 (F = 3.28, p = 0.053). Significant differences were observed in attention and executive function between groups P1 and P3 (Digit Span_backward: F = 6.07, p < 0.05; visual span_forward: F = 4.19, p < 0.05; executive intelligence quotient: F = 3.55, p < 0.05). CONCLUSION: Greater memory impairment was detected in subjects having an earlier age of the first blackout. The longer the duration after the onset of blackout, the more impaired their attention and executive function skills.

Homotopic functional connectivity in patients with amnestic mild cognitive impairment / 中国医学影像技术

Objective: To observe interhemispheric and interregional resting-state functional connectivity using voxel-mirrored homotopic connectivity (VMHC) in patients with amnestic mild cognitive impairment (aMCI). Methods Totally 47 aMCI patients (aMCI group) and 43 gender, age and education matched normal controls (control group) were enrolled. The cranial structural MRI and resting-state fMRI data were collected. VMHC between both groups were compared to obtain the brain areas with altered VMHC. Using the altered VMHC areas as ROIs, the functional connectivity to the whole brain areas was calculated to observe the brain areas with different functional connection. Correlation analysis was performed between altered functional connection and neurocognitive scores. Results aMCI patients showed decreased inter-hemispheric VMHC primarily at bilateral inferior frontal gyrus, anterior insula and putamen. No area showed increased VMHC was found in aMCI patients. In aMCI patients, the functional connection of anterior insula to default mode network (DMN) regions including the posterior cingulate cortex (PCC) and the medial prefrontal cortex (MPFC) increased, and to attention control network and cerebellum decreased, and the functional connection of the left anterior insula to PCC and MPFC was positively correlated with recognition scores of auditory verbal learning test (r=0.38, 0.33, both P<0.05). Conclusion aMCI patients show deficits in inter-hemispheric VMHC and altered functional connection between different brain networks, suggesting an important new avenue for better understanding of the nature of cognitive changes in patients with aMCI.

Amnesia anterógrada debida a lesión bilateral de los hipocampos en un paciente probablemente intoxicado con metanol / Anterograde amnesia due to bilateral lesion of the hippocampus in a patient probably intoxicated with metanol

RESUMEN Se presenta el caso clínico de un hombre de 56 años que ingresó con un cuadro agudo de alteración de la conciencia luego de intoxicación alcohólica. Durante su hospitalización se evidenció alteración de la memoria anterógrada y neuropatía óptica derecha. Las imágenes diagnósticas demostraron lesiones bilaterales de los hipocampos, globos pálidos y corteza cerebral frontal paramediana. La evaluación neuropsicológica confirmó una grave amnesia anterógrada que mejoró muy poco al cabo de 2 años de seguimiento. A pesar de la falta de confirmación por el laboratorio, las manifestaciones clínicas y las imágenes están a favor de una intoxicación por metanol. Se llama la atención sobre esta rara presentación clínica.

SUMMARY We report the case of a 56-year-old man who was hospitalized because acute altered consciousness after alcoholic intoxication. During his hospitalization, there was observed an alteration of anterograde memory and right optic neuropathy. Diagnostic images showed bilateral lesions of the hippocampus, globus pallidus and paramedian cerebral frontal cortex. The neuropsychological evaluation confirmed a severe anterograde amnesia that barely improved after 2 years of follow up. Despite the lack of confirmation by the laboratory, the clinical manifestations and imaging results are in favor of methanol intoxication. Attention is drawn to this rare clinical presentation.