ABSTRACT
Secondary localized cutaneous amyloidosis appears in association with a variety of inflammatory skin diseases and skin tumors. The presence of dermal amyloid deposits in lesions of porokeratosis has rarely been described in the literature. We describe a Korean case of disseminated superficial porokeratosis, with clear histologic evidence of amyloid deposition in the upper dermis.
Subject(s)
Amyloid , Amyloidosis , Dermis , Plaque, Amyloid , Porokeratosis , Skin , Skin DiseasesABSTRACT
Objective To investigate the effects of A? subunit vaccine immunization on amyloid plaques and behavioural impairment in Tg2576 mice. Methods Twenty-four Tg2576 mice were randomly divided into A?-(1-15) group,A?-(36-42) group,A?-(42) group and control group.Tg2576 mice were inoculated by corresponding vaccine in 9 month old.Indirect ELISA was used to assay antibody against A?-(42) in the serum and homogenate of brain.The method of immunohistochemical staining was performed to observe deposition of amyloid plaques and using method of Morris water maze to test mouse's learning and memory.Histochemical staining was used to observe the morphology of brain,liver,spleen,lung and kidney to assess safety of subunit vaccine. Results After the second inoculating,antibody against A?-(42) began to develop in experimental group mice.The titer increased with inoculating times.Once the inoculating was stopped,the titer of antibody was decreased.The low titer of antibody against A?-(42) could be also detected in supernatant of homogenated brain.After six month inoculating,amyloid deposition in cortex and hippocampi were significantly reduced in A?-(42),A?-(1-15) and A?-(36-42) group.Compared with control group,they were greatly decreased in experimental groups(P0.05).The effect of A?-(1-15) subunit vaccine had more superior than that of A?-(36-42) vaccine(P