ABSTRACT
Objective To observe the influence of Ligustrazine on the hemodynamic effects and prognosis in elderly patients with early cerebral ischemia following intracranial aneurysm operation ,and explore the therapeutic value .Methods 43 elderly patients with ECI following intracranial aneurysm operation were randomly divided into the Ligustrazine group (20 cases) ,and the conven-tional treatment group(23 cases)according to the table of random numbers .The patients in the Ligustrazine group were given intra-venously Ligustrazine injection and combined with conventional therapy ,whereas ,other patients were given conventional treat-ments .Results The clinical effective rate in Ligustrazine group was significantly higher than conventional treatment group (P<0 .05) .Patients recovered well in conventional treatment group were 7 cases(30 .43% ) ,mild disability 8 cases(34 .78% ) ,severe dis-ability 4 cases(17 .39% ) ,plant survival 1 case(4 .34% ) ,3 cases died(13 .06% ) ,data peer-based in the Ligustrazine group were 12 cases(60 .00% ) ,5 cases(25 .00% ) ,2 cases(10 .00% ) ,0 case and 1 case(5 .00% ) ,which were significantly lower than that of con-ventional treatment group .The prognostic scores in Ligustrazine group were apparently higher than conventional treatment group by using Glasgow outcome scale and Chinese stroke scale(P<0 .05) .Meanwhile ,the indicators of hemodynamic effects also reflec-ted that the Ligustrazine improved the blood circulation of patients with ECI ,which was better than the conventional treatment group(P<0 .05) .Conclusion The Ligustrazine Phosphate for injection showed better curative effect and prognosis in elderly pa-tients with ECI following intracranial aneurysm operation .
ABSTRACT
Global orbital infarction is a rare disorder resulting from ischemia of the intraocular and intraorbital structures due to hypoperfusion of the ophthalmic artery and its branches. The syndrome can occur with common carotid artery occlusion, orbital mucormycosis, giant cell arteritis and complications of surgery and manifests protosis, ophthalmoplegia, and blindness. Protrusion of the eyeball(proptosis) is the result of expansion of tissue within orbital cavity and is the hallmark of orbital diseases. Expansion lesions may be benign or malignant and may arise from bone, muscle, nerve, blood vessel, or connective tissue. We report a case of combined ophthalmic artery occlusion, optic neuropathy, and third nerve palsy involving pupil in a 32-year-old patient with unilateral idiopathic proptosis following anterior choroidal aneurysm operation, and discuss possible mechanism with literature review.
Subject(s)
Adult , Humans , Aneurysm , Blindness , Blood Vessels , Carotid Artery, Common , Choroid , Connective Tissue , Exophthalmos , Giant Cell Arteritis , Infarction , Intracranial Aneurysm , Ischemia , Mucormycosis , Oculomotor Nerve Diseases , Ophthalmic Artery , Ophthalmoplegia , Optic Nerve Diseases , Orbit , Orbital Diseases , PupilABSTRACT
Somatosensory evoked potentials(SEPs) in response to median nerve stimulation have been recorded as a guide to cortical function during temporary occlusion of the parent vessels in the treatment of 27 aneurysms of middle cerebral artery and internal carotid artery. The central conduction time(CCT), the time between the N14 peak and the N20 peak, were preserved for variable times during temporary occlusion, ranging from no significant change after 18 minutes of occlusion to disappearance of the N20 after 2 minutes. The rapid disappearance of N20 within three minutes after temporary occlusion was observed in all three cases which was developed new postoperative neurological deficits, neither permanent, and in one case of death. The total arterial occlusion time of each of these postoperative deficit cases was no longer than 20 minutes and the shortest time was 12 minutes. The rapid loss of the cortical wave after temporary occlusion, therefore, suggests the safty duration of the temporary occlusion would be short. Monitoring of the SEPs during intracranial aneurysm surgery can help the surgeon in the management of proximal vessel control and reduce the morbidity of aneurysm operation.
Subject(s)
Humans , Aneurysm , Carotid Artery, Internal , Evoked Potentials , Evoked Potentials, Somatosensory , Intracranial Aneurysm , Median Nerve , Middle Cerebral Artery , Monitoring, Intraoperative , ParentsABSTRACT
Somatosensory evoked potentials(SEPs) in response to median nerve stimulation have been recorded as a guide to cortical function during temporary occlusion of the parent vessels in the treatment of 27 aneurysms of middle cerebral artery and internal carotid artery. The central conduction time(CCT), the time between the N14 peak and the N20 peak, were preserved for variable times during temporary occlusion, ranging from no significant change after 18 minutes of occlusion to disappearance of the N20 after 2 minutes. The rapid disappearance of N20 within three minutes after temporary occlusion was observed in all three cases which was developed new postoperative neurological deficits, neither permanent, and in one case of death. The total arterial occlusion time of each of these postoperative deficit cases was no longer than 20 minutes and the shortest time was 12 minutes. The rapid loss of the cortical wave after temporary occlusion, therefore, suggests the safty duration of the temporary occlusion would be short. Monitoring of the SEPs during intracranial aneurysm surgery can help the surgeon in the management of proximal vessel control and reduce the morbidity of aneurysm operation.