Angiomiofibroblastoma vulvoperineal, presentación de un caso / Vulvoperineal angiomyofibroblatoma, a case report

An angiomyofibroblastoma is a benign tumor that may present itself in the genital tract of a reproductive age woman. Despite it being a benign neoplasia, unable to be invasive, it can reach large sizes, producing discomfort, pain, and anatomical deformation. A late diagnosis may result in increased surgical difficulty for resection. The following is the clinical case of a woman with a vulvo-perineal tumor of 6 years of evolution, with a final diagnosis of angiomyofibroblastoma, in which complete resection of the lesion was achieved with good cosmetic results. The highlight of this tumor is its slow, silent, but progressive growth, leading to diagnoses that are often confused and late, with a consequent delay in treatment. Among the common differential diagnoses are the Bartholin gland cyst and the aggressive angiomyxoma.

El angiomiofibroblastoma es un tumor benigno que puede presentarse en el tracto genital de la mujer en edad reproductiva. A pesar de ser una neoplasia benigna, sin capacidad invasora, puede alcanzar grandes tamaños, produciendo molestia, dolor y alteración importante de la anatomía. Si el diagnóstico es tardío, aumenta la dificultad quirúrgica en su resección. A continuación, se presenta el caso clínico de una mujer con un tumor vulvoperineal de 6 años de evolución, con diagnóstico final de angiomiofibroblastoma, en el que se logró la resección completa de la lesión con un buen resultado estético. La importancia de este tumor está dada por su crecimiento lento, silencioso, pero progresivo, llevando a que su diagnóstico sea en muchas ocasiones confuso y tardío, con el consecuente retraso en el tratamiento. Dentro de los diagnósticos diferenciales comunes se encuentran el quiste de la glándula de Bartholino y el angiomixoma agresivo.

Angiomyofibroblastoma of scalp: a rare soft tissue tumour at an unusual site

Angimyofibroblastoma is a very rare, benign mesenchymal soft tissue tumour which involves the vulvovaginal area of females of reproductive age group. These tumours are usually slow growing and painless which has a very low tendency for local recurrence. In women it is common in female genital tract, vulva, and posterior perivesical space. In men it occurs in spermatic cord. Here a report of 47 year old male patient from VMKV Medical College and Hospital, Salem was presented with a swelling in the posterior aspect of scalp from 6 months with no any associated symptoms. A preoperative diagnosis of dermoid scalp was made and patient was subjected for excision.

Angiomyofibroblastoma of the vulva: A diagnostic dilemma / Philippine Journal of Obstetrics and Gynecology

@#Angiomyofibroblastoma (AMFB) is a rare, benign, well-circumscribed mesenchymal soft tissue neoplasm redominantly occurring in the vulvovaginal region among women of reproductive age (35-45 years old). Histologically, it is characterized by presence of alternating hypo and hypercellular areas containing spindle and round stromal cells admixed with blood vessels. At present, there are 137 cases reported since it was first described in 1992. Currently, there are no published cases of Angiomyofibroblastoma in the Philippines. This is a case report of a 31 year old, nulligravid patient who presented with unilateral labial enlargement which was noted to be painless and slow growing. The initial impression was that of a benign tumor of the labia. The mass was excised and histopathologic results were consistent with the microscopic findings of Angiomyofibroblastoma. Simple excision of the mass is the only treatment, as in this case, and is noted to have extremely low rate of recurrence. The clinical importance to distinguish this unusual neoplasm from Aggressive Angiomyxoma and other mesenchymal malignant neoplasm with metastatic potential should be emphasized for appropriate management.

Concurrent Utero-Vaginal Prolapse with Cervical Angiomyofibroblastoma: A Rare Disease with Distinct Entity

We report the case of a rare, benign mesenchymal tumour arising from the cervix. A 53-year-old post-menopausal woman presented with mass per vagina. Examination revealed stage 2 utero-vaginal prolapse and multiple elongated polyps seen at the cervix. She underwent local excision. Histopathological examination findings and the immunohistochemical studies were consistent with Angiomyofibroblastoma.

Angiomyofibroblastoma of the vulva

Angiomyofibroblastoma (AMFB) is an uncommon benign mesenchymal tumor. AMFB occurs almost in the vulvo-vaginal area of women. The gross features of AMFB are well-circumscribed so it clinically is often thought as Bartholin gland cyst or aggressive angiomyxoma. Usually, most tumors grow slowly, and patients do not feel pain. It also has low tendency for local recurrence. The histologic findings of the tumors are abundant thin-walled blood vessels with hypocellular and hypercellular areas. Almost all tumor cells have immunoreactivity for both desmin and vimentin. It also has estrogen and/or progesterone receptors, but staining for cytokeratin is negative. Here is a case of AMFB of the vulva occurring in a 40-year-old woman, involving the right labia majora. The patient described that her vulva mass grew in about few months. The maximum dimension of the tumor was measured as 2 cm, and we resected the tumor one month after as her second visit.

Lipomatous variant of angiomyofibroblastoma on the vulva: A case report / 대한산부인과학회지

Lipomatous variant of angiomyofibroblastoma is a rare tumor of the vulva. Most of cases are usually premenopausal and present with a slowly growing mass without pain. A 46-year-old woman presented with a swelling of the left labium major. The lesion was thought to be a Batholin's gland cyst or a lipoma preoperatively and a local excision was performed. The tumor was well demarcated and rubbery. On microscopic examination, the alternating hypercellular and edematous hypocellular component with abundant vessels was noted. A large amount of adipose tissue was scattered in the lesion. Stromal cells were positive for vimentin, estrogen receptor, and progesterone receptor and negative for desmin antibody immunostaining. The local excision was enough for complete treatment. No recurrence was noted for 7 months after surgery.

Angiomyofibroblastoma Arising from the Posterior Perivesical Space: a Case Report with MR Findings

Angiomyofibroblastoma is a rare benign soft tissue neoplasm that predominantly occurs in the genital region of middle-aged women. We present a case of an angiomyofibroblastoma that involved the posterior perivesical space in a 48-year-old woman. We have documented the magnetic resonance imaging features of this case.

A Case of Vaginal Angiomyofibroblastoma / 대한산부인과학회지

Angiomyofibroblastoma is an uncommon mesenchymal tumor and was first described by Fletcher as a well-circumscribed, benign subcutaneous vulvovaginal tumor. The tumor occurs mainly, but not exclusively, in the vulva of premenopausal women. It can also arise in other sites such as perineum, inguinal area, fallopian tube, vaginal portion of cervix and vagina in females and scrotum in males. The importance of this entity is related to its potential mimicry of a more infiltrative and prognostically less favorable lesion found in the same anatomic area, namely aggressive angiomyxoma. The occurrence of angiomyofibroblastoma is uncommon and its vaginal presentation is exceedingly rare. We experienced a case of vaginal angiomyofibroblastoma in a 50-year-old female and present it with a review of literatures.

A Case of Angiomyofibroblastoma of the Vulva / 대한산부인과학회잡지

Angiomyofibroblastoma of the vulva is a recently described mesenchymal tumor. It can be distinguished from an aggressive angiomyxoma by its circumscribed borders, higher cellularity, more numerous blood vessels, the frequent presence of stromal cells, minimal stromal mucin, and rarity of erythrocyte extravasation. We experienced a case of angiomyofibroblastoma of the vulva occurring in a 52-year-old woman. The lesion was a well-circumscribed mass, measuring 4x5 cm in size. Histologically, the mass was characterized by alternating hypercellular and hypocellular edematous zones in which abundant blood vessels were irregularly distributed. The stromal cells were concentrated around the blood vessels, or loosely dispersed in the hypocellular area. Immunohistochemically, the stromal cells were diffusely reactive for vimentin, focally reactive for desmin, but not for smooth muscle actin.

Angiomyofibroblastoma Occupying Paravesical Space / 대한산부인과학회잡지

Angiomyofibroblastoma is a benign, distinctive, and rare soft tissue tumor of vulva and vagina that might be mistaken for aggressive angiomyxoma. It is suggested that angiomyofibroblastoma is slow-growing in nature and consistent with the benign clinical course reported in the literatures. 21-year-old woman complained of lower abdominal pain and odorous vaginal discharge. She had a large paravaginal mass obliterating vaginal canal. It was maybe absent 3 months ago, but it was occupied in paravesical space later. It revealed angiomyofibroblastoma, which rapid grew and located in vagina. It was removed by vaginal approach. This report describes a case of angiomyofibroblastoma in paravaginal space characterized by rapid growth.

A Case of Angiomyofibroblastoma of the Vulva / 대한산부인과학회잡지

Angiomyofibroblastoma is a recently described mesenchymal tumor characterized by unique morphologic features, a propensity to arise in the vulva, and a non-aggressive beni-gn biologic behavior. It is typically well circumscribed and superficially located tumor and its cellularity is variable with hypercellular and hypocellular areas composed of bland-looking, pump stromal cells showing the immunophenotype of vimentin-/desmin - positive, and muscle specific actin(MSA)-/alpha-smooth muscle actin(ASMA) - negative. Spindle or plasm-acytoid cells are the characteristic cell types of most tumors. It is similar to an aggressive pelvic angiomyxoma in histology. Because of histologic similarity and differences in the clinical course and treatment, distinction from aggressive angiomyxoma was needed. It rep-resents new type in the expanding spectrum of tumors of which myofibroblasts constitute an integral component. We experienced a case of angiomyofibroblastoma of the vulva occuring in a 42 years old woman. The lesion was relatively well encapsulated mass(3 X 1.5 X 0.9 cm in dimension), showing intimate admixture of hypercellular and hypocellular area. The tumor contained prominent, somewhat ectatic vessels surrounded by smooth muscle cells, some of which blend or fan out from the muscular walls of the vessels. The margin was relatively free from tumor cells. At immunohistochemical stain, vimentin and desmin was diffuse and weak positive, smooth muscle actin was very a few and weak positive in tumor cells.

Angiomyofibroblastoma of the Vulva: A case report

Angiomyofibroblastoma is a distinctive, hitherto uncharacterized, benign soft tissue tumor of the vulva with histology similar to an aggressive pelvic angiomyxoma. It can be distinguished from an aggressive angiomyxoma by its circumscribed borders, higher cellularity, more numerous blood vessels, the frequent presence of plump stromal cells, minimal stromal mucin, and rarity of erythrocyte extravasation. We experienced a case of angiomyofibroblastoma of the vulva occurring in a 45-year-old woman. The lesion was a well-defined but not encapsulated mass, 4.5x4.2 cm. Histologically the mass was characterized by alternating hypercellular and hypocellular edematous zones in which abundant blood vessels were irregularly distributed. Immunohistochemically, the spindled, plump spindled, and oval stromal cells were reactive for vimentin and desmin, but not for cytokeratin, or S-100 protein.

Recurred Angiomyofibroblastoma of the Vulva: Report of a case

Angiomyofibroblastoma is a rare, benign mesenchymal tumor of the vulva. Since it was described in 1992 by Fletcher, 15 cases have been reported in literature. We recently experienced a recurred angiomyofibroblastoma of the vulva. A 45-year-old woman was presented initially in 1991 with a mass of labium major and local excision of tumor mass had been performed. A histologic diagnosis was made of angiomyxoma, but this diagnosis was revised to angiomyofibroblastoma by the authors. The recurred mass was well circumscribed, measuring 2.5x1.6x1.5cm in dimensions. Microscopically the tumor was characterized by high cellularity, numerous blood vessels(which lack prominent hyalinization), and plump stromal cells. Immunohistochemically, the stromal cells were reactive for vimentin and desmin, but not alpha-smooth muscle actin, or S-100 protein. We thought that this case was a recurred angiomyofibrblastoma of the vulva due to incomplete surgical excision.

Angiomyofibroblastoma of Vulva: A case report

Angiomyofibroblastoma of the vulva is a rare mesenchymal tumor. It has been diagnostically confused with aggressive angiomyxoma which has a somewhat different clinical course and therapy. Herein we report a case of angiomyofibroblastoma of the vulva in a 46-year-old female. Microscopically, there were alternating hypercellular and hypocelluar edematous zones in which abundant capillary blood vessels were irregularly distributed. Spindle, plump spindle, and oval stromal cells were concentrated around the blood vessels, or loosely dispersed in the hypocellular area. Immunohistochemically, the stromal cells were positive for desmin, vimentin, muscle-specific actin and weakly positive for S-100 protein. Ultrastructural studies showed well developed rough endoplasmic reticulum, abundant intermediate filaments, and pinocytic vesicles in the stromal cells.