ABSTRACT
Resumen Objetivo: Determinar la frecuencia de prescripción del losartán por encima de 100 mg/día, notificar a los responsables de la atención sanitaria los limitados beneficios y conseguir una reducción en el número de quienes así lo utilizan. Métodos: Estudio cuasiexperimental, antes y después, sin un grupo control, sobre los prescriptores de pacientes con diagnóstico de hipertensión arterial en manejo con losartán entre el 1 de enero de 2010 (41.624 pacientes) y el 31 de diciembre de 2014 (75.126 pacientes). Posteriormente se identificaron las personas que recibieron dosis superiores a 100 mg/día. Se realizaron intervenciones educativas a partir de junio de 2012 y se evaluaron los resultados en términos de proporción de pacientes que dejaron de utilizarlo en estas dosis. Resultados: En el año 2012 se identificaron 7.205 sujetos (12,8% de pacientes con losartán) con más de 100 mg/día, que tras 108 actividades educativas se redujeron a 5.373 en el año 2014 (7,1% de usuarios del antihipertensivo; reducción de 25,4%), a pesar que la población afiliada tuvo un incremento del 29,3% en el período de seguimiento. Tras la intervención se consiguió un ahorro de COP$ 204.293.878 en dos años. Conclusiones: Se logró reducir la prescripción del losartán en dosis superiores a las estimadas como efectivas, lo que implica una reducción en el riesgo de la hiperkalemia y de los costos por dosificación mayor a la recomendada. Es importante reforzar las actividades de educación médica continuada para promover el uso apropiado de los medicamentos.
Abstract Objetive: To determine frequency of prescription of losartan over 100 mg/day, to notify the physicians responsible for the healthcare about the limited benefits and to thus achieve a decrease in the number of individuals taking this dose. Methods: Quasi-experimental study, before and after, without a control group, on prescription factors in patients with a diagnosis of arterial hypertension taking losartan between January 1st 2010 (41,624 patients) and December 31st 2014 (75,126 patients). Afterwards, people receiving doses over 100 mg/day were identified. Educational interventions were conducted starting June 2012, and results were measured in terms of the proportion of patients who stopped taking losartan in these doses. Results: In 2012, 7,205 individuals were identified (12.8% of patients with losartan) with more than 100 mg/day, who after 108 educational activities were reduced to 5,373 by year 2014 (7.1% of patients taking antihypertensive agents; a 25.4% decrease) despite a 29.3% rise in registered participants during the follow-up period. After the intervention, a COP$ 204,293,878 saving was achieved over the course of two years. Conclusions: Prescriptions of losartan in doses higher as what were deemed effective were reduced, which implies a reduction of both the risk of hyperkalemia and the costs due to taking a higher dose than recommended. It is important to reinforce ongoing medical education activities in order to promote appropriate drug consumption.
Subject(s)
Male , Female , Middle Aged , Pulmonary Arterial Hypertension , Pharmacology , Epidemiology , Angiotensin Receptor AntagonistsABSTRACT
Chronic treatment with renin-angiotensin system antagonists frequently causes deleterious hypotension during anesthesia. We present a case of marked intra-operative refractory hypotension in a 61-year-old male patient undergoing elective total thyroidectomy. He has been chronically treated for hypertension with angiotensin-converting enzyme inhibitors, angiotensin II receptor antagonists and atenolol, which were taken until the morning of surgery. After induction of anesthesia, marked hypotension which was refractory to fluid therapy occurred and did not respond to ephedrine administration. After continuous norepinephrine infusion, blood pressure increased and remained stable during the anesthesia period. Before extubation, norepinephrine was discontinued and recovery took place without complications. We discuss the anesthetic implication of chronic renin-angiotensin system antagonists treatment and intra-operative hemodynamic instability.