ABSTRACT
Resumen El granuloma actínico es una dermatosis granulomatosa poco frecuente, que se observa en adultos de mediana edad con antecedentes de fotoexposición. Su patogénesis no es clara; siendo la teoría más aceptada la radiación solar como factor disparador. Se caracteriza por placas anulares con atrofia central y bordes eritematosos elevados que son similares a los observados en el granuloma anular. Se presenta el caso clínico de una paciente de 71 años, con placas anulares en antebrazos compatibles con granuloma actínico. Se comunica el caso por lo infrecuente de esta entidad y se realiza una revisión bibliográfica.
Abstract Actinic granuloma is a rare granulomatous dermatosis, seen in middle-aged adults with a history of photoexposure. Its pathogenesis is not clear; the most accepted theory being solar radiation as a triggering factor. It is characterized by annular plaques with central atrophy and raised erythematous borders that are similar to those seen in granuloma annulare. The clinical case of a 71-year-old patient with annular plaques on the forearms compatible with actinic granuloma is presented. The case is reported due to the infrequent nature of this entity and a bibliographical review is carried out.
ABSTRACT
@#BACKGROUND. Annular elastolytic giant cell granuloma (AEGCG) is a rare skin disease, characterized by loss of elastic tissue due to elastophagocytosis by multinucleated giant cells in the upper part of dermis, which clinically presents as multiple annular plaques with raised erythematous border and central atrophy. We report a first case of AEGCG in dermatology practice in Mongolia. Its clinical and histological features, differential diagnosis and treatment modalities are described and discussed in detail.
ABSTRACT
Annular elastolytic giant cell granuloma is a rare form of granulomatous dermatosis, characterized clinically by annular plaques with slightly elevated margins, and histopathologically by the phagocytosis of elastic fibers by multinucleated giant cells. It typically occurs in sun-exposed areas of the skin in middle-aged women. However, some cases involving unexposed areas have been described. A 57-year-old man had erythematous plaques on both palms accompanied by a sensation of heat for 2 weeks. Histopathological examination revealed granulomatous infiltration with multinucleated giant cells and elastophagocytosis, which is consistent with annular elastolytic giant cell granuloma. Herein we report an interesting case of annular elastolytic giant cell granuloma that occurred on non-sun-exposed skin, palms.
Subject(s)
Female , Humans , Middle Aged , Elastic Tissue , Giant Cells , Granuloma, Giant Cell , Hot Temperature , Phagocytosis , Sensation , Skin , Skin DiseasesABSTRACT
Papular elastolytic giant cell granuloma is an unusual variant of annular elastolytic giant cell granuloma, characterized by the development of asymptomatic, multiple, small erythematous papules on both sun-exposed and non-sun-exposed area. Histopathologically, it shows a granulomatous infiltration, accompanied by the absence of the elastic tissue and phagocytosis of elastic fibers by multinucleated giant cell. An 83-year-old man was presented with a 1 year history of multiple erythematous papules on his abdomen and lower legs. Histopathologic finding showed a non-palisading granulomatous infiltration with multinucleated giant cells and engulfing elastic fibers. We, herein, report an unusual case of papular elastolytic giant cell granuloma, which occurred on non-sun-exposed skin.
Subject(s)
Aged, 80 and over , Humans , Abdomen , Elastic Tissue , Giant Cells , Granuloma, Giant Cell , Leg , Phagocytosis , SkinABSTRACT
El granuloma actínico es una rara afección de la piel que se desarrolla en general en áreas expuestas al sol. Su patogénesis no es clara.La teoría más aceptada es la implicancia de la radiación solar como factor disparador. Típicamente la enfermedad se presenta en individuos mayores de 30 años con historia de exposición solar. Se manifiesta con lesiones anulares de bordes elevados y atrofia central,asintomáticas, con poca tendencia a la involución. Se han probado múltiples terapéuticas con éxito variado. Esta entidad poco frecuente fue descripta por primera vez en 1975 por O`Brien. Presentamos dos pacientes con granuloma actínico. El primero correspondió a una mujer de 83 años de edad con una lesión en pómulo izquierdo. El segundo a un varón de 70 años con una gran lesión que se extendía desde el epigastrio hasta las clavículas.
Actinic granuloma is a rare skin disorder usually developing uponsun-exposed areas. While its pathogenesis is unclear, the acceptedhypothesis maintains that solar radiation is the triggering factor.Typically the disease develops in individuals over 30 years of age witha history of sun exposure, showing annular lesions with raised bordersand central atrophy, asymptomatic, with little tendency to regression.Multiple therapies have been tested with variable response. Thisuncommon entity was described for the first time in 1975 by OBrien.We present two patients with actinic granuloma. The first onecorresponded to an 83 years-old woman with a lesion on the leftcheek. The second one was a 70 years-old male with a large lesion thatextended from the epigastrium to the collar bones.
Subject(s)
Humans , Aged , Granuloma Annulare/diagnosis , Granuloma Annulare/etiology , Granuloma Annulare/pathology , Granuloma, Giant Cell/diagnosis , Granuloma, Giant Cell/pathology , Skin/pathology , Elastic Tissue/pathology , Photosensitivity Disorders/diagnosis , Ultraviolet RaysABSTRACT
Annular elastolytic giant cell granuloma (AEGCG) is a rare granulomatous and elastolytic skin disease of unknown pathogenesis. Therapy for AEGCG is controversial. The data about the effectiveness of chloroquine in the treatment of AEGCG are also variable. Here, we report a case of AEGCG with significant improvement after a total treatment period of 22 weeks with hydroxychloroquine. Although a possibility of spontaneous remission cannot be ruled out, we think that chloroquine can be considered as an effective treatment of this chronic disorder.
ABSTRACT
Annular elastolytic giant cell granuloma (AEGCG) is an inflammatory disorder characterized by the annular plaques with serpiginous raised borders on the sun-exposed area. Its pathologic finding shows the patchy granulomatous infiltration composed of multinucleated giant cells, histiocytes, lymphocytes and disappearance of the elastic fibers secondary to being engulfed by the giant cells. We report a case of AEGCG in a 59-year-old-male. He had several annular, erythematous plaques with raised borders on his dorsum of the hand, neck, back and the typical histologic features of AEGCG.