A Case Report of Annular Elastolytic Giant Cell Granuloma / 罕见病研究

Annular elastolytic giant cell granuloma(AEGCG) is a rare granulomatous skin condition. We present a case of a 67-year-old man with annular plaques on the face, neck, shoulder, back and upper limbs, and mildly pruritis exceeding one year. Histopathological examination demonstrated granulomatous inflammatory infiltration of lymphocytes, histiocytes and multinuclear giant cells in the middle and the upper dermis, with more local eosinophils. Elastic fiber staining showed that elastic fibers were absent in granuloma area and were engulfed by multinucleated giant cells. Based on the clinical and histopathological findings, a diagnosis of AEGCG was made. The etiology and pathogenesis of this condition are unclear, and atypical manifestations of non-exposed areas can also occur.It is usually related to systemic diseases lacks specific treatment at present.

Secondary Syphilis Is Presented as a Solitary Annular Plaque on the Scalp / 대한피부과학회지

A 32-year-old man is being presented with a 1-week history of erythematous annular flat plaque with scales on his scalp. He displays only a solitary skin lesion on his scalp without any presence or other histories for other skin lesions or constitutional symptoms. It is difficult to consider the possibilities of syphilis based on such clinical findings. A diagnosis of syphilid is being made on the basis of clinical, serological and histological findings. Herein, we report an interesting case of secondary syphilis which is presented as a solitary annular plaque on the scalp.

Tinea Faciei-like Demodicidosis / 대한피부과학회지

Demodex folliculorum is a common mite of the pilosebaceous unit. Usually demodex infestation does not lead to the manifestation of pathologic skin diseases. But, in specific environments such as immunologic deficiency, they can proliferate and provoke cutaneous lesions. A 58-year-old patient presented with multiple, erythematous, annular-shaped plaques on the nose and right cheek. He had a 9-year history of Sjogren disease and she was treated with oral steroids and methotrexate. We found numerous Demodex folliculorum mites through a KOH microscopic examination and histologic examination of the right cheek. Biopsy resultd revealed that Demodex folliculorum mites were contained in the dilated follicular infundibulum. We diagnosed this case as an unusual manifestation of a Demodex infestation in a patient with Sjogren disease. We report an annular plaque-forming demodicidosis treated successfully with metronidazole.