ABSTRACT
Oxalis barrelieri is used in the folk medicine for diarrhea treatment. The effects of the aqueous extract of Oxalis barrelieri on castor oil-induced diarrhea and intestine transit were investigated in rats. To induce the diarrhea and enteropooling, animals orally received castor oil (1 mL/100 g bw). Each rat received 30 minutes after, one of the single oral doses of O. barrelieri aqueous extract: 0, 25, 50, 100, 200 and 250 mg/kg bw or loperamide (5 mg/kg bw). The frequency and the total diarrheal weight for diarrhea and the intestine content for enteropooling were measured. To value the extract effect on intestine transit, normal rats received or not acetylcholine 0.1 mg/kg bw i.p. and then different dose of plant extract 50 and 100 mg/kg bw. The extract produced significant (p<0.01) decrease: respectively 95 %, 96.36 %, 99 % and 100 % in the severity of diarrhea. The 50 and 100 mg/kg bw extract produced remarkable (p<0.01) decrease in castor oil-induced enteropooling (59 % and 71.43%), intestine transit (42.12 % and 46.50 %), and reduced acetylcholine action (-65.90 % and -53.73 %) respectively. The results provide evidence that the aqueous extract of O. barrelieri could act on secretory diarrhea and intestinal motility, and thus could justify its traditional use.
ABSTRACT
The aim of this study was to evaluate the anti-diarrheal, anti-diabetic activity of barks and leaves of the plant V. cinerea. The acute toxicity test was also carried out on the stems, barks and the leaves of the plant V.Cineria was sun dried and extracted using methanol. Later the crude methanolic extract was fractionated into three different fractions using carbon-tetrachloride, di-chloromethane and water. The anti-diarrheal activity was tested using the non polar carbon-tetra-chloride fraction in a dose dependent manner and it was found that the fraction does not possess any anti-diarrheal activity. The anti-diabetic study was done in rats using the alloxan-induced diabetes method. The carbon tetrachloride fraction of methanolic stem-bark and leaves extract of V. cinerea in all the doses used caused a time dependent and significant (p < 0.05) reduction of the blood glucose levels of the alloxan-induced diabetic rats when compared to the negative control group. The highest activity of V. cinerea extract in this experiment was observed at the dose of 500 mg/kg. Acute toxicity was done by following the method of Lorke. The acute toxicity in rats produced no death or signs of toxicity even at the highest dose of the extract (3500 mg/kg).
ABSTRACT
Diuretic activities of both polar and non-polar extract of leaves of Brassica oleracea were investigated on male white rabbits and male Sprague-Dawley rats. Anti diarrheal activity of the same extract was investigated on male and female swiss albino mice. Both polar and non-polar extract exhibited anti diuretic activities on both rats and rabbits. Polar and Non-polar extract also showed anti diarrheal activity on male and female mice. Anti diarrheal activity affects both latent period and number of stools.