ABSTRACT
We report a case with squamous cell lung cancer with concomitant Guillain-Barre syndrome (GBS) as a paraneoplastic syndrome. A 67-year-old patient who was previously diagnosed as metastatic squamous cell lung cancer developed mild symmetrical weakness, paresthesia and sensory ataxia. Nerve conduction study showed sensorimotor polyneuropathy. Analysis of cerebrospinal fluid showed high tilter for monospecific anti-GD1b IgG antibody without onconeuronal antibodies. After treatment with intravenous immunoglobulin, the patient's symptoms improved.
Subject(s)
Aged , Humans , Antibodies , Ataxia , Cerebrospinal Fluid , Guillain-Barre Syndrome , Immunoglobulin G , Immunoglobulins , Lung Neoplasms , Neural Conduction , Paraneoplastic Syndromes , Paresthesia , PolyneuropathiesABSTRACT
No abstract available.
Subject(s)
Humans , Antibodies , Cerebellar Ataxia , Guillain-Barre SyndromeABSTRACT
Acute sensory neuropathy (ASN) is rare and is characterized by acute onset of sensory ataxia, loss of deep tendon reflexes and impaired vibratory and joint position sensations. Similar to Guillain-Barre syndrome (GBS) with prominent sensory ataxia, a few cases of ASN associated with antiganglioside antibodies have been reported. This suggests that a common autoimmue mechanism operates in some cases of ASN and of GBS with sensory ataxia. We report a patient with ASN associated with anti-GD1b IgG antibody.