Phenolic glycosides from root of Oplopanax elatus / 中草药

Objective To investigate the hydrophilic constituents from the anti-colorectal cancer extract of Oplopanax elatus. Methods The compounds were isolated and purified using macroporous resin, silica gel, ODS gel and pre-HPLC, and their chemical structures were identified by spectral data and physicochemical properties. The extracts and compounds from O. elatus were screened for anti-proliferation on HCT-116 and HT-29 cancer cell lines. Results Eleven phenolic compounds had been purified and identified from the n-butanol fraction including six phenylpropanoid glycosides: (E)-sinapic acid-4-O-β-D-glucopyranoside (1), 3- hydroxyphenethyl alcohol-4-O-β-D-glucopyranoside (2), 3-methoxycinnamyl alcohol-4-O-β-D-glucopyranoside (3), homovanillyl alcohol-4-O-β-D-glucopyranoside (4), dihydrosyringin (5), and syringin (6); And five lignan glycosides: 3,3'-dimethoxy-4,9,9'- trihydroxy-4',7-epoxy-5',8-lignan-4,9-bis-O-β-D-glucopyranoside (7), (+)-5,5'-dimethoxylariciresinol 4'-O-β-D-glucopyranoside (8), (+)-isolariciresinol-9'-O-β-D-glucopyranoside (9), (+)-isolariciresinol-4-O-β-D-glucopyranoside (10), and (+)-5,5'-dimethoxylariciresinol- 9'-O-β-D-glucopyranoside (11). All the phenolic glycosides showed no significant effects on the proliferation of HCT-116 and HT-29 cancer cell lines with IC50 > 100 μmol/L. Conclusion Compounds 4, 6, 9, and 11 are isolated and purified from this herb for the first time, while compounds 1, 2, and 10 are firstly obtained from the genus Oplopanax.

Research progress on anti-colorectal cancer effect and mechanism of ginsenosides and their derivatives / 中草药

Ginsenosides and their derivatives have been shown significant anti-colorectal cancer effect. They exert anti-colorectal cancer effects via inhibiting cancer cell proliferation and migration, blocking cell cycle progression, and inducing cell autophagy and apoptosis. Recently some active studies demonstrated that ginsenosides and their derivatives exhibited a synergistic anti-colorectal cancer effect with the drug. In this study, we summarized the progress in the research of ginsenosides and their derivatives in the treatment of colorectal cancer as well as analyzed their mechanisms, to provide the basis for the discovery and development of targeting anti-colorectal cancer drugs.