ABSTRACT
Cerebrovascular diseases (CVD) with high morbidity, disability, mortality, and recurrence rate have become the focus in the medical research. Modern researches have indicated that Guizhi Fuling Prescription (GFP) possesses anti-inflammatory, immune-modulation and anti-oxidative effects and so on. Investigations showed that GFP had been used in the researches of ischemic and hemorrhagic cerebrovascular diseases, mainly used in the clinical research of ischemic cerebrovascular, in which the research of treating acute cerebral infarction gets the best clinical effect of all. In order to provide theoretical reference for intensive research of GFP in treatment of CVD, this article reviewed the research progress in clinical application and mechanisms of GFP in treatment of CVD.
ABSTRACT
Objective: To study the alkaloids from Corydalis saxicola and their anti-oxidative activities. Methods: The alkaloids were separated and purified by various column chromatography and identified according to their spectral analyses. The anti-oxidation activities were investigated on DPPH radical scavenging assay. Results: Sixteen compounds were obtained and identified as cavidine (1), stylopine (2), canadine (3), tetrahydropalmatine (4), cheilanthifoline (5), scoulerine (6), protopine (7), dehydrocheilanthifoline (8), dehydroisoapocavidine (9), berberine (10), dehydrodiscretamine (11), chelerythrine (12), dehydrocavidine (13), corypalline (14), isocorydine (15), and pallidine (16). The alkaloids from C. saxicla were measured by the model of scavenging the stable DPPH radical, which showed a concentration dependent scavenging effect. Conclusion: Compounds 3, 5, 8, 11, and 16 are isolated from C. saxicola for the first time. Compounds 5 and 16 show the strong anti-oxidative activities.