ABSTRACT
The antimicrobial activity and cytotoxicity in vitro of the fermentation broth of 10 endophytic strains isolated from Lycium barbarum were determined to screen high activity endophytic strains. Sequences analysis of ITS and 16S rDNA was used for molecular identification of the strains. The results showed that 5 endophytic fungi had no inhibitory activity against the tested pathogens. Endophytic actinomycete strain AL6 had a certain inhibitory effect on 3 kinds of pathogenic fungi, and strain AL5 only had strong inhibitory activity against Staphylococcus aureus. However, the anti-tumor activity of endophytic fungi was significantly higher than that of actinomycetes. Four endophytic fungi strains exhibited the growth inhibition rate of above 50% against at least one of the tested tumor cells when the concentration of fermentation broth was 0.2 g•L⁻¹. Sequences analysis showed that 5 endophytic fungi strains belonged to genus Aspergillus, Penicillium and Emericella, and the 5 endophytic actinomycetes strains belonged to genus Aspergillus, Penicillium and Emericella. Aspergillus strain FL1 had stronger inhibitory activity against A549 and HeLa cells, and the IC₅₀ values were 0.022，0.028 g•L⁻¹, respectively, which was worthy of further study.
ABSTRACT
It has been reported that celastrus orbiculatus has anti-cancer activities. The mechanism mainly lies in its functions of inhibiting tumor cell proliferation, inducing tumor cell apoptosis, repressing tumor angiogenesis, and reversing tumor multidrug resistance, etc. To study the material basis of its anti-cancer pharmacodynamics and the mechanism of tumor inhibition has significant meanings and a wide application perspective.
ABSTRACT
Recently, there has been increased interest in the potential health benefits of plant lectins, particularly due to their anti-cancer effect. This updated review discusses literature data published on the anticancer activities of plant lectins and their possible molecular mechanism(s) of action.
La importancia de estudiar compuestos naturales para utilizarlos como opciones médicas terapéuticas, específicamente contra el cáncer, nos da la pauta para realizar una revisión exhaustiva de la literatura concerniente a la actividad biológica de las lectinas vegetales, las cuales han sido reportadas por poseer propiedades tóxicas, citotóxicas, antitumorales y anticancerígenas. En este trabajo revisamos diferentes estudios publicados sobre el mecanismo de acción de las lectinas con respecto a su efecto antitumoral.