ABSTRACT
Objective To evaluate anticoagulation without heparin during continuous venovenous hemofiltration.Methods From January to April of 2005,forty-two critically ill patients by therapy of continuous venovenous hemofiltration(CVVH)were enrolled in our study.Nineteen patients with high risk of bleeding who had received anticoagulation without heparin were as observation group,and the rest of the patients who had received anticoagulation with low molecular weight heparin were as control group.In the two groups,the replacement fluid rate was 3 000 mL/h;the therapy time was 12 hours/day;the bicarbonate replacement fluid were infused by the mode of predilution.Results The serum level of urea and creatinine were significantly decreased after treatment in the two groups,but there were no difference in the decrease of solution between the two groups.APTT was significantly extended in control group(P