ABSTRACT
Background: Antiphospholipid syndrome is a multisystem auto-immune disordercharacterized by arterial or venous thrombosis in children. Case characteristics: 11-year-old child with pneumococcal meningitis also had cerebral sinus vein thrombosis andpulmonary artery segmental thrombosis. Observation: Pro-thrombotic evaluation showedpositive lupus anticoagulant at baseline and after 12 weeks. Investigations for lupus werenegative at admission and after one year of follow-up. Message: Antiphospholipidsyndrome is a possibility even in thrombosis occurring in the setting of meningitis
ABSTRACT
A 10-year-old girl presented with sudden onset recurrent ventricular tachycardia and symmetrical distal peripheral gangrene. She also had pulmonary thromboembolism and cerebral sinus venous thrombosis. Investigations revealed anemia, hemolysis, hypocomplementemia, and elevated IgM anti-beta2 glycoprotein antibody levels. Electrocardiogram and echocardiogram suggested features of a rare cardiac anomaly, which was confirmed at autopsy.