ABSTRACT
Purpose–To study the clinical prole and management of herpes zoster ophthalmicus over a period of two and half years in a tertiary health care centre. Material and methods- it is a prospective study done on 32 patients who were diagnosed with herpes zoster ophthalmicus clinically. Predisposing factors like diabetes mellitus, HIV, hepatitis B, Hepatitis C, anemia, patients having leukaemia and taking chemotherapy were evaluated. Result-Diabetes mellitus was commonest association. Common presentations were periorbital vesicular rash and corneal involvement. Conclusion: commonest presentation was periorbital vesicular rash. Systemic antivirals are efcacious in immunocompromised cases. . Patients were followed up for one year.
ABSTRACT
Objective To explore the clinical curative effect of immunopotentiator combined with antiviral therapy in the treatment of children with recurrent respiratory tract infections.Methods 56 children with recurrent respiratory tract infections were selected as study subjects,and they were divided into two groups according to different therapeutic methods,28 cases in each group.The control group was given conventional antiviral treatment,the observation group was treated with immunopotentiator combined with antiviral therapy.The serum levels of IgA,IgG,IgM and peripheral blood T cell subsets CD3+,CD4+,CD8+ levels were detected in the two groups before treatment and after treatment.The fading away of the main symptoms and signs,and the clinical efficacy were observed.Results The fever subsided time [(1.98 ± 0.64) d],cough fade time [(1.65 ± 0.47) d] and lung's fading time [(2.38 ± 0.57) d] of the observation group were significantly shorter than those of the control group(all P ＜ 0.05).The total effective rate of the observation group was 92.86％,which was obviously higher than 67.86％ of control group(x2 =5.54,P ＜ 0.05).The serum immunoglobulin IgG [(9.09 ± 3.01) g/L],IgA [(1.75 ± 0.57) g/L],IgM [(1.39 ± 0.42) g/L] of the observation group after treatment had statistically significant differences compared with the control group (t =0.038,0.041,0.027,all P ＜0.05).The T lymphocyte subsets CD~ [(59.4 ± 8.9) ％],CD4+ [(40.5 ±4.4)％],CD8+ [(29.8 ± 4.7) ％] of the observation group after treatment had statistically significant differences compared with the control group (t =0.044,0.039,0.037,all P ＜ 0.05).Conclusion The application of immunopotentiator combined with antiviral therapy in the treatment of children with recurrent respiratory tract infections had exactly clinical curative effect,and it is worthy of popularization and application.
ABSTRACT
Objective To identify impacts of antiviral therapy on the frequency and interferon (IFN)-?-producing ability of circulating type 2 pre-dendritic cells(pDC2)as well as lymphocyte subsets in patients with chronic hepatitis B virus (HBV)infection. Methods Thirty-three patients with chronic HBV infection and 25 healthy individuals as controls were enrolled in our study. Two kinds of drugs, lamivudine and IFN-?, were used in antiviral regimen respectively. Absolute numbers of circulating pDC2 and lymphocyte subsets were analyzed by flow cytometry consecutively. The IFN-?-producing function of peripheral blood mononuclear cells (PBMCs) representing the circulating pDC2 was determined by ELISA assay. Results In patients with chronic HBV infection, the frequency and function of pDC2 decreased compared with those found in healthy controls. After antiviral treatment for 6 months, lamivudine seemed to induce the increase of frequency and absolute number of pDC2. The absolute numbers of peripheral CD8~+ T-cells and NK cells were simultaneously found to ascend. A similar result was also observed in chronically HBV-infected humans with 6 months duration of IFN-? therapy. Conclusions Our results showed that lamivudine or IFN-? antiviral treatment could increase the number of peripheral pDC2 and CD8~+ T-cells in the patients with chronic HBV infection.