ABSTRACT
El cáncer de canal anal y ano, es considerado como poco frecuente, sin embargo, ha aumentado ligeramente su incidencia representando del 1 al 2% de todas las neoplasias del intestino grueso. Dentro de los factores que se asocian a la génesis de estos tumores se encuentra la afección por el virus del papiloma humano. Se presenta el caso de una paciente femenina de 32 años que acude al servicio de Radioterapia del Hospital Clínico Quirúrgico Hermanos Ameijeiras, con antecedentes de Síndrome de Down y diagnóstico de un carcinoma epidermoide del ano y región perianal, variante exofítico y con antecedentes de infección por el virus del papiloma humano. Es evaluada en equipo multidisciplinario y no tiene criterio de cirugía por el tamaño tumoral, por lo que se decidió según estadiamiento la quimioradioterapia concurrente. La paciente presentó una respuesta completa al tratamiento con radioterapia, sin presentar complicaciones, con lo que se demuestra la efectividad de la radioterapia en los tumores del ano y canal anal.
Cancer of the anal canal and anus is considered rare, however, its incidence has slightly increased representing 1 to 2% of all neoplasms of the large intestine. Among the factors that are associated with the genesis of these tumors is the condition by the human papillomavirus. We present the case of a 32-year-old female patient who attends the Radiotherapy service of the Hermanos Ameijeiras Clinical Surgical Hospital, with a history of Down Syndrome and a diagnosis of a squamous cell carcinoma of the anus and perianal region, exophytic variant and with a history of infection by the human papillomavirus. It is evaluated in a multidisciplinary team and has no surgical criteria due to tumor size, so it was decided according to staging concurrent chemoradiotherapy. The patient presented a complete response to treatment with radiotherapy, without presenting complications, which demonstrates the effectiveness of radiotherapy in tumors of the anus and anal canal.
O câncer do canal anal e do ânus é considerado raro, porém, sua incidência aumentou ligeiramente representando 1 a 2% de todas as neoplasias do intestino grosso. Entre os fatores associados à gênese desses tumores está a condição pelo papilomavírus humano. Apresentamos o caso de uma paciente do sexo feminino de 32 anos que atende ao serviço de Radioterapia do Hospital Cirúrgico Clínico Hermanos Ameijeiras, com histórico de Síndrome de Down e diagnóstico de carcinoma celular escamoso do ânus e região perianal, variante exofítica e com histórico de infecção pelo papilomavírus humano. É avaliado em equipe multidisciplinar e não possui critérios cirúrgicos devido ao tamanho do tumor, por isso foi decidido de acordo com a chemoradioterapia simultânea. O paciente apresentou resposta completa ao tratamento com radioterapia, sem apresentar complicações, o que demonstra a eficácia da radioterapia em tumores do ânus e do canal anal.
ABSTRACT
Objective Large sample data of HPV genotyping on anus and anal canal condyloma acuminata (CA) tissue were rarely reported in China.This study is aimed to investigate the clinical value of the distribution of different kinds of genotype of human papillomavirus within regional (mainly in Jiangsu Province)patients of both male and female with anus and anal canal condyloma acuminata(CA).Methods We collected tissue specimens from 326 male and female patients with anus and anal canal condyloma acuminata(CA) from 4 hospitals in Jiangsu and Anhui provinces from August 1985 to July 2017.HPV DNA was extracted and through the combination of gene chip and polymerase chain reaction technology,23 genotypes of HPV were detected.Results Among 179 male cases,136 were found with HPV.The total HPV detection rate was 75.98％(136/179),and of which,single genotype detection rate was 55.31％ (99/179) while multiple genotypes detection rate was 20.67％ (37/179).Meanwhile,in the 147 female cases,108 cases with HPV represented the total HPV detection rate of 73.47％ (108/147),of which single genotype detection rate was 48.79％ (72/147) and multiple genotypes detection rate was 24.49％ (36/147).342 were detected for all the genotype frequency totally and the low-risk HPV genotype was appered for 267 times while 75 times for high-risk HPV in this term.Among all the genotypes,6,11,16,18 took the top 4 respectively.Conclusion Among the regional (mainly in Jiangsu Province) male and female cases with anus and anal canal (CA),HPV 6,11,16,18 were the most common types.HPV was mostly distributed in the population of male younger than 30 years old.
ABSTRACT
Objective To study the genotypes of human papillomavirus (HPV)infection in female anus and anal canal condylo-ma acuminata(CA)tissues and their clinical significance.Methods 23 kinds of HPV-DNA were extracted from the paraffin-embed-ded anus and anal canal tissue samples in 140 cases of female CA and detected by using PCR combined with the gene-chips tech-nique.Furthermore the related clinical pathological data of the patients were analyzed.Results Among 140 female anus and anal ca-nal CA tissue samples,103 cases were HPV positive and the total HPV infection rate was 73.57%(103/140).Among them,68 ca-ses were single type HPV infection,the positive detection rate was 48.57%(68/140)and 35 cases were multiple types HPV infec-tion,the positive detection rate was 25.00% (35/140).In single type HPV infection,34 cases were HPV11 and the positive detec-tion rate was 24.29% (34/140),HPV11 was the main infection type,followed by HPV 6 in 27 cases,its positive detection rate was 19.29%(27/140).In the multiple types HPV infection,13 cases were HPV 6 + 11,accounting for 37.14% (13/35 )of multiple types infection,followed by HPV11 +18 in 3 cases and HPV 6+11+16 in 3 cases,each accounting for 8.57%(3/35)of the multi-ple types infection.Conclusion HPV 6,11 ,6+11,11 +18 and 6+11+16 are the main infection genotypes in female anus and anal canal CA.PCR combined with the gene-chips technique is a diagnostic method more suitable for clinical development of HPV geno-typing detection,which has high sensitivity and good specificity and is especially suitable for the molecular epidemiology study of HPV infection.