ABSTRACT
Objective To investigate the safety, reliability and effectiveness of supra - aortic artery stenting angioplasty via transradial access in treating supra-aortic artery occlusion or stenosis. Methods The clinical data of 325 consecutive patients with supra-aortic artery occlusion or stenosis, who were admitted to authors' hospital during the period from January 2012 to January 2016 to receive stenting angioplasty, were retrospectively analyzed. According to patient's own will, the 325 patients were divided into transradial access group (n=52) and transfemoral access group (n=273). The results of the puncturing, the operative results, the duration of operation, the amount of intraoperative blood loss, the postoperative complications, the time of postoperative rest in bed, the average time of hospitalization of both groups were recorded. Results No statistically significant differences in the success rate of puncturing, the success rate of operation and the amount of intraoperative blood loss existed between the two groups (P＞0. 05). In 73. 1％ of patients (38/52) of the transradial access group the duration of operation was ≤30 min, while only in 43. 2％ of patients (118/ 273) of the transfemoral access group the duration of operation was ≤30 min, the difference between the two groups was statistically significant (P＜0. 000 1). After the operation, in transradial access group puncture point bleeding was seen in 8 patients and hematoma at the puncture site in one patient, the complication rate was 17. 3％ (9/52), while in transfemoral access group puncture point bleeding was observed in 23 patients, hematoma at the puncture site in 7 patients, pain of puncture site in one patient, and cerebral hemorrhage in one patient, the total complication rate was 11. 7％ (32/273); but the difference between the two groups was not statistically significant (χ2=1. 236, P=0. 266). Patients in the transradial access group could get out of bed immediately after the operation. No statistically significant difference in the average time of hospitalization existed between the two groups (P＞0. 05). Conclusion In performing endovascular stenting angioplasty for supra-aortic artery occlusion or stenosis, both transradial access and transfemoral access are safe, reliable and effective. Transradial access can be used as a replacement of transfemoral access. (J Intervent Radiol, 2018, 27:207-210)
ABSTRACT
Introducción: El péptido natriurético tipo C (CNP) ha cobrado relevancia por sus efectos sobre la regulación de la función y la morfología del corazón y los vasos sanguíneos. Previamente demostramos in vitro que el CNP incrementa la actividad del sistema del óxido nítrico (NO) en ratas espontáneamente hipertensas (SHR). Objetivo: Estudiar el efecto del tratamiento crónico con CNP sobre la presión arterial sistólica (PAS), la función cardíaca y vascular y el sistema del NO en ratas espontáneamente hipertensas y normotensas. Material y métodos: Se emplearon ratas Wistar macho de 12 semanas de edad normotensas y espontáneamente hipertensas. Los animales recibieron infusión crónica de solución salina o CNP (0,75 mg/hora/rata) durante 14 días mediante la implantación de bombas osmóticas subcutáneas. Se midió la PAS y se realizaron un electrocardiograma y un ecocardiograma. Se extrajeron el ventrículo izquierdo y la arteria aorta torácica y se determinó la actividad, con L-[U14C]-arginina, de la óxido nítrico sintasa (NOS) y se realizaron estudios de reactividad vascular. Resultados: La administración crónica de CNP disminuyó la PAS en las SHR. Se observó menor volumen minuto en las SHR y el CNP incrementó dicho volumen, en tanto que no indujo cambios en las ratas normotensas. En las SHR se observó un desequilibrio en las respuestas vasodilatadora y vasoconstrictora en la arteria aorta y el tratamiento con CNP mejoró la función vascular respecto de las ratas normotensas. En ambos tejidos, la actividad de la NOS fue mayor en las SHR y se incrementó con la infusión durante 14 días de CNP. Sin embargo, dicho incremento fue menor en las SHR. Conclusión: El CNP induce cambios a nivel cardiovascular y en el sistema del NO que podrían resultar beneficiosos en este modelo de hipertensión arterial.
Background: C-type natriuretic peptide (CNP) plays an important role in the regulation of cardiovascular function and morphology. We have previously demonstrated that CNP increases nitric oxide (NO) system activity in vivo in spontaneously hypertensive rats (SHR). Objective: The goal of this study is to evaluate the effect of chronic CNP administration on systolic blood pressure (SBP), cardiovascular function and the NO system in spontaneously hypertensive and normotensive rats. Methods: Twelve-week-old normotensive male Wistar rats and SHR were used. They received chronic infusion of saline or CNP (0.75 mg/h/rat) for 14 days via subcutaneously implanted osmotic pumps. Systolic blood pressure was measured and an electrocardiogram and echocardiogram were performed. The left ventricle and the thoracic aorta were resected; nitric oxide synthase (NOS) activity was determined using L-[U14C]-arginine and vascular reactivity was assessed. Results: Chronic administration of CNP decreased SBP in SHR. Cardiac output was lower in SHR and increased with CNP; however, CNP had no effect in normotensive rats. Spontaneously hypertensive rats had unbalanced aortic vasodilation and vasoconstriction responses, and CNP improved the vascular function. Nitric oxide synthase activity was greater in SHR and increased with the 14-day CNP infusion, but this increase was lower than in normotensive rats. Conclusion: C-type natriuretic peptide induces cardiovascular and NO system changes which may be beneficial in this model of hypertension.
ABSTRACT
Objective To investigate the functional features of resveratrol on vasodilatation of abdominal aorta in rat and its underlying mechanism. Methods Isolated aortic ring was perfused and the tension of the vessel was measured. Results Resveratrol showed a dose-dependent relaxant effect on rat aorta at 4?10 -9～4?10 -5mol/L. At the concentration of 4?10 -5mol/L, the effect was attenuated by (74.9?1.9)% in the endothelium removal group, and it was significantly different from the control group (P0.05). At the concentration of 7?10 -5mol/L, resveratrol showed an relaxant effect on de-endothelium vessels. Conclusion Resveratrol relaxes the aorta in both endothelium dependent and independent manner. In the endothelium-dependent manner, the mechanism of vasodilatation may be associated with NO system and KATP channel, while in the endothelium-independent manner effect of resveratrol might be a direct one.
ABSTRACT
Objective To investigate the CT findings and guidance significance of multi-slice computed tomography(MSCT) in aortic intramural hematoma(IMH).Methods The clinical data and MSCT findings of 35 cases of aortic intramural hematomas diagnosed by MSCT with continuous volume scanning were analyzed.Results The direct signs of IMH were crescent or circular thickening of aortic wall without intimal flap and true and false lumens in all 35 patients.The indirect signs were penetrating ulcer(18 cases),calcification ingression(7 cases),atherosclerosis(16 cases)and single or bilateral pleural effusion(21 cases).The complicated signs were aneurysms(5 cases) and typical type B aortic dissection(3 case).Conclusion MSCT is a fast and noninvasive examinational technique,by which the direct,indirect and complicated signs of aortic IMH can be clearly revealed.All these signs have important guidance values for clinical diagnosis and management.