Advancement of apoptosis stimulating proteins of p53 in tumor / 国际肿瘤学杂志

The apoptosis stimulating proteins of p53 (ASPP) are important regulatory proteins of p53 family, consisting of ASPP1, ASPP2 and iASPP. ASPP combine with p53 ,and ASPP1 and ASPP2 promote cell apoptosis of p53 specifically,where as iASPP inhibit the tumor suppressing function of p53 by combining with p53. Thus,ASPP family of proteins,especially iASPP, may be a novel target for cancer therapy.