ABSTRACT
Objective:To develop a more suitable sterile examination method for artemether injection in order to control its quality better. Methods:The direct inoculation and the membrane filtration was respectively used for the sterile examination of artemether in-jection. Results:In the direct inoculation method, Staphylococcus aureus, Bacillus subtilis and Clostridium perfringens grew well in the test tubes containing artemether injection in 24 h, and Escherichia coli, Aspergillus niger and Candida albicans grew well in 48 h. In the membrane filtration method, Staphylococcus aureus grew well in 24 h in the test group containing artemether injection, and the other 5 strains grew well in 48 h. Conclusion:The positive strains can grow well in the applicability test of both methods. However, due to the simpler operation and higher accuracy of membrane filtration method, it is recommended to be used for the sterile test of artemether injection.
ABSTRACT
Objective:To develop a more suitable sterile examination method for artemether injection in order to control its quality better. Methods:The direct inoculation and the membrane filtration was respectively used for the sterile examination of artemether in-jection. Results:In the direct inoculation method, Staphylococcus aureus, Bacillus subtilis and Clostridium perfringens grew well in the test tubes containing artemether injection in 24 h, and Escherichia coli, Aspergillus niger and Candida albicans grew well in 48 h. In the membrane filtration method, Staphylococcus aureus grew well in 24 h in the test group containing artemether injection, and the other 5 strains grew well in 48 h. Conclusion:The positive strains can grow well in the applicability test of both methods. However, due to the simpler operation and higher accuracy of membrane filtration method, it is recommended to be used for the sterile test of artemether injection.
ABSTRACT
Objective: To investigate the clinical efficacy of Wei Chang An Pills combined with Artemether Injection in the treatment of malaria (gastrointestinal type). Methods: Patients (253 cases) with malaria (gastrointestinal type) in Hospital de L'amitie Sino-Congolaise in The Republic of Congo from July 2013 to December 2014 were randomly divided into control and treatment groups. Patients (130 cases) in the treatment group were im administered with Artemether Injection and po administered with Wei Chang An Pills. Patients (123 cases) in the control group were im administered with Artemether Injection and po administered with Vitamin B6 Tablets. Patients in both two groups were treated for 7 d. After the treatment, the efficacy was evaluated, and the improvement of nausea, vomiting, abdominal pain, and diarrhea was observed, white blood cells and red blood cells in feces were simultaneously detected, numbers of plasmodium in peripheral blood were counted. Results: After the treatment for 5 d, the clinical symptoms of all the patients (130 cases) in the treatment group disappeared. After the treatment for 7 d, clinical symptoms of patients (87 cases) in the control group disappeared, and there were differences between two groups (P < 0.05). Compared to the control group, white blood cells and red blood cells in feces of patients in the treatment group decreased significantly (P < 0.05). The number of plasmodium in peripheral blood of patients in the treatment group was significantly decreased. Conclusion: Wei Chang An Pills combined with Artemether Injection have the good effect in the treatment of malaria (gastrointestinal type), and can improve the clinical symptoms of patients and shorten the course, and also have anti-malarial function.