A systemic review on association between on maternal atmospheric pollution exposure during pregnancy and childhood obesity / 环境与职业医学

Background Maternal atmospheric pollution during pregnancy may alter fetal intrauterine development programming, thereby increasing the risk of childhood obesity in the future. Objective To investigate the effects of atmospheric pollution exposure during pregnancy on the incidence of childhood obesity in offspring. Methods English databases (PubMed, Web of Science, and Medline) and Chinese databases (Wanfang Data Knowledge Service Platform, China National Knowledge Infrastructure, and VIP Information Chinese Journal Service Platform) were searched for literature reporting exposure to atmospheric pollution during pregnancy and childhood obesity published from 1 January 2000 to 31 August 2023. The quality of the included literature was evaluated using the quality assessment tools for observational cohort and cross-sectional studies recommended by the US National Institutes of Health. Results Twenty-four studies meeting the inclusion criteria were identified and the associated atmospheric pollutants included particulate matter, ozone, nitrogen oxide, carbon oxide, and sulfur oxide. In comparison to the non-exposed group, prenatal exposure to various common atmospheric pollutants were significantly associated with an elevated risk of childhood obesity in offspring. Conclusion Maternal exposure to atmospheric pollution during pregnancy is associated with an elevated risk of childhood obesity in subsequent years. Future studies should pay more attention to the effects of atmospheric pollution on the distribution of children's body fat and metabolic development, and further identify potential mechanisms of atmospheric pollutant exposure leading to childhood obesity.

Intraocular pressure changes under an atmospheric pressure spectrum in a multiplace hyperbaric chamber / Análise de alterações da pressão intraocular (PIO) sob o espectro da pressão atmosférica em uma câmara hiperbárica multi-lugar

ABSTRACT Purpose: To evaluate the influence of atmospheric pressure changes on the behavior of intraocular pressure of healthy military individuals-students and instructors of the National Navy's Diving & Rescue School at the "ARC BOLÍVAR" naval base-during a simulated immersion in the hyperbaric chamber of the Naval Hospital of Cartagena. Methods: A descriptive exploratory study was performed. The intraocular pressure was measured at different atmospheric pressures during 60-min sessions in the hyperbaric chamber while breathing compressed air. The maximum simulated depth was 60 feet. Participants were students and instructors of the Naval Base's Diving and Rescue Department. Results: A total of 48 eyes from 24 divers were studied, of which 22 (91.7%) were male. The mean age of the participants was 30.6 (SD=5.5) years, ranging from 23 to 40. No participant had a history of glaucoma or ocular hypertension. The mean base intraocular pressure at sea level was 14 mmHg, which decreased to 13.1 mmHg (decreased by 1.2 mmHg) at 60 feet deep (p=0.0012). However, during the safety stop at 30 feet, the mean IOP kept decreasing until reaching 11.9 mmHg (p<0.001). By the end of the session, the mean intraocular pressure reached 13.1 mmHg, which is inferior and statistically significant when compared with the intraocular pressure base mean (p=0.012). Conclusions: In healthy individuals, the intraocular pressure decreases when reaching a depth of 60 feet (2.8 absolute atmosphere pressure) and it decreases even more during ascension at 30 feet. Measurements at both points were significantly different when compared with base intraocular pressure. The final intraocular pressure was lower than the baseline intraocular pressure, suggesting a residual and prolonged effect of the atmospheric pressure on intraocular pressure.

RESUMO Objetivo: Avaliar a influência das alterações da pressão atmosférica no comportamento da pressão intraocular de indivíduos militares saudáveis-alunos e instrutores da Escola de Mergulho e Resgate da Marinha Nacional na base naval "ARC BOLÍVAR"-durante uma imersão simulada na câmara hiperbárica do Hospital da Marinha de Cartagena. Métodos: Realizamos um estudo exploratório descritivo. A pressão intraocular foi medida em diferentes pressões atmosféricas durante sessões de 60 minutos na câmara hiperbárica respirando ar comprimido. A profundidade máxima simulada foi de 60 pés. Os participantes eram alunos e instrutores do Departamento de Mergulho e Resgate da Base Naval. Resultados: Quarenta e oito olhos de 24 mergulhadores foram estudados. Vinte e dois participantes (91,7%) eram do sexo masculino. A média de idade dos participantes foi de 30,6 (DP=5,5) anos, variando de 23 a 40. Nenhum participante tinha histórico de glaucoma ou hipertensão ocular. A média de base da pressão intraocular ao nível do mar foi de 14 mmHg, diminuindo para 13,1 mmHg (queda de 1,2 mmHg) a 60 pés de profundidade (p=0,0012). Entretanto, durante a parada de segurança a 30 pés, a pressão intraocular média continuou diminuindo até atingir 11,9 mmHg (p<0,001). Ao final da sessão, a pressão intraocular média atingiu 13,1 mmHg, valor inferior e estatisticamente significativo quando comparada à média de base da pressão intraocular (p=0,012). Conclusões: Em indivíduos saudáveis, a pressão intraocular diminui ao atingir uma profundidade de 60 pés (2,8 de pressão atmosférica absoluta) e diminui ainda mais durante a ascensão a 30 pés. As medidas em ambos os pontos foram significativamente diferentes quando comparadas à pressão intraocular de base. A pressão intraocular final foi menor do que a pressão intraocular de base, sugerindo um efeito residual e prolongado da pressão atmosférica sobre a pressão intraocular.

Association between atmospheric particulate matters and outpatient visits for respiratory disorders in Jiaxing City of Zhejiang Province from 2019 to 2021： a time series analysis / 上海预防医学

ObjectiveTo explore the effect of exposure to atmospheric particulate matters on the outpatient visits of respiratory disorders in Jiaxing City，Zhejiang Province. MethodsDaily air pollutant monitoring data，meteorological data and outpatient visits of respiratory disorders in Jiaxing City from 2019 to 2021 were collected．A generalized additive model was applied to evaluate the effect and laggeel effect of the concentrations of atmospheric particulates for outpatient visits of respiratory disorders after adjusting for secular trend， day-of-the-week effect， holiday effect， and meteorological variables. ResultsThe daily average concentrations of PM2.5， PM10， O3 and NO2 exceeded the standard， and the proportion of days exceeding the standard was 3.4%， 1.3%， 11.0% and 0.8%， respectively. Every 10 μg·m-3 increase in PM2.5 concentration showed the strongest effects on the daily outpatient visits of respiratory disorders， adult and childhood respiratory disorders all on lag07 with ER（95%CI） being 2.29%（1.35%‒3.24%）， 2.31% （1.39%‒3.23%） and 2.65 % （1.36%‒3.96%）， respectively. The maximum ER of outpatient visits for respiratory disorders in children was higher than that in adults. Every 10 μg·m-3 increase in PM10 concentration showed the strongest effects on the daily outpatient visits of respiratory disorders on lag07， adult respiratory disorders on lag06 and childhood respiratory disorders on lag07 with ER（95%CI） being 1.42% （0.87%‒1.96%）， 1.49%（0.99%‒1.99%） and 1.61% （0.87%‒2.36%）， respectively. The results of double-pollutant model showed that the effect of atmospheric particulate reduced after O3 was introduced into the model. ConclusionThere are a short-term effect and a laggeel effect of atmospheric particulate on the outpatient visits of respiratory disorders. It is necessary to strengthen the health protection of the respiratory system of the population， especially the children.

Breeding of Chlorella mutants deficient in chlorophyll synthesis and evaluation of its protein yield and quality / 生物工程学报

The aim of this study was to construct Chlorella mutants deficient in chlorophyll synthesis by atmospheric pressure room temperature plasma (ARTP) mutagenesis, and screen novel algal species with very low chlorophyll content which is suitable for protein production by fermentation. Firstly, the lethal rate curve of mixotrophic wild type cells was established by optimizing the mutagenesis treatment time. The mixotrophic cells in early exponential phase were treated by the condition of over 95% lethal rate, and 4 mutants with the visual change of colony color were isolated. Subsequently, the mutants were cultured in shaking flasks heterotrophically for evaluation of their protein production performance. P. ks 4 mutant showed the best performance in Basal medium containing 30 g/L glucose and 5 g/L NaNO3. The protein content and productivity reached 39.25% dry weight and 1.15 g/(L·d), with an amino acid score of 101.34. The chlorophyll a content decreased 98.78%, whereas chlorophyll b was not detected, and 0.62 mg/g of lutein content made the algal biomass appear golden yellow. This work provides a novel germplasm, the mutant P. ks 4 with high yield and high quality, for alternative protein production by microalgal fermentation.

Aplicação do plasma de baixa temperatura sob pressão atmosférica como adjuvante ao tratamento da mucosite oral / Application of low temperature atmospheric pressure plasma as an adjuvant in treatment oral mucositis

A mucosite oral é um quadro clínico que acomete frequentemente pacientes sob terapia antineoplásica na região de cabeça e pescoço e caracteriza-se por ulcerações na mucosa que geram intensa dor local, odinofagia, aumento do risco de infecções, do uso de antibióticos e do tempo de hospitalização. A correlação entre mucosite oral, infecção fúngica e o potencial de disseminação fúngica sistêmica foi recentemente descrita. Apesar do impacto desse quadro clínico sobre a qualidade e tempo de vida dos pacientes oncológicos, não há consenso sobre a profilaxia e o protocolo terapêutico. O plasma de baixa temperatura sobre pressão atmosférica (LTAPP) apresenta efeito antimicrobiano, anti-inflamatório e reparador tecidual, o que sugere que possa ser promissor no tratamento da mucosite oral. Os objetivos gerais deste projeto foram divididos em dois subprojetos: 1) Definir os melhores parâmetros in vitro com efeito antifúngico e não tóxico e avaliar o LTAPP no tratamento de lesão de mucosite oral em modelo murino de mucosite por quimioterapia e 2) avaliar se o tratamento com LTAPP pode prevenir a disseminação fúngica sistêmica em ratos a partir de infecção experimental de lesões de mucosite oral por Candida albicans. Para tal, foram incluídos no estudo 100 ratos (Rattus norvegicus) com 90 a 100 dias de idade. No subprojeto 1, a lesão de mucosite oral foi induzida por administração de 5 fluorouracila (5-FU), enquanto no subprojeto 2, utilizou-se 5-FU associada à cisplatina ambas associadas à aplicação tópica de ácido acético 50%. Para o subprojeto 1, os animais foram randomicamente divididos em 2 grupos experimentais (n=30): a) Grupo mucosite; b) Grupo mucosite tratado com LTAPP, avaliados após 1, 5 e 12 dias do tratamento. Durante o período experimental, as lesões foram fotografadas e a gravidade da mucosite classificada por meio da atribuição de escores. Após a eutanásia e o processamento, os cortes histológicos corados por hematoxilina-eosina (HE) foram analisados microscopicamente. Para o subprojeto 2, o estudo de disseminação sistêmica fúngica nos grupos de mucosite infectada com C. albicans tratado ou não com LTAPP foi conduzido pelo isolamento fúngico a partir de amostras de sangue total e macerado dos órgãos. Para tanto foram estudados 2 grupos de ratos (n=20): c) Grupo mucosite infectado com C. albicans e d) Grupo mucosite infectado com C. albicans tratada com LTAPP, avaliados após 24 e 72 h do tratamento. Para ambos os projetos, o melhor parâmetro in vitro foi selecionado, isto é aquele com maior atividade antifúngica e baixa toxicidade. Dessa forma, as lesões foram expostas ao LTAPP de hélio por 5 min na distância de 1,5 cm na potência de 1 W. Os resultados in vitro mostraram que o LTAPP teve efeito antifúngico e baixa toxicidade para células de mamíferos. Os resultados in vivo mostraram que 5-FU afetou a saúde geral dos animais, evidenciada pela perda de peso corporal. Em ambos os grupos, houve reparo tecidual após 12 dias do tratamento, com resolução quase completa da lesão, o que foi corroborado pelos achados microscópicos. O grupo LTAPP exibiu uma tendência maior de redução da lesão, após 12 dias de tratamento. Além disso, o LTAPP apresentou efeito inibitório sobre C. albicans após 5 minutos, de exposição, com redução da recuperação fúngica da língua após 24 h (p<0.05). A disseminação fúngica sistêmica foi reduzida significativamente após 24 e 72 h do tratamento. Com base nos resultados obtidos, conclui-se que o LTAPP é uma ferramenta promissora para futura aplicação clínica em pacientes com mucosite oral. (AU)

Oral mucositis is a clinical condition that frequently affects patients undergoing antineoplastic therapy in the head and neck region and is characterized by mucosal ulcerations that generate intense local pain, odynophagia, increased risks of infections, use of antibiotics and the length of hospital stay. The correlation among oral mucositis, fungal infection and the potential for systemic fungal dissemination has recently been described. Despite the impact of this clinical condition on the quality and life expectancy of cancer patients, there is no consensus on prophylaxis and the therapeutic protocols. Low temperature atmospheric pressure plasma (LTAPP) has antimicrobial, anti-inflammatory and tissue repairing effects, which suggests that it can be promising in the treatment of oral mucositis. The general objectives of this project were divided into two subprojects: 1) Define the best antifungal and non-toxic in vitro parameters and to evaluate the application of LTAPP in the treatment of oral mucositis in murine model for chemotherapy, and 2) to evaluate whether treatment with LTAPP can prevent systemic fungal dissemination in rats from experimental infection of oral mucositis lesions by Candida albicans. A total of 100 rats (Rattus norvegicus) aged 90 to 100 days were included in the study. In subproject 1, oral mucositis lesion was induced by administration of only 5- fluorouracil (5-FU), while in subproject 2, administration and systemic administration of 5-FU associated with cisplatin, both associated with topical application of 50% acetic acid. For subproject 1, the animals were randomly divided into 2 experimental groups (n=30):a) Mucositis group and b) Mucositis group treated with LTAPP evaluated after 1, 5 and 12 days of treatment. During the experimental period, the lesions were photographed, and the severity of mucositis was classified into scores. After euthanasia and processing, the histological cuts stained by hematoxylin-eosin (HE) were analyzed. For subproject 2, the study of fungal systemic dissemination in groups of mucositis infected with C. albicans treated or not with LTAPP was conducted by fungal isolation from whole blood and macerated organs. Therefore, 2 groups of rats (n=20) were studied: c) Mucositis group infected with C. albicans and d) Mucositis group infected with C. albicans treated with LTAPP, evaluated after 24 and 72 h of treatment. For both subprojects, the best in vitro parameter was selected, that is, the one with the greatest antifungal effect and low toxicity. Thus, the lesions were exposed to helium LTAPP for 5 min at a distance of 1.5 cm at power of 1 W. In vitro results showed that LTAPP has an antifungal effect and low toxicity. In vivo results showed that 5-FU affected the general health of animals evidenced by body weight loss. In both groups, there was tissue repair after 12 days of treatment, with almost complete resolution of the lesion, which was corroborated by the microscopic findings. LTAPP group showed a greater trend of reduction of lesion, after 12 days of the treatment. Furthermore, LTAPP showed inhibitory effect on C. albicans after 5 min of exposition, with reduction in fungal recovery from the tongue after 24 h (p<0.05). Reduction in fungal dissemination was observed after 24 and 72 h of LTAPP treatment (p<0.05). Based on the obtained results, it was concluded that LTAPP is a promising tool for future clinical application in patients with oral mucositis.(AU)

Pollution characteristics, long-term variation trend, and health risk assessment of lead in ambient PM2.5 in Jinan / 环境与职业医学

Background A number of studies have shown that heavy metals in atmospheric PM2.5 have impacts on human health, while studies on the impact of long-term and low-concentration exposure to lead in PM2.5 on human health are limited. Objective To investigate the pollution characteristics of lead in ambient PM2.5 and assess its chronic health risks. Methods Daily PM2.5 concentration data in Jinan from 2014 to 2019 were collected, and the year-by-year trend of PM2.5 concentration was analyzed. Licheng District (an industrial area) and Shizhong District (a residential area) were elected to install an ambient PM2.5 monitoring stationrespectively. The sampling instrument was a 100 L·min−1 high-flow PM2.5 sampler, with a cumulative sampling time of 20-24 h per day, using a quartz fiber filter membrane for lead detection and a glass fiber filter membrane for PM2.5 determination. The sampling frequency was 7 consecutive days per month from the 10th to the 16th (A total of 493 d were sampled and some were missing; 172 d during the heating period and 321 d during the non-heating period). Two PM2.5 samples were collected in one monitoring site each day. A total of 986 samples were collected in one monitoring site. The lead content in PM2.5 samples was detected by inductively coupled plasma mass spectrometry. The concentration of PM2.5 was measured by weighing method. The annual average concentration and enrichment factor of lead in PM2.5, the change trend of lead content per unit mass of PM2.5, and the difference between heating period and non-heating period from 2014 to 2019 were estimated. Technical guide for environment health risk assessment of chemical exposure (WS/T 777-2021) was used to assess the health risks of exposure to lead in PM2.5. Results The average annual concentration of lead in PM2.5 ranged from 23.2 ng·m−3 to 154.7 ng·m−3. The average concentration in heating period from 2015 to 2019 was higher than that in non-heating period, and the differences in 2015, 2017, and 2019 were statistically significant (P < 0.01 or 0.001). The enrichment factors ranged from 200 to 1342 in 2014 to 2019. The average enrichment factors in heating period in 2015, 2017, and 2018 was higher than those in non-heating period, and the difference was statistically significant (P < 0.05 or 0.001). The lead contents per unit mass of PM2.5 ranged from 493 ng·mg−1 to 1944 ng·mg−1, and the differences between heating period and non-heating period in 2014, 2017, and 2018 were statistically significant (P < 0.05 or 0.001). The average annual concentration and enrichment factor of lead in PM2.5 showed a downward trend, and thus the lead content per unit mass of PM2.5 also decreased. From 2014 to 2019, the carcinogenic risk of lead in PM2.5 in Jinan ranged from 1.69×10−8 to 2.45×10−6, showing a significant downward trend year by year, and the 95th percentile decreased by 3%-46% from the previous year. The carcinogenic risk level of lead was reduced to an acceptable level (<1×10−6) after 2017. Conclusion From 2015 to 2019, lead concentration and enrichment factor in PM2.5 increase during heating period compared with non-heating period, but it is not completely consistent of lead content in PM2.5 per unit mass. From 2014 to 2016, exposure to lead in PM2.5 may elevate carcinogenic risk to human. After 2017, the carcinogenic risks of exposure to lead in PM2.5 are at an acceptable level.

Estimation of atmospheric environmental radiation capacity in an isotope industrial park / 中国辐射卫生

Objective To study and estimate the public dose constraint and the atmospheric radiation capacity of an isotope industrial park, and to provide a basis for management of radioactive effluent discharge in isotope industrial parks. Methods We collected the natural environment data, meteorological data, and population distribution and dietary data as well as the source terms of radioactive airborne effluents of an isotope industrial park. The public dose constraint value of the isotope industrial park was determined based on the natural environmental radiation hazard level. The atmospheric environmental radiation capacity of the industrial park was estimated by the all-pathways method. Results The public dose constraint value of the industrial park was 0.2 mSv/a. At the end of industrial park planning, the maximum individual effective dose to the public caused by airborne effluent discharge was 1.07×10−6 Sv/a, which accounted for 0.54% of the public dose constraint value. The proportions of discharges of airborne radionuclides to respective environmental radiation capacities ranged from 0.04% to 4.34%. Conclusion The determined public dose constraint value of the isotope industrial park can be used as the total radiation capacity of the regional atmospheric environment to constrain the discharge of radioactive effluents. The environmental radiation capacity of each radionuclide can be estimated by the all-pathways method considering the comprehensive impact of radionuclide discharges, which is suitable for the control and management of isotope production enterprises in industrial parks.

O Conceito de Violência Atmosférica em Fanon: contribuições aos Estudos de Gênero / The Concept of Atmospheric Violence by Fanon: contributions to Gender Studies / El Concepto de Violencia Atmosférica en Fanon: aportes a los Estudios de Género

Este artigo objetiva colocar em evidência o debate acerca da categoria de violência em Fanon, com o objetivo de discutir seu uso também para os estudos de gênero. Faz-se isso a partir da análise de um conceito específico de sua obra e ainda pouco discutido: violência atmosférica. Diante de um número expressivo de produções acadêmicas sobre este autor no Brasil, este trabalho busca contribuir para o debate em torno deste conceito, na direção de percorrer os momentos em que ele é debatido pelo autor e também algumas das reações ao seu pensamento. É possível afirmar que Fanon apresenta uma epistemologia contracolonial da violência e que esse debate é um fio condutor em seus escritos. Como epistemologia, defende-se que o uso da categoria de violência em Fanon possa ser deslocado também ao campo dos estudos de gênero, de modo a compreender as diferentes formas que a violência se objetifica, bem como os contextos em que ela ocorre.

The purpose of this work is to put in evidence the debate around the category of violence by Fanon, with the objective of discussing its need to gender studies, too. We've done it from the analysis of a specific concept of his literary work that it is still little discussed: atmospheric violence. Facing an expressive number of academic works about this author in Brazil, this one looks for contributing with the discussion over this concept, to go through the moments when the subject is debated by the own author and some reactions about his thought. It's possible to affirm that Fanon shows a countercolonial epistemology and that this debate is a connection on his writings. As epistemology we defend that the violence category using by Fanon can be also moved to the gender studies area, in a way to understand the different manners which the violence is objectified as well as those contexts where it occurs.

Este artículo tiene como objetivo mostrar el debate sobre la categoría de violencia en Fanon, con el objetivo de discutir también su uso para los estudios de género. Para ello partimos del análisis de un concepto específico de su obra que es aún poco discutido: la violencia atmosférica. Frente a un número llamativo de producciones académicas sobre este autor en Brasil, este trabajo busca contribuir al debate en torno a este concepto, recurriendo a los momentos en que tal concepto es debatido por el autor y también a algunas de las reacciones a su pensamiento. Es posible afirmar que Fanon desarrolla una epistemología contra colonial de la violencia y que este debate es un hilo conductor en sus escritos. Como epistemología, argumentamos que el uso de la categoría de violencia en Fanon también puede trasladarse al campo de los estudios de género, con el fin de comprender las diferentes formas en que ésta se materializa, así como los contextos en los que se produce.

Determination of In-door Air Quality by Estimating Microbiological Load from the Ambient Air among Basic Health Units in the City of Januaria, Brazil - A Cross Sectional Study

Aims: Poor air quality can compromise the health and recovery of patients and even compromise the quality of life and productivity of health professionals, affecting the speed of recovery of patients and allowing the occurrence of nosocomial infections. The present work evaluated the microbiological quality of ambient air in Basic Health Units (BHU), determining the degree of microbiological safety for the population served. Study Design: This study was conducted with triplicate evaluation of samples of ambient air. Place and Duration of Study: This study was conducted in the city of Janu醨ia, state of Minas Gerais, Brazil, between March 2016 and July 2016. Methodology: Environmental air samples were collected in five BHU in the urban area of the city, evaluating the contamination by aerophilic mesophilic microorganisms, enterobacteria, molds and yeasts, using the simple sedimentation technique in a Petri dish. Results: It was verified the presence of mesophilic aerobic bacteria and molds and yeasts in amounts higher than the recommendation used as a parameter for this study, indicating that the hygienic-sanitary conditions in the evaluated BHU are not adequate. Conclusion: The presence of Enterobacteriaceae in some evaluated sites suggests the possibility of the presence of pathogenic microorganisms, which may pose risks to the health of the population.

Effect of non-thermal atmospheric pressure plasma and ErCr YSGG LASER activation of three fluoride varnishes on surface re-mineralization of enamel A SEM-EDX analysis

Effect of non-thermal atmospheric pressure plasma and ErCr YSGG LASER activation of three fluoride varnishes on surface re-mineralization of enamel A SEM-EDX analysisBackground: Dental remineralization is the process of transporting minerals from the surrounding environment (i.e., saliva and biofilm) into partially demineralized tooth structures. Remineralization can be induced by professional therapies such as fluoride-based treatments that have the highest level of supporting evidence. High-intensity LASER and nonthermal atmospheric pressure plasma therapy have been known to increase the resistance of enamel to demineralization by surface modification. Aim: The aim of the study was to evaluate and compare the surface remineralization of enamel using ErCr:YSGG LASER and nonthermal atmospheric pressure plasma (NTP) activation with three different fluoride varnishes. Methodology: Sixty-eight extracted premolars were used which were sectioned mesiodistally to obtain 135 specimens and artificial caries were induced on the experimental surface. They were then randomly divided into three groups (n = 45): MI Varnish (GC Japan), Vanish Varnish (3M ESPE), and Embrace Varnish (Pulpdent). After varnish application, these groups were further divided into three subgroups based on the activation therapy used. Fifteen samples from each group were treated with ErCr:YSGG LASER, 15 samples with NTP, and 15 samples were the control that did not undergo activation. After 9 days of pH cycling, the mean ion concentration of the surface calcium and phosphate ions was recorded using FEG-SEM and EDX analysis. The data were statistically analyzed. Results: One-way ANOVA and post hoc Tukey test accepting P < 0.05 were performed for comparisons between all analyses groups. Vanish Varnish showed a higher Ca/P ratio in LASER, NTP, and control subgroups, followed by MI Varnish and Embrace Varnish. ErCr:YSGG LASER therapy showed an improved Ca/P ratio in all varnishes than NTP therapy and control. Conclusion: ErCr:YSGG LASER therapy showed positive effects toward improving the Ca/P, followed by NTP therapy as compared to control in all three varnishes indicating their role in enhancing the effects of remineralization. Vanish Varnish showed a higher Ca/P ratio indicating better remineralization post activation.

Barotrauma y barodontalgia en la aviación / Barotrauma and barodontalgia in Aviation / Barotrauma e barodontalgia na aviação

Introducción: se ha estudiado ampliamente la importancia de los cambios de presión y sus consecuencias en el cuerpo humano. De esto se desprenden dos conceptos importantes: el barotrauma que se define como el daño producido por cambios en la presión atmosférica; y la barodontalgia que se define como el dolor dentario producido por variaciones de presión barométrica, por ejemplo cuando existen gases atrapados en restauraciones o en la cámara pulpar y/o conducto radicular. Estos conceptos se fundamentan en las leyes de los gases: la Ley de Difusión Gaseosa, la Ley de Dalton, la Ley de Boyle, la Ley de Charles y la Ley de Henry. Discusión: el estudio y prevención de la barodontalgia es de suma importancia, ya que aunque no tiene alta prevalencia entre los aviadores, su aparición es súbita y de alta intensidad, lo que puede provocar en el piloto una incapacidad física y mental, que aumenta el riesgo de accidentes. Conclusiones: en esta revisión, se reúnen las estrategias recomendadas para prevenir su aparición.

Introduction: the importance of pressure changes and their consequences on the human body has been widely studied. Two important concepts arise from this: barotrauma, which is defined as the damage produced by changes in atmospheric pressure; and barodontalgia, which is defined as dental pain produced by variations in barometric pressure, for example when gases are trapped in restorations or in the pulp chamber and/or root canal. These concepts are based on the gas laws: the Law of Gaseous Diffusion, Dalton's Law, Boyle's Law, Charles' Law and Henry's Law. Discusion: the study and prevention of barodontalgia is of utmost importance, since although it is not highly prevalent among aviators, its onset is sudden and of high intensity, which can cause physical and mental incapacity in the pilot, increasing the risk of accidents. Conclusions: this review brings together the recommended strategies to prevent its occurrence.

Introducão: a importância das mudanças de pressão e suas conseqüências sobre o corpo humano têm sido amplamente estudadas. Dois conceitos importantes podem ser derivados disto: barotrauma, que é definido como o dano produzido por mudanças na pressão atmosférica; e barodontalgia, que é definida como a dor dental produzida por variações na pressão barométrica, por exemplo, quando os gases estão presos em restaurações ou na câmara de polpa e/ou canal radicular. Estes conceitos são baseados nas leis do gás: a Lei de Difusão Gasosa, a Lei de Dalton, a Lei de Boyle, a Lei de Charles e a Lei de Henry. Discusion: o estudo e prevenção da barodontia é de suma importância, pois embora não seja muito prevalente entre os aviadores, seu início é repentino e de alta intensidade, o que pode causar incapacidade física e mental no piloto, aumentando o risco de acidentes. Conclusões: esta revisão reúne as estratégias recomendadas para evitar sua ocorrência.

Discussion on dose estimation methods for internal exposure to tritiumm / 中国辐射卫生

@#<b>Objective</b> To discuss the selection of dose estimation methods for internal exposure to tritium, their applicable working scenarios, and accurate dose estimation. <b>Methods</b> We compared the process and formula of two methods of urine tritium concentration monitoring in estimating the committed effective dose, explained the limitations of the atmospheric tritium concentration monitoring method, and compared the three methods from the aspects of the application scope and measurement methods. <b>Results</b> The atmospheric tritium concentration monitoring and urine tritium concentration monitoring methods provided opposite results of the magnitude of the committed effective doses for persons 3 and 10. The mean of the absolute values of the percentages by which <i>E</i>(<i>τ</i>)₁values were higher than <i>E</i>(<i>τ</i>)₃values was 29.6%, and that of <i>E</i>(<i>τ</i>)₂ higher than <i>E</i>(<i>τ</i>)₃was 72.4%. The consistency between the reference man-based tritium dose estimation method and the atmospheric tritium concentration monitoring method was better. The atmospheric tritium concentration monitoring method tended to underestimate the committed effective dose of tritium. <b>Conclusion</b> We suggest urine tritium concentration monitoring for estimating the committed effective dose, rather than atmospheric tritium concentration monitoring. The use of the reference man-based tritium dose estimation method or urine tritium activity concentration integration method should be based on individual metabolic conditions, working environment, and intake time, and urine sampling should be on time and repeated for monitoring..

Suitability of methods for Plasmodium falciparum cultivation in atmospheric air

BACKGROUND One of the most controversial factors about malaria parasite culture is the gaseous composition used. The most commonly used one consists of a mixture poor in O2 and rich in CO2. OBJECTIVES The present study aimed to share standard methods from our research group simplifying Plasmodium falciparum cultures by employing atmospheric air (ATM) and reusable glass bottles under agitation. METHODS Here, it was compared the parasite viability, free oxygen in media, and drug sensitivity between different strains and isolates maintained for long periods under ATM or classic conditions. FINDINGS The oxygen concentration in media under ATM was slightly superior to that observed in human blood and the media under the classic gaseous mixture. However, ATM or the use of glass bottles did not affect parasitic proliferation after several years of culture. Noticeably, the introduction of ATM altered reversibly the efficacy of several antimalarials. This influence was different between the strains and isolate. CONCLUSIONS ATM conditions and shaken flasks could be used as a standard method condition for culture manutention since they do not differ greatly from classical 5% O2 gas mixtures in terms of parasite proliferation and do not impose non-reversible changes to P. falciparum physiology.

Local Atmospheric Electric Circuit Model Using Electrostatic Pickups on a 375kV Transmission Line

Abstract: The global atmospheric electric circuit is based on a model of electrical connection between the earth and the ionosphere (waveguide), capable of representing the flow of electric current in this waveguide. In the proposed model, a storm acts as a generator, allowing the ionosphere to maintain its highest electrical potential (approximately 300kV) in relation to Earth. When a storm forms, the bottom of the cloud becomes negatively charged. This study is focused on modeling this specific part of the global atmospheric electric circuit, which is renamed local atmospheric electric circuit. In the methodology, we use an RLC circuit to calculate the effects of electrified clouds in a 375kV transmission line considering an electrical coupling between them (an RLC circuit is an electrical circuit consisting of a resistor (R), an inductor (L), and to capacitor (C). The mathematical formulation was developed using transmission line theory considering a connection with the top of the storm cloud. Then, a model simulation using GNU Octave was performed, and the results demonstrated how this coupling affects voltage drop and phase shift in a 375kV transmission line. Thus, a local atmospheric electric circuit model, considering the particularities of the environment immersed in a real transmission line model, configures an important model in the perspective of project management of electric energy transmission networks.

Principal component regression analysis demonstrates the collinearity-free effect of sub estimated climatic variables on tree growth in the central Amazon / El análisis de regresión por componentes principales muestra el efecto libre de colinealidad de variables climáticas subestimadas sobre el crecimiento de los árboles en la Amazonía central

Abstract Introduction: Climatic variables show a seasonal pattern in the central Amazon, but the intra-annual variability effect on tree growth is still unclear. For variables such as relative humidity (RH) and air vapor pressure deficit (VPD), whose individual effects on tree growth can be underestimated, we hypothesize that such influences can be detected by removing the effect of collinearity between regressors. Objective: This study aimed to determine the collinearity-free effect of climatic variability on tree growth in the central Amazon. Methods: Monthly radial growth was measured in 325 trees from January 2013 to December 2017. Irradiance, air temperature, rainfall, RH, and VPD data were also recorded. Principal Component Regression was used to assess the effect of micrometeorological variability on tree growth over time. For comparison, standard Multiple Linear Regression (MLR) was also used for data analysis. Results: Tree growth increased with increasing rainfall and relative humidity, but it decreased with rising maximum VPD, irradiance, and maximum temperature. Therefore, trees grew more slowly during the dry season, when irradiance, temperature and VPD were higher. Micrometeorological variability did not affect tree growth when MLR was applied. These findings indicate that ignoring the correlation between climatic variables can lead to imprecise results. Conclusions: A novelty of this study is to demonstrate the orthogonal effect of maximum VPD and minimum relative humidity on tree growth.

Resumen Introducción: Las variables climáticas muestran un patrón estacional en la Amazonía central, pero el efecto de la variabilidad intra-anual en el crecimiento de los árboles aún no está claro. Para variables como la humedad relativa (HR) y el déficit de presión de vapor (VPD), cuyo efecto individual en el crecimiento de los árboles puede ser subestimada, planteamos la hipótesis de que tales influencias pueden detectarse eliminando el efecto de colinealidad entre regresores. Objetivo: Este estudio tuvo como objetivo determinar el efecto libre de colinealidad de la variabilidad climática sobre el crecimiento de los árboles en la Amazonía central. Métodos: Se midió el crecimiento radial mensual en 325 árboles desde enero 2013 hasta diciembre 2017. También se registraron datos de irradiancia (PAR), temperatura del aire, lluvia, humedad relativa (RH) y déficit de presión de vapor de aire (VPD). Se utilizó la regresión de componentes principales para evaluar el efecto de la variabilidad micrometeorológica a lo largo del tiempo sobre el crecimiento de los árboles. Para comparación, también se utilizó la regresión lineal múltiple (MLR) estándar para el análisis de datos. Resultados: El crecimiento de los árboles incrementó con el aumento de las precipitaciones y la humedad relativa, y disminuyó con el aumento de la VPD máxima, la irradiancia y la temperatura máxima. Por lo tanto, los árboles crecieron más lentamente durante la estación seca, cuando la irradiancia, la temperatura y la VPD eran más altas. La variabilidad micrometeorológica no afectó el crecimiento de los árboles cuando se aplicó MLR. Estos hallazgos indican que ignorar la correlación entre las variables climáticas puede conducir a resultados imprecisos. Conclusiones: Una novedad de este estudio es demostrar el efecto ortogonal del VPD máximo y la humedad relativa mínima sobre el crecimiento de los árboles.

Análise do monitoramento ambiental da incineração de resíduos sólidos urbanos na Europa e a necessidade de alterações na legislação brasileira / Environmental monitoring analysis of municipal solid waste incineration in Europe and the needs for changes in brazilian legislation

RESUMO A incineração é uma tecnologia de tratamento térmico de resíduos sólidos cujo principal objetivo é a redução do volume e da massa dos resíduos a serem depositados em aterros. Os incineradores construídos nas últimas décadas trazem a possibilidade de recuperação energética dos resíduos, na forma de vapor e/ou energia elétrica, entretanto essa tecnologia ainda gera questionamentos sobre possíveis impactos ambientais relacionados às suas emissões. A incineração é regulada na Europa por legislação específica que, entre outras questões, obriga a divulgação de dados de monitoramento ambiental de incineradores. No presente trabalho, são analisados dados de emissões atmosféricas de incineradores associados à Confederation of European Waste-to-Energy Plants (CEWEP), por meio de buscas nos websites dos respectivos incineradores, em artigos científicos e relatórios técnicos. Foram examinados dados de monitoramento de todos os poluentes de medição contínua e periódica definidos na legislação da UE, em séries temporais de 2010 a 2017. Todos os valores médios anuais de emissões nos incineradores analisados estiveram abaixo dos limites definidos pela diretiva europeia, com pequena variação ao longo dos anos observados. A comparação dos padrões de emissão europeus com os brasileiros mostra a necessidade de mudança na legislação local referente à incineração para que, caso essa tecnologia seja implementada no Brasil, ela possa operar respeitando limites seguros, com garantia de minimização de impactos ao ambiente e às populações do entorno.

Abstract Incineration is a solid waste treatment technology whose main purpose is to reduce the volume and mass of the waste to be disposed of in landfills. The incinerators built in the last decades bring the possibility of energy recovery from waste, in the form of steam and/or electric energy. However, this technology still raises questions about possible environmental impacts related to its emissions. Incineration is regulated in Europe through specific legislation which, among other issues, requires the disclosure of environmental monitoring data for incinerators. In the present work, atmospheric emissions data from incinerators associated with the Confederation of European Waste-to-Energy Plants (CEWEP) are analyzed by searching the websites of the respective incinerators, scientific articles and technical reports. Monitoring data on all continuous and periodic measured pollutants defined in the legislation in time series from 2010 to 2017 were analyzed. All annual average emission values of the incinerators analyzed were below the limits defined by the European Union's Directive, with little variation over the observed years. The comparison of European with Brazilian emission standards shows the need for a change in local legislation on incineration so that, if this technology is implemented in Brazil, it will operate within safe limits, with a guarantee of minimizing impacts on the environment and surrounding populations.

Monitoring and analysis of activity concentrations of 7Be and 210Pb in atmospheric aerosol in Beijing from 2017 to 2020 / 中华放射医学与防护杂志

Objective:To monitor and analyze the activity concentrations of 7Be and 210Pb in atmospheric aerosol in Beijing from 2017 to 2020. Methods:Totally 1 074 atmospheric aerosol samples were collected by high flow air sampler (SnowWhite) including 275 in spring, 266 in summer, 262 in autumn and 271 in winter and subjected to analysis by low background high-purity germanium gamma-ray spectrometery (ORTEC) to determine the activity concentrations of 7Be and 210Pb. Results:The activity concentrations of 7Be in atmospheric aerosol were from 0.56 to 14.84 mBq/m 3, with an avearage of 6.84 mBq/m 3, and from 0.01 to 9.37 mBq/m 3 for 210Pb, with an avearage 3.19 mBq/m 3. The differences in activity concentrations of 7Be and 210Pb in atmospheric aerosol among differernt seasons were statistically significant ( F=32.66, 93.93, P<0.05). Activity concentration of 7Be was highest in spring, followed by autumn, and lowest in summer and winter. Activity concentration of 210Pb ranged from winter, autumn, spring to summer in descending order. Conclusions:The activity concentrations of 7Be and 210Pb in atmospheric aerosol in Beijing from 2017 to 2020 fluctated within the range of normal level.

Relationship between the Epidemiology of Chronic Rhinitis and Atmospheric Environmental Factors in Wuhan / 公共卫生与预防医学

Objective To investigate the relationship between the epidemiology of chronic rhinitis and atmospheric environmental factors in Wuhan. Methods A total of 3 371 patients with chronic rhinitis in Wuhan seventh hospital from January 2017 to January 2020 were enrolled. The incidence of chronic rhinitis in different years and seasons was compared. Then the influence of atmospheric environmental factors such as air pollution index (API), fine particulate matter (PM2.5), inhalable particulate matter (PM10), nitrogen dioxide (NO2), sulfur dioxide (SO2), diurnal patterns of relative humidity, wind speed, air temperature, air pressure wind speed and temperature range on occurrence of chronic rhinitis was analyzed. Results The incidence of chronic rhinitis in Wuhan showed an annual decreasing trend from 2017 to 2020, so the incidence rate was the highest in 2017 (38.83%, 1309/3371) and was the lowest in 2020 (28.98%, 977/3371). In terms of different seasons, the incidence rate was the highest in winter (33.67%, 1135/3371), and was the lowest in summer (16.11%, 543/3371). The main factors affecting the incidence of chronic rhinitis were API, PM2.5, and PM10 in spring, which were NO2, SO2, and daily average relative humidity in summer, those were API, PM2.5, PM10, NO2, and SO2 in autumn, and were API, PM2.5, PM10, NO2, SO2, and daily range of air temperature in winter. The lag response of patients with chronic rhinitis to atmospheric environmental factors was 2-5 days in spring, 1-6 days in summer, 0-5 days in autumn and 3-6 days in winter. Patients with chronic rhinitis have the fastest response to API and PM2.5 in spring, the fastest response to API in summer, and the fastest response to API and PM2.5 in autumn, respectively. Conclusion The incidence of chronic rhinitis in Wuhan is decreasing year by year, and the incidence is related to environmental and meteorological factors, and the disease onset has the characteristics of lag due to seasonal factors.

Efecto de atmósferas modificadas con CO 2 sobre la germinación de banco de semillas de malezas / Effect of atmospheres modified with CO 2 on the germination of weed seed bank

RESUMEN Aumentos en la concentración de dióxido de carbono -CO2- atmosférico, pueden generar modificaciones sobre la composición florística, biología y ecología de malezas, lo que puede implicar modificaciones en el manejo de las mismas. Con el objetivo de reconocer el efecto del CO2 sobre la germinación de un banco de semillas de malezas, proveniente de un suelo de uso agrícola, se ejecutó un diseño experimental completamente al azar, el cual, se planteó como un arreglo factorial con muestras de suelo, provenientes de 2 profundidades, 5 dosis de CO2, 4 réplicas por tratamiento y 3 medidas repetidas en el tiempo. Evaluándose el efecto de 5 concentraciones atmosféricas de CO2 -400, 500, 700, 800, 900ppm-, sobre la germinación del banco de semillas. Para esto, se tomaron materos con muestras de suelo, que fueron llevados a cámaras confinadas, en donde se adicionó CO2, hasta el valor de referencia. Allí, se mantuvieron en condiciones de germinación durante todo el experimento. Los resultados indican diferencias significativas en los tratamientos en los que se adicionó CO2, los análisis fitosociológicos muestran que el tratamiento de 900ppm de CO2 presentó la mayor riqueza y diversidad, según índice de Shannon (H´) y el tratamiento de 800ppm presentó la mayor cantidad de individuos. Lolium temuletum L. fue la especie dominante del banco de semillas, evidenciándose una respuesta positiva de la especie en relación al enriquecimiento atmosférico. Los resultados indican que ambientes enriquecidos de CO2 inducen una variación en la diversidad poblacional del banco de semillas evaluado.

ABSTRACT Increases in atmospheric carbon dioxide concentration - CO2-, can be able generate modifications on the floristic composition, biology and ecology of weeds, what can to imply modifications in their management. With the aim of recognizing the effect of CO2-modified atmospheres on germination of weed seed bank from an agricultural soil, a completely randomized experimental design was executed, which was proposed as a factorial arrangement with soil samples from 2 depths, 5 doses of CO2, 4 replicates per treatment and 3 measures repeated over time. Evaluating the effect of 5 atmospheric concentrations of CO2-400,500,700,800,900ppm-, on the germination of the seed bank. For this, pot was taken with soil samples, which were taken to confined chambers where CO2 was added up to the reference value. There they were kept under germination conditions throughout the experiment. The results indicate significant differences in the treatments in which CO2 was added, the phytosociological analyzes show that the treatment of 900ppm of CO2 presented the greatest richness and diversity according to the Shannon index (H´) and the 800ppm treatment presented the largest number of individuals. Lolium temuletum L. was the dominant species in the seed bank, showing a positive response of the species in relation to atmospheric enrichment. The results indicate CO2 enriched environments induce a variation in the population diversity of the evaluated seed bank.

Characteristics of electrophysiological changes in the process of astrocytes pyroptosis after hyperoxia exposure / 中南大学学报(医学版)

OBJECTIVES@#To observe the electrophysiological changes of astrocytes in the process of hyperoxia induced apoptosis and analyze the relationship between electrophysiological characteristics and morphological changes.@*METHODS@#Astrocytes were exposed to 90% hyperoxia for 12-72 h. The electrophysiological characteristics of astrocytes in each group were detected by patch clamp technique, and the morphological characteristics of astrocytes were observed at the same time. Then the same batch of astrocytes were collected, and the expression levels of caspase-1, caspase-3, gasdermin D (GSDMD) and gasdermin E (GSDME) were detected by Western blotting.@*RESULTS@#From 12 h to 72 h after hyperoxia exposure, the inward current was significantly lower than that of the control group (0.05). At each time point, the morphology of cells changed correspondingly. Western blotting showed that the expression of caspase-1 was increased significantly at 24 h and decreased significantly at 72 h after hyperoxia exposure (0.05), but began to decrease at 48 h (<0.05); GSDME increased gradually at 24 h after hyperoxia exposure (<0.05).@*CONCLUSIONS@#Under hyperoxia exposure, the ion channels of astrocytes are damaged, which can maintain the dysfunction of ion homeostasis, activate GSDME, induce the damaged cells to break away from the apoptotic pathway, and mediate the pyroptosis.