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Objective:To evaluate the feasibility of measuring pulmonary venous blood flow spectrum by transesophageal ultrasound in assessing intraoperative left atrial pressure (LAP) in pediatric patients with complex congenital heart disease.Methods:Twenty-five pediatric patients with complex congenital heart disease of either sex, aged < 3 yr, of American Society of Anesthesiologists physical status Ⅲ or Ⅳ, with New York Heart Association class Ⅲ or Ⅳ, undergoing surgery with general anesthesia and requiring LAP monitoring during surgery, were selected.Transesophageal echocardiography was used to record the left pulmonary venous blood flow spectrum during surgery.S wave velocity (PV S), D wave velocity (PV D), AR wave velocity (PV AR), and deceleration time of pulmonary venous diastolic flow (DT D) were measured at 15 min after termination of CPB.The ratio of S wave peak velocity to D wave peak velocity (S/D ratio) was calculated.Measurement was carried out for 3 consecutive cardiac cycles, and the average value was calculated.The LAP was simultaneously measured through the left atrial piezometer.Pearson correlation analysis was performed between PV S, PV D, PV AR, DT D, S/D ratio and LAP. Results:PV S, PV D, PV AR and S/D ratio had no correlation with LAP ( r=-0.06, 0.21, 0.19, -0.38, respectively, P>0.05), while DT D was negatively correlated with LAP ( r=-0.84, P<0.05). Conclusions:DT D measured by transesophageal ultrasound can be used to evaluate intraoperative LAP in pediatric patients with complex congenital heart disease.
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Objective@#To evaluate the association between the ratio of early diastolic transmitral velocity to early diastolic mitral annular velocity (E/E') and left atrial pressure (LAP) estimated from invasive catheter measurements in patients with atrial fibrillation (AF).@*Methods@#A total of 46 consecutive patients with non-valvular AF and preserved left ventricular ejection fraction (LVEF) admitted in our department to receive the first radiofrequency ablation from May to July 2017 were included. All patients underwent echocardiography at 24-48 hours before radiofrequency ablation, and LAP was invasively measured during the ablation procedure. According to mean LAP, patients were divided into 2 groups of normal LAP (LAP≤12 mmHg(1 mmHg=0.133 kPa, n=31) and elevated LAP (LAP>12 mmHg, n=15). Linear correlation analysis was used to evaluate the relationship between E/E' and LAP.@*Results@#E/E' correlated well with LAP (septal E/E' (E/E'sep), r= 0.397, P=0.006; lateral E/E' (E/E'lat), r=0.433, P=0.003; mean E/E' (E/E'mean), r=0.431, P=0.003). Using receiver operating characteristic analysis, the optimal cut-off for E/E'sep was 12.5 (sensitivity 73.3%, specificity 67.7%), E/E'lat was 10.8 (sensitivity 80.0%, specificity 77.4%), E/E'mean was 11.0 (sensitivity 86.7%, specificity 64.5%) to predict mean LAP>12 mmHg.@*Conclusion@#E/E', especially the E/E'lat, is positively correlated with LAP in patients with AF and preserved LVEF, and may be used to estimate the diastolic function in AF patients with preserved LVEF.
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Uno de los retos para el cardiólogo es conseguir una volemia óptima, es decir, mejorar el gasto cardiaco, evitando un exceso de volemia que pudiera favorecer un pronóstico negativo. Actualmente se sabe que el balance positivo se asocia con un incremento en la mortalidad; en la actualidad contamos con diversos parámetros para evaluar la precarga; sin embargo, ninguno es altamente fidedigno. El objetivo del presente artículo de revisión es dar un recordatorio de este concepto fisiológico así como sus utilidades en el monitoreo del paciente.
One challenge for the cardiologist is to achieve optimal blood volume for to improve cardiac output, and avoid excessive blood volume that could favor a negative prognosis. Now is known that the positive balance is associated with increased mortality; today we have different standards for assessing preload yet none is highly reliable; the objective of this review is to give a reminder of its physiological concept and profits in patient monitoring.
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Objective To investigate the effects of spontaneous agonal respiration on coronary perfusion pressure (CPP) during untreated cardiac arrest (ventricular fibrillation) in swine model.Methods Ten male healthy domestic swines (25.0 ± 1.5) kg were anaesthetised,intubated and mechanically ventilated.The catheterizations were separately inserted into the right atrium and thoracic aorta to monitor aortic pressure (AOP) and right atrial pressure (RAP).A pacing electrode was inserted into the right ventricle to induce ventricular fibrillation (VF).VF was induced by intra-ventricular stimulation withalternating electric current and untreated for 8 minutes.AOP and RAP were recorded until respiratory activity ceased.The CPP before and after agonal respiration was calculated and analyzed by paired-sample T test.Results All animals presented with agonal respiration from 1 to 6 minutes after VF during the first attempt.The CPP was (7.18 ±4.22) mmHg at 1 sec before agonal respiration,(11.78 ±5.16) mmHg at 0 sec after agonal respiration,(8.75 t:4.38) mmHg at 5 sec after agonal respiration and (8.23 ± 4.55)mmHg at 6 sec after agonal respiration.The CPP at 0 sec after agonal respiration was higher than that before agonal respiration (t =-3.140,P =0.012).The CPP at 5 sec after agonal respiration was higher than that at 1 sec before agonal respiration (t =-2.828,P =0.020).There was no difference in CPP between at 6 sec after agonal respiration and at 1 sec before agonal respiration (t =-1.778,P =0.109).Conclusions Agonal respiration accompanies ventricular fibrillation.After agonal respiration,the coronary perfusion pressure is increased for 5 seconds being in favor of cardiaopulmonary resuscitation.
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BACKGROUND AND OBJECTIVES: Although a prominent large V wave in left atrial pressure tracing (PVLAP) has been reported to be associated with significant mitral regurgitation (MR) or decreased left atrial compliance (LAC), it is sometimes observed in patients with tight mitral stenosis (MS). The purpose of this study was to determine the prevalence and the hemodynamic significance of PVLAP in tight MS. MATERIALS AND METHODS: Catheterization data before percutaneous mitral balloon valvuloplasty (PMV) were analyzed in 84 consecutive patients and PVLAP was defined as V wave 10 mm Hg higher than mean left atrial pressure (MLAP). RESULTS: PVLAP was observed in 45% (38/84) and factors associated with PVLAP were younger age (p=0.02), higher MLAP (p<0.01), higher mitral gradient (p=0.04), smaller valve area (p=0.01) and low echo score (p=0.02): among them MLAP was the only independent factor in multivariate analysis. The presence of PVLAP had no effect on the result of PMV and successful PMV abolished PVLAP. CONCLUSION: PVLAP was observed not infrequently in these selected patients with MS referred for PMV. The presence of PVLAP was not associated with MR and had good correlation with MLAP, which suggest that PVLAP be determined by decreased LAC.
Subject(s)
Humans , Atrial Pressure , Balloon Valvuloplasty , Catheterization , Catheters , Compliance , Hemodynamics , Mitral Valve Insufficiency , Mitral Valve Stenosis , Multivariate Analysis , PrevalenceABSTRACT
BACKGROUND: The left atrium functions as a reservoir for blood stored during ventricular systole, a conduit for pulmonary venous flow during ventricular diastole, and as a pump augmenting left ventricular filling during atrial systole. Cardiac angiography and Doppler echocardiography have been used in the assessment of atrial function. These measurements are, however, quite sensitive to ventricular and atrial loading conditions. Instantaneous pressure-volume relations of the left atrium have been described by a time-varying elastance model in the isolated left atrium and intact circulation in animal models. The mitral stenosis can be characterized hemodynamically as increased afterload of the left atrium. Percutaneous mitral balloon valvuloplasty, which results in a dramatic increase in the mitral orifice area in patients with mitral stenosis, is a well-suited clinical model for physiological assessment of the left atrial function in response to acute change of the left atrial afterload. The purpose of this study was 1) to evaluate the feasibility of the left atrial pressure-volume loop using automatic boundary detection method, 2) to obtain the left atrial pressure-volume loop in patients with mitral stenosis and to compare with that of normal controls, and 3) to assess the changes of the left atrial wall tesion and stroke work after percutaneous mitral balloon valvuloplasty in patients with mitral stenosis using the left atrial pressure-volume relations. METHODS: Twelve patients had simultaneous measurements of left atrial pressure and left atrial volume using trasseptal catheterization and two-dimensional echocardiography with automatic boundary detection technology. The left atrial pressure-volume was constructed by a computer workstation interfaced with an ultrasound system. Left atrial volumetric parameters, areas of A and V loops, and peak wall tension were measured and compared before and after percutaneous mitral balloon valvuloplasty. RESULTS: 1) The left atrial pressure-volume loop could be obtained without complications in the control group as well as in patients with mitral stenosis. 2) The left atrial peak wall tension and A and V loop areas were significantly increased in mitral stenosis compared to the control group. 3) Left atrial maximal volume, minimal volume and volume before active atrial contraction were significantly increased in mitral stenosis compared to control group. 4) Left atrial ejection fraction and left atrial active emptying fraction were significantly reduced in mitral stenosis. Left atrial passive emptying fraction was slightly reduced in mitral stenosis compared to control group without statistical significance. 5) Left atrial peak wall tension and A loop area were significantly reduced after percutaneous mitral balloon valvuloplasty. 6) There were no significant changes in left atrial maximal volume, minimal volume, volume before active atrial contraction, total volume change, passive emptying volume, active emptying volume, passive emptying fraction, active emptying fraction, V loop area and left atrial ejection fraction after percutaneous mitral balloon valvuloplasty. CONCLUSION: The left atrial stroke work and peak wall tension can be assessed quantitatively using left atrial pressure-volume relations in patients with mitral stenosis and those are significantly reduced after percutaneous mitral balloon valvuloplasty. The analysis of left atrial pressure-volume loop is a potentially useful means in the assessment of left atrial function.
Subject(s)
Humans , Angiography , Atrial Function , Atrial Function, Left , Atrial Pressure , Balloon Valvuloplasty , Catheterization , Catheters , Diastole , Echocardiography , Echocardiography, Doppler , Heart Atria , Mitral Valve Stenosis , Models, Animal , Stroke , Systole , UltrasonographyABSTRACT
BACKGROUND: To evaluate the left heart function, left atrial pressure(LAP) has been monitored directly via LA catheter and indirectly via Swan-Ganz catheter. But indirect pressure monitor cannot often reflect the LAP precisely. We compared the LAP via LA catheter with central venous pressure(CVP), diastolic pulmonary artery pressure(DPAP) and pulmonary capillary wedge pressure(PCWP) by Swan-Ganz catheter. METHODS: Eleven cardiac-surgical patients whose LAP measurements were needed for clinical management were the subjects of this study. The CVP, DPAP and PCWP by Swan-Ganz catheter, and LAP were measured just after cardiopulmonary bypass, just after sternal closure, after 6 hours and 18 hours from the end of operation. And we divided them into two groups which consisted below 35 mmHg(group I) and over 35 mmHg(group II) of systolic pulmonary artery pressure(SPAP), and compared two groups. RESULTS: In group I, the LAP, CVP, DPAP and PCWP was 11.7+/-3.9 mmHg, 10.5+/-3.9 mmHg, 12.5+/-5.1 mmHg and 12.5+/-4.4 mmHg respectively, and correlation coefficiency of LAP with CVP, DPAP and PCWP was 0.7478, 0.7128 and 0.9002 respectively(p<0.05). In the group II, the LAP, CVP, DPAP and PCWP was 16.5+/-3.2 mmHg, 12.8+/-2.9 mmHg, 23.4+/-3.8 mmHg and 20.8+/-4.7 mmHg respectively and there was no correlation between LAP, CVP, DPAP and PCWP. CONCLUSIONS: The Swan-Ganz catheterization for the estimation of LAP is useful in the patients without pulmonary hypertension, but in the patient with pulmonary hypertension, CVP, DPAP and PCWP do not reflect the LAP.
Subject(s)
Humans , Atrial Function, Left , Atrial Pressure , Capillaries , Cardiopulmonary Bypass , Catheterization, Swan-Ganz , Catheters , Central Venous Pressure , Heart , Hypertension, Pulmonary , Pulmonary Artery , Pulmonary Wedge PressureABSTRACT
BACKGROUND: To evaluate the left heart function, left atrial pressure(LAP) has been monitored directly via LA catheter and indirectly via Swan-Ganz catheter. But indirect pressure monitor cannot often reflect the LAP precisely. We compared the LAP via LA catheter with central venous pressure(CVP), diastolic pulmonary artery pressure(DPAP) and pulmonary capillary wedge pressure(PCWP) by Swan-Ganz catheter. METHODS: Eleven cardiac-surgical patients whose LAP measurements were needed for clinical management were the subjects of this study. The CVP, DPAP and PCWP by Swan-Ganz catheter, and LAP were measured just after cardiopulmonary bypass, just after sternal closure, after 6 hours and 18 hours from the end of operation. And we divided them into two groups which consisted below 35 mmHg(group I) and over 35 mmHg(group II) of systolic pulmonary artery pressure(SPAP), and compared two groups. RESULTS: In group I, the LAP, CVP, DPAP and PCWP was 11.7+/-3.9 mmHg, 10.5+/-3.9 mmHg, 12.5+/-5.1 mmHg and 12.5+/-4.4 mmHg respectively, and correlation coefficiency of LAP with CVP, DPAP and PCWP was 0.7478, 0.7128 and 0.9002 respectively(p<0.05). In the group II, the LAP, CVP, DPAP and PCWP was 16.5+/-3.2 mmHg, 12.8+/-2.9 mmHg, 23.4+/-3.8 mmHg and 20.8+/-4.7 mmHg respectively and there was no correlation between LAP, CVP, DPAP and PCWP. CONCLUSIONS: The Swan-Ganz catheterization for the estimation of LAP is useful in the patients without pulmonary hypertension, but in the patient with pulmonary hypertension, CVP, DPAP and PCWP do not reflect the LAP.