Acupoint Autohemotherapy Attenuates Atopic Dermatitis Lesions by Regulating Th1/Th2 Balance in DNCB-Induced BALB/c Mice / 中国结合医学杂志

OBJECTIVE@#To evaluate the therapeutic effects of acupoint autohemotherapy (A-AHT) on 1-chloro-2,4-dinitrobenzene (DNCB)-induced atopic dermatitis (AD) in mice focusing on regulating T helper 1/T helper 2 (Th1/Th2) immune responses.@*METHODS@#Thirty BALB/c mice were divided into 5 groups by a random number table, including normal control (NC), AD model (AD), A-AHT, sham A-AHT (sA-AHT), and acupoint injection of normal saline (A-NS) groups, 6 mice per group. Mice were challenged by DNCB for the establishment of experimental AD model. On the 8th day, except for the NC and AD groups, the mice in the other groups received management once every other day for a total of 28 days. For the A-AHT and sA-AHT groups, 0.05 mL of autologous whole blood (AWB) was injected into bilateral Zusanli (ST 36) and Quchi (LI 11) and sham-acupoints (5 mm lateral to ST 36 and LI 11), respectively. The A-NS group was administrated with 0.05 mL of normal saline by acupoint injection into ST 36 and LI 11. Dermatitis severity for dorsal skin of mice was determined using the Severity Scoring of Atopic Dermatitis (SCORAD) every week. The total immunoglobulin E (IgE), interleukin-4 (IL-4), and interferon-gamma (IFN-γ) cytokine levels in serum were examined by enzyme-linked immunosorbent assay (ELISA). Spleen Th1/Th2 expression were analyzed via flow cytometry and immunohistochemical assay was used to detect T-box expressed in T cell (T-bet) and GATA-binding protein 3 (GATA3) expressions in skin lesions of mice.@*RESULTS@#Compared with the AD group, both A-AHT and sA-AHT reduced the SCORAD index and serum IgE level (P<0.05 or P<0.01); A-AHT, sA-AHT and A-NS down-regulated serum IL-4 level and upregulated IFN-γ/IL-4 ratio (P<0.05 or P<0.01); A-AHT regulated the Th1/Th2 shift specifically and increased the related transcription factors such as T-bet expression and T-bet/GATA3 ratio (P<0.05).@*CONCLUSION@#A-AHT showed significant effectiveness on the AD model mice, through regulating Th1/Th2 immune responses.

Successfully treated recalcitrant atopic eczema with acupoint autohemotherapy: A case report and hypothesized mechanism of the therapy / 中西医结合学报

Acupoint autohemotherapy at bilateral Zusanli (ST36) and Xuehai (SP10) was used to treat a 26-year-old female patient who had suffered from recalcitrant atopic eczema (AE) for five years. The treatment was applied at a frequency of once per week for the first month, followed by a three-month period of once every other week. At the end of treatment, the patient's AE symptoms were entirely resolved, and by the end of a six-month follow-up her immunoglobulin E level had returned to the normal range. Further, there was no relapse of AE symptoms during the six-month follow-up. Therefore, we hypothesized that after the repeated treatments the local inflammatory reaction induced by autologous blood injection triggered a local immune response, followed by a systemic immune response after the repeated treatment, finally leading to the anti-inflammation and immunomodulation effects. This case suggests that acupoint autohemotherapy could be used as an effective complementary treatment for recalcitrant AE, especially in cases where other treatments have failed. Further comparative studies are needed to corroborate the value and mechanisms of this therapy.

Tratamientos alternativos en tumor venéreo transmisible en caninos / Alternative treatments in transmissible venereal tumor in canines / Tratamentos alternativos em tumor venéreo transmissível em caninos

Resumen El Tumor Venéreo Transmisible (TVT), es una neoplasia común de la especie canina, se localiza principalmente en la mucosa de los genitales; es altamente contagiosa y es la única que puede ser transmisible mediante el trasplante celular por contacto directo. Se diagnostica por estudio citológico y su tratamiento es la quimioterapia con sulfato de vincristina, fármaco de elección por tener un alto porcentaje de efectividad y baja recidiva; sin embargo, se han descrito efectos adversos como trastornos digestivos, hemáticos y nerviosos por parte de la población tratada. El objetivo de este trabajo es dar a conocer la efectividad y comportamiento de otras alternativas para el tratamiento de TVT; primero con un protocolo de autohemoterapia y el otro mediante la inmunoterapia con ácido yatrénico mas caseína, que actúan sobre el sistema inmunológico del animal, haciendo que sea el mismo organismo quien realice la eliminación del tumor.

Abstract Transmissible Venereal Tumor (TVT) is a common canine neoplasia; it is mainly located in the genital mucosa. This pathology is highly contagious and can be transmitted by direct contact cell transplantation from a diseased to a non-diseased mucosa. It is primarily diagnosed by cytology and its treatment is chemotherapy being the vincristine sulfate the medicine of choice. The Vincristine has a high rate of effectiveness and low recidivism; however, this alternative has important side effects. The treatment with Vincristine could cause primarily digestive upset, hematological, and nervous diseases. The objective of this work is to determine the efficacy and performance of alternative therapies for the treatment of TVT, firstly, with an autohemoterapy protocol, and using an immunotherapy treatment with yatrenic acid and casein, which acts in the animal's immune system and causes the same organism to eradicate the tumor.

Resumo O Tumor Venéreo Transmissível (TVT), é uma neoplasia comum da espécie canina, localiza-se principalmente na mucosa dos genitais; é altamente contagioso e é o único que pode ser transmitido por transplante de células de contato direto. É diagnosticado por estudo citológico e seu tratamento é a quimioterapia com sulfato de vincristina, a droga de escolha por apresentar alto percentual de eficácia e baixa recorrência; entretanto, efeitos adversos como distúrbios digestivos, sanguíneos e nervosos foram relatados na população tratada. O objetivo deste trabalho é apresentar a eficácia e o comportamento de outras alternativas para o tratamento do TVT; a primeira com um protocolo de auto-hemoterapia e a outra por meio de imunoterapia com ácido yatrênico mais caseína, que atuam no sistema imunológico do animal, fazendo com que o mesmo organismo realize a retirada do tumor.

What happened in the acupoint area of mouse after blood injection? / 南方医科大学学报

OBJECTIVE@#Autologous blood acupoint injection has practiced for treatment of various diseases, but its therapeutic mechanism remains unknown. This study aimed to explore the histological changes in the acupoint area after blood injection.@*METHODS@#Blood samples (0.1 mL) collected from donator mice was injected in the recipient mice at the acupoint of left Zusanli (ST- 36). At 0, 6, 12, 24, 48, 72 and 96 h after the injection (3 mice at each time point), peripheral blood and muscular tissue were collected from the injection site for blood cell classification and histological study with HE staining.@*RESULTS@#White blood cells and lymphocytes tended to increase but platelets tended to decrease at the acupoint after blood injection, but these changes were not statistically significant. Within 24 h after blood injection, acute inflammation occurred at the acupoint, and the injected blood components were infiltrated by neutrophils; a small number of monocytes were observed at the injection site, where red blood cells gradually disappeared. From 24 to 96 h, the injected area showed chronic inflammation with infiltration by mononuclear cells, macrophages, and lymphocytes, and the number of fibroblasts increased and neutrophils decreased gradually over time; the local muscle fibers were destroyed, and proliferation of fibrous tissue could be seen.@*CONCLUSIONS@#Blood injection at the acupoints can mimic the process of hematoma absorption in the muscular tissue, and local inflammation is initiated to engulf and clear the blood components, which may be the basis for the therapeutic effects induced by acupoint stimulation.

Tratamiento de la Psoriasis vulgar con Autohemoterapia menor. Hospital "Celia Sánchez Manduley". 2016-2018 / Treatment of vulgar Psoriasis with minor autohemotherapy. Hospital "Celia Sánchez Manduley". 2016-2018 / Tratamento da psoríase vulgar com auto-hemoterapia menor. Hospital "Celia Sánchez Manduley". 2016-2018

RESUMEN Se realizó un estudio cuasi experimental con Autohemoterapia menor a los pacientes con Psoriasis vulgar, en el hospital "Celia Sánchez Manduley" desde marzo 2016 - mayo 2018; con el objetivo de describir la respuesta de estos pacientes a dicho tratamiento. La población objeto de estudio quedó conformada por 71 pacientes que cumplieron con los criterios de inclusión/exclusión establecidos. Los datos se obtuvieron de las historias clínicas y encuestas realizadas a los pacientes y los resultados se presentaron en tablasde contingencias mediante el sistema Windows Vista. Se estudiaron las variables: respuesta clínica, tiempo de evolución de la enfermedad, número de sesiones, efectos adversos, tiempo de aparición de brotes. Se realizó el cálculo inicial del PASI y en cada consulta de evaluación y al final del tratamiento; se calculó el porciento del cambio del PASI, pues la respuesta clínica se realizó teniendo en cuenta las categorías de éste. Se concluyó que en el estudio predominaron los pacientes respondedores al tratamiento con Autohemoterapia menor, sin influir en la respuesta el tiempo de evolución de su enfermedad. Necesitó la mayoría de los psoriásicos la mayor cantidad de sesiones para la mejoría o desaparición de las lesiones y se logró con esta terapéutica espaciar los brotes sin efectos adversos en ningún enfermo.

ABSTRACT A quasi-experimental study with less autohemotherapy was performed on patients with vulgar Psoriasis, at the "Celia Sánchez Manduley" hospital from March 2016 - May 2018; with the objective of describing the response of these patients to said treatment. The study population consisted of 71 patients who met the established inclusion / exclusion criteria. The data were obtained from the clinical histories and surveys made to the patients and the results were presented in contingency tables using the Windows Vista system. The variables were studied: clinical response, time of disease evolution, number of sessions, adverse effects, time of appearance of outbreaks. The initial calculation of the PASI was performed and in each evaluation consultation and at the end of the treatment; the percentage of the PASI change was calculated, since the clinical response was made taking into account the categories of the latter. It was concluded that in the study the patients responding to treatment with minor autohemotherapy predominated, without influencing the response time of their disease evolution. The majority of psoriatics needed the most sessions for the improvement or disappearance of the lesions and this therapy was achieved by spacing the outbreaks without adverse effects in any patient.

RESUMO Um estudo quase experimental com menos auto-hemoterapia foi realizado em pacientes com psoríase vulgar, no hospital "Celia Sánchez Manduley", de março de 2016 a maio de 2018; com o objetivo de descrever a resposta desses pacientes ao referido tratamento. A população do estudo consistiu de 71 pacientes que preencheram os critérios de inclusão / exclusão estabelecidos. Os dados foram obtidos dos prontuários e levantamentos feitos aos pacientes e os resultados foram apresentados em tabelas de contingência utilizando o sistema Windows Vista. As variáveis ​​estudadas foram: resposta clínica, tempo de evolução da doença, número de sessões, efeitos adversos, tempo de aparecimento dos surtos. O cálculo inicial do PASI foi feito e em cada consulta de avaliação e no final do tratamento; o percentual de mudança do PASI foi calculado, uma vez que a resposta clínica foi feita levando-se em consideração as categorias deste último. Concluiu-se que o estudo predominou em pacientes que responderam ao tratamento com auto-hemoterapia menor, sem influenciar o tempo de resposta da evolução de sua doença. A maioria dos pacientes com psoríase precisou da maioria das sessões para a melhora ou desaparecimento das lesões e foi conseguida com essa terapia para espaçar os surtos sem efeitos adversos em nenhum paciente.

Efficacy and safety of autohemotherapy at acupoint for acne: systematic review / 中国针灸

OBJECTIVE@#To evaluate the efficacy and safety of autohemotherapy at acupoint for acne.@*METHODS@#Randomized controlled trials (RCTs) regarding autohemotherapy at acupoint for acne were searched in CNKI, WanFang, VIP database and PubMed. According to the inclusion and exclusion criteria, two investigators performed the literature screening, data extraction and basis evaluation, independently. Meta analysis was performed by using Review Manager 5.3 software.@*RESULTS@#Eight RCTs were included, involving 573 patients. The combined effect of effective rate was 1.21 (95% : 1.12, 1.30); the combined effect of skin lesions improvement was -1.00 (95%: -2.14, -0.14, ＝1.73, =0.08); the combined effect of recurrence rate was 0.44 (95%: 0.09, 2.15, ＝1.01, =0.31).@*CONCLUSION@#The autohemotherapy at acupoint has better efficacy and skin lesions improvement for acne than control treatment, and autohemotherapy is safer.

Prevalência de aloimunização eritrocitária em pacientes portadores de anemia falciforme / Prevalence of red blood cell alloimmunization in patients with sickle cell anemia

Embora as transfusões de concentrado de hemácias sejam importantes para o tratamento de pacientes com anemia falciforme, elas acarretam riscos imunológicos tais como a aloimunização a antígenos eritrocitários. Aproximadamente 50% dos pacientes de anemia falciforme recebem transfusões no decorrer da vida, e entre 5% a 10% destes pacientes são submetidos a um programa de transfusão crônica. A aloimunização eritrocitária é uma complicação séria da transfusão, mas relativamente comum. Esta condição pode inclusive levar a reações transfusionais hemolíticas tardias e contribuir para aumentar as comorbidades da doença. Importantes medidas para prevenção destas complicações nestes pacientes são o uso de hemácias previamente fenotipadas, além da fenotipagem do próprio receptor de concentrado de hemácias, determinando seu correto perfil fenotípico e possibilitando a escolha de concentrado de hemácias com antígenos correspondentes ao do paciente a ser transfundido. Extensa genotipagem eritrocitária profilática para selecionar doadores para pacientes que receberão repetidas transfusões durante um longo período é uma aplicação atraente de tipagem de sangue baseados em DNA. Isto é, particularmente relevante para pacientes com doença falciforme onde a taxa de aloimunização é elevada.

Although packed red blood cells transfusions are important for treating patients with sickle cell anemia, this intervention may lead to immunological disturbs, such as alloimmunization by erythrocyte antigens. Approximately 50% of patients with sickle cell anemia receive blood transfusions during their life span, and about 5 to 10% of them require a chronic transfusion scheme. The red blood cell alloimmunization is a serious but common transfusion reaction. This condition could lead to delayed hemolytic transfusion reactions, contributing to increase comorbidities of the disease. Important measures to prevent these complications in patients are the use of previously phenotyped red blood cells, in addition to the phenotyping of red blood cells from the acceptor patient, determining the correct phenotypic profile and enabling the choice of red blood cells with corresponding antigens to the patient to be transfused. Extensive prophylactic red blood cell genotyping to select donors for patients receiving repeated transfusions over a long period of time is a compelling application of DNA-based blood typing. This is particularly relevant for patients with sickle cell disease where the rate of alloimmunization is high.

Regulating Yin and Yang to Reach the Balance—Discussion on Effective Mechanism of Autohemotherapy Based on Th1/Th2 Immune Deviation / 世界科学技术-中医药现代化

Based on previous clinical and basic research on autohemotherapy,its effective mechanism was explored.Autohemotherapy was used as the keyword in the document retrieval of databases such as the Pubmed,CNKI,Wanfang,VIP,and etc.from 1990 to 2017.Previous clinical and basic research results of our team were also combined in the analysis of effective mechanism study on autohemotherapy in the treatment of acne.The results showed that autohemotherapy displayed the treatment effect of acne vulgaris through the regulation of Th1/Th2 immune deviation and micro ecological imbalance of local lesions,which may be one of the important ways in the treatment of acne vulgaris by autohemotherapy.It also reflected the regulation of Yin and Yang to reach the balance.It was concluded that in the future research,taking the effect of Th1/Th2 immune deviation and micro ecological imbalance of local lesions as the starting point,it will provide experimental basis for the effect of regulating Yin and Yang to reach the balance.It can provide certain scientific basis for its clinical application.

curative effect and nursing of medical ozone autohemotherapy in clinical treatment / 中国实用护理杂志

Objective To investigate the curative effect and nursing of medical ozone autohemotherapy in clinical treatment. Methods 45 cases of cerebral infarction patients with medical ozone self blood therapy spells, psychological guidance and health education before operation in the sterile operation, postoperative nursing, education results. Results 45 cases of cerebral infarction in patients with very good completed treatment, 2 cases because of dizziness aggravated, 2 cases of vascular puncture for difficult to stop treatment, the rest were different extent achieved certain effect. Conclusions the clinical experiment showed that the nursing, preoperative education, psychological guidance and sterile operation, postoperative is an effective measure for ensuring medical ozone autohemotherapy smooth finish.

Effect of moxibustion combined with autohemotherapy of acupoint injection for life quality of allergic rhinitis withdeficiency of lung and spleen:a randomized controlled trial / 中国针灸

<p><b>OBJECTIVE</b>To observe the effects of moxibustion combined with autohemotherapy of acupoint injection and simple moxibustion for allergic rhinitis(AR) withdeficiency of lung and spleen and to explore its mechanism.</p><p><b>METHODS</b>By random number table,75 patients who matched the criteria were assigned into a moxibustion combined with autohemotherapy of acupoint injection group(a combination group,37 cases) and a moxibustion group(38 cases). In the combination group,moxibustion was used at bilateral Yingxiang(LI 20) and injection bila-teral Feishu(BL 13),Pishu(BL 20) and Zusanli(ST 36). In the moxibustion group,moxibustion was applied bilaterally at all the above acupoints. Acupoint injection was given twice a week,and moxibustion once a day,seven days as a course. The patients were observed for four courses and followed up half a year after treatment. Rhinoconjunctivitis quality of life questionnaire(RQLQ) was compared before and after treatment and at follow-up. The short-term and long-term effects as well as the changes of interferon-(IFN-),interleukin-4(IL-4) and immunoglobulin E(IgE) were observed in the two group.</p><p><b>RESULTS</b>After treatment,the obviously effective rate of the combination group was 75.68%(28/37),which was higher than 52.63%(20/38) of the moxibustion group(<0.05). But at follow-up, the obviously effective rate of the moxibustion group was 47.37%(18/38),which was better than 24.32%(9/37) of the combination group(<0.05). Life quality of the two group in all aspects after treatment and at follow-up were apparently improved compared with the baseline(<0.01,<0.05). After treatment,the life quality,sleep condition,non nasal-eye symptoms,behavior issue of the combination group were superior to those of the moxibustion group(all<0.05),and at follow-up,the above outcomes,the eye and nasal symptoms as well as emotional response of the mo-xibustion group were better(all<0.05). There was statistical significance in the two group about serum IFN-,IgE,IL-4 before and after treatment(<0.01,<0.05),and significance existed between the two groups(<0.05).</p><p><b>CONCLUSIONS</b>Moxibustion combined with autohemotherapy of acupoint injection can effectively improve the short-term quality of life of AR withdeficiency of lung and spleen. The mechanism may be related to balancing the immune response of Th1 and Th2.</p>

Análise dos níveis de imunoglobulinas séricas e monócitos de pacientes em tratamento com auto-hemoterapia / Analysis of serum immunoglobulin levels and monocytes in patient treated with autohemotherapy

A auto-hemoterapia (AHT) é uma prática de uso clínico crescente, que vem sendo utilizada como tentativa no tratamento de diversos problemas de saúde, tanto em humanos como em animais. Esse estudo teve como objetivo avaliar o efeito da AHT por meio da avaliação dos níveis de imunoglobulinas e de monócitos de pacientes que realizaram pela primeira vez o tratamento. Foi realizada a coleta de sangue antes e após 24 horas da realização da AHT, e também durante nove dias consecutivos em dez participantes, sendo cinco homens e cinco mulheres. Para realização da AHT foi coletado 10 mL de sangue venoso e aplicado no quadrante látero-superior do músculo glúteo máximo. Dos dez participantes analisados nove apresentaram aumento do número de monócitos que variou de 17% a 250%. Observou-se também aumento da Imunoglobulina M em nove dos indivíduos estudados, que variou de 10 a 28%. O aumento da Imunoglobulina G foi demonstrado em todos os participantes e variou de 13 a 36%. Foi observado também aumento de 2,6 a 89% da Imunoglobulina A em nove pacientes e aumento de 2,7 a 88,2% da Imunoglobulina E em oito indivíduos. Conclui-se que a auto-hemoterapia é fator de incremento da imunidade do organismo, pois mostrou aumento do número de monócitos e de imunoglobulinas.

Autohemotherapy (AHT) is a practice that has increasing clinical use, which is being used in an attempt to treat various health problems in both humans and animals. This study aimed to evaluate the effect of AHT by evaluating the levels of immunoglobulins and monocytes of patients who underwent the treatment for the first time. Blood was collected before and 24-hours after the AHT was performed, and also for nine consecutive days, in ten participants, five men and five women. For the AHT, a total of 10mL venous blood was collected and applied to the lateral-upper quadrant of the gluteus maximus muscle. From the ten participants analyzed, nine presented an increased number of monocytes, ranging from 17% to 250%. An increase in immunoglobulin M was observed in nine of the study subjects, ranging from 10 to 28%. An increased Immunoglobulin G was shown in all participants, which ranged from 13 to 36%. An increase of 2.6 to 89% in immunoglobulin A was observed in nine patients, and an increase of 2.7 to 88.2% in immunoglobulin E in eight individuals. It can be concluded that autohemotherapy is a factor of increased immunity of the body, since it showed an increase in the numbers of monocytes and immunoglobulins.

OZONE-A REVIEW

Ozone (O3) gas discovered in the mid-nineteenth century is a molecule consisting of three atoms of oxygen in a dynamically unstable structure due to the presence of mesomeric states. Ozone therapy has been utilized and heavily studied for more than a century. Its effects are proven, consistent, safe and with minimal and preventable side effects. Medical O3 is used to disinfect and treat disease. Mechanism of actions is by inactivation of bacteria, viruses, fungi, yeast and protozoa, stimulation of oxygen metabolism, activation of the immune system. Medication forms in a gaseous state are somewhat unusual, and it is for this reason that special application techniques have had to be developed for the safe use of O3. In local applications as in the treatment of external wounds, its application in the form of a transcutaneous O3 gas bath has established itself as being the most practical and useful method, for example at low (sub-atmospheric) pressure in a closed system guaranteeing no escape of O3 into the surrounding air. Ozonized water, whose use is particularly known in dental medicine, is optimally applied as a spray or compress. Diseases treated are infected wounds, circulatory disorders, geriatric conditions, macular degeneration, viral diseases, rheumatism/arthritis, cancer, SARS and AIDS.

Observations on the Therapeutic Effect of Acupuncture plus Autohemotherapy on Allergic Rhinitis / 上海针灸杂志

Objective To investigate the clinical efficacy of acupuncture plus autohemotherapy in treating allergic rhinitis. Methods Eighty-nine patients with allergic rhinitis were randomized into a treatment group of 45 cases and a control group of 44 cases. The treatment group was intervened by acupuncture plus autohemotherapy, and the control group was by regular acupuncture treatment. The clinical therapeutic effects were compared between the two groups after three courses of treatment. Results The cure rate and the total efficacy rate were 66.7%and 95.6%, respectively, in the treatment group and 45.4%and 88.6%, respectively, in the control group. There was a statistically significant difference in the cure rate between the two groups (P＜0.05). Conclusion Acupuncture plus autohemotherapy is an effective way to allergic rhinitis.

Clinical Observations on the Efficacy of Autohemotherapy plus Pricking-cupping Bloodletting in Treating Common Acne / 上海针灸杂志

ObjectiveTo investigate the clinical efficacy of autohemotherapy plus pricking-cupping bloodletting in treating common acne.MethodFifty-six patients with common acne were randomly allocated to a treatment group of 28 cases and a control group of 28 cases. The treatment group received autohemotherapy plus pricking-cupping bloodletting and the control group, oral administration of licorzinc plus external application of benzoyl peroxide gel. In the two groups, the skin injury scorewas recorded and the overall therapeutic effects were evaluated.ResultThere was a statistically significant pre-/post-treatment difference in the skin injury score in the two groups (P<0.05). The skin injury score decreased more in the treatment group than in the control group (P<0.05). There was a statistically significant difference in the overall therapeutic effect between the two groups (P<0.01). The therapeutic effect was significantly better in the treatment group than in the control group.Conclusion Autohemotherapy plus pricking-cupping bloodletting is an effective, reliable, safe and convenient way to treat common acne.

Clinical effect of autohemotherapy combined loratadine on 120 cases of ASST positive chronic idiopathic urticaria / 重庆医学

Objective To investigate the efficacy and safety of autohemotherapy therapy in ASST positive chronic idiopathic ur‐ticaria .Methods One hundred and twenty cases of chronic idiopathic urticaria treated in our department from April ,2012 to Janu‐ary ,2013 were divided into treatment group and control group ,60 cases in each group .Patients in treatment group were given oral ioratadine (10 mg/d) ,supplemented by autohemotherapy ;patients in control group were only given oral ioratadine (10 mg/d) .Both of the two groups were treated with twelve weeks ,then observed the effectiveness and safety of two kinds of treatment .Results The effective rate of treatment group and control group were 68 .33% and 48 .33% respectively ,and there was significant difference between the two groups (P<0 .01) .Conclusion Autohemotherapy combined antihistamine was of high efficiency and safety in the treatment of ASST positive chronic idiopathic urticaria ,while the long‐term curative effect remains to be observed .

Clinical research of autohemotherapy combined with bacillus calmette-guerin polysaccharide and nucleic acid in treatment of facial steroid-dependent dermatitis / 中国医师进修杂志

Objective To observe the clinical effect and security of autohemotherapy combined with bacillus calmette-guerin polysaccharide and nucleic acid in treatment of facial steroid-dependent dermatitis.Methods The 74 patients with facial steroid-dependent dermatitis were divided into treatment group (38patients) and control group (36 patients) according to the treatment method.The patients in treatment group were treated with autohemotherapy combined with bacillus calmette-gnerin polysaccharide and nucleic acid 1 ml muscle injection,every 3 days a time for 4 weeks.The patients in control group were treated with bacillus calmette-guerin polysaccharide and nucleic acid,every 3 days a time for 4 weeks.The effect was compared between the two groups.Results The total effective rate in treatment group was 84.2％(32/38),in control group was 63.9％(23/36),there was significant difference between the two groups (P ＜ 0.05).No serious adverse reaction was found in two groups.Conclusion Autohemotherapy combined with bacillus calmettegnerin polysaccharide and nucleic acid is safe and effective in treatment of facial steroid-dependent dermatitis.

Auto-hemoterapia, intervenção do estado e bioética / Autohemoteraphy, state intervention and bioethics

A auto-hemoterapia é uma prática de uso clínico crescente, mas com potencial risco à saúde dos indivíduos, uma vez que se trata de procedimento terapêutico sem comprovação científica. Até o momento não existem estudos clínicos que comprovem a eficácia e a segurança deste procedimento; apenas pesquisas experimentais com resultados questionáveis, tanto em seres humanos quanto em animais. Nos últimos anos, a área de Vigilância Sanitária (VS) do Ministério da Saúde ampliou suas ações preventivas e de controle de riscos tanto no âmbito privado como coletivo. As ações da VS têm, muitas vezes, como base o poder legal de polícia administrativa que a legislação lhe confere. Esse poder é entendido como a faculdade que dispõe a Administração Pública para condicionar e restringir o uso e gozo de bens, atividades e direitos individuais, em benefício da coletividade ou do próprio Estado. Recentemente, o Estado, por meio do poder de polícia da VS, interveio na prática da auto-hemoterapia no Brasil. O presente estudo analisa e defende a ação interventiva da VS na prática clínica da auto-hemoterapia no país, tendo como base de sustentação argumentativa os "Quatro Pês" desenvolvidos pela chamada "Bioética de Intervenção" - prevenção, proteção, precaução e prudência.

The increasingly frequent practice of autohemotherapy entails a potential risk to the health of individuals since it is scientifically unproven. There are practically no clinical studies showing the efficacy and safety of this procedure; only experimental research with questionable results from studies on human beings and animals. Over the last years, the sanitary surveillance area has expanded its preventive and risk control actions based upon a precautionary philosophy in the private as well as the public sphere. By observing the theoretical and practical reference points of the "four Ps" (prevention, protection, precaution and prudence), in accordance with the epistemology developed within Intervention Bioethics, sanitary surveillance actions are based upon legal administrative policing powers. These powers are understood to be the Public Administration's competence to set conditions on and restrict the use and benefit of goods, activities and individual rights, on behalf of the common well being of people or the State itself. The Brazilian State, through its sanitary surveillance policing powers at the three levels of government, has intervened in the practice of autohemotherapy. Considering the responsible State intervention in situations of collective interest, vulnerability and susceptibility, the present study proposed to analyze the practice of autohemotherapy in the light of sanitary surveillance actions and their relationship with the "four Ps" of Intervention Bioethics.