La ozonoterapia: revisión bibliográfica / Therapy with ozone: bibliographic revision

Hablar de ozonoterapia es hablar de una alternativa médica, que debe actuar como coadyuvante de otras terapias tradicionales. Es una técnica antigua, data desde la primera guerra mundial, donde se observaron sus sorprendentes resultados en el tratamiento de heridas sépticas. Actualmente se conoce que el ozono regula el estrés oxidativo celular, incrementa el metabolismo del oxígeno, modula la actividad inmune, activa la circulación, es analgésico y anti-inflamatorio, además de un potente germicida, cualidades que han hecho que esta técnica ocupe un lugar muy importante en la Comunidad Europea, ya que en algunos países como Alemania e Italia, es usada por hospitales del Seguro Social, por su efectividad y costo. La ozonoterapia no ha reportado efectos indeseables o dañinos en la literatura médica mundial. Debido a los diferentes lugares de acción puede tratar muchas patologías, que a veces la medicina alopática no lo puede hacer. Hay que recalcar que el ozono no es un milagro y si hay algo evidente son los resultados, pero también hay fracasos y pacientes que no responden al tratamiento, como lo hacen frente a otras opciones terapéuticas, por lo que no es justo y pertinente que se lo desprestigie ni a quienes lo utilizan con criterio científico.

Speaking of therapy with ozone is to speak of a medical alternative, which must act as a help of other traditional therapies. It is an ancient technique; it is used since First World War, when its amazing results were observed treating septic wounds. Now we know that ozone regulates the cellular oxidative stress, increases oxygen metabolism, modulates immunological activity, activates circulation, it is analgesic and anti-inflammatory, besides it is a powerful germicide. These features have made that of this technique has a very important place in European Community, since in some countries like Germany and Italy it is used in social Security hospitals because its effectiveness and cost. Therapy with ozone has not reported undesirable side effects or damages in the world medical literarture. Because of the different places where it can act, it can treat many pathologies that some times allopathic medicine can’t treat. We must emphasize that ozone is not a miracle and if something is evident, it is its results, but there are also failures and patients that do not respond to this treatment, as they do to other therapeutical options, which is why it is not fair nor appropriate to discredit it or who use it with a scientific approach.

The effect of medical ozone injection for the treatment of knee joint osteoarthritis on serology:a comparative study between intra-articular and intravenous injection in rabbit models / 介入放射学杂志

Objective To compare the variations of serum cytokines before and after ozone injection with different dosages and between intra-articular injection of knee joint and autohemotransfusion injection in experimental rabbits,to make a further understanding of the biologic mechanism of ozone therapy on osteoarthritis(OA).Methods Thirty-six New Zealand white rabbits were equally and randomly divided into six groups:(1) normal group,(2) OA model group,receiving no treatment,(3) group L10,receiving 10 ?g/ml ozone per intra-articular injection,(4) group L30,receiving 30 ?g/ml ozone per intra-articular injection,(5) group S10,receiving autohemotransfusion with 10 ?g / ml of ozonized blood per injection and(6) group S30,receiving autohemotransfusion with 30 ?g/ml of ozonized blood per injection.OA models were prepared by injecting 0.5 ml of collagenase II solution into the knee joint space two times with an interval of three days.Blood samples of all groups were collected 4 weeks after the last ozone treatment for further analysis.Serum levels of NO,T-SOD,TNF-? and IL-1? were estimated.Results The serum levels of NO,T-SOD,TNF-? and IL-1? in the model group and all treated groups were significantly higher than that in normal group(P0.05).Conclusion(1) An increase in the serum levels of NO,T-SOD,TNF-? and IL-1? exists in rabbit OA models.(2) Ozone has no inhibitary effect on the serum levels of NO,T-SOD,TNF-? and IL-1?,regardless of what route of administration of ozone is adopted.(3) The effect of "oxidative preconditioning" is not local,but rather systemic.