Hashimoto‘S Encephalopathy Case Reports Of Hashimoto‘S Encephalopathy In Tertiary Care Hospital

Hashimoto's encephalopathy (HE) is an uncommon syndrome and rare disease, associated with Hashimoto thyroiditis. It is characterized by a acute to chronic loss of cognitive dysfunction ,subacute onset of confusion with altered level of consciousness, stroke like episodes , neuropsychiatric manifestations ,seizures, and myoclonus. HE is believed to be an immune-mediated disorder rather than representing the direct effect of an altered thyroid state on the central nervous system. Hashimoto encephalopathy or Steroid-responsive encephalopathy associated with autoimmune thyroiditis (SREAT) and a more general term, nonvasculitic autoimmune meningoencephalitis, are also used to describe this condition. Here we are reporting 3 cases of hashimoto encephalopathy in the tertiary care centre who presented with acute to chronic memory loss , neuropsychiatric disturbances, complex parital seizures visual hallucinations and myoclonus and responded to steroids. A negative microbiological screen of the CSF and serum along with raised CSF protein, elevated serum antithyroid antibodies, characteristic EEG and neuroimaging findings yielded the diagnosis

A Patient of Thyroid Storm with Neurological Manifestations and MRI Abnormalities

Thyrotoxicosis autoimmune encephalopathy (TAE) and Hashimoto's encephalopathy (HE) are steroid responsive disorders of persistent or relapsing neurological or neuropsychological deficits associated with elevated serum concentrations of an antithyroid antibody. Most patients with TAE or HE are reported to have normal brain imaging findings at the time of presentation. We report here a rare case of TAE in whom brain MRI abnormalities were associated with clinical manifestations of thyroid storm.