ABSTRACT
Resumen La investigación en cognición implícita ha aumentado de manera vertiginosa durante las últimas décadas, principalmente por el uso generalizado de procedimientos experimentales conocidos como medidas implícitas. A diferencia de los cuestionarios de autoinforme, estas metodologías impiden que sesgos como la deseabilidad social afecten las respuestas de los participantes, lo que permite abordar temas sensibles. Sin embargo, las medidas implícitas difieren en aspectos como las instrucciones, los materiales o los indicadores conductuales analizados. Debido a esto, hay controversia sobre la naturaleza de los procesos que están siendo medidos, las características que se les atribuyen y, por ende, la posibilidad de hacer comparaciones entre los estudios que emplean diferentes medidas implícitas. Basándose en un modelo de procesamiento dual, este trabajo propone que las medidas implícitas pueden entenderse como indicadores de procesos automáticos. A partir de dicha propuesta, se discuten los requisitos que las medidas implícitas deben cumplir y algunos desafíos para la investigación en automaticidad.
Abstract The research on implicit cognition has increased dramatically over the past few decades, mainly because of the widespread use of experimental procedures known as implicit measurements. In contrast to self-report questionnaires, these methodologies prevent biases as social desirability from affecting participants' responses, allowing sensitive issues to be addressed. However, the implicit measures differ in central aspects as the instructions, materials, or behavioral indicators analyzed. For those reasons, there is controversy about the nature of the processes being measured, the characteristics attributed to them, and, therefore, the possibility of making comparisons between studies that use different implicit measures. Based on a dual processing model, this paper proposes that implicit measures can be understood as indicators of automatic processes. Finally, we will discuss the requirements that implicit measures must satisfy, and some challenges for research in automaticity.
ABSTRACT
Objective This article discussed individualized and self-organized psychotherapy .Methods This therapy utilized the“sensory experience”as the entry point ,the systematic regulating mechanism underlying the human body was activated by stimula-ted the automaticity movement of organisms ,so as to realized the treatment of mental illness .Results It could effectively cured va-rious functional diseases such as endocrine disorder ,depression and cancer ,etc .Conclusion As a“de-psychologized”method ,“Sen-sory experience” is distinct from other psychological methods that are based on cognitive psychology .This difference brings about not only an innovation in psychotherapy ,but also profound philosophic considerations .
ABSTRACT
Since first discovered in chick skeletal muscles, stretch-activated channels (SACs) have been proposed as a probable mechano-transducer of the mechanical stimulus at the cellular level. Channel properties have been studied in both the single-channel and the whole-cell level. There is growing evidence to indicate that major stretch-induced changes in electrical activity are mediated by activation of these channels. We aimed to investigate the mechanism of stretch-induced automaticity by exploiting a recent mathematical model of rat atrial myocytes which had been established to reproduce cellular activities such as the action potential, Ca2+ transients, and contractile force. The incorporation of SACs into the mathematical model, based on experimental results, successfully reproduced the repetitive firing of spontaneous action potentials by stretch. The induced automaticity was composed of two phases. The early phase was driven by increased background conductance of voltage-gated Na+ channel, whereas the later phase was driven by the reverse-mode operation of Na+/Ca2+ exchange current secondary to the accumulation of Na+ and Ca2+ through SACs. These results of simulation successfully demonstrate how the SACs can induce automaticity in a single atrial myocyte which may act as a focus to initiate and maintain atrial fibrillation in concert with other arrhythmogenic changes in the heart.
Subject(s)
Animals , Rats , Action Potentials , Atrial Fibrillation , Fires , Heart , Models, Theoretical , Muscle Cells , Muscle, SkeletalABSTRACT
The mechanism of antiarrhythmic effects of palmatine( Pal), an benzoquinolizine compound were studied in experimental animals.In the isolated guinea pig papillary muscles, Pal 50 ?mol/L markedly prolonged the functional refractory period(FRP)and decreased the automaticity induced by adrenaline, but exerted no effect on excitabj- iity and contractility of the muscles.Pal(10 ?mol/L ) prolonged both APD20 and APD90 of the action potential of guinoa pig papillary muscles. The Vmax was decreased at 100 ?mol/L Pal, but the action potential amplitude( APA ) and resting potential ( RP ) were unaltered.The antiarrhythmic action of Pal may be due to its ability to decrease automaticity and to proloagate FRP and APD of the myocardium.
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The effect of 4 -Phosphate- lydroxypiperaquine ( PHPQ) on the phsiologic properties in isolated auricle of guinea pig was studied.Twenty minutes after PHPQ 30 ?mol/L was added, the contractility & dT/dtmax of the left atria of guinea pig were decreased to 74.4 ? ( SD ) 5.3%(n=6, P
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Corydalis amabilis Migo total alkaloids (COAMTA) possessed antihypertensive and vaso-dilatative action in animal experiments. Its effects on the physiological properties in isolated guinea pig papillary muscles & atrium preparations were described in this papar.10mg/L COAMTA markedly prolonged the functional refractory period(FRP) and inhibited epinephrine induced automaticity. Suppression of normal & abnormal automaticity and prolongation of FRP may contribute to the effectiveness of COAMTA on arrhythmia.
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Intravenous injection of SPD 10 mg/kg could increase the tolerant dose of ouabain, and prevent the arrhythmias induced by acute myo-cardial ischemia in rats and that elicited by adrenaline-chloroform model in rabbits. SPD 60 mg/kg intraperitoneally could abolish the ventricular fibrillation produced by chloroform inhalation in mice. It inhibited the contractility, prolonged the functional refractory period and decreased the automaticity significantly of the isolated guinea pig papillary muscles, but no significant effect on excitability.
ABSTRACT
7-Bromethyoxybenzentetrahydropalmatine ( EBP) possessed antiarr-hythmic effect in several animals models.The authors studied the direct influence of EBP on the automaticity, refractory period, excitability and the contractility of isolated papillary muscle and atrium of guinea pig.EBP was found to decrease the automaticity and prolong the functional refractory period and increase the contractility of guinea pig papillary muscle, but it exerted no influence on its excitability.The decrease in automoticity and prolongation of refractory period was thought to be ascribed to its antiarrhythmic action.