ABSTRACT
Viral diseases caused by virus infection have the characteristics of strong pathogenicity, high incidence of disease and easy to produce drug resistance. At present, chemical drugs are commonly used in clinical treatment to fight viral diseases, but the therapeutic effect of chemical drugs is not significant and most of them have toxic and side effects, which are easy to cause secondary injury to patients. The complexity of the active ingredients of Chinese materia medica makes it play an antiviral role at multiple levels and targets. Marine traditional medicine species are rich and diverse, it has been suggested that they have good antiviral effect and low side effects. The development and application of marine Chinese materia medica with anti-virus effect will attract more attention in the future, and has a broad market prospect. In this paper, 250 kinds of marine Chinese materia medica with antiviral effect recorded in the book "Marine traditional Chinese medicine" were reviewed, hoping to provide some reference for the basic and clinical research of marine Chinese materia medica with antiviral effect.
ABSTRACT
Objective To investigate the chemical constituents in the aerial parts of mangrove plant Avicennia marina. Methods The isolated compounds Ⅰ-Ⅹ were obtained by the combination of silica gel, Sephadex LH-20 column chromatographies and by semi-preparative HPLC separation. Structural elucidation was conducted by the modern spectral method. Results Ten compounds were isolated and identified from the aerial parts of A. marina, including acteoside (Ⅰ), isoacteoside (Ⅱ), syringaresinol (Ⅲ), 5, 7-dihydroxy-3′, 4′, 5′-trimethoxyflavone (Ⅳ), indolyl-3-carboxylic acid (Ⅴ), betulinic acid (Ⅵ), betullin (Ⅶ), lupeol (Ⅷ), avicequinone C (Ⅸ), and kaempferol (Ⅹ). Conclusion Compounds Ⅰ-Ⅵ are isolated from A. marina for the first time.