O trauma de face submetido a cirurgia: Uma análise epidemiológica de 10 anos no interior do Brasil / Facial trauma undergoing surgery: A 10-year epidemiological analysis in the interior of Brazil

Introdução: O trauma de face representa significativa incapacitação para a vítima, além de um desafio para as equipes de saúde devido a sua complexidade e envolvimento de estruturas nobres. Analisar a sua epidemiologia permite coordenar medidas em saúde pública para melhorar o atendimento e a prevenção. Método: Estudo observacional, descritivo, longitudinal, com abordagem retrospectiva a partir dos prontuários dos pacientes vítimas de trauma de face atendidos pela clínica cirúrgica no período entre 2010 e 2019. Resultados: Dentre os 529 prontuários incluídos no estudo e analisados, 71,08% tratava-se de cirurgias eletivas e o restante, 28,92%, de cirurgias de urgência. O trauma foi mais frequente em indivíduos de 20 a 29 anos, o que corresponde a 31,76% do total de casos. Também foi mais frequente em indivíduos do sexo masculino, correspondendo a 78,45% do total de casos. Acidentes automobilísticos foram a causa mais comum, descrita em 22,31% dos prontuários, e a principal fratura, presente em 85,83% dos casos, foi dos ossos próprios do nariz. Conclusão: As vítimas de traumatismo bucomaxilofacial atendidas no Hospital de Clínicas da Universidade Federal do Triângulo Mineiro são predominantemente homens na terceira década de vida, envolvidos em acidentes automobilísticos, com lesões em ossos do nariz que foram abordadas de forma eletiva.

Introduction: Facial trauma represents significant incapacitation for the victim, as well as a challenge for healthcare teams due to its complexity and involvement of important structures. Analyzing its epidemiology allows us to coordinate public health measures to improve care and prevention. Method: Observational, descriptive, longitudinal study with a retrospective approach based on the medical records of patients who suffered facial trauma treated by the surgical clinic between 2010 and 2019. Results: Among in individuals aged 20 to 29 years, which corresponds to 31.76% of total cases. It was also more common in males, corresponding to 78.45% of total cases. Car accidents were the most common cause, described in 22.31% of medical records, and the main fracture, present in 85.83% of cases, was of the bones of the nose. Conclusion: Victims of oral and maxillofacial trauma treated at the Hospital de Clínicas da Universidade Federal do Triângulo Mineiro are predominantly men in their third decade of life, involved in automobile accidents, with injuries to the bones of the nose that were treated electively.

Biotipo facial y clasificación esquelética maxilomandibular en pacientes angolanos con anomalías dentomaxilofaciales

Fundamento las mediciones cefalométricas son un instrumento útil en la atención ortodóncica, pues junto a otras mediciones cefalométricas completan y guían el plan de tratamiento que el especialista puede trazar en función de la resolución de las anomalías dentomaxilofaciales. Objetivo determinar la comorbilidad entre el biotipo facial y la clasificación esquelética maxilomandibular en pacientes angolanos con anomalías dentomaxilofaciales. Métodos se realizó un estudio descriptivo transversal, en la Clínica Meditex, en Luanda, Angola, en el período agosto/2021-julio/2023. La población de estudio fue de 123 telerradiografías del perfil de pacientes con anomalías dentomaxilofaciales, ingresados en la consulta de Ortodoncia. Para el análisis de la telerradiografía de perfil se realizaron mediciones del cefalograma de Ricketts y de Steiner, y se utilizó el software Facad versión 3403. Se estudió la clasificación esquelética maxilomandibular (clase I, clase II, clase III) y el biotipo facial (dolicofacial, mesofacial, braquifacial). Resultados el 46,34 % de los pacientes presentó una clase II esquelética maxilomandibular. Mediante el índice VERT de Ricketts, el 49,59 % de los casos fue clasificado como dolicofacial, seguido del 42,27 % como braquifacial. El 83,60 % de los pacientes con biotipo dolicofacial se caracterizó por presentar una clase II esquelética maxilomandibular, y el 76,92 % de aquellos con biotipo braquifacial clasificó como clase III. Se encontró una asociación significativa entre el biotipo facial y la clasificación esquelética maxilomandibular (p= 0,000). Conclusiones en la mayoría de los pacientes con anomalías dentomaxilofaciales se evidenció una relación entre el biotipo dolicofacial y la clase II esquelética maxilomandibular, por lo que existe una comorbilidad entre ambas características esqueléticofaciales.

Foundation cephalometric measurements are a useful instrument in orthodontic care, since together with other cephalometric measurements they complete and guide the treatment plan that the specialist can draw up based on the resolution of dentomaxillofacial anomalies. Objective to determine the comorbidity between facial biotype and maxillomandibular skeletal classification in Angolan patients with dentomaxillofacial anomalies. Methods a cross-sectional descriptive study was carried out at the Meditex Clinic, in Luanda, Angola, from August/2021 to July/2023. The studied population was 123 patients' profile teleradiographs with dentomaxillofacial anomalies, admitted to the Orthodontic clinic. For the analysis of the profile teleradiography, measurements of the Ricketts and Steiner cephalogram were made, and the Facad software version 3403 was used. The maxillomandibular skeletal classification (class I, class II, class III) and the facial biotype (dolichofacial, mesofacial, brachyfacial) were studied. Results 46.34% of patients presented maxillomandibular skeletal class II. Using the Ricketts VERT index, 49.59% of cases were classified as dolichofacial, followed by 42.27% as brachyfacial. 83.60% of patients with dolichofacial biotype were characterized by having maxillomandibular skeletal class II, and 76.92% of those with brachyfacial biotype were classified as class III. A significant association was found between facial biotype and maxillomandibular skeletal classification (p= 0.000). Conclusions in the majority of patients with dentomaxillofacial anomalies, a relationship was evident between the dolichofacial biotype and the maxillomandibular skeletal class II, so there is a comorbidity between both skeletal-facial characteristics.

Assessing peri-implant bone microarchitecture: conventional vs. osseodensification drilling - ex vivo analysis

Abstract: The aim was to evaluate primary implant stability and bone microarchitecture in two drilling situations, by comparing the conventional technique (CT) and osseodensification (OD) (Versah Burs - Jackson - Mississippi - USA). The implant insertion torque (IT), implant stability quotient (ISQ), and the peri-implant trabecular microstructure were assessed on bone fragments obtained from pig's tibia (n=12), divided between CT (n=6) and OD (n=6). After the drilling procedure, the implants were installed (3.5x8.5 mm, Epikut - SIN - São Paulo - Brazil). The IT and ISQ were measured using a digital torque wrench and resonance frequency analysis. Then, the bone fragments containing the implants were removed with a trephine and analyzed by Microtomography (µCT, 8.0 µm). The comparison between groups was performed using the unpaired t-test (α=0.05). The results revealed that OD promotes a higher insertion torque (CT: 7.67±2.44 Ncm; OD: 19.78±5.26 Ncm) (p=0.0005), although ISQ was not different (CT: 61.33±4.66; OD: 63.25±4.58) (p=0.48). There was a significant increase in peri-implant bone volume (CT: 23.17±3.39 mm3; OD: 32.01±5.75 mm3) (p=0.008), and trabecular parameters: separation (CT: 0.4357±0.03 mm; OD: 0.3865±0.04 mm) (p=0.0449), number (CT: 1.626±0.18 1/mm; OD: 1.946±0.13 1/mm) (p=0.007), and thickness (CT: 0.1130±0.009 mm; OD: 0.1328±0.015 mm) (p=0.02). Structure model index (SMI) data demonstrate no significant differences between groups (CT: 1.7±0.2; OD: 1.4±0.4) (p=0.12). In conclusion, OD increases the insertion torque values and promotes beneficial changes regarding bone microarchitecture compared with CT, revealing more peri-implant bone volume with consequent higher primary stability.

Resumo O objetivo deste estudo foi avaliar a estabilidade de implante e a microarquitetura óssea em duas técnicas de fresagem, comparando a técnica convencional (CT) e a osseodensificação (OD) (Versah Burs - Jackson - Mississippi - EUA). O torque de inserção do implante (IT), quociente de estabilidade primária (ISQ) e a estrutura trabecular peri-implantar foram avaliados em fragmentos ósseos obtidos de tíbia de porco (n=12), divididos entre CT (n=6) e OD (n=6). Após o procedimento de fresagem, foram instalados implantes (3,5x8,5 mm, Epikut - SIN - São Paulo - Brasil). O IT e o ISQ foram aferidos por meio de um torquimetro digital e análise de frequência de ressonância. Em seguida, os fragmentos ósseos contendo os implantes foram removidos com trefina e analisados ​​por microtomografia computadorizada (µCT, 8,0 µm). A comparação entre os grupos foi realizada por meio do teste-t não-pareado (α=0.05). Os resultados revelaram que a OD promove maior torque de inserção (CT: 7,67 ± 2,44º Ncm; OD: 19,78 ± 5,26 Ncm) (p=0,0005), embora a estabilidade primária não tenha sido diferente (CT: 61.33 ± 4.66; OD:63.25 ± 4.58) (p=0,48). Houve um aumento significativo no volume ósseo peri-implantar (CT: 23,17±3,39 mm3; OD: 32,01±5,75 mm3) (p=0,0089) e parâmetros trabeculares: separação (CT: 0,4357 ± 0,03 mm; OD: 0,3865 ± 0,04 mm) (p=0,0449), número (CT: 1,626 ± 0,18 1/mm; OD: 1,946 ± 0,13 1/mm) (p=0,007) e espessura (CT: 0,1130 ± 0,009 mm; OD: 0,1328 ± 0,015 mm) (p=0,02) O índice de modelo estrutural (SMI) não demostrou diferença estatisticamente significativa (p=0.1228). Concluindo, OD apresenta maiores valores de torque de inserção e promove mudanças benéficas na microarquitetura óssea em comparação com a TC, revelando maior volume ósseo peri-implantar.

Tratamiento de las fracturas maxilofaciales en un hospital cubano durante la pandemia de COVID-19

Introducción: La epidemiología de las fracturas maxilofaciales varía en dependencia de los estilos de vida, el nivel cultural y el estatus socioeconómico en diferentes zonas geográficas. Objetivo: Caracterizar epidemiológica y terapéuticamente a los pacientes con fracturas maxilofaciales, atendidos en un hospital universitario cubano durante la pandemia de COVID-19. Métodos: Se realizó un estudio observacional, descriptivo y transversal a los pacientes atendidos en el Servicio de Cirugía Maxilofacial del Hospital General Universitario "Carlos Manuel de Céspedes" de Bayamo, provincia Granma, durante el 1 de enero y el 31 de diciembre de 2020. Se estudiaron variables epidemiológicas y terapéuticas. Resultados: Se incluyeron 85 pacientes con 220 fracturas. Los hombres fueron los más afectados (n = 74; 87,06 %) y la proporción hombre/mujer resultó de 6,73:1. El grupo etario de 41-60 años (n = 40; 47,06 %) sobresalió. En el 38,89 % de los casos el trauma se relacionó con violencia interpersonal. Cincuenta y cuatro pacientes (63,52 %) tuvieron fracturas del complejo cigomático. El ángulo mandibular constituyó la localización anatómica más afectada. Las fracturas mandibulares se trataron fundamentalmente mediante reducción cerrada. Conclusiones: El perfil epidemiológico de las fracturas maxilofaciales se destacó en los pacientes adultos masculinos debido, principalmente, a la violencia interpersonal. Las fracturas complejas del tercio medio facial se trataron por método abierto. La distribución temporal de los casos mostró el impacto de la COVID-19 en la epidemiología de estos traumas.

Introduction: The epidemiology of maxillofacial fractures varies according to lifestyles, cultural level and socioeconomic status in different geographical areas. Objective: To characterize epidemiologically and therapeutically the patients with maxillofacial fractures treated in a Cuban university hospital during the COVID-19 pandemic. Methods: An observational, descriptive and cross-sectional study was carried out on patients attended at the Maxillofacial Surgery Service of the General University Hospital "Carlos Manuel de Céspedes" of Bayamo, Granma province, between January 1 and December 31, 2020. Epidemiological and therapeutic variables were studied. Results: 85 patients with 220 fractures were included. Men were the most affected (n = 74; 87.06 %) and the male/female ratio was 6.73:1. The age group 41-60 years (n = 40; 47.06 %) stood out. In 38.89 % of the cases the trauma was related to interpersonal violence. Fifty-four patients (63.52 %) had fractures of the zygomatic complex. The mandibular angle was the most damaged anatomical location. Fractures were treated primarily by closed reduction. Conclusions: The epidemiological profile of maxillofacial fractures was prominent in adult male patients mainly due to interpersonal violence. Complex fractures of the midfacial third were treated by open method. The temporal distribution of the cases showed the impact of COVID-19 on the epidemiology of these traumas.

Os Intermetatarseum: A Rare Variation of Great Relevance / Os Intermetatarseum: Una Rara Variación de Gran Relevancia

SUMMARY: The os intermetatarseum is an accessory bone located in the foot, usually between the first 2 metatarsals and the cuneiform bone. It can be presented as free, articulated or in a fused fashion. It is a very unusual variation found in less than 13 % of the population. A 27-year-old patient presented to the emergency service due to an ankle lesion. Physical exam showed pain and limited range of motion while supporting partial load. Radiographic imaging showed a bony trace near the base of the first and second metatarsals, diagnosed as the os intermetatarseum. Formation of this supernumerary bone begins as a separate ossification center. Most cases are asymptomatic; however, compression of the deep peroneal nerve branches by the os intermetatarseum can lead to pain. Some authors suggest that the presence of this bone may cause hallux valgus. The intermetatarseum can lead to diagnostic confusion, mainly related to Lisfranc fracture. Its origin is still little understood.

El os intermetatarseum es un hueso accesorio ubicado en el pie, generalmente entre los 2 primeros metatarsianos y el hueso cuneiforme. Puede presentarse de forma libre, articulada o fusionada. Es una variación muy inusual que se encuentra en menos del 13 % de la población. Paciente de 27 años que acude a urgencias por lesión en tobillo. El examen físico mostró dolor y rango de movimiento limitado mientras soportaba una carga parcial. Las imágenes radiológicas mostraron un rastro óseo cerca de la base del primer y segundo metatarsianos, diagnosticado como os intermetatarseum. La formación de este hueso supernumerario comienza como un centro de osificación separado. La mayoría de los casos son asintomáticos; sin embargo, la compresión de las ramas profundas del nervio fibular en el espacio intermetatarsiano puede provocar dolor. Algunos autores sugieren que la presencia de este hueso puede provocar hallux valgus. El hueso intermetatarsiano puede llevar a confusión diagnóstica, principalmente relacionada con la fractura de Lisfranc. Su origen aún es poco comprendido.

Analysis of the Asterion Morphology in Relation to Its Clinical Significance / Análisis de la Morfología del Asterion en Relación con su Importancia Clínica

SUMMARY: The asterion presents a significant anthropological marking and meeting point between three sutures. It is a surface landmark for the transverse-sigmoid venous sinus complex and is also a surgical landmark for access to the posterior cranial fossa, giving it clinical importance. The aim of this research was to analyze the shape of the asterion and to set the measurement methods that will determine distance between the asterion and surrounding features. The study sample, as a part of the Osteological collection of the Department of Anatomy, Faculty of Medicine Novi Sad, consisted of 43 skulls. Morphometric analysis was related to the measurement of the defined parameters and descriptive analysis presented the classification of asterion in relation to the presence of sutural bones, as well as the determination of the position of the asterion according to the transverse-sigmoid venous complex. There was a statistically significant difference between male and female skulls for all the measured parameters. The results show that 34.88 % were type 1 (one or more sutural bones are present) and 65.12 % were type 2 asteria (no sutural bones are present). More frequent occurrence of asteria type 2 was seen on both, male and female skulls. The most frequent position of the asteria on both sides of the skull was in the transverse- sigmoid venous complex (76.92 % on the right side vs. 72.22 % on the left cranial side). Clinical significance of knowing the area of asterion is reflected in order to make the surgical, as well as diagnostic procedures, as successful as possible.

El asterion presenta una importante marca antropológica y punto de encuentro entre tres suturas. Es un punto de referencia de superficie para el complejo del seno venoso sigmoideo transverso y también es un punto de referencia quirúrgico para el acceso a la fosa craneal posterior, lo que le confiere importancia clínica. El objetivo de esta investigación fue analizar la forma del asterión y establecer los métodos de medición que determinarán la distancia entre el asterión y las características circundantes. La muestra del estudio, que forma parte de la colección osteológica del Departamento de Anatomía de la Facultad de Medicina de Novi Sad, estuvo compuesta por 43 cráneos. El análisis morfométrico se relacionó con la medición de los parámetros definidos y el análisis descriptivo presentó la clasificación del asterion en relación a la presencia de huesos suturales, así como la determinación de la posición del asterion según el complejo venoso transverso-sigmoideo. Hubo una diferencia estadísticamente significativa entre los cráneos masculinos y femeninos para todos los parámetros medidos. Los resultados muestran que el 34,88 % eran tipo 1 (hay uno o más huesos suturales presentes) y el 65,12 % eran asteria tipo 2 (no hay huesos suturales presentes). Se observó una aparición más frecuente de asteria tipo 2 en cráneos tanto masculinos como femeninos. La posición más frecuente de la asteria en ambos lados del cráneo fue en el complejo venoso sigmoideo transverso (76,92 % en el lado derecho vs. 72,22 % en el lado craneal izquierdo). La importancia clínica de conocer el área de asterion se refleja en que los procedimientos quirúrgicos y de diagnóstico tengan el mejor resultado posible.

Fratura de mandíbula: análise de 50 casos cirúrgicos em um hospital escola / Jaw fracture: analysis of 50 surgical cases in a teaching hospital

Introdução: A mandíbula é o maior e mais forte dos ossos da face. Em razão de sua topografia, apresenta vulnerabilidade nos traumas. A análise de dados sobre as fraturas de mandíbula se mostram fundamentais para auxiliar no tratamento e em políticas de saúde pública. O objetivo desse estudo é realizar um levantamento epidemiológico de fraturas mandibulares tratadas cirurgicamente. Método: Triagem através do sistema de informação hospitalar, buscando pacientes submetidos a cirurgia para fratura de mandíbula realizadas em um hospital escola pela equipe de cirurgia plástica, em Campinas-SP, de abril de 2015 a abril de 2020. Foram, então, coletados dados por meio da análise de prontuários. Resultados: Foram incluídos 50 pacientes, sendo 90% do sexo masculino. A média de idade foi 30,7 anos. A etiologia predominante foi acidente automotivo e a região mais fraturada na mandíbula foi a parassínfise. A mediana de tempo entre o trauma e cirurgia foi de 19 dias. Onze (22%) pacientes apresentavam alguma comorbidade. Quatorze pacientes (28%) foram internados em Unidade de Terapia Intensiva (UTI) e 42% operaram com outra especialidade além da Cirurgia Plástica. Dez (20%) pacientes apresentaram alguma complicação da cirurgia, sendo a mais comum a deiscência de ferida operatória. Conclusão: Houve predominância entre homens jovens e de acidentes de trânsito como etiologia. As fraturas foram localizadas preferencialmente na região da parassínfise e foram tratadas por meio de fixação interna rígida. Os elevados índices de internação em UTI, lesões associadas e realizações de procedimentos cirúrgicos por outras especialidades evidenciam a gravidade dos pacientes assistidos no serviço.

Introduction: The mandible is the largest and strongest of the bones in the face. Due to its topography, it is vulnerable to trauma. Data analysis on mandible fractures is fundamental for treatment and public health policies. This study aims to conduct an epidemiological survey of surgically treated mandibular fractures. Method: Screening through the hospital information system, seeking patients undergoing surgery for jaw fracture performed at a teaching hospital by the plastic surgery team in Campinas-SP from April 2015 to April 2020. Data were then collected through analysis of medical records. Results: 50 patients were included, 90% male. The average age was 30.7 years. The predominant etiology was an automobile accident, and the most fractured region in the mandible was the parasymphysis. The median time between trauma and surgery was 19 days. Eleven (22%) patients had some comorbidity. Fourteen patients (28%) were admitted to the Intensive Care Unit (ICU), and 42% underwent surgery with another specialty besides Plastic Surgery. Ten (20%) patients had some complication of the surgery, the most common being surgical wound dehiscence. Conclusion: There was a predominance among young men and traffic accidents as etiology. Fractures were preferably located in the parasymphysis region and were treated using rigid internal fixation. The high rates of ICU admission, associated injuries, and surgical procedures carried out by other specialties demonstrate the severity of the patients assisted in the service.

A Importância dos Métodos de Determinação das Idades Esquelética e Dentária na Ortodontia e Odontopediatria ­ uma Revisão de Literatura / The Importance of Methods for Determination of Squeletal and Dental Age in Orthodontics and Pediatric Dentistry ­ a Literature Review

O estágio de desenvolvimento humano é intimamente relacionado à sua maturidade óssea ou dentária, sendo essencial para a escolha do tratamento de alterações dentofaciais em crianças e adolescentes por ortodontistas e odontopediatras. Existem diversos indicadores biológicos para determinar a maturação do indivíduo, como a idade cronológica e as alterações hormonais, porém esses indicadores podem sofrer interferências. Visando uma determinação de desenvolvimento e dos picos de crescimento mais precisa, para um melhor diagnóstico e plano de tratamento, foram desenvolvidos diversos métodos para determinar a idade esquelética e a idade dentária, sendo estes a avaliação da maturação carpal, da morfologia das vértebras cervicais, da fusão óssea da sincondrose esfeno-occipital e da sutura palatina mediana, bem como dos estágios da calcificação dentária. A avaliação das radiografias de mão e punho é o padrão ouro da predição da idade esquelética, e sua correlação com outros métodos já é evidente. Sendo assim, é possível utilizar a avaliação das vértebras cervicais e das idades dentárias de Nolla e Demirjian.

The stage of human development is closely related to bone or dental maturity, being essential for the choice of treatment for dentofacial changes in children and adolescents by orthodontists and pediatric dentists. There are several biological indicators to determine an individual's maturation, such as chronological age and hormonal changes, but these indicators can suffer interference. Aiming at a more accurate determination of development and growth peaks, for a better diagnosis and treatment plan, several methods have been developed to determine skeletal age and dental age, these being the assessment of carpal maturation, the morphology of the cervical vertebrae, bone fusion of the spheno-occipital synchondrosis and the median palatal suture, as well as the stages of dental calcification. The evaluation of hand and wrist radiographs is the gold standard for predicting skeletal age, and its correlation with other methods is already evident. Therefore, it is possible to use the assessment of cervical vertebrae and dental ages by Nolla and Demirjian.

Characterization of the Masquelet Induced Membrane Technique in a Murine Segmental Bone Defect Model / Caracterização da membrana induzida pela técnica de Masquelet em modelo murino de defeito ósseo segmentar

Abstract Objective To reproduce in an animal model the surgical technique of Masquelet used in the treatment of critical bone defects and to analyze the characteristics of the membrane formed around the bone cement. Methods A 10mm critical defect was created in the femoral shaft of 21 Sprague-Dawley rats. After resection of the central portion of the diaphysis, the defect was stabilized with a Kirschner wire introduced through the medullary canal and with the interposition of a bone cement spacer. After 2, 4, and 6 weeks of the surgical procedure, the animals were euthanized and evaluated on radiographs of the posterior limb regarding the size of the defect, alignment and stability of the osteosynthesis. The membranes formed around the spacer were subjected to histological analysis to assess thickness, connective tissue maturation and vascular density. Results Over time, the membranes initially made up of loose connective tissue were replaced by membranes represented by dense connective tissue, rich in thick collagen fibers. At six weeks, membrane thickness was greater (565 ± 208μm) than at four (186.9 ± 70.21μm, p = 0.0002) and two weeks (252.2 ± 55.1μm, p = 0.001). All membranes from the initial time showed foci of osteogenic differentiation that progressively reduced over time. Conclusion In addition to the structural and protective function of the membrane, its intrinsic biological characteristics can actively contribute to bone regeneration. The biological activity attributed by the presence of foci of osteogenesis confers to the membrane the potential of osteoinduction that favors the local conditions for the integration of the bone graft.

Resumo Objetivo Reproduzir em modelo animal a técnica cirúrgica de Masquelet utilizada no tratamento de defeitos ósseos críticos e analisar as características da membrana formada em torno do cimento ósseo. Métodos Um defeito crítico de 10mm foi realizado na diáfise femoral de 21 ratos Sprague-Dawley. Após a ressecção da porção central da diáfise o defeito foi estabilizado com fio de Kirschner introduzido pelo canal medular e com a interposição de espaçador de cimento ósseo. Após 2, 4, e 6 semanas do procedimento cirúrgico os animais foram eutanasiados e avaliados em radiografias do membro posterior quanto ao tamanho do defeito, o alinhamento e a estabilidade da osteossíntese. As membranas formadas em torno do espaçador foram submetidas a análise histológica para avaliação da espessura, da maturação do tecido conjuntivo e da densidade vascular. Resultados Ao longo do tempo as membranas inicialmente constituídas por tecido conjuntivo frouxo foram substituídas por membranas representadas por tecido conjuntivo denso, rico em fibras colágenas espessas. Com seis semanas a espessura das membranas foi maior (565 ± 208μm) do que com quatro (186,9 ± 70,21μm, p = 0,0002) e duas semanas (252,2 ± 55,1μm, p = 0,001). Todas as membranas do tempo inicial apresentaram focos de diferenciação osteogênica que reduziram progressivamente ao longo do tempo. Conclusão Além da função estrutural e protetora da membrana, suas características biológicas intrínsecas podem contribuir ativamente para a regeneração óssea. A atividade biológica atribuída pela presença de focos de osteogênese confere à membrana potencial de osteoindução que favorece as condições locais para a integração do enxerto ósseo.

Alterações osteometabólicas em pacientes em tratamento antineoplásico: revisão de escopo / Osteometabolic changes in patients under antineoplastic treatment: scoping review

Objetivo: sintetizar as principais evidências acerca das alterações osteometabólicas presentes nos pacientes em tratamento antineoplásico. Métodos: trata-se de uma revisão de escopo, seguindo a metodologia do Instituto Joanna Briggs, nas bases de dados PubMed/MedLine, Cochrane Library, LILACS, The British Library e Google Scholar. A revisão está protocolada no Open Science Framework. Resultados: muitos antineoplásicos possuem efeito na arquitetura óssea, reduzindo sua densidade, tais como moduladores seletivos de receptores de estrogênio, inibidores da aromatase, terapia de privação androgênica, e glicocorticoides. Para evitar tais desfechos, o tratamento e prevenção podem ser realizados pela suplementação de cálcio e vitamina D, exercícios físicos, uso de bifosfonatos, denosumab, e moduladores seletivos do receptor de estrogênio. Conclusão: pessoas com maior risco de desenvolver câncer também possuem maior risco de osteopenia e osteoporose, quando processo já estabelecido e em tratamento antineoplásico, devido ao compartilhamento de fatores de risco. Torna-se evidente a necessidade da densitometria óssea nos pacientes em tratamento contra o câncer para de prevenção e promoção de saúde óssea nesses pacientes, além de mais pesquisas com alto nivel de evidência para subsidiar tal uso.

Objective: To summarize the main evidence regarding osteometabolic changes in patients undergoing antineoplastic treatment. Methods: This is a scoping review, following the methodology of the Joanna Briggs Institute, using PubMed/MedLine, Cochrane Library, LILACS, The British Library, and Google Scholar. This review is registered in the Open Science Framework. Results: Many antineoplastics affect bone architecture by reducing its density, such as selective estrogen receptor modulators, aromatase inhibitors, androgen deprivation therapy, and glucocorticoids. To avoid such outcomes, treatment and prevention can be achieved by calcium and vitamin D supplementation, physical exercise, use of bisphosphonates, denosumab, and selective estrogen receptor modulators. Conclusion: people at a higher risk of developing cancer also have a higher risk of osteopenia and osteoporosis when the process is already established and undergoing antineoplastic treatment because of the grouping of risk factors. The need for bone densitometry in patients undergoing cancer treatment to prevent and promote bone health in these patients is evident, in addition to more research with a high level of evidence to support such use.

Protocolo de osteotecnia aplicado a manos humanas

R E S U M E N El estudio del componente osteoarticular de la mano humana, requiere de estrategias didácticas que le permitan al estudiante comprender sus relaciones y accidentes óseos. La osteotecnia, permite obtener modelos óseos y facilita el proceso de aprendizaje del estudiante al tener un acercamiento real con las piezas. El objetivo fue presentar un protocolo de osteotecnia aplicado a manos humanas. Este trabajo se realizó en el laboratorio de anatomía del Departamento de Morfología de la Universidad del Valle en Cali - Colombia; se utilizaron cuatro manos humanas entregadas en custodia por el Instituto Nacional de medicina legal y ciencias forenses. El protocolo se desarrolló en dos fases; fase I, manejo de tejidos blandos y fase II, manejo de tejido óseo. Se obtuvieron cuatro modelos anatómicos del componente óseo de la mano: dos articulados y dos desarticulados para uso académico. Con la aplicación del protocolo no solo se obtuvo modelos anatómicos óseos de larga durabilidad que benefician a los estudiantes y al docente en las clases teórico-prácticas; si no, el estudiante ejecutor que profundizó en el conocimiento de este segmento corporal durante y después del desarrollo de la técnica.

The study of the osteoarticular component of the human hand requires didactic strategies which enable the student to understand its osseous relationships and related accidents. Osteotechnics, permits the use of bone models, and facilitate a student's learning process by having access to real pieces. The objective was to present an osteotechnical protocol applied to human hands This study was carried out in the anatomy laboratory of the Morphology Department of the Universidad del Valle in Cali, Colombia, four human hands handed over to the custody of the National Institute of Legal Medicine and Forensic Sciences were used the protocol was developed in two phases: Phase I: handling of soft tissues; Phase II: handling of bone tissue. Of the four anatomical models of the bone component of the hand obtained, two were articulated and two disarticulated for academic use. With the application of the protocol, not only were anatomical bone models of long durability obtained, benefitting both student and teacher in the theoretical-practical classes, but also, the student who carried out the procedure deepened their knowledge of this anatomical segment during and after the development of the technique.

O estudo do componente osteoarticular da mão humana requer, estratégias didáticas que permitem ao aluno compreender suas relações e acidentes ósseos. Osteotecnia, permite obter modelos ósseos e facilita o processo de aprendizagem do aluno, tendo uma aproximação real com o peças. O objetivo foi apresentar um protocolo osteotécnico aplicado em mãos humanas. Este trabalho foi realizado no laboratório de anatomia do Departamento de Morfologia da Universidad del Valle em Cali - Colômbia. Foram utilizadas quatro mãos humanas disponibilizadas ao Instituto Nacional de Medicina Legal e Ciências Forenses. O protocolo foi desenvolvido em duas fases. Fase I, gerenciamento de tecidos moles. Fase II, gerenciamento de tecido ósseo. Quatro modelos anatômicos do componente ósseo do mão foram obtidos: dois articuladas e dois desarticulados para uso acadêmico. Com a aplicação do protocolo, não só foram obtidos modelos ósseos anatômicos de longa duração que beneficiam aos alunos e ao professor nas aulas teórico-práticas, mas também ao aluno executor que aprofundou no conhecimento deste segmento durante e após o desenvolvimento da técnica.

Bone involvement in non-congenital syphilis / Compromiso óseo por sífilis no congénita

We documented two stages of bone involvement due to syphilis in two adult patients infected with human immunodeficiency virus. Bony lesions of secondary versus tertiary syphilis cannot be differentiated on clinical or radiologic grounds alone. Given the rarity of this clinical presentation, there is no consensus on treatment duration and related outcomes.

Se describen dos etapas de compromiso óseo por sífilis en dos pacientes adultos infectados por el virus de la inmunodeficiencia humana. Las lesiones óseas de la sífilis secundaria y de la sífilis terciaria no se pueden diferenciar únicamente por características clínicas o radiológicas. Dada la rareza de esta presentación clínica, no hay consenso sobre la duración del tratamiento y los resultados relacionados.

Caracterización clínica y epidemiológica de pacientes con fractura nasal atendidos en un hospital universitario cubano / Clinical and epidemiological characterization of patients with nasal fracture treated in a Cuban university hospital

Introducción: Las fracturas nasales son las más comunes de la región maxilofacial. Sin embargo, la literatura cubana sobre el tema es escasa y desactualizada, por lo que surgió la motivación para realizar esta investigación. Objetivo: Caracterizar clínica y epidemiológicamente los pacientes con fractura nasal atendidos en un hospital universitario cubano. Métodos: Se realizó un estudio observacional, descriptivo y transversal en pacientes atendidos en el Servicio de Cirugía Maxilofacial del Hospital General Universitario "Carlos Manuel de Céspedes" de Bayamo, provincia Granma, Cuba, en el período comprendido entre el 1 de enero y el 31 de diciembre del 2020. Se estudiaron variables clínicas, epidemiológicas y terapéuticas. Resultados: Se incluyeron 99 pacientes, de los cuales 74 (74,75 por ciento) fueron masculinos. En el 44,44 por ciento de los casos las edades estuvieron comprendidas entre los 21 y 40 años. Cincuenta pacientes (50,51 por ciento) tuvieron fracturas producto de la violencia interpersonal. Noventa y siete pacientes (97,98 por ciento) presentaron epistaxis. Cincuenta y nueve pacientes (59,60 por ciento) recibieron reducción cerrada asociada con taponamiento nasal y fijación externa con yeso. Conclusiones: Predominó el sexo masculino y el grupo de edades de 21 a 40 años. La principal etiología fue la violencia interpersonal. En la mayoría de los casos la epistaxis estuvo presente. Prevalecieron las fracturas cerradas, así como las que tuvieron el dorso desviado lateralmente(AU)

Introduction: Nasal fractures are the most common fractures of the maxillofacial region. However, Cuban literature on the subject is scarce and outdated, so the motivation for this research arose. Objective: To characterize patients with nasal fractures treated in a Cuban university hospital in a clinical and epidemiological manner. Methods: An observational, descriptive and cross-sectional study was carried out in patients treated at the Maxillofacial Surgery Service of the University General Hospital. "Carlos Manuel de Céspedes" of Bayamo, Granma province, Cuba, from January 1 to December 31, 2020. Clinical, epidemiological and therapeutic variables were studied. Results: 99 patients were included, of whom 74 (74.75 percent) were male. In 44.44 percent of the cases the ages were between 21 and 40 years. Fifty patients (50.51 percent) had fractures resulting from interpersonal violence. Ninety-seven patients (97.98 percent) presented epistaxis. Fifty-nine patients (59.60 percent) received closed reduction associated with nasal packing and external fixation with plaster cast. Conclusions: Male gender and age group 21 to 40 years predominated. The main etiology was interpersonal violence. Epistaxis was present in most cases. Closed fractures prevailed, as well as those with laterally deviated dorsum(AU)

Osteological Study of the Parietal Foramen in the Adult Human Skull Bones and its Clinical and Surgical Correlations / Estudio Osteológico del Foramen Parietal en los Huesos del Cráneo Humano Adulto y sus Correlaciones Clínicas y Quirúrgicas

SUMMARY: Parietal emissary foramina (PEF) are small holes, which are localized between the middle and posterior thirds of the parietal bone posterior surface close to the sagittal suture. PEF are important structures that protect the parietal emissary vein, which passes through it. During neurosurgery procedures, parietal foramina (PF) knowledge is crucial. This work aimed to evaluate presence and location of the PF in the skull of an adult human. Moreover, measure the distance amidst PF and the sagittal suture's midline to ascertain its clinical repercussions. 74 adult human skulls, without gross pathology, were observed for the PF's existence. The PF's and sagittal suture's midline distance were measured. According to the PF patterns of presence, five groups were distributed. Finally, specimens were photographed and subjected to statistical analysis. The PF was absent in 7 skulls (9.5 %). There were 9 skulls (12.2 %) exhibited central parietal foramen where the parietal foramen lies on the sagittal suture. 17 skulls (23 %) showed right unilateral parietal foramen, whereas 15 skulls (20.3 %) demonstrated left unilateral parietal foramen. The final 26 skulls (35.1 %) exhibited bilateral parietal foramen. This descriptive study supplies valuable information of PF variations, which is crucial for neurosurgeons in modifying surgical techniques and procedures to alleviate injury to PF-emerging structures such as emissary veins.

Los forámenes emisarios parietales (FEP) son pequeños orificios que se localizan entre los tercios medio y posterior de la superficie posterior del hueso parietal, cerca de la sutura sagital. Los FEP son estructuras importantes que protegen la vena emisaria parietal, que lo atraviesa. Durante los procedimientos de neurocirugía, el conocimiento de los forámenes parietales (FP) es crucial. Este trabajo tuvo como objetivo evaluar la presencia y ubicación del FP en el cráneo de hombres adultos, además, medir la distancia entre el FP y la línea mediana de la sutura sagital para conocer su repercusión clínica. Se examinaron 74 cráneos humanos adultos, sin patología grave, para determinar la existencia del FP. Se midió la distancia de la línea mediana de la sutura sagital y del FP. De acuerdo con los patrones de presencia del FP, se distribuyeron en cinco grupos. Finalmente, los especímenes fueron fotografiados y sometidos a análisis estadístico. El PF estaba ausente en 7 cráneos (9,5 %). Hubo 9 cráneos (12,2 %) que presentaban un PF central localizándose en la sutura sagital. 17 cráneos (23 %) presentaban un FP unilateral derecho, mientras que 15 cráneos (20,3 %) se observó un FP unilateral izquierdo. Los 26 cráneos restantes (35,1 %) exhibieron FP bilaterales. Este estudio descriptivo proporciona información valiosa sobre las variaciones del FP, que es fundamental para los neurocirujanos en el momento de modificar las técnicas y los procedimientos quirúrgicos para aliviar las lesiones de las estructuras emergentes del FP, como las venas emisarias.

Estimation of Stature Based on Metatarsal Bones in a Thai Population / Estimación de la Estatura Basada en los Huesos Metatarsianos en una Población Tailandesa

SUMMARY: Stature estimation is one of the essential procedures for personal identification in forensic osteology. Therefore, the purposes of this study are to analyze the correlation between length and width of metatarsal measurements and stature, and to develop the regression equations for a Thai population. In this study, the samples were divided into two groups. The first group was called the "training group" for generating stature estimation equations, comprised of 200 skeletons, aged between 19-94 years. The second group was called the "test group" for evaluating the accuracy of generated equations, comprising 40 skeletons. The correlation between metatarsal parameters and stature were moderate to high, and all variables had positive significant correlation with stature. For males, the left ML2 is the length variable that showed the most correlation degree against stature (r=0.702), and the left MSW4 is the width variable that had the most correlation degree against stature (r=0.483). For females, right ML1 is the length variable that had the most correlation degree against stature (r=0.632), and right PW3 is the width stature that had the most correlation degree against stature (r=0.481). For all samples, left ML1 was the length variable that had the most correlation degree against stature (r=0.796) and right PW3 was the width variable that had the most correlation degree against stature (r=0.712). The results of generating multiple regression equations using a stepwise method reveals that the correlation coefficient (R) and standard error of estimate (SEE) were 0.761 and 4.96 cm, respectively, for males, and 0.752 and 4.93 cm for females, with 0.841 and 5.26 cm for all samples, respectively. According to these results, the mean of absolute error from the test group ranged from 3 to 5 cm. Therefore, stature estimation equations using length and width of metatarsals from our study can be applied to estimate stature in the Thai population.

La estimación de la estatura es uno de los procedimientos esenciales para la identificación personal en osteología forense. Por lo tanto, los propósitos de este estudio fueron analizar la correlación entre la longitud y el ancho de las medidas metatarsianas y la estatura, y desarrollar las ecuaciones de regresión para una población tailandesa. Las muestras se dividieron en dos grupos. El primer grupo se denominó "grupo de entrenamiento" para generar ecuaciones de estimación de estatura, compuesto por 200 esqueletos, con edades comprendidas entre los 19 y los 94 años. El segundo grupo se denominó "grupo de prueba" para evaluar la precisión de las ecuaciones generadas, que comprende 40 esqueletos. La correlación entre los parámetros metatarsianos y la estatura fue de moderada a alta, y todas las variables tuvieron una correlación significativa positiva con la estatura. Para el sexo masculino, la variable longitud ML2 izquierda es la que mayor grado de correlación presentó con la estatura (r=0,702), y la izquierda MSW4 fue la variable ancho la que mayor grado de correlación presentó con la estatura (r=0,483). Para el sexo femenino, ML1 derecho fue la variable longitud que tuvo mayor grado de correlación con la estatura (r=0,632), y PW3 derecha fue la variable ancho estatura que tuvo mayor grado de correlación con la estatura (r=0,481). Para todas las muestras, ML1 izquierdo fue la variable longitud que tuvo mayor grado de correlación con la estatura (r=0,796) y PW3 derecha fue la variable ancho que tuvo mayor grado de correlación con la estatura (r=0,712). Los resultados de generar ecuaciones de regresión múltiple usando un método paso a paso revela que el coeficiente de correlación (R) y el error estándar de estimación (SEE) fueron 0,761 y 4,96 cm, respectivamente, para los hombres y 0,752 y 4,93 cm para las mujeres, con 0,841 y 5,26 cm para todas las muestras, respectivamente. De acuerdo con estos resultados, la media del error absoluto del grupo de prueba osciló entre 3 y 5 cm. Por lo tanto, las ecuaciones de estimación de la estatura que utilizan la longitud y el ancho de los metatarsianos de nuestro estudio se pueden aplicar para estimar la estatura en la población tailandesa.

Late consolidation of the scaphoid. Case report and literature review / Consolidación tardía del escafoides. Reporte de un caso y revisión de la literatura

Abstract: Scaphoid fractures are a common wrist injury accounting for 2-7% of all adult fractures. Nonunion is described in 5-12% of cases leading to osteoarthritis. Several classifications have been developed focused on this pathology and its complication. We present a case of a 28 years old male patient with a scaphoid fracture and nonunion who spontaneously consolidates without treatment. We performed a literature review to recognize this pathology, its common evolution and possible treatment options.

Resumen: Las fracturas de escafoides son una lesión frecuente de la muñeca y representan de 2-7% de todas las fracturas en adultos. La no unión se describe en 5-12% de los casos y conduce a la osteoartritis. Se han desarrollado varias clasificaciones centradas en esta patología y su complicación. Presentamos el caso de un paciente varón de 28 años con fractura y no unión de escafoides que consolida espontáneamente sin tratamiento. Realizamos una revisión bibliográfica para reconocer esta patología, su evolución habitual y las posibles opciones de tratamiento.

Antifertility activity of Oroxylum indicum (L.) Kurz:In vitro and in vivo study on human sperm and male wistar rats

Oroxylum indicum (L.) Kurz, commonly called as Broken bones tree or Indian trumpet flower, belonging to Fam. Bignoniaceae, is traditionally used as a contraceptive by ethnic people of Tripura, North-East India. Here, we investigated the scientific basis for use of O. indicum as male antifertility agent by folklore healers. In vitro spermicidal activity of aqueous (AEOI) and methanolic (MEOI) extracts of O. indicum stem bark were studied on human sperm. The in vivo activity was experimented on male albino rats. The treated animals were allowed to mate and the pups delivered by female rat partners were counted. Phytochemical estimation of test samples was done using HPLC. The AEOI and MEOI treatments significantly decreased human sperm motility and viability. Test extracts have increased the hypo-osmotic swelling of sperm. Both the extracts were significantly declined the weight of reproductive organ. The MEOI treated rats have shown significant decrease in sperm motility and sperm counts. AEOI and MEOI treatment significantly reduced level of testosterone, but sharply raised dihydrotestosterone and prostaglandin in rats. Results testified the traditional claim for use of O. indicum as a male contraceptive agent, where MEOI have shown reversible action on male reproductive system leading to contraception without harming the libido.

Osteomielitis hematógena del fémur en el adulto

Introducción: Las infecciones del tejido óseo por gérmenes patógenos por la vía hematógena son frecuentes en el niño en las zonas metafisarias y columna vertebral en el adulto. Objetivo: Presentar el caso de una paciente adulta con osteomielitis del fémur por vía hematógena. Caso clínico: Paciente de 38 años de edad, blanca, femenina sin comorbilidad conocida, la cual acude a la consulta de Ortopedia y Traumatología por referir dolor intenso a nivel del muslo derecho que no remite al tratamiento ambulatorio con analgésicos. Mediante la exploración física se observó ligero aumento de volumen a nivel del muslo distal. A la palpación se detectó hiperestesia cutánea en especial hacia la cara lateral. La tomografía axial computarizada detectó a nivel de la diáfisis distal del fémur derecho, lesión osteolítica con presencia de una hiperdensidad en su interior con densidad ósea. Al tener en cuenta todos los elementos anteriores, se decide llevar la paciente al quirófano, para tratamiento de tipo quirúrgico, donde se realizó incisión quirúrgica lateral en la zona distal del muslo derecho, se avanzó por planos quirúrgicos y se realizó punción ósea con trocar de ocho milímetros donde se observó salida de pus espeso. Conclusiones: La osteomielitis hematógena es una enfermedad típica del paciente con epífisis abiertas y en la columna vertebral del adulto. La invasión al tejido óseo por la vía hematógena en el adulto que no sea en la columna es muy infrecuente.

Introduction: Infections of the bone tissue by pathogenic germs by hematogenous route are frequent in the child in the metaphyseal zones and in the spine in the adult. Objective: To present an adult patient with osteomyelitis of the femur by hematogenous route. Clinical case: A 38-year-old white female patient with no known morbidity, clinical record 253853, named MRA, who went to the Orthopedics and Traumatology clinic for reporting severe pain at the level of the right thigh that did not respond to treatment with ambulatory pain relievers. Physical examination revealed a slight increase in volume at the level of the distal thigh. On palpation, skin hyperesthesia was detected, especially towards the lateral aspect of the knee. A computed tomography scan detected an osteolytic lesion at the distal diaphysis of the right femur with the presence of hyperdensity with bone density. Taking all the above elements into account, it was decided to take the patient to the operating room for surgical treatment, where a lateral surgical incision was made in the distal area of the right thigh, surgical plans were performed, and an eight millimeters trocar bone puncture was used to open the bone where thick pus was observed. Conclusions: Hematogenous osteomyelitis is a typical entity of the patient with open epiphyses and in the adult spine. Invasion of bone tissue by the hematogenous route in adults other than in the spine is very rare.

Cortical microarchitecture and remodeling-associated gene expression related to oral cancer prognosis

Abstract The objective of this study was to assess the remodeling-associated gene expression in the mandible of patients diagnosed with oral squamous cell carcinoma (OSCC), investigating the cortical microarchitecture, and their influence on disease-free survival (DFS) and overall survival (OS) rates. A total of twenty-four patients who underwent mandibulectomy for OSCC treatment had two bone fragments harvested from the mandible for gene expression (RANK, RANKL, OPG, and SOST), and microarchitecture analysis, including bone volume, surface, mineral density, degree of anisotropy, and fractal dimension. The prognosis of the patients was assessed. The results revealed that RANK, RANKL, and SOST were predominantly downregulated, while OPG was completely downregulated. Tumors located adjacent to the posterior region of the mandible (p = 0.02), with a bone mineral density below 1.03 g/cm3 HA (p = 0.001), and a bone volume less than 86.47% (p = 0.03) were associated with poor outcomes. In conclusion, bone-remodeling-associated genes exhibited downregulation in the cortex of the mandible in OSCC patients. Additionally, the tumor's location within the mandible, bone volume, and cortical bone mineral density were identified as factors impacting DFS.

Effect of micro-CT acquisition parameters and individual analysis on the assessment of bone repair

Abstract This study aimed to investigate whether two acquisition parameters, voxel size and filter thickness, used in a micro-computed tomography (micro-CT) scan, together with the examiner's experience, influence the outcome of bone repair analysis in an experimental model. Bone defects were created in rat tibiae and scanned using two voxel sizes of 6- or 12-µm and two aluminum filter thickness of 0.5- or 1-mm. Then, bone volume fraction (BV/TV) and trabecular thickness (Tb.Th) were analyzed twice by two groups of operators: experienced and inexperienced examiners. For BV/TV, no significant differences were found between scanning voxel sizes of 6 and 12 µm for the experienced examiners; however, for the inexperienced examiners, the analysis performed using a 12-µm voxel size resulted in higher BV/TV values (32.4 and 32.9) than those acquired using a 6-µm voxel size (25.4 and 24.8) (p < 0.05). For Tb.Th, no significant differences between the analyses performed by experienced and inexperienced groups were observed when using the 6-µm voxel size. However, inexperienced examiners' analysis revealed higher Tb.Th values when using the 12-µm voxel size compared with 6 µm (0.05 vs. 0.03, p < 0.05). Filter thickness had no influence on the results of any group. In conclusion, voxel size and operator experience affected the measured Tb.Th and BV/TV of a region with new bone formation. Operator experience in micro-CT analysis is more critical for BV/TV than for Tb.Th, whereas voxel size significantly affects Tb.Th evaluation. Operators in the initial phases of research training should be calibrated for bone assessments.