ABSTRACT
Objective:To use the resting state functional network connectivity (FNC) method based on independent component analysis (ICA) to analyze the characteristics of FNC changes in patients with basal ganglia aphasia (BGA) after stroke, and to explore its occurrence and recovery mechanism under the intervention of acupuncture combined with language rehabilitation training.Methods:Using a prospective observational research method, 16 right-handed BGA patients who were treated at Beijing Hospital of Traditional Chinese Medicine, Capital Medical University from July 2021 to December 2022, as well as 14 healthy subjects matched in age, gender, education level, and handedness, were included. The resting state functional magnetic resonance imaging, demographic information, and Western Aphasia Examination data of healthy subjects and BGA patients before and after intervention were collected. The GIFT toolbox based on MATLAB platform was applied for ICA and resting state brain network FNC analysis. The FNC differences between BGA patients and healthy subjects were compared horizontally, and the FNC changes in BGA patients before and after intervention were compared vertically.Results:Compared with healthy subjects, post-stroke BGA patients showed decreased connectivity between the basal ganglia network, default network, and visual network before intervention, while increased connectivity between the auditory network, right frontoparietal network, and anterior cuneiform network; After the intervention of acupuncture combined with language rehabilitation training, the connectivity between the basal ganglia network, visual network, and anterior cuneiform network decreased, while the connectivity between the anterior convex network and bilateral frontoparietal network decreased, while the connectivity between the default network, auditory network, right frontoparietal network, and visual network increased. The BGA patient group showed enhanced connectivity between the basal ganglia network and the left frontoparietal network before and after intervention.Conclusions:The FNC changes between the basal ganglia network and other brain networks are key to reflecting the mechanism of BGA occurrence and language function recovery. Acupuncture combined with language rehabilitation training may improve language function by enhancing the connectivity between the basal ganglia network and the left frontoparietal network, and the redistribution of attention resources may also be one of the reasons for promoting language function recovery in BGA patients.
ABSTRACT
Objective To explore the effect of music therapy on post-stroke depression (PSD) with left basal ganglia aphasia. Methods From April, 2013 to July, 2016, 60 patients with PSD and left basal ganglia aphasia were selected as control group (n=30) and research group (n=30). Both groups accepted routine medicine and rehabilitation, and the research group accepted music therapy in addition, for three months. They were assessed with modified Stroke Aphasic Depression Questionnaire Hospital Version (SADQ-H) and China Rehabilitation Research Center Aphasia Examination (CRRCAE) before and after treatment. Results The incidence of serious depression was less in the re-search group than in the control group after treatment, according to the score of SADQ-H (χ2=8.926, P5.707, P<0.001). Conclusion Music therapy helps to relief depression and improve speech in patients with PSD and basal ganglia aphasia.