Consumo de psicoestimulantes por estudantes de medicina em um centro universitário privado / Consumption of psychostimulants by medical students in a private university center

O consumo de psicoestimulantes tem crescido exponencialmente, sobretudo entre estudantes de medicina, na busca por aumentar o rendimento acadêmico. Atualmente, a extensa carga horária de aulas e estudos, exigências de produtividade e altos níveis de estresse podem desencadear o uso. Objetivo: Analisar o uso de psicoestimulantes por estudantes do curso de Medicina de um Centro Universitário privado em Minas Gerais. Métodos: Foi realizado um estudo descritivo, quantitativo, com delineamento transversal entre os discentes do 1° ao 5° ano do curso de Medicina no 2° semestre de 2021. Os participantes responderam ao questionário semi-estruturado elaborado pelos autores. Os dados obtidos foram tabulados no software Statistical Product and Service Solutions. Resultados: Dos 244 entrevistados, cerca de 57.4% faziam uso de algum psicoestimulante. Houve maior uso entre os estudantes do 2° ano e as principais substâncias utilizadas foram: cafeína (85%), energético (65%) e metilfenidato (60%). A melhora na concentração (97%) foi o efeito mais percebido pelos usuários, seguido de redução do sono (83%) e melhora de raciocínio (80%). Muitos consideraram que os estimulantes cerebrais têm o potencial de melhorar o rendimento acadêmico, mas pode reduzir a qualidade do sono e consequentemente torná-los susceptíveis a outras enfermidades. Conclusão: É notável que existe uso abusivo de estimulantes cerebrais, sendo fundamental o trabalho em conjunto entre instituição de ensino e familiares, em prol da prevenção e do controle de danos causados por esse hábito

The consumption of psychostimulants has grown exponentially, especially among medical students, in the quest to increase academic performance. Currently, the extensive workload of classes and studies, productivity demands and high levels of stress can trigger use. Objective: To analyze the use of psychostimulants by medical students at a private University Center in Minas Gerais. Methods: A descriptive, quantitative, cross-sectional study was carried out among students from the 1st to the 5th year of the medicine course in the 2nd semester of 2021. The participants answered the semi-structured questionnaire prepared by the authors. The data obtained were tabulated in the Statistical Product and Service Solutions software. Results: Of the 244 respondents, about 57.4% used some psychostimulant. There was greater use among 2nd year students and the main substances used were: caffeine (85%), energy drink (65%) and methylphenidate (60%). Improved concentration (97%) was the effect most perceived by users, followed by reduced sleep (83%) and improved thinking (80%). Many considered that brain stimulants have the potential to improve academic performance, but can reduce sleep quality and consequently make them susceptible to other illnesses. Conclusion: It is notable that there is abusive use of brain stimulants, and it is essential to work together between educational institutions and family members in order to prevent and control the damage caused by this habit

A vitamina C na esquizofrenia apresenta benefício? Estudo preliminar com análise comportamental em ratos / Does vitamin C have benefit in schizophrenia? Preliminary study with behavioral analysis in rats

RESUMO Objetivo O objetivo deste estudo foi analisar em ratos modelos de esquizofrenia, induzidos pela administração de cetamina, a possibilidade dos efeitos benéficos do ácido ascórbico na esquizofrenia, por meio do teste comportamental. Métodos O estudo preliminar foi simples-cego e randomizado. Foi realizado o protocolo de psicose por cetamina em 24 ratos Wistar submetidos posteriormente à análise comportamental. No primeiro grupo, foram administradas: água e cetamina; no segundo: ácido ascórbico e cetamina; no terceiro: antipsicótico, ácido ascórbico e cetamina; e no quarto: antipsicótico, água e cetamina. A análise comportamental foi feita por meio do Open Field Test, considerado o método-padrão para avaliar comportamento em modelos animais de esquizofrenia. A análise estatística foi realizada pelo software IBM-SPSS, por meio dos Modelos Lineares Generalizados. Resultados O tratamento em monoterapia de haloperidol (Média Quadrante: 44,5 ± 15,8; IC: 13,54-75,46/Média Centro: 2,67 ± 0,67; IC: 1,63-4,35) e aquele em conjunto com a vitamina C (Média Quadrante: 38,67 ± 15,8; IC: 7,71-69,52/Média Centro: 2,00 ± 0,58; IC: 1,14-3,52) demonstraram benefícios nos ratos modelos de esquizofrenia induzidos por cetamina (Média Quadrante: 108,5 ± 15,8; IC: 77,54-139,46/Média Centro: 11,33 ± 1,37; IC: 8,94-14,37) (p < 0,001). O tratamento isolado com a vitamina C não apresentou resultado significante (Média Quadrante: 62,00 ± 15,8; IC: 31,04-92,96/Média Centro: 7,00 ± 1,08; IC: 5,17-9,47). Conclusão A associação de antipsicótico e vitamina C e somente o antipsicótico demonstraram efeito terapêutico em relação aos controles. A vitamina C isolada não apresentou benefício.

ABSTRACT Objective The objective of this study was to analyze in rats models of schizophrenia, induced by the administration of ketamine, the possibility of the beneficial effects of ascorbic acid in schizophrenia, through the behavioral test. Methods This preliminary study was simple blind and randomized. The ketamine psychosis protocol was carried out in 24 Wistar rats, which were subsequently submitted to behavioral analysis. The first group was supplied with: water and ketamine; the second: ascorbic acid and ketamine; the third: antipsychotic, ascorbic acid and ketamine; the fourth: antipsychotic, water and ketamine. Behavioral analysis was performed using the Open Field Test, considered the standard method for assessing behavior in animal models of schizophrenia. Statistical analysis was performed by the IBM-SPSS software, using the Generalized Linear Models. Results Treatment in haloperidol monotherapy (Quadrant Average: 44.5 ± 15.8; CI: 13.54-75.46/Center Average: 2.67 ± 0.67; CI: 1.63-4.35) and combined with vitamin C (Quadrant Average: 38.67 ± 15.8; CI: 7.71-69.52/Center Average: 2.00 ± 0.58; CI: 1.14-3.52), demonstrated benefits in the animal model of schizophrenia induced by ketamine (Quadrant Average: 108.5 ± 15.8; CI: 77.54-139.46/Center Average: 11.33 ± 1.37; CI: 8.94- 14.37) (p < 0.001). The isolated treatment with vitamin C did not show a significant result (Quadrant Average: 62.00 ± 15.8; CI: 31.04-92.96/Mean Average: 7.00 ± 1.08; CI: 5.17-9.47). Conclusion The association of antipsychotic and vitamin C and only the antipsychotic demonstrated a therapeutic effect respecting to controls. Vitamin C manage separately had no benefit.

Challenges and opportunities in the science of research to practice: lessons learned from a randomized controlled trial of a sexual risk-reduction intervention for psychiatric patients in a public mental health system

Objective: Human immunodeficiency virus (HIV) prevention efficacy trials with psychiatric patients have been conducted in research settings in high-resourced countries, establishing short-term efficacy for reducing sexual risk behavior. None has been implemented within systems of care. In the last decade, overcoming this research-to-practice gap has become a focus of implementation science. This paper describes the first and only HIV Prevention intervention trial for psychiatric patients conducted in real-world outpatient psychiatric settings facilitated by trained clinic-based providers. Methods: The HIV Prevention intervention, which uses the Information-Motivation-Behavioral Skills model to achieve sexual risk-reduction, was rigorously adapted to the local context and clinic services' needs. Participants from eight clinics were randomized to HIV Prevention or Health Promotion conditions. Results: HIV Prevention participants showed significant improvement in Information-Motivation-Behavioral domains; in this group, behavioral intentions were associated with significantly fewer unprotected sex occasions, but reduction of unprotected sex occasions was similar in both conditions. Conclusion: Our trial was conducted before implementation studies became widely funded. Transporting an intervention to a new culture or into real-world practice settings may require adaptations. Our results demonstrate that clear guidelines are needed regarding whether to conduct efficacy, effectiveness, and/or implementation research as the most appropriate next step. Clinical trial registration: NCT00881699

Criteria for assessing peripheral nerve injury. Behavioral and functional assessment in non-operated Wistar rats

Abstract Purpose To evaluate the normality pattern in functional tests of peripheral nerves. Methods Sixty female and sixty male Wistar rats were submitted to vibrissae movement and nictitating reflex for facial nerve; grooming test and grasping test for brachial plexus; and walking tracking test and horizontal ladder test for lumbar plexus. The tests were performed separately, with an interval of seven days between each. Results All animals showed the best score in vibrissae movement, nictitating reflex, grooming test, and horizontal ladder test. The best score was acquired for the first time in more than 90% of animals. The mean of strength on the grasping test was 133.46±12.08g for the right and 121.74±8.73g for the left anterior paw. There was a difference between the right and left sides. There was no difference between the groups according to sex. There is no statistical difference comparing all functional indexes between sex, independent of the side analyzed. The peroneal functional index showed higher levels than the sciatic and tibial functional index on both sides and sex. Conclusions The behavioral and functional assessment of peripheral nerve regeneration are low-cost, easy to perform, and reliable tests. However, they need to be performed by experienced researchers to avoid misinterpretation.

Nivel de ansiedad de los pacientes antes de ingresar a la consulta odontológica / Dental Anxiety Before a Dentist Appointment / Nível de ansiedade em pacientes antes de ingressar à consulta odontológica

Resumen Introducción: la ansiedad dental o miedo al tratamiento odontológico es una de las dificultades más frecuentes para el profesional, y esto puede tener un impacto considerable en la salud oral. El objetivo es evaluar el nivel de ansiedad de los pacientes que acudieron a las consultas en la clínica odontológica de una empresa privada de servicios odontológicos, en 2015. Materiales y métodos: estudio transversal en el que se utilizó la Escala de Ansiedad Dental de Corah Modificada (MDAS), y se interrogó sobre la ansiedad que generan los componentes de la consulta odontológica. Resultados: participaron un total de 297 adultos de los cuales 54.85 % fueron varones y la mediana de edad fue 28 años. Se obtuvo un bajo número de pacientes con ansiedad extrema (7.74 %), siendo el porcentaje más elevado para la inyección de anestésico local (85.52 %). El 17.85 % obtuvo un nivel de ansiedad elevada y el 17.85 % severa. El componente de la consulta odontológica que generó mayor nivel de ansiedad fue la extracción dental con 40.40 %. Conclusión: el paciente debe sentirse lo más relajado posible al ir a una consulta odontológica por lo que se necesitan charlas a los proveedores de salud dental acerca de las diferentes técnicas para disminuir la ansiedad dental del paciente.

Abstract Introduction: Dental anxiety or consulting fear to dentist appointment and/or dental treatment, is one of the most frequent problems to the professional which can have an impact to the oral health. The objective is to assess the level of anxiety in patients that attend to appointments in a dental clinic from a private company of dental care in the year of 2015. Materials and methods: The study design is cross-sectional, Corah's Modified Dental Anxiety Scale (MDAS) was utilized. And question were made about the components of dental services that generate dental anxiety. Results: The sample consisted of 297 adult patients, 54.85 % were males and middle age was 28. It was obtained a low number of patients with extreme anxiety (7.74 %) according to the questions; being the highest percentage for local anesthetic injection for dental treatment (85.52 %). A 17.85 % had a high level of anxiety and 17.85 % had a severe level of anxiety. The component that caused anxiety the most was tooth extraction with a 40.40 %. Conclusion: The patient must feel as relax as possible when going to a dentist appointment that is why would be needed to speak with care providers about different techniques to reduce dental anxiety on patients.

Resumo Introdução: a ansiedade dental ou medo ao tratamento odontológico, é uma das dificuldades mais frequentes para o profissional, que pode ter impacto na saúde oral. O objetivo é avaliar o nível de ansiedade dos pacientes que acudiram às consultas na clínica odontológica de uma empresa privada de serviços odontológicos, no ano 2015. Materiais e métodos: estudo transversal no qual utilizou-se a Escala de Ansiedade Dental de Corah Modificada (MDAS), e se interrogou sobre a ansiedade que geram os componentes da consulta odontológica. Resultados: participaram um total de 297 adultos dos quais 54.85 % foram homens e a idade média foi 28 anos. Obteve-se um número baixo de pacientes com ansiedade extrema (7.74 %), senda a porcentagem mais elevado para a injeção de anestésico local (85.52 %). O 17.85 % obteve um nível de ansiedade elevada e o 17.85 % severa. O componente da consulta odontológica que gerou maior nível de ansiedade foi a extração dental com 40.40 %. Conclusão: o paciente deve se sentir o mais relaxado possível ao ir a uma consulta odontológica pelo que precisam-se conversas aos provedores de saúde dental acerca das diferentes técnicas para diminuir a ansiedade dental do paciente.

Creación de un cuestionario de clima organizacional para hospitales de alta complejidad, Chile / Creation of a Questionnaire of Organizational Climate for Hospitals of High Complexity, Chile / Criação de um questionário de clima organizacional para hospitais de alta complexidade, Chile

En el contexto de un sector salud chileno en proceso de transformaciones, se propuso crear un cuestionario validado para medir el clima organizacional en hospitales de alta complejidad. Para su formulación se identificaron dimensiones y variables de diversos autores y se revisaron diferentes cuestionarios, validaciones y constructos utilizados en diferentes propuestas a nivel internacional. La investigación es de tipo descriptivo, cuantitativo e inferencial y se realizó sobre una base de datos de 561 empleados hospitalarios, a quienes se les aplicó un cuestionario por la vía de una entrevista personalizada en el lugar de trabajo, que consta de 71 variables agrupadas en 14 dimensiones. La aplicación del instrumento, así como los estudios de validez y de confiabilidad, permitieron dar origen a un nuevo cuestionario validado que cuenta con 10 factores y 44 reactivos de alta confiabilidad, que explican el 52,181% de la varianza total, alcanzando un alfa de Cronbach total de 0,89.

In the context of a Chilean health sector undergoing a process of transformations, it was proposed to create a validated questionnaire to measure the organizational climate in high complexity hospitals. In order to prepare it, dimensions and variables by diverse authors were identified and diverse questionnaires, validations and constructs used in different proposals at the international level were reviewed. The research is descriptive, quantitative and inferential and it was conducted on a database of 561 hospital employees, to whom a questionnaire was applied, through a personalized interview at their work place, consisting of 71 variables grouped in 14 dimensions. The application of the instrument, as well as the validity and reliability studies, allowed giving origin to a new validated questionnaire with 10 factors and 44 high-reliability reagents that explain 52.181 % of the total variance, reaching a total Cronbach's alpha 0.89.

No contexto de um processo de transformações do setor saúde chileno, propõe-se criar um questionário validado para medir o clima organizacional em hospitais de alta complexidade. Para sua formulação dimensões e variáveis de diversos autores foram identificadas e se revisaram diferentes questionários, validações e construtos utilizados em diferentes propostas do nível internacional. A pesquisa é de tipo descritivo, quantitativo e inferencial e foi realizado sobre uma base de dados de 561 funcionários hospitalares, a quem foi aplicado questionário pela via de entrevista pessoalizada no local de trabalho, que consta de 71 variáveis agrupadas em 14 dimensões. A aplicação do instrumento, bem como os estudos de validez e confiabilidade, permitiu dar origem a um novo questionário validado que conta com 10 fatores e 44 reagente de alta confiabilidade, que explicam o 52,181% da variância total, atingindo um alfa de Cronbach total de 0,89.

The Intra- and Inter-rater Reliability and the Learning Curve for a Simple Neurological Score for Rats

OBJECTIVE: To measure the intra- and inter-rater reliability of a simple sensorimotor performance test for rats, and to evaluate the learning efficiency of a novice rater for the test. METHOD: Middle cerebral arteries were occluded by intraluminal sutures in 25 male Sprague-Dawley rats (10~12 weeks old). The sensorimotor performance test was performed by a novice and an experienced rater, with each rater performing the test twice each week for 3 consecutive weeks. A ten-minute standardized video about the rating method was shown to the novice rater after the second test each week. RESULTS: The intra- and inter-rater agreement was determined using Cohen's weighted kappa coefficient. The intra-rater reliability was initially poor for the novice (κ [95% confidence interval], 0.31[-0.02, 0.64]), but it improved significantly after 3-week self education using the standardized video (0.81 [0.69, 0.93], showing almost perfect agreement. The reliability of the experienced researcher was good at all times (κ = 0.64, 0.76, 0.71, for week 1, 2, 3, respectively), indicating substantial agreement. The inter-rater reliability showed clear improvement after self-education (κ = 0.44, 0.69, 0.69, for week 1, 2, 3, respectively). Although the total sum score was highly reliable, some of the individual items showed lower intra-and inter-rater agreement. However, each rater showed greater within-rater variability for different subtests. CONCLUSION: The simple sensorimotor performance test showed high degree of intra- and inter-rater agreement when performed by experienced or properly educated raters. The inaccuracy of the novice was rectified by 3-week self-education using a video.

Analysis of TV, advertising and other behavioral determinants of overweight and obesity in childhood / Análisis de la televisión, la publicidad y otros determinantes conductuales del sobrepeso y la obesidad en la infancia

Worldwide obesity has reached the proportion of an epidemic. A well-established fact is that nowadays many low-and middle-income countries are facing a "double burden" of disease, dealing with under-nutrition on one side, and on the other experiencing a rapid rise in non-communicable disease risk factors such as obesity and overweight, particularly in urban settings. Behavioral components are strongly influencing obesity spread and development, especially when considering TV and advertising. There is, therefore, the need of multi-cultural and cross-cultural research, in order to gain a full understanding of the association between obesity and different risk factors, in different scenarios, providing the best evidence to decision makers, grounding prevention on evidence-based strategies rather than focusing on single factors without the recognition of their mutual influence.

La obesidad en todo el mundo tiene una prevalencia similar a la de una epidemia. Los países de bajos y medianos ingresos se enfrentan hoy a una "doble carga" de enfermedad: por un lado la desnutrición y, por otro, un rápido aumento de enfermedades como la obesidad y el sobrepeso, especialmente en el ambiente urbano. Los componentes comportamentales tienen fuerte influencia sobre la propagación y el desarrollo de la obesidad, especialmente los relacionados con la televisión y la publicidad. Se tiene, por lo tanto, la necesidad de realizar investigaciones multiculturales e interculturales, con el fin de obtener una plena comprensión de la relación entre la obesidad y los diferentes factores de riesgo en varios escenarios. Ello proveería mejor evidencia para los órganos de decisión, que podrían generar estrategias de prevención basadas en enfoques ambientales, en lugar de centrarse en factores individuales, sin el reconocimiento de su influencia mutua.

Intervention Strategies Based on Information-Motivation-Behavioral Skills Model for Health Behavior Change: A Systematic Review

PURPOSE: This study systematically reviewed research on behavioral interventions based on the information-motivation-behavioral skills (IMB) model to investigate specific intervention strategies that focus on information, motivation, and behavioral skills and to evaluate their effectiveness for people with chronic diseases. METHODS: A systematic review was conducted in accordance with the guidelines of both the National Evidence-based Healthcare Collaborating Agency and Im and Chang. A literature search was conducted using electronic databases. Randomized controlled trials that tested behavioral interventions based on the IMB model for promoting health behaviors among people with chronic diseases were included. Four investigators independently reviewed the studies and assessed the quality of each study. A narrative synthesis was used. RESULTS: A total of 12 studies were included in the review.Nine studies investigated patients with HIV/AIDS. The most frequently used intervention strategies were instructional pamphlets for the information construct, motivational interviewing techniques for the motivation construct, and instruction or role playing for the behavioral skills construct. Ten studies reported significant behavior changes at the first post-intervention assessment. CONCLUSION: This review indicates the potential strength of the IMB model as a theoretical framework to develop behavioral interventions. The specific integration strategies delineated for each construct of the model can be utilized to design model-based interventions.

The effects of family feeding pattern on the physical growth of infants / 中国基层医药

Objective To explore the relationship between physical growth of infants and family feeding be -havior.Methods Demographic information was collected from 516 objects.Height,weight,head circumference,chest circumference were measured and feeding behavior was evaluated using prospective observational study method . Results (1) Feeding behavior score was positively associated with infant physical development indicators ,the be-tween groups differences of infant age ,body weight,body length were statistically significant (P<0.05).(2)The re-sults of Pearson correlation analysis showed that weight , head circumference of infants at 18 months and length at 24 months were significantly correlated with feeding behavior score (P<0.05).(3)The analysis of feeding behavior factors found that food preparation was associated with weight infants at 18 months(P<0.05);behavior of infants and height,weight,head circumference,chest circumference of children in the 18 months of age were related(P<0.05);infant feeding environment in the 18-month-old was related with their height,weight,head circumference(P<0.05). Conclusion It is suggested that well family feeding pattern might be a certain stimulative role in young children ′s physical growth and development .

Experiencias sobre el impacto del Programa de Formación en Ética de la Investigación Biomédica y Psicosocial en el ámbito de la salud mental y la investigación conductual / Experiências sobre o impacto do Programa de Formação em Ética da Pesquisa Biomédica e Psicossocial no âmbito da saúde mental e pesquisa comportamental / Experiences about the impact of the Ethics of Biomedical and Psychosocial Research Training Program in mental health and behavioral research field

El propósito de este trabajo es presentar el impacto y la integración que los conocimientos adquiridos en el Programa Internacional de Formación en Ética de la Investigación Biomédica y Psicosocial de la Universidad de Chile han tenido en mi experiencia profesional, en el ámbito de la investigación psicosocial en un Instituto de Salud de México. Para este objetivo, expondré tres áreas en las cuales se ha podido evidenciar tal impacto: trabajo en los comités de ética, desarrollo de programas de académicos en bioética e investigación y publicación sobre ética y bioética. El motivo que me llevó a incursionar en el Programa fue que su enseñanza vincula la investigación psicosocial con la ética y la bioética, lo cual me permitió dirigir este tipo de reflexión hacia problemas como violencia, suicidio, adicciones, depresión y salud mental, y a nuevos campos como los estudios comunitarios, con poblaciones en riesgo o vulnerables, en los cuales las diversas implicaciones son difíciles de indagar.

The purpose of this article is to present the impact and the integration of knowledge acquired in the international ethics of biomedical and psychosocial research training program of the University of Chile has had in my professional experience in the field of psychosocial research at a Mental Health Institute in Mexico. With this purpose, I will develop three areas of clear impact: participation in scientific ethical review committees, development of academic programs in bioethics and research and publication on ethics and bioethics. My motivation to enter in the program was that this training links psychosocial research with ethics and bioethics, which allows me to apply this type of reflection to problems such as violence, suicide, addictions, depression and mental health, and new fields such as community studies with vulnerable or at risk populations, in which the diverse implications are difficult to inquire.

O propósito deste trabalho é apresentar o impacto e a integração que os conhecimentos adquiridos no Programa Internacional de Formação em Ética da Pesquisa Biomédica e Psicossocial da Universidade do Chile tiveram em minha experiência profissional no âmbito da pesquisa psicossocial no Instituto de Saúde do México. Para este objetivo, mostrarei três áreas nas quais foi possível evidenciar tal impacto: trabalho nos comitês de ética, desenvolvimento de programas acadêmicos em bioética e pesquisa e publicação sobre ética e bioética. O motivo que me levou a incursionar no Programa foi que o seu aprendizado vincula a pesquisa psicossocial com a ética e a bioética, o que me permitiu dirigir este tipo de reflexão para problemas como violência, suicídio, toxicofilias, depressão e saúde mental, e a novos campos como os estudos comunitários com populações em risco ou vulneráveis, nas quais as diversas implicações são difíceis de indagar.

Percepción de la motivación de los directivos intermedios en tres hospitales de la Región del Maule, Chile / Motivation perception measurement of intermediate directors in three complex hospitals of the Region of the Maule, Chile

OBJETIVO: En este trabajo se diseña un cuestionario y se cuantifican las percepciones de motivación-desmotivación de los jefes intermedios de tres hospitales de la Región del Maule, Chile. MATERIAL Y MÉTODOS: El trabajo de campo se realizó entre septiembre y octubre de 2006, se aplicó un cuestionario con 57 afirmaciones de medición de actitudes que se calificó de acuerdo con una escala tipo Likert de cinco puntos. La población objeto de la investigación fue de 125 profesionales bajo cuya supervisión se encuentran alrededor de 3 800 funcionarios. RESULTADOS: Se identificaron 10 variables, cinco motivacionales y cinco desmotivacionales. Entre las primeras destacan vocación y espíritu de servicio; entre las segundas falta de reconocimiento y falta de compromiso. DISCUSIÓN: Se confirma que tanto las variables motivacionales como las desmotivacionales son esencialmente cualitativas y que las variables económica y de sueldos son menos relevantes y de inferior jerarquía.

OBJECTIVE: In this work, a questionnaire was designed and perceptions of motivation and demotivation of middle managers in three hospitals in the Region del Maule, Chile were measured. MATERIAL AND METHODS: The fieldwork was carried out between September and October, 2006. A questionnaire that included 57 statements to measure attitude was administered and qualified according to a five-point Likert-type scale. The population studied included l25 professionals that supervise roughly 3 800 employees. RESULTS: Ten variables were identified, 5 motivational and 5 demotivational. Notable among the motivational variables are vocation and service-oriented spirit; among the demotivational variables are lack of recognition and commitment. DISCUSSION: It is affirmed that both motivational variables as well as demotivational variables are essentially qualitative and that economic and salary variables are less relevant and less hierarchical.

Effect of transplanted human bone marrow mesenchymal stem cells on behavioral changes of cerebral ischemic rats / 基础医学与临床

Objective Investigate the behaviors of cerebral ischemic rats after treatment with bone marrow mesenchymal stem cells(BMSCs).Methods Bone marrow was collected and BMSCs were separated and cultivated.Twenty-four adult male Sprague-Dawley rats were performed transient(2 hours) middle cerebral arterial occlusion(MCAO) and then divided into treated group(n=12) and control group(n=12).All rats received corresponding behavioral training before surgery,15 ?L hBMSCs(2?1010cells/L) and D-hanks(15 ?L) were injected into the brain cortex after 24 h of MCAO.Morris water maze test,NSS,Rotarod test and adhesive-removal test were performed serially and cyclically from the 4th day after transplantation.Results Since the 8th day after transplantation,the mean escape time and the mean swimming distance of treated group significantly are shorter than control's in Morris water maze test(P