ABSTRACT
El mieloma múltiple es una enfermedad caracterizada por una proliferación de: células B en la cual la afección renal es una complicación frecuente tanto al momento del diagnóstico como durante su evolución. La nefropatía es multifactorial siendo el riñón del mieloma la más frecuente. Además existen factores precipitantes que agravan la afección. Se presenta el caso de un paciente con el diagnóstico de mieloma múltiple de cadenas ligeras kappa que debutó con afección renal Recibió manejo de sostén combinado con quimioterapia presentando una evolución favorable y reversibilidad de la afección renal que mejora la supervivencia.
Multiple myeloma is a disease characterized by a proliferation of B cells in which renal disease is a common complication at diagnosis and during its evolution Nephropathy is multifactorial and myeloma kidney is the most common cause. There are also precipitating factors that aggravate the condition. This is a case of a male adult patient diagnosed with multiple myeloma kappa light chain who debuted with kidney disease. He received support management combined with chemotherapy and he had a favorable evolution and reversibility of renal disease.
Subject(s)
Kidney DiseasesABSTRACT
Objective To evaluate immunofixation electrophoresis (IFE) and to compare it with conventional manual heat test method for detection of Bence Jones (BJ) protein in nonconcentrated urine. Methods We performed IFE and heat test for urinary protein analysis in 116 urine samples and evaluated a new immunofixation electrophoresis system by urinary protein analysis in 20 patients with multiple myeloma. Results 20 patients with multiple myeloma were detected to have BJ proteins (8 ? and 12?) in urine by IFE, whereas no urine BJ proteins by heat test. Conclusion The heat test for BJ proteins should be replaced by IFE because of its insensitivity and unspecificity. The IFE method is higherly sensitive and specific for screening and identification of BJ proteins in urine.