ABSTRACT
Objective To explore features and relevant factors affecting the ecological executive function in benign epilepsy children with centrotemporal spikes(BECT). Methods The behavior rating in-ventory of executive function (BRIEF) parental questionnaires were used to evaluate the executive function of 50 children with BECT (BECT group) and 50 normal children (control group) matched with BECT group (sex,age,education years). The differences of ecological executive function between the two groups were compared. Results (1)In BECT group,the scores of global executive composite (GEC),behavioral regula-tion index (BRI) and metacognition index (MI) ((51. 64±10. 30),(49. 02±8. 98),and (52. 78±10. 92), respectively) were significantly higher than those of the control group ((45. 70± 6. 55),(44. 96± 5. 35), (46. 72±6. 96),respectively,t=3. 440,2. 747,3. 309, all P<0. 05). Meanwhile,in BECT group,inhibit ((49. 90±10. 62),initiate (51. 76±11. 90),and working memory index scores (55. 58±10. 95) were also higher than those of the control group (44. 94± 6. 05,43. 74± 7. 63,47. 54± 7. 15,respectively,t=2. 870, 4. 014,4. 345, all P<0. 05). ( 2) Patients' condition had a negative predictive effect on inhibition ( β= -8. 926,P=0. 002),BRI ( β=-5. 422, P=0. 025), working memory ( β=-4. 980, P=0. 008), MI ( β=-4. 962,P=0. 034)and total score of scale( β=-6. 164,P=0. 004); attack times had a positive predictive effect on BRI(β=2. 555,P=0. 002),task initiation( β=7. 471,P<0. 01),working memory(β=5. 384,P<0. 01),MI (β=4. 726,P<0. 01) and total score of scale(β=4. 221,P<0. 01). Conclusion Children with BECT have ecological executive dysfunction. The number of epileptic seizures and the control of the disease are the main factors affecting the ecological executive function.
ABSTRACT
Objective To investigate the theory of mind ( TOM) and eye basic emotion recognition in benign epilepsy children with centrotemporal spikes( BECT) . Methods Totally 51 BECT patients( BECT group) and 51 healthy controls( control group) were studied by Yoni task and Eye Basic Emotion Discrimi-nation Task (EBEDT). Results ①Compared with healthy controls,BECT got significantly lower score ((54. 02±6. 03) vs (58. 04±5. 41),F(1,100)=10. 34,P<0. 05))in Yoni task,especially in affective(hot) TOM .②There was no significant difference between the BECT group(M(P25,P75):103(96,108)) and the control group(M(P25,P75):105(96,110))in the total score of Eye Basic Emotion Discrimination Task(Z=-1. 37,P>0. 05),but got significantly lower score in recognizing sadness(M(P25,P75):16(14,17) vs 18 (15,19),Z=-3. 05,P<0. 05)and fear(M(P25,P75):15(14,17) vs 16(16,18),Z=-2. 21,P<0. 05).③Pearson or Spearman correlation analysis showed that there was no significant correlation between the total score of TOM and the age,age of onset, education,seizure total number,MMSE,the Digital Span test, the verbal fluency test and eye basic emotion recognition ( r=-0. 257-0. 908,all P>0. 05) . Conclusion BECT children have impairments in sadness and fear emotion recognition and TOM aspects.
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Objective To investigate the ability of decision-making under risk condition in benign epilepsy children with centrotemporal spikes (BECT).Method Seventy-eight BECT patients and seventyfive healthycontrols were studied by Iowa Gambling Task (IGT) with inexplicit probability and Game of Dice Test (GDT) with explicit probability.Results (1) There was a significant difference in IGT task scores between the two group (t=-2.56,P＜0.05).The total number of advantageous choices in IGT were lower in BECT group (49.35±5.38) than that in healthy control group (52.24±6.23).BECT group (-1.41 ± 10.60) performed worse on task than healthy control group (4.43±11.88),and the difference was statistically significant (t=-3.21,P＜0.05).The control group scored higher on Blockl,Block4 and Block5 than that of BECT group (P＜0.05).(2) There was no significant difference between the BECT group (4.42±7.74) and the control group(5.49±6.81) in the GDT test scores (t=-0.91,P=0.37).(3) Pearson correlation analysis showed that there was no significant correlation between the age,age of onset,education,seizure frequency and onset duration and the score of IGT and GDT (r =-0.091-0.274,all P ＞ 0.05).Conclusion There is no significant decision-making disability in children with BECT under the condition of certain risk probability,while there is significant impairment under the condition of uncertain risk probability.The decision-making disability may be associated with impaired frontal lobe function.
ABSTRACT
Objective To investigate the characteristics of attention networks impairment in benign epilepsy children with centrotemporal spikes.Methods The attention network test was performed in benign epilepsy children with centrotemporal spikes (n =75) and normal controls (n =75) on the efficiency of three anatomically defined attention networks:alerting,orienting,and execrtive control.Results The correct rate of attention network test was significantly lower in benign epilepsy children with centrotemporal spikes (95.77％ ± 5.63％) than that in normal controls (98.55％ ± 1.80％ ; t =4.063,P ＜ 0.05).The total average response time was significantly longer in benign epilepsy children with centrotemporal spikes ((946.87 ± 199.82) ms) than that in normal controls ((729.00 ± 146.75) ms ; t =-7.611,P ＜ 0.05).The orienting network effect (29 (12,56)ms) was lower in benign epilepsy children with centrotemporal spikes than in normal controls (51 (21,78) ms; Z =-2.771,P =0.006).The executive control network effect was higher in benign epilepsy children with centrotemporal spikes (80 (50,105) ms) than in normal controls (57 (25,88) ms; Z =-2.146,P =0.032).However,the difference in alerting network effects between the two groups was not statistically significant (P ＞ 0.05).Logistic regression analysis showed that the age on onset of the disease was an independent risk factor for the correct rate of attention network test and the total average response time (OR =1.830,95％ CI 1.193-2.807,P =0.006 ; OR =1.635,95％ CI 1.176-2.275,P =0.003).Conclusions The benign epilepsy children with centrotemporal spikes have impairment of attention networks.The age on onset of the disease has a significant impact on the attention of children with rolandic epilepsy.