ABSTRACT
ABSTRACT Hemosiderotic adenodermatofibroma is a recently recognized lesion, characterized by a dermal nodule with cystic structures of an apocrine gland, surrounded by a dermatofibroma-like stroma with hemosiderotic macrophages. We present the first case report of this entity in Brazil together with representative images, in addition to a review on the subject and discussion about the apocrine origin of this lesion.
RESUMEN El dermatoadenofibroma hemosiderótico es una lesión recientemente descrita, caracterizada por un nódulo dérmico con estructuras quísticas de una glándula apocrina, rodeado por un estroma del tipo dermatofibroma con macrófagos hemosideróticos. Presentamos el primer reporte de caso de esa entidad en Brasil, junto a imágenes representativas, además de una revisión del tema y discusiones acerca del origen apocrina de esa lesión.
RESUMO Adenodermatofibroma hemossiderótico é uma lesão recentemente conhecida, caracterizada por um nódulo dérmico com estruturas císticas de uma glândula apócrina, circundado por um estroma do tipo dermatofibroma com macrófagos hemossideróticos. Apresentamos o primeiro relato de caso dessa entidade no Brasil junto a imagens representativas, além de uma revisão do assunto e discussões sobre a origem apócrina dessa lesão.
ABSTRACT
Fibrous histiocytoma (FH) commonly occurs in the superficial layers of the skin. Orbit and limbus are documented ophthalmic sites of involvement but isolated corneal FH has never been reported in literature. We present the first case of FH exclusively involving the cornea where a 10-year-old male child presented with a 3-month history of a painless growth on the superior cornea of the right eye with deterioration of vision. Tumor excision with therapeutic penetrating keratoplasty was done and the histopathological examination confirmed the diagnosis. There was no recurrence and the corneal graft was clear at 1 year.
ABSTRACT
Abstract: We report a rare clinical case of hemosiderotic dermatofibroma in a 36-year-old female patient. The main dermatoscopic finding was represented by homogeneous blue-gray pigmentation. The aim of this report is to demonstrate the rarity of the lesion and the dermatoscopic importance it assumes by sharing a blue-gray homogeneous pattern with other benign and malignant lesions.
Subject(s)
Humans , Female , Adult , Skin Neoplasms/pathology , Hemosiderosis/pathology , Melanoma/pathology , Diagnosis, DifferentialABSTRACT
The fibrous histiocytoma is a soft tissue neoplasm that affects the dermis and the subcutaneous tissue, rarely is found in the oral cavity and perioral regions, and is originated from the proliferation of fibroblasts and histiocytes. The objective of this paper is to report a case of Benign Fibrous Histiocytoma in a 30-year-old male patient, complaining of a painless nodule in the tongue for about six months. With diagnostic clinical hypotheses of Fibrous Hyperplasia, Neurofibroma, Traumatic Neuroma, Fibrous Histiocytoma, Granular Cell Tumor or Ectomesenchymal Chondromyxoid Tumor a excisional biopsy was performed. The histopathological examination revealed a non-encapsulated proliferation of spindle cells with some giant multinucleated cells in the periphery of the lesion. Immunohistochemical reactions were performed, staining only for vimentin in the spindle cells and for CD68 in the multinucleated giant cells. According to these characteristics, the final diagnosis was Benign Fibrous Histiocytoma. The correct diagnosis of spindle shaped cell neoplasia must be performed with the aid of histopathological analysis and immunohistochemistry, mainly because the morphological similarities with other benign and malignant lesions. (AU)
O Histiocitoma Fibroso é uma neoplasia de partes moles que acomete a derme e o tecido subcutâneo, raramente é encontrado na cavidade oral e regiões periorais, e tem origem a partir da proliferação de fibroblastos ou histiócitos. O objetivo deste artigo é relatar um caso de Histiocitoma Fibroso Benigno em um paciente masculino, 30 anos de idade, com um nódulo indolor, bem delimitado, com duração de cerca de seis meses, localizado no dorso anterior da língua. Com as hipóteses clínicas diagnósticas de Hiperplasia Fibrosa, Neurofibroma, Neuroma Traumático, Histiocitoma Fibroso, Tumor de Células Granulares e Tumor Condromixoide Ectomesenquimal uma biópsia foi realizada sob anestesia local e a lesão foi fixada em formol a 10% e enviada para análise histopatológica. O exame histopatológico revelou uma proliferação não-encapsulada de células fusiformes com algumas células gigantes multinucleadas na periferia da lesão. A marcação imunohistoquímica foi positiva para CD68 nas células gigantes multinucleadas e para vimentina nas células fusiformes. O diagnóstico final foi de Histiocitoma Fibroso Benigno. Para um diagnóstico correto, este deve ser feito correlacionando características clínicas, análise histopatológica e imunohistoquímica devido à similaridade microscópica do Histiocitoma Fibroso com outras lesões com aspecto fusocelular, assim como similaridade clínica com outras lesões benignas e malignas.(AU)
Subject(s)
Humans , Male , Adult , Fibroblasts , Histiocytes , Histiocytoma, Benign FibrousABSTRACT
Some morphological variants of benign fibrous histiocytoma (dermatofibroma) present with distinct clinical features. In particular, atypical, aneurysmal, and cellular fibrous histiocytoma are associated with a significant risk of local recurrence. Furthermore, very rarely, cutaneous fibrous histiocytoma can lead to metastatic disease. Deep benign fibrous histiocytoma is an uncommon and poorly recognized clinical subtype that arises in subcutaneous or deep soft tissue. Deep benign fibrous histiocytoma has many histologic features in common with cellular fibrous histiocytoma. Deep benign fibrous histiocytoma recurs in approximately 20% of cases and may rarely metastasize. We report a rare case of deep benign fibrous histiocytoma with metastatic potential in a 38-year-old man who presented with a 2-year history of a recurrent hard mass on his left shoulder.
Subject(s)
Adult , Humans , Aneurysm , Histiocytoma, Benign Fibrous , Neoplasm Metastasis , Recurrence , ShoulderABSTRACT
Objective To explore the imaging radiological and clinicopathological characteristics of benign fibrous histiocytoma (BFH) of bone, in order to improve the imaging diagnostic accuracy of the disease Methods Radiological and clinical data of 16 patients with BFH confirmedbypathology were retrospectively analyzed , and relevant literatures were reviewed. Results The X-ray findings of 14 BFHpatients were osteolytic lesion , expansive destruction of bone,without soft tissue involvement, 10 with residual apophysis,9 with osteosclerosis marginal; CT was performed on 2 patients. Expansive destruction of bone and soft tissue densities were seen inside the loops , 1 case remarkable enhancement of the lesion. MRI was performed on 9 patients and 5 cases showed long T1 and T2 signal intensity; 1case showed equal T1 and long T2 signal intensity in cystic part and equal T1 and T2 signal intensity in the solid part. One patient had pathological fracture, and the surrounding soft tissue invaded, showing equal T1 and long T2 signal intensity. Two lesions located at spinous process of cervical vertebra , showing long T1 short T2 and equal T1 and T2 signal intensity. Linear low signal separation shadow in T1 and T2 could be seen in 6 cases. Long T1 and short T2 sclerotic ring were seen in 4 cases. Solid part of tumor and linear separator were obviously enhanced. Conclusions The radiological findings of benign fibrous histioeytoma of bone indicate some characteristics. The combination with X-ray , CT and MRI examination is helpful to improve the diagnostic accuracy of the disease before operation.
ABSTRACT
Benign fibrous histiocytoma (BFH) is a rare benign primary skeletal tumor that occurs commonly in the long bones, spine and pelvis. BFH constitutes a diagnostic challenge because it shares clinical background, radiological characteristics, and histological features with other fibrous lesions such as non-ossifying fibroma, giant cell tumor. We present a case of BFH with cystic change that occurred in the distal femur. We did not identify any case of BFH with cystic change involving the majority of the lesion that occurred in the metaepiphysis of the long bone.
Subject(s)
Femur , Fibroma , Giant Cell Tumors , Hemorrhage , Histiocytoma, Benign Fibrous , Pelvis , SpineABSTRACT
Fibrous histiocytoma is a benign soft tissue neoplasm that may present as a fi brous mass any-where in the human body. Th e involvement of the oral cavity is extremely rare and very few cases have been reported in the literature until date. We here report a case of benign fi brous histiocytoma localized in the oral cavity in mandibular chin region and the treatment approach that need to be followed for such cases. Th e clinical and histological features of the lesion are discussed precisely in the light of a literature review of this pathology occurring in soft tissues in the head and neck region.
Subject(s)
Adult , Chin/pathology , Histiocytoma, Benign Fibrous/anatomy & histology , Histiocytoma, Benign Fibrous/surgery , Humans , Male , Mouth/pathology , Review Literature as TopicABSTRACT
Benign fibrous histiocytoma (BFH) is a mesenchymal tumor which commonly affects the skin of extremities. Histologically, BFH of soft tissues and bone shows similar features, but BFH of the bone is rare with less than 100 cases reported worldwide and usually it involves tibia, femur, and pelvic bone. As far as the oral cavity is concerned, majority of the BFHs are found in the soft tissues of the buccal mucosa, gingiva, lower and upper lips, soft palate, and floor of the mouth. Occurrence of this tumor in the jaw bones is extremely rare as only one case of the maxilla and six cases of the mandible have been reported so far . Hence, the purpose of this article is to report the second case of BFH of the maxilla in a 23-year-old female patient and to review the literature of this entity affecting the jaws.
Subject(s)
Female , Histiocytoma, Benign Fibrous/diagnosis , Histiocytoma, Benign Fibrous/epidemiology , Maxilla , Review Literature as Topic , Young AdultABSTRACT
BACKGROUND: The effects of the Notch signaling pathway in fibroproliferative skin diseases have not been fully elucidated. OBJECTIVE: The aim of this study was to investigate the expression of activated Notch signaling molecules in various skin fibroproliferative diseases. METHODS: Immunohistochemical analysis of Notch intracellular domain (NICD) expression in keloid, hypertrophic scar, morphea, dermatofibroma, and normal control skin specimens was performed, and the clinical characteristics of patients with various skin fibroproliferative diseases were analyzed. RESULTS: NICD was highly expressed in fibroblasts of keloids and moderately to highly expressed in hypertrophic scars and dermatofibromas, whereas low or no expression was detected in the fibroblasts of normal skin specimens and morpheas. NICD was constitutively expressed in keratinocytes, endothelial cells, and immune cells in normal skin specimens. CONCLUSION: NICD was significantly expressed in human fibroproliferative skin disorders, especially keloids, suggesting that an activated Notch signaling pathway is involved in the pathogenesis of skin fibrosis.
Subject(s)
Humans , Cicatrix, Hypertrophic , Endothelial Cells , Fibroblasts , Fibrosis , Histiocytoma, Benign Fibrous , Keloid , Keratinocytes , Receptors, Notch , Scleroderma, Localized , Skin Diseases , SkinABSTRACT
Benign fibrous histiocytoma (BFH) is a benign fibrohistiocytic neoplasm. It is documented to occur in all anatomic sites with a strong predilection for sun exposed skin surfaces. Intra oral occurrence of BFH comprises a lesser percentage of cases with tongue being the least reported site. We report a case of BFH of the tongue with an emphasis on its histogenesis and a review of the literature.
ABSTRACT
Compared to cutaneous benign fibrous histiocytoma (BFH), deep-seated BFH is very rare and poorly recognized. Both cutaneous and deep-seated BFH are usually asymptomatic. We herein report a 25 year-old woman who presented with a painful mass in her foot that was poorly controlled by analgesics and associated with walking difficulty. After preoperative ultrasonographic evaluation, the mass was completely excised and histologic exam showed spindle cells loosely arranged in storiform architecture, with CD34-, desmin-, S-100-, focal CD68+, vimentin+, smooth muscle actin+, and factor XIIIa+. The patient was diagnosed with deep-seated BFH based on the histologic, radiologic and intraoperative findings.
Subject(s)
Female , Humans , Analgesics , Foot , Histiocytoma, Benign Fibrous , Muscle, Smooth , WalkingABSTRACT
Fibrous histiocytoma usually develops indiscriminately in skin and any soft tissues of the body. To date, tumors occurring in soft tissues of the head and neck, especially around the nose, have been rarely reported. In most cases, benign fibrous histiocytoma develops as a painless mass lesion and most commonly originates in sun-exposed skin, extremities, and orbital tissue. Recently, we experienced a case of benign fibrous histiocytoma in the nasal dorsum in a 36-year-old woman who complained of a mass in the nasal dorsum. To the best of our knowledge, this is the first reported case of benign fibrous histiocytoma originating in the nasal dorsum in a Korean.
Subject(s)
Adult , Female , Humans , Extremities , Head , Histiocytoma, Benign Fibrous , Neck , Nose , Orbit , SkinABSTRACT
Subject(s)
Extremities , Fibroblasts , Histiocytoma, Benign Fibrous , Jaw , Mandible , Neoplasm Metastasis , Recurrence , SkinABSTRACT
A rare case of benign fibrous histiocytoma arising in the upper lip in a 76-year-old female is presented. A well-defined tumor measuring 1 cm existed in the submucosal area of the right side of the upper lip. With the patient under local anesthesia, the tumor was excised. Microscopically, the excised tumor was diagnosed as a benign fibrous histiocytoma. There has been no evidence of tumor recurrence after the operation.
ABSTRACT
Benign fibrous histiocytomas are relatively common nodules that are histologically characterized by a proliferation of fibroblastic and histiocytic cells in the dermis. Rarely, some show such cellular atypia that there are some difficulties in differentiating the lesion from sarcoma. Herein we report a 42-year-old man with asymptomatic, solitary, 11 cm sized, red-to-brown colored, broad-based, and firm nodule on the right forearm for about 2 years. Histologically, the lesion was composed of histiocytes, fibroblasts and pleomorphic, bizarre multinucleated giant cells. Despite the cellular atypia, mitotic figures were not found.
Subject(s)
Adult , Humans , Dermis , Fibroblasts , Forearm , Giant Cells , Histiocytes , Histiocytoma, Benign Fibrous , SarcomaABSTRACT
Fibrous histiocytoma or other tumors of this group, benign or malignant, usually develop indiscriminately in any skin and soft tissues of the body. Up to the present, tumors occurring in the nasal cavity, paranasal sinuses or nasopharynx have been rarely reported. Most benign fibrous histiocytoma often develop as a painless mass lesion and mostly occur in the-sun-exposed skin and orbital tissue. However, it has also been found in the aerodigestive tract, salivary gland, and deep layers of the scalp and face. The age ranges from 1 to 70 with a male to female ratio of 2.5:1. Recently, we experienced a case of benign fibrous histiocytoma in the frontoethmoid sinus in a 63-year-old woman, whose case was initially considered as a mucocele. The authors believe this is the first reported case of benign fibrous histiocytoma originating in the frontoethmoid sinus.