ABSTRACT
In order to explore the effect of hepatocholangiolithiasis on hepatobiiiary system, 160 patients with gallstone were observed by using choledochofiberscope, microscope and electnonic microscope. Damage of bile ducts was found in 84 cases(52.5%) and damage of the liver in 40 cases (25% ) with naked eyes. However, denaturation of hepatocytes occured in nearly all of the cases under microscope. To testify the clinical finding, animal experiments were made in 60 rabbits including infusion of gallstone or silt into bile ducts in groupl, 2, and subacute toxiologic experiment was made by direct injection of gallstone or silt into liver tissue(group3, 4). The results showed that under same condition damage of liver and bile duct caused by gallstone is more severe than that caused by silt. The authers suggest that hepatocholangiolithiasis can damage the hepatobiiiary system no matter whether there is obstruction or not. The harmful substance of gallstones can damage liver tissue directly. So effective therapy should be given as early as possible when the dis-gnosis of hepatocholangiolithiasis is made.