ABSTRACT
SUMMARY: This review article will present an overview of biological profiles in forensic utilities. The biological profile of the skull in the existing literature can help to identify humans, especially if the condition of the victim found is a result of mutilation or a bomb explosion. When it comes to the precision of identifying skeletal remains, the human skull is frequently cited as being first in the estimation of age and ancestry and second in terms of sex and stature. It can be an alternative to assessing the following biological parameters: sex, age, stature, and ancestry. The implementation of biological profiles in the identification process is very important considering that some cases require the assistance of forensic anthropology. This review article shows the importance of the value of skulls. The method that can be applied is craniometry which can be used to determine sex, age, stature, and estimated ancestry. Different results will occur depending on the completeness of the skull. Therefore, estimation formulas have different accurate results. Discriminant function analysis has been performed on various measurement sets and its discriminant power has been validated by many researchers. Geometric morphometric analysis has become the main tool for shape analysis and many attempts have been made to use it in analyzing skulls. Several methods supported by technology have also been developed. It is hoped that the review article will show significant differences in results between studies in Thailand and Indonesia, even though they are in the same racial group.
Este artículo presenta una descripción general de los perfiles biológicos en las utilidades forenses. El perfil biológico del cráneo en la literatura existente puede ayudar a identificar a los humanos, especialmente si la condición en la que se encuentra la víctima es el resultado de una mutilación o la explosión de una bomba. Cuando se trata de la precisión en la identificación de restos óseos, el cráneo humano se cita con frecuencia como el primero en la estimación de edad y ascendencia y el segundo en términos de sexo y estatura. Puede ser una alternativa para evaluar los siguientes parámetros biológicos: sexo, edad, estatura y ascendencia. La implementación de perfiles biológicos en el proceso de identificación es importante considerando que algunos casos requieren la asistencia de la antropología forense. Este artículo de revisión muestra la importancia del valor de las cnezas óseas. El método que se puede aplicar es la craneometría para determinar el sexo, la edad, la estatura y la ascendencia estimada. Se pueden obtener diferentes resultados dependiendo de la integridad del cráneo. Por lo tanto, las fórmulas de estimación tienen resultados precisos diferentes. Se ha realizado un análisis de función discriminante en varios conjuntos de medidas y muchos investigadores han validado su poder discriminante. El análisis a través de la morfometría geométrica se ha convertido en la principal herramienta para el análisis de formas y se ha utilizado frecuentemente en el análisis de cráneos. También se han desarrollado varios métodos apoyados en la tecnología. Se espera que este trabajo muestre diferencias significativas en los resultados entre los estudios realizados en Tailandia e Indonesia, aunque pertenezcan al mismo grupo racial.
Subject(s)
Humans , Male , Female , Skull/anatomy & histology , Age Determination by Skeleton , Sex Determination by Skeleton , Pedigree , Thailand , Body Height , IndonesiaABSTRACT
<p><b>INTRODUCTION</b>This study aimed to analyse the concordance rate, sensitivity, specificity, positive predictive value (PPV) and negative predictive value of core needle biopsy (CNB) and subsequent surgical specimen (SS) in assessing levels of oestrogen receptor (ER), progesterone receptor (PgR) and human epidermal growth factor receptor 2 (HER2/neu). It also evaluated the revised American Society of Clinical Oncology/College of American Pathologists (ASCO/CAP) guidelines for ER/PgR positivity.</p><p><b>METHODS</b>We analysed the breast cancer database of KK Women's and Children's Hospital, Singapore, from 1 June 2005 to 30 December 2012. Invasive breast cancer patients who had CNB and subsequent SS were included.</p><p><b>RESULTS</b>A total of 560 patients were included. The concordance of ER, PgR and HER2/neu positivity between CNB and SS was 96.1%, 89.1% and 96.8%, respectively. When the 'ER ≥ 10% positive' group was compared with the 'ER ≥ 1% positive' group, specificity increased from 79.7% to 92.5% and PPV increased from 93.9% to 97.5%. When the 'PgR ≥ 10% positive' group was compared with the 'PgR ≥ 1% positive' group, specificity increased from 84.2% to 89.3% and PPV improved from 89.7% to 92.9%. The revised ASCO/CAP guidelines decreased discordant results by > 50% for ER and by 18.2% for PgR.</p><p><b>CONCLUSION</b>CNB has high concordance with SS in the evaluation of the molecular profile of invasive breast cancer. Thus, molecular evaluation does not need to be repeated with SS except for ER-, PgR- and HER2/neu-negative CNB results. The revised ASCO/CAP guidelines resulted in more precise ER and PgR status on CNB.</p>
Subject(s)
Female , Humans , Middle Aged , Automation , Biopsy, Large-Core Needle , Breast Neoplasms , Diagnosis , Pathology , Immunohistochemistry , Predictive Value of Tests , Receptor, ErbB-2 , Metabolism , Receptors, Estrogen , Metabolism , Receptors, Progesterone , Metabolism , Sensitivity and Specificity , SingaporeABSTRACT
El objetivo de este estudio fue describir el perfil biológico y social del paciente pediátrico con trasplante hepático por insuficiencia hepática aguda (IHA) y la evolución postrasplante. Material y Método: trabajo retrospectivo, descriptivo y observacional, se revisaron la base de datos de 142 pacientes trasplantados por IHA desde 1992 al 2008. Se describieron los datos demográficos y sociales, indicaciones de trasplante, tipo de injerto utilizado, compatibilidad del grupo ABO, evolución pos trasplante (resultados primarios), complicaciones del trasplante y sobrevida. Resultados: El 51% de los casos de IHA fue asociado a la hepatitis infecciosa por virus A (HAV) y el 41% correspondió a las IHA indeterminadas. El 85% de la población trasplantada (120 casos) recibió un donante de tipo cadavérico (DC) y la compatibilidad de grupo ABO fue del 85%. Las complicaciones más frecuentes fueron: biliares 33 casos, infecciones bacterianas 20 casos y vasculares 13 casos. El rechazo agudo estuvo presente en 72 casos mientras que el rechazo crónico se diagnosticó en 7 casos. La sobrevida de la IHA al año del postrasplante fue del 80% y a los 5 y 10 años fue del 77%. La conciencia de enfermedad reflejada en el cumplimiento de las consignas médicos sociales estuvo presente en un 86,25%. El 70% de los padres de los niños trasplantados eran biológicos y el 52% de la población provino del área centro (Buenos Aires, Córdoba, Entre Ríos, y Santa Fe). La cobertura estuvo a cargo del estado en el 45% de la muestra (AU)
The aim of this study was to describe the social and biological profile of pediatric patients who undergo liver transplantation because of acute liver failure (ALF) and post-transplant outcome. Material and Methods: A retrospective, descriptive, and observational study was conducted. The database of 142 patients who underwent liver transplantation because of ALF between 1992 and 2008 was reviewed. Demographic and social features, indication for transplantation, type of graft used, ABO group compatibility, post-transplant outcome (primary results), complications of the transplantation and survival were evaluated. Results: ALF was associated with infectious hepatitis A (HAV) in 51% of the cases and with indeterminate ALF in 41%. Overall, 85% of the transplanted patients (120 cases) received a deceased donor (DD) organ and ABO group compatibility was 85%. Most common complications were: biliary in 33 cases, bacterial infections in 20 cases, and vascular in 13 cases. Acute rejection was observed in 72 cases while chronic rejection was diagnosed in seven cases. Oneyear post-transplant survival after ALF was 80%, while 5- and 10-year survival was 77%. Disease awareness expressed in compliance with medical and social indications was observed in 86%. Seventy percent of the parents of transplanted children were there biological parents and 52% of the population came from the central area of the country (Buenos Aires, Córdoba, Entre Ríos, y Santa Fe). Forty-five percent of the sample had public health care coverage (AU)
Subject(s)
Humans , Infant , Child, Preschool , Child , Adolescent , Liver Failure, Acute/surgery , Liver Transplantation/adverse effects , Socioeconomic Factors , Transplantation/rehabilitation , Treatment Outcome , Family , Postoperative ComplicationsABSTRACT
When forensic anthropologists tried to reconstruct the biological profile, they would rely on the statistical data of documented human osteological/anatomical specimens. However, the metric data of Korean ancestry which is suitable for determining sex has not been established because documented human skeletal specimens are lack in Korean. The aim of this study is to discuss the possibility of determination of sex by metric data of atlas in Koreans. We measured 43 (male 25 and female 18) atlas from the department of anatomy, College of Medicine, Soonchunhyang University and the department of anatomy, Yonsei University College of Medicine. We measured 21 measurements of atlas using digimatic caliper and performed statistic analysis using SPSS to establish the discriminant functions. Among 21 measurements of atlas, the measurement values of the width of atlas exhibited the strongest relation with sexes. The accuracy of arbitrary discriminant functions derived from 6 measurements exhibited 93.9% and that of stepwise discriminant functions derived from 3 measurements exhibited 97.0%. In conclusion, this study could indicate that metric data of atlas is helpful to determine the sex in Koreans, but a further investigation should be followed.