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OBJECTIVE：To provide reference for furthe r promoting the high-quality development of the biomedical industry in Guangdong-Hong Kong-Macao Greater Bay Area. METHODS ：Through summarizing the development status and development environment of the biomedical industry in the Guangdong-Hong Kong-Macao Greater Bay Area ，the construction experience of foreign advanced biomedical industrial park was introduced ，and the problems and challenges faced by the biomedical industry in the Guangdong-Hong Kong-Macao Greater Bay Area were sorted out so as to put forward relevant countermeasures and suggestions. RESULTS & CONCLUSIONS ：Guangdong-Hong Kong-Macao Greater Bay Area has received multiple policy support，which is conducive to the development of biomedical industry. The industrial chain is complete ，and the scale advantage of biological industry is showing day by day. Biological industry has achieved fruitful innovation achievement ，and its R&D investment is in the leading position in the country. The pharmaceutical manufacturing industry is developed and the total amount of medical resources is large. The financial advantages are obvious ，and institutional innovation is conducive to the development of biomedical industry. The process of internationalization takes the leading place ，which is conducive to continuously promoting foreign cooperation. However ，compared with foreign advanced biomedical industrial parks ，Guangdong-Hong Kong-Macao Greater Bay Area still has some deficiencies in management mode ，service mode and “industry-university-institute”cooperation. It also faces the following problems that the legal systems and industry norms of the three places need to be further connected ；there is a talent gap ；the industrial chain is not perfect ；the support for new drug R&D is insufficient ；the“industry-university-institute” cooperation needs to be strengthened ；the level of financial support needs to be improved. Accordingly ，it is recommended to break down institutional barriers ，and promote the connection between the legal system and industry norms ；innovate talent policies ，and continue to attract excellent R&D talents ；introduce leading companies ，and improve the industrial chain ；open up clinical trial channels and promote the transformation efficiency of scientific research achievements ；strengthen“industry-university-institute” cooperation，and promote the improvement of biomedical innovation ability ；make good use of financial support to help the rapid rise of biomedical industry enterprises ，so as to promote the high-quality development of biomedical industry in Guangdong-Hong Kong-Macao Greater Bay Area.
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Objective This study aims to analyze and investigate the major factors that affecting stem cell clinical research,explore corresponding countermeasures,to further promote the clinical research and translational application of stem cells.Methods Comprehensive investigation were conducted to analyze and summarize the the most recent basic research of stem cells,standardization of stem cell preparation sources,human personnel,clinical research and supporting systems.Results The slow progress of stem cell clinical research could attribute to several factors,including sluggish frontier basic research of stem cells;lack of high-quality,clear-source,and controllable samples for stem cell research institutes,lack of standard operation codes,professional consensus,guidelines in multi-center clinical research and stem cell research,and unsound supporting system of stem cell clinical research.Conclusions Based on the analysis and summaries,combined with the practice and exploration of the author in past decade.Our recommendations include:focus on human major diseases,strive to make breakthroughs in key scientific problems of stem cell and translational research,establish a national stem cell resource bank,and conduct multi-center stem cell clinical research.Besides,increase the effort in personnel training in various related fields,establish a scientific system and mechanism for the supervision of stem cell clinical research,accelerate the clinical research and translation of stem cells,and finally contribute to the "Healthy China 2030" national strategy to provide better service to public.
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OBJECTIVE：To prov ide re ference for the development of biomedical industry in China. METHODS ：The policies and documents issued by 169 national high-tech industrial development zone （hereinafter reffered to as “National high-tech zone ”） official websites from Jan. 2010 to Dec. 2019 were collected to screen policies specifically for the biomedical industry and the development policy of biomedical industry mentioned in all industrial policies. Excel 2019 software was used to summarize and analyze policy information. Gensim package was used to preprocess the policy texts and construct LDA topic model to extract the potential semantic information from the policy texts. RESULTS ：A total of 518 policy texts were collected ，including 58 617 effective words ；high-frequency words included project ，talent，support，subsidy，innovation，etc.；8 themes were extracted ， ranked by theme intensity as technological innovation ，talent construction ，financing support ，project financial support ，tax incentives，resource guidance ，export trade ，and construction of small and medium-sized enterprises ，with the intensities of 0.299， 0.168，0.134，0.116，0.113，0.063，0.058 and 0.049，respectively. CONCLUSIONS ：The biomedical industry policy of the national high-tech zone is mainly based on technological innovation ，talent construction and financing support ，and lacks attention to the construction of small and medium-sized enterprises ，resource guidance ，and export trade. In the future ，the national high-tech zone ’s policy support and system construction for the biomedical industry should focus on improving policy incentives and balancing the proportion of policy applications in various fields ；encourage enterprises to expand overseas markets ，learn overseas advanced technologies ，and strengthen multilateral cooperation in scientific research and other fields ；support the corresponding policies to enhance exchanges and cooperation between enterprises ，give play to the leading role of leading enterprises and famous brand products ，and promote the development of small and medium-sized enterprises.
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A large number of starring biomedical industry clusters are emerged in recent years with the develop-ment of biomedical industry. The information access approaches of users in biomedical industry clusters consisting of higher education institutions, scientific research institutions and enterprises, the types of biomedical information they need, the transformation ways of their achievements, and the major barriers of information access were thus in-vestigated in this paper with questionnaires. The different information behaviors were compared between the users of scientific research group and enterprise group. The characteristics of information need of users in biomedical indus-try clusters were summarized, and following suggestions were put forward, namely establishing information service platform, perfecting institution-oriented information service model, and improving information service system for bi-omedical industry clusters.
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The construction plan of information service platform for biomedical industry groups was proposed, including expert intelligence database, special database, advanced information service platform and biomedical achievements transformation platform.The information ( including names, subject fields and research interests of experts) in expert intelligence database can be searched according to the subject fields and research interests of experts.The special database is consisted of database of special literature, genes, proteins, special drugs, achievements, patents and demands.The information service platform can provide literature retrieval service, literature novelty assessment service, data-mining service, information analysis service, decision-making support service, and competitive informa-tion service.The biomedical achievements transformation platform can provide service for transforming achievements and for solving difficulty demand problems.