ABSTRACT
Objective To observe the clinical efficacy of collateral-pricking bloodletting therapy plusXiao Feng San in treating chronic urticaria due to blood deficiency and wind dryness.Method A total of 150 patients with chronic urticaria due to blood deficiency and wind dryness were randomized into a treatment group and a control group, 75 cases each. The treatment group was intervened by collateral-pricking bloodletting plus oral administration ofXiao Feng San, while the control group was intervened by oral administration ofXiao Feng San alone. Before and after 4-week treatment, the serum indexes [immunoglobulin E (IgE), eosinophil count, C3, C4, interleukin (IL)-2, IL-4] of the two groups were observed, and the clinical efficacies were also compared.Result The total effective rate and markedly effective rate were respectively 100.0％ and 86.7％ in the treatment group versus 80.0％ and 52.0％ in the control group, and the between-group differences were statistically significant (P<0.05,P<0.01). After the treatment, the serum indexes were significantly changed in the treatment group (P<0.05). The levels of IgE, eosinophil count, IL-2 and IL-4 were significantly changed after the treatment in the control group (P<0.05). There were significant differences in comparing the serum indexes between the two groups after the intervention (P<0.05).Conclusion Collateral-pricking bloodletting therapy plusXiao Feng San is an effective method in treating chronic urticarial due to blood deficiency and wind dryness, and it can improve the serum indexes.