ABSTRACT
OBJECTIVE To investigate the influence of tea polyphenol in alcoholic liver(hurted) rat by observing its blood plasma endotoxin level,and to provide the direction of new(treatments) and means for the prevention of alcoholic liver disease.METHODS Thirty S-D rats(15 female,15 male) were divided into five groups randomly(noted as A,B,C,D,and E,with equal male and female),and fed in the cleanliness class laboratory.Excepting group E which was given saline,all other groups were given alcohol(56% Hongxing spirits) with the dosage of 7 g/kg once everyday.At the same time,rats in groups B,C and D were given tea polyphenol with the dosage of 0.05,0.125,0.25 g/kg.In the end of the fourth week,got the rats vein blood to determinae serum ALT,AST level and blood plasma endotoxin level.RESULTS The serum AST of the group A was higher than other 4 groups;the blood plasma endotoxin level in groups B,C,and D were(consequently) lower than in group A.CONCLUSIONS The tea polyphenol could reduce the blood plasma endotoxin level in alcoholic liver hurted rat.Its possible mechanism is to repress the isotopy of bowel flora,and to maintain the normal function of bowel mucous membrane.This research provides a new way for curing the alcohol liver hurt.