ABSTRACT
Background: The lack of vitamin D deficiency has been found to be closely associated with many health problems such as metabolic syndrome, cancer, cardiovascular disease, and type 2 diabetes. This interest has also arisen due to the identification that most cells, along with the pancreatic beta-cells, incorporate the vitamin D receptor. Aims and Objectives: In this study, we tested the potential anti-diabetic effect of cholecalciferol, one of the vitamin D analogs, alone or in combination with vildagliptin in type 2 diabetic rats. Materials and Methods: Type 2 diabetic model rats were induced by intraperitoneal injection of streptozotocin followed by nicotinamide. Rats were assigned into five groups each of six rats divided as follows: Normal (non-diabetic) control (Group A), untreated diabetic group receiving the vehicles only (Group B), cholecalciferol-treated group (Group C), vildagliptin-treated group (Group D), and group receiving a combination of cholecalciferol and vildagliptin (Group E). The treatment course lasted for 1 month. For the estimation of fasting blood sugar, the rats were kept deprived of food overnight and were allowed free access to water. Blood samples were collected from the tail of rat with the help of glucometer. Statistical analysis was performed using SPSS version 20 software. One-way ANOVA test was used to compare the effect of drugs on different group. Post hoc analysis was done using Turkeys HSD (honestly significant difference) test. Differences were considered significant at (P < 0.05). Results: Mean FBS value of vitamin D, vildagliptin, and their combination was 181.50 mg/dl, 95.0 mg/dl, and 84.83 mg/dl on day 28. It showed that the combination of both drugs acquired much closer value of FBS as compared to normal non-diabetic control group and thus achieved normal glucose level more effectively. Furthermore, coadministration showed greater fall in fasting blood glucose at the extent of 61.15% as compared to 56.45% by vildagliptin and 17% by cholecalciferol alone on day 28. Conclusion: Therefore, it may be suggested through this study that vitamin D has blood glucose lowering property and coadministration of vitamin D and vildagliptin potentiate the action of each other.
ABSTRACT
The study was analysed to ?nd out the relationship of psychological well being with blood glucose levels of diabetic type II subjects. Only aged male patients (N=30) were selected as subjects for this study and age ranged from 45 to 55 years. The fasting blood glucose level was measured for the measurement of these glucose levels to the nearest mg/dl. Carol Ryff psychological well-being questionnaire was used for measuring the psychological well-being. Co- ef?cient correlation method was applied to investigate the relationship of depression with blood glucose levels. The results of this study suggest that there is a negative relationship between blood glucose level and the psychological well-being at 0.05 level of con?dence.
ABSTRACT
Background:Studies suggest an association between Helicobacter pylori (H. pylori)infection and extra gastrointestinal disease. Limited studies provided conflicting results on the association between H. pyloriinfection and diabetes. The present study was aimed at examining the association between H. pyloriinfection and diabetes among Sudanese patients.Methods:This was case control study conducted among Sudanese diabetic patients during the period fromMay 2018 to July 2021. A total of 181 diabetics patients are involved in this study. Blood, stool samples were collected from each participant. All stool samples were tested for the presence of H. pylori antigen by using commercially available H. pyloriantigen detection card. Based on the result examination for H. pylori the study population are sub grouped in two groups one group 124 of cases with Positive H. pyloriantigen and another group 57 of controls with negative H. pylori infection. Both groupswere assessed for the level of fasting blood glucose. Data was gathered and analyzed by using SPSS version 20.Results: among cases group the mean of fasting blood glucose was 201.94± 90.45 mg/dl compared to 199.40± 97.83 mg/dl among control group. The statistical analysis was showed insignificant difference between cases and controls in the level of fasting blood glucose with P-value of 0.864 . In addition, among cases group the mean of male’s blood glucose 213.0±91.52 mg/dl was higher than females blood glucose level 185.0 ±87.0 mg/dl.Conclusion: They were insignificant association between blood glucose level and H. pylori infection among diabetes patents, However, the subgroup analysis suggested that H. pylori infection was possibly associated with increased risk of diabetes among males. Future cohort studies are needed to verify this association in females and to address possible implication in the prevention of diabetes
ABSTRACT
Objective: To prepare naringenin herbosome and evaluate its antidiabetic activity. Methods: Herbosomes were prepared by the solvent evaporation method. In vitro parameters like particle size, polydispersity index, zeta potential, and entrapment efficiency were estimated and in vitro diffusion study was performed. The in vivo studies were also performed in streptozotocin-induced diabetic male Sprague Dawley rats to evaluate blood glucose, total cholesterol, triglyceride, blood urea nitrogen, total protein, albumin level, aspartate aminotransferase, and alanine aminotransferase levels. Results: The optimized herbosome batch showed a particle size of 564.4 nm, a polydispersity index of 0.412, and zeta potential of-39.3 mV. The percentage entrapment of this formulation was 84.04%, with complete drug release within 8 h. Treatment of diabetic rats with naringenin herbosomes for 28 d significantly reduced the elevated level of plasma glucose as compared to plain naringenin. In biochemical parameters, the treatment showed a significant decrease in total cholesterol, triglyceride, and blood urea nitrogen; while elevated levels of aspartate aminotransferase and alanine aminotransferase were returned to normal. Pure naringenin and herbosome formulation at high dose increased the total protein whereas albumin level significantly increased in naringenin herbosomes at the highest dose but not in the pure naringenin treatment group. Conclusions: Naringenin herbosomes could improve the metabolic profile of diabetic rats, indicating enhanced antidiabetic activity of herbosome formulation.
ABSTRACT
【Objective】 To explore the effects of gestational diabetes mellitus (GDM) and mid-pregnancy blood glucose levels on gestational weeks in Northwestern China. 【Methods】 For this prospective cohort study, we recruited the first-trimester pregnant women who underwent obstetrical examinations at Northwest Women’s and Children’s Hospital from July 2018 to July 2019 as the cohort. We investigated their socio-demographic characteristics and risk factors of adverse pregnancy outcomes. Additionally, we collected the OGTT test results of pregnant women in mid-pregnancy and followed up their pregnancy outcomes. The relationship of GDM and blood glucose levels with gestational weeks was analyzed by using the generalized linear model. 【Results】 A total of 2 434 subjects were included in this study. There were 668 pregnant women with GDM, with a ratio of 27.44%. GDM in pregnant women shortened the gestational weeks (β=-0.17, 95% CI: -0.28—-0.05). Fasting blood glucose, OGTT-1 h blood glucose, and OGTT-2 h blood glucose increased by 1 mmol/L; gestational weeks were shortened by 0.17 (95% CI: -0.28—-0.05), 0.05 (95% CI: -0.09—-0.02) and 0.07 (95% CI: -0.12—-0.03). Fasting blood glucose and OGTT-1 h blood glucose abnormalities shortened gestational weeks by 0.18 (95% CI: -0.31—-0.05) and 0.28 (95% CI: -0.47—-0.10) respectively. An increase by 1 mmol/L or abnormality of fasting blood glucose would increase preterm delivery risk by 1.44 (95% CI: 1.01-2.06) and 1.73 times (95% CI: 1.10-2.69), respectively. 【Conclusion】 GDM in pregnant women may shorten their gestational weeks; the abnormal and elevated fasting blood glucose, in particular, would increase the risk of preterm delivery. Therefore, we should carry out active health education to control the blood glucose and other risk factors of GDM patients and promote healthy pregnancy.
ABSTRACT
Background: The study was done to investigate whether the raised levels of C-reactive protein (CRP), differential count and random blood glucose, besides echocardiogram, enhances the assessment process of acute coronary syndrome (ACS).Methods: This prospective study was done on 100 patients with typical chest pain attending to the department of medicine at K.A.P.V Medical College and Hospital, Trichy during the period from 2015 to 2017. The serum was assayed on admission for CRP, differential count and random blood glucose. Correlation of these parameters with incidence of ACS was calculated.Results: Male preponderance was seen in the study. Out of 100 patients, majority of about 60% of ACS patients had raised JVP. Elevated level of CRP was seen in 73% patients, 70% had elevated level of ejection fraction percentage. 71% had elevated level of WBC and 58% had elevated level of RBS. Statistically significant correlation was observed with the level of CRP (p=0.044), differential WBC count (p=0.037) and random blood glucose levels (p=0.001).Conclusions: Our study indicates that elevated CRP levels, increased random blood sugars and leucocytosis in ACS patient are positively correlated with decreased ejection fraction. Hence, measuring the levels of these parameters will helps in identifying incidence of acute coronary syndrome without echocardiogram.
ABSTRACT
Diabetes has become a serious threat to mankind, as it is found in all parts of the world. Alloxan induced diabetic mice were treated by metformin to study the impact of oxidative stress and endogenous antioxidants. Due to the establishment of diabetes, the oxidative stress indicators were found to be positively correlated with the elevation in the levels of endogenous antioxidants. Whereas, in metformin-treated diabetic mice, the data revealed the correction of diabetes by lowering of blood glucose level along with body weight. But the levels of endogenous antioxidants were not recorded to increase except GST. It shows that under in vivo system level of oxidative stress increases due to the metformin. The data revealed that metformin treatment of mice, however, manage the glucose level but not effective in controlling oxidative stress.
ABSTRACT
Background: Diabetes, a chronic disease, is presently a rapidly growing epidemic globally. The risk of diabetes type 2 is greatly increasing with change in lifestyle factors, urbanization, high blood pressure, overweight or obesity, physical inactivity and poor diet. It’s one of the reasons for premature death and disability and the number of cases are drastically increasing every year.Methods: 81 subjects above 18 years of age were considered for the screening. Random blood glucose levels were tested using the Thyrocare Sugar scan glucometer strips. Physical activity data was collected using a questionnaire. Based on the extent of physical activity, the subjects we grouped into three different categories. Data was analyzed and expressed using basic statistical tools in MS Excel 2007.Results: 6.17% of the rural population of Kendri, with mean age 47.4 years, had undiagnosed diabetes. The mean blood glucose level in diabetes positive cases was 279.8 mg/dL. A correlation of random blood glucose levels of the subjects with the extent of their physical activity was observed, where a decrease in physical activity/increase in physical inactivity showed an increase in blood glucose levels.Conclusions: From our study we conclude that undiagnosed diabetes is prevalent amongst the rural populations of Kendri, Chhattisgarh and low physical activity correlated with an increase of blood glucose levels, suggesting an urgent need to create health awareness, with emphasis on increase in physical activity, literacy and diabetes management, obesity, specifically among the illiterate and underprivileged rural populations.
ABSTRACT
Background: Being overweight is a risk factor in developing many chronic diseases, and globally, the frequency of obesity rapidly increases. Our study aims to investigate the effects of an exercise program on Body Mass Index (BMI) and fasting blood glucose (FBG) level in overweight and obese subjects who have a diet program. Methods: 61 overweight and obese women subjects were included in this study. The subjects were randomly divided into two groups. The Control Group (CG) was included 32 women and received only a diet program. And, Experimental Group (EG) was included 29 women and received both diet and exercise program. A dietitian recorded weight, height, and BMI, and fasting blood glucose levels were recorded by blood test asking from subjects before and after program. Results: There was statistically significant decrease in BMI in both groups (p<0,05). When the CG and the EG group were compared, there was more decrease in the EG group. Fasting blood glucose level decreased statistically significantly in the exercise and diet groups (p <0.05). When the mean changes between the groups were compared, the difference in the FBG level in the exercise and diet groups was not statistically found even though it was higher than the dietary group. Conclusion: The 6-week exercise program which was applied in addition to diet programs for overweight and obese people led to improvement in BMI and FBG level, we think that a multidisciplinary team should follow these people.
ABSTRACT
Background: There is growing interest in the use of natural foods in the management of chronic diseases like diabetes. Ibyer is a fibre rich gruel consumed amongst the Tiv people of Benue State made from whole sorghum or millet flours. Aim: The aim of the study was to evaluate the effect of sorghum-tigernut ibyer on the fasting blood glucose levels and body weight of alloxan monohydrate-induced diabetic rats. Methods: Sorghum flour (SF) and tigernut flour (TNF) were blended at different proportions (100:00; 90:10; 80:20; 70:30) for the purpose of ibyer production. The flour samples were subjected to proximate analysis using standard analytical procedures, the sensory attributes of ibyer produced from the different flour samples was evaluated on a 9-point hedonic scale. Thirty (30) male Wistar rats (100–180 g body weight) were grouped into five (1-5) each group containing six rats. They were induced with diabetes by injecting them with 150ml/kg of body weight with alloxan monohydrate dissolved in saline water (0.9% NaCl) except for group 1. Blood samples were collected from the tail of the rats, prior to induction, 48hrs after induction and 72 hrs after three days of continuous feeding with test diet. Fasting blood glucose was measured using a standard glucometer and test strips. Results: The sensory attributes indicated that ibyer produced from the flour samples were generally acceptable. Fasting blood glucose levels after 72 hrs of feeding were found to be lowered more in groups giving flours with a higher proportion of Tigernut. Conclusion: The results indicated that sorghum-tigernut ibyer exerted hypoglycaemic effect on the experimental animals.
ABSTRACT
Objective: To observe the mechanism of Alpinia (A.) oxyphylla in the treatment of diabetic nephropathy by regulating blood glucose level. Methods: A total of 40 db/db diabetic nephropathy mice were randomly divided into four groups including model group, irbesartan group, A. oxyphylla compound formula high dose group and A. oxyphylla compound formula low dose group with 10 in each group. Ten normal mice served as normal control group. Normal group and model group were given normal saline only. Irbesartan group and A. oxyphylla compound formula high and low dose group were given corresponding drugs once a day for 4 weeks (about 0.2 mL, once a day). Blood glucose, BUN, urine protein, SCr excretion, GSH and CAT activity were detected. Results: Compared with normal group, the blood glucose of model group were increased significantly (P<0.05). While compared with model group, the blood glucose of irbesartan group and A. oxyphylla compound formula groups (both high and low dose) decreased significantly after 4 weeks' treatment. Compared with model group, 24 h urine protein, BUN and SCr of A. oxyphylla compound formula groups (both high and low dose) decreased significantly(P<0.05) after 4 weeks' treatment. Compared with normal group, GSH, CAT of model group decreased significantly (P<0.05). While compared with model group, GSH, CAT of irbesartan group and A. oxyphylla compound formula high dose group increased significantly (P<0.05). Conclusions: A. oxyphylla compound formula can protect diabetic nephropathy mice by reducing the blood glucose level, decreasing the excretion of urine protein, BUN, SCr, and increasing the activites of CAT and GSH.
ABSTRACT
Background: With the advent of multimodality treatment approach, the number of cancer survivors is increasing which push us further to increase our knowledge on potential sites which could be exploited for the survival benefit of the patients. Insulin resistance has long been known to be a risk factor in various malignancies including breast, colon and endometrium. Insulin, a member of the family of growth factors that includes insulin-like growth factors IGF 1, IGF II, exerts mitogenic effects on normal and mitogenic breast epithelial cells acting via insulin and IGF 1 receptor. Insulin resistance leads to overexpression of the above-mentioned receptors and malignant transformation of cells. Aim of the study: To assess the prevalence of insulin resistance in non-diabetic carcinoma breast patients and to document fasting insulin levels in the same cohort of patients. Materials and methods: This was a prospective study conducted in the Department of General Surgery, Government Stanley Medical College in 2018. This study included all patients diagnosed as carcinoma breast, who was a non-diabetic. The relevant details collected included a clinical, radiological, pathological and biochemical profile of patients with carcinoma breast. Results: In our study, the majority of the patients had T3 lesion, with an almost equal incidence of T2. The incidence of T1 lesion was almost nil, which might indirectly indicate the lack of identification of carcinoma breast at an earlier stage in spite of widespread screening tests and campaign. In our study, the prevalence of insulin resistance was 17.2%. Five patients out of 29 of our study group had fasting insulin levels > 25µIU/L and found to have insulin resistance, with blood glucose levels within normal range. Conclusion: The study stated that insulin resistance which is considered a risk factor for many cancers, including carcinoma breast, might be prevalent in patients with normal glucose levels and in the absence of any symptoms. Screening them may be useful in identifying this cohort of patients and Princess Beulah, Vignesh. A study on fasting insulin levels in non-diabetic carcinoma breast patients. IAIM, 2019; 6(3): 194- 200. Page 195 treating them with tailored insulin resistance lowering agents like metformin which was found to have anti tumourigenic activity, as well as complete pathological response.
ABSTRACT
The objective of the study was to identify the relationship between gestational weight gain, type of treatment used, and the weight of the baby at birth. This being an observational retrospective study, the primary outcomes evaluated were: the type of treatment used and the classification of the baby's weight at birth. Collection occurred from January 2013 to May 2015. Multivariate multinomial logistic regression models were used to calculate odds ratios. Of the 682 pregnant women, 393 (57.6%) had a weight gain that was less than adequate, 140 (20.5%) showed adequate weight gain, and 149 (21.9%) had a weight gain that was higher than adequate. Weight gain that was less than adequate did not correlate with treatment used or with birth weight classification; higher-than-adequate weight gain was also not associated with the type of treatment used but decreased the chance of having a child considered normal for its gestational age by 50% and doubled the chance of having child considered large for gestational age. Comparing the groups according to the weight gain by means of the odds ratio, no difference was found in the therapy used
O objetivo do estudo foi o de identificar qual a relação entre o ganho de peso gestacional, tipo de tratamento utilizado e peso do bebê ao nascer. Estudo retrospectivo observacional, os desfechos primários avaliados foram: tipo de tratamento utilizado e classificação de peso do bebê ao nascer. Coleta: janeiro de 2013 a maio de 2015. Modelos de regressão logística multivariada multinomial para cálculo de razão de chance. Das 682 gestantes, 393 (57.6%) tiveram um ganho de peso abaixo do adequado, 140 (20.5%) tiveram um ganho de peso adequado e 149 (21.9%) tiveram um ganho de peso acima. O ganho de peso abaixo do adequado não apresentou relação com tratamento utilizado ou na classificação de peso do bebê ao nascer, o ganho de peso acima do adequado também não apresentou associação com o tratamento utilizado, porém diminuiu a chance de ter um filho adequado para a idade gestacional em 50% e dobrou a de ter um filho grande para a idade gestacional. Comparando os grupos, conforme o ganho de peso através da razão de chance, não foi encontrada diferença na terapêutica utilizada
Subject(s)
Humans , Female , Birth Weight , Weight Gain , Diabetes, Gestational , Glycemic IndexABSTRACT
Objective To explore the relationship between different blood glucose levels and prognosis in patients with acute severe craniocerebral injury.Methods Clinical data of 120 patients with acute severe craniocerebral injury from Jun.2014 to Jun.2017 in Department of Neurosurgery,Tongren Hospital of Wuhan University were analyzed retrospectively.The patients were divided into the group of acute severe craniocerebral injury and the group of acute extra-severe craniocerebral injury according to the Glasgow coma score (GCS).Blood glucose levels were detected at the time of admission,the 1st day,the 3rd day,the 7th day and the 14th day after operation.According to the blood glucose levels on admission,the patients were divided into the normal blood glucose group,the blood glucose value of 6.1-10.0 mmol/L group,the blood glucose value ＞ 10.0 mmol/L group.The prognosis was evaluated by Glasgow Outcome Score (GOS) 3 months after discharge.The relationship between the blood glucose levels and GOS score in different groups was analyzed.Results The blood glucose levels in the group of acute extra-severe craniocerebral injury were higher than those in the group of acute severe craniocerebral injury,and the difference was statistically significant (P＜0.05).Of the patients with acute severe craniocerebral injury,54 had good prognosis,and 16 had poor prognosis.Of the patients with acute extra-severe craniocerebral injury,28 had good prognosis,and 22 had poor prognosis.The rate of good prognosis were 77.1％ and 56％ respectively,and the difference had statistical significance (P=0.014,x2=6.025).The good prognosis of patients with normal blood glucose group was 23 and the poor prognosis was 4,with a good prognosis rate of 85.2％ (23/27).Among patients with blood glucose of 6.1-10.0 mmol/L,30 had good prognosis and 8 had poor prognosis,with a good prognosis rate of 78.9％(30/38).Among patients with blood glucose ＞10.0 mmol/L,31 had good prognosis and 24 had poor prognosis,with a good prognosis rate of 56.4％ (31/55).With the increase of blood glucose,the good prognosis rate gradually decreased and the poor prognosis rate gradually increased,and the difference was statistically significant(P=0.010,x2=9.283).Conclusion Blood glucose level has influence on the prognosis of patients with acute severe craniocerebral injury,and the good prognosis of patients with acute severe craniocerebral injury is severely affected by hyperglycemia.
ABSTRACT
In food science, natural ingredients that can inhibit dipeptidyl peptidase IV ( DPP IV ) may be useful for preventing diabetes mellitus. This study aimed to evaluate the effectiveness of bonito dashi having a high DPP IV inhibitory activity (IC50 ; 3049 µg/ ml) on the postprandial increase in blood glucose levels in 14 subjects. Bonito dashi (5 g) was subsequently subjected to oral glucose tolerance tests. Blood glucose levels of all subjects were measured at fasting and at 30 min after ingesting of bonito dashi or of warmed tap water as a control, and were also measured at 30, 45, 60, 75, 90, 120, and 150 min after ingestion of cooked rice. The maximum blood glucose level between 0 and 150 min after ingesting of bonito dashi was for 30 min, of warmed tap water for 45 min ). The blood glucose levels after ingestion of bonito dashi and warmed tap water were 135.6 ± 8.7 mg/ dl and 140.3 mg/ dl, respectively at 30 min ( p = 0.602 ); 135.6 ± 8.7 mg/ dl and 144.1 ± 10.7 mg/ dl, respectively at 45 min ( p = 0.057 ); 120.0 ± 4.9 mg/ dl and 136.8 ± 7.8 mg/ dl, respectively at 60 min ( p = 0.063 ); 110.0 ± 5.9 mg/ dl and 134.9 ± 6.9 mg/ dl, respectively at 75 min ( p = 0.006 ); 110.3 ± 6.8 mg/ dl and 129.3 ± 6.6 mg/ dl, respectively, at 90 min ( p = 0.036 ); 103.4 ± 4.1 mg/ dl and 118.7 ± 8.0 mg/ dl, respectively, at 120 min ( p = 0.091 ); 91.5 ± 3.8 mg/ dl and 102.3 ± 5.9 mg/ dl, respectively, at 150 min ( p = 0.232 ). The area under the curve for blood glucose levels after ingestion of bonito dashi and warmed tap water was 4753.1 ± 439.7 mg/ dl ×min and 6879.4 ± 728.1 mg/ dl ×min, respectively ( p = 0.005 ). Postprandial increase in blood glucose levels was lower in subjects ingestion of bonito dashi than in those ingestion of the warmed tap water. No serious adverse events related to ingestion of bonito dashi were observed. Our findings suggested that the ingestion of bonito dashi (5 g) suppressed postprandial increase in blood glucose levels in our subjects.
ABSTRACT
Background: Smoking harms nearly every organ of the body and diminishes a person’s overall health. Millions and millions of peoples have health problems due to the habit of smoking. It is now a burden worldwide because smoking addiction of teenagers increasing immensely. Globally, smoking is not only a leading cause of cancer as well as various heart diseases. Smoke contains several carcinogenic pyrolytic products like Polycyclic Aroma0tic Hydrocarbons (PCAH), acrolein etc. are irreversible binds to DNA, causes genetic mutation and cancer. Aim: To evaluate the effect of smoking on Blood biochemistry parameters. Materials and methods: Totally 68 subjects were included in the study. 34 current smokers who came from in and around Chidambaram to the RMMC and Hospital who fulfilled the inclusion criteria were selected as an experimental group. Another 34 non-smokers of the same age group were included separately in this study as a control group. So a total of 68 respondents were contacted for the study. The primary data were collected during the 2016-2017 period of around one year. biochemical parameters such as blood glucose, blood urea, and lipid profile were analyzed using standard methods. Results: While comparing the mean Blood sugar, Serum Cholesterol, Triglycerides, HDL, and LDL values, it was found to be more in smokers compared to that of non-smokers and this was significant at 5% level for Blood sugar and at 1% level for other values like cholesterol, TGL, HDL, and LDL. The mean Blood urea value had no significant association with smoking. Conclusion: Subchronic and acute exposure to tobacco smoke and various tobacco smoke constituents have been shown to elicit a wide variety of cardiovascular effects in animal models. These effects include decreased oxygen-carrying capacity, resulting in ischemia, platelet activation, endothelial damage, altered lipoprotein levels and increased arterial wall thickness which can promote atherosclerosis, and thrombosis. Ischaemia, atherosclerosis, and thrombosis increase the risk of myocardial infarction and other serious cardiovascular effects.
ABSTRACT
Objective To investigate the impact of blood glucose level on the recurrence of liver cancer after laparoscopic surgery. Methods The clinical data of 98 patients with primary hepatocellular carcinoma from January 2012 to January 2015 were retrospectively analyzed. All patients were treated by laparoscopic radical resection of hepatocellular carcinoma. Patients were divided into elevated blood glucose group (n = 23) and control group (n = 75) according to whether the fasting blood glucose was ≥6.1 mmol/L. The recurrence of liver cancer in 1 year and 2 years after operation was compared. The factors influencing the recurrence of liver cancer were analyzed by univariate and multivariate analysis. Results The recurrence rates were 47.82% and 21.33% respectively in the patients with elevated blood glucose and the control group. The recurrence rates were 73.91% and 36.00%respectively in the 2-year postoperative patients with blood glucose and 1 year and 2 years. The recurrence rate was higher than that of the control group, the difference was statistically significant (P < 0.05). Logistic multivariate analysis showed that fasting blood glucose was high, Child-Pugh grade B, intraoperative blood transfusion, lymphatic invasion, high clinical pathology stage, postoperative alpha-fetoprotein (AFP) high, no postoperative adjuvant therapy (P < 0.05). Conclusion The recurrence rate of patients with elevated liver cancer after laparoscopic surgery is high, and fasting blood glucose is high, Child-Pugh grade is B grade, blood transfusion is high, there is lymphatic invasion, high clinical pathology stage after AFP high, no postoperative adjuvant therapy for its postoperative recurrence of risk factors, should strengthen the monitoring of high-risk patients, reduce postoperative recurrence rate.
ABSTRACT
Objective To explore the effect of smoking on blood glucose level among male patients with type 2 diabetes in Changshu City.Methods Totally 41 57 male patients with type 2 diabetes involved in the national basic public health service were selected and assigned into four groups,including heavy smokers,current mild smokers,former smokers and non -smokers.All of them were investigated about the general social demographic data,living habits and health condition.Height,weight,waist and hipline were measured.BMI and WHR were calculated.FPG and HbA1 c were checked.Covariance analysis was used to correct the confounding factors,and the methods of multiple linear regression and partial correlation were used to evaluate the relationship between smoking and blood glucose level.Results FPG of the heavy smokers was higher than the current mild smokers,former smokers and non -smokers(P <0.05),but after the correction of the confounding factors,the differences were not statistically significant(P >0.05).HbA1 c of the heavy smokers and current mild smokers were higher than the former smokers and non -smokers(P <0.05 ),and after the correction of the confounding factors,the differences were still statistically significant(all P <0.05).Daily smoking amount was one of the influencing factors of HbA1 c(β=0.07,P <0.05).There was no correlation between the age of smoking initiation and FPG,HbA1 c(P >0.05).Daily smoking amount was positively correlated with HbA1 c(r =0.06,P <0.05), but was not correlated with FPG(P >0.05).Conclusion Smoking has a certain degree of influence on blood glucose level among male patients with type 2 diabetes in Changshu City,and we need to reduce the smoking rate among male patients with type 2 diabetes by health education.
ABSTRACT
BACKGROUND/AIMS: Glycated hemoglobin (HbA1c) is widely used as a marker of glycemic control. Translation of the HbA1c level to an average blood glucose level is useful because the latter figure is easily understood by patients. We studied the association between blood glucose levels revealed by the oral glucose tolerance test (OGTT) and HbA1c levels in a Korean population. METHODS: A total of 1,000 subjects aged 30 to 64 years from the Cardiovascular and Metabolic Diseases Etiology Research Center cohort were included. Fasting glucose levels, post-load glucose levels at 30, 60, and 120 minutes into the OGTT, and HbA1c levels were measured. RESULTS: Linear regression of HbA1c with mean blood glucose levels derived using the OGTT revealed a significant correlation between these measures (predicted mean glucose [mg/dL] = 49.4 × HbA1c [%] - 149.6; R2 = 0.54, p < 0.001). Our linear regression equation was quite different from that of the Alc-Derived Average Glucose (ADAG) study and Diabetes Control and Complications Trial (DCCT) cohort. CONCLUSIONS: Discrepancies between our results and those of the ADAG study and DCCT cohort may be attributable to differences in the test methods used and the extent of insulin secretion. More studies are needed to evaluate the association between HbA1c and self monitoring blood glucose levels.
Subject(s)
Humans , Blood Glucose , Cohort Studies , Diabetes Mellitus , Fasting , Glucose , Glucose Tolerance Test , Glycated Hemoglobin , Insulin , Linear Models , Metabolic DiseasesABSTRACT
Clitoria ternatea belonging to the family Fabaceae, commonly known as Butterfly pea. A wide range of secondary metabolites including triterpenoids, flavonol glycosides, anthocyanins and steroids were isolated from Clitoria ternatea Linn. GC-MS analyses of CHCl3 and EtOAc fractions were performed on Gas Chromatography with mass spectrometer. The aim of the present study was to evaluate the radical scavenging ability, using the stable radical DPPH and anti-diabetic activity in alloxan induced diabetes in albino rats was evaluated from the flowers extract of Clitoria ternatea. The blood glucose level in the different groups was assayed and biochemical parameters were assessed to support the proposed hypothesis. During the experimental period, body weight of all the rats was determined at regular intervals of time. The serum glucose lowering activity was compared with glibenclamide, a standard hypoglycemic drug.