ABSTRACT
OBJECTIVE: To synthesize bornyl salicylate and study its transdermal absorption in vitro. METHODS: Bornyl salicylate was prepared by esterification reaction of (+)-borneol and salicylic acid. The penetration of bornyl salicylate through mouse skin in vitro was measured using Franz diffusing cell with 2% azone as the penetration enhancer. The content of bornyl salicylate was determined by ultraviolet spectrophotometry. RESULTS: The structure of the target compound was identified by UV, IR and 1H-NMR. The transdermal absorption of bornyl salicylate was in accordance with Higuchi equation, in which cumulative dose of skin permeation (Q) has a linear relationship with the time. The average cumulative dose of skin permeation of bornyl salicylate for 12 h was 2.6112 mg, and the rate constant was 0.2539 mg m-2-1. CONCLUSION: The synthesis method of bornyl salicylate is simple. Bornyl salicylate can penetrate the skin of mice well with 2% azone as the penetration enhancer.