Recommendations of the Brazilian College of Radiology, the Brazilian Society of Mastology and the Brazilian Federation of Gynecology and Obstetrics Associations for breast cancer screening in Brazil

Objective: To present the updated recommendations of the Brazilian College of Radiology and Imaging Diagnosis, the Brazilian Society of Mastology and the Brazilian Federation of Gynecology and Obstetrics Associations for breast cancer screening in Brazil. Methods: Between January 2012 and July 2022, searches for scientific evidence published in MEDLINE, Embase, Cochrane Library, EBSCO, CINAHL and LILACS were carried out. The recommendations were based on this evidence, with the consensus of a committee of experts from the three institutions. Recommendations: The annual mammography screening is recommended for normal-risk patients aged between 40 and 74 years. For women aged more than 75 years, it is reserved for those whose life expectancy is longer than seven years. Women whose risk is higher than normal, such as those with dense breasts, personal history of atypical lobular hyperplasia, classic in situ lobular carcinoma, atypical ductal hyperplasia, women undergoing breast cancer treatment or thoracic irradiation before the age of 30, or those with genetic mutation or strong family history, benefit from complementary screening, being considered in an individual manner. Tomosynthesis is an evolution of mammography and should be considered in screening whenever accessible and available

Recommendations for the Screening of Breast Cancer of the Brazilian College of Radiology and Diagnostic Imaging, Brazilian Society of Mastology and Brazilian Federation of Gynecology and Obstetrics Association / Recomendações para o rastreio do câncer de mama do colégio brasileiro de radiologia e diagnóstico por imagem, sociedade brasileira de mastologia e associação da federação brasileira de ginecologia e obstetrícia

Abstract Objective To present the update of the recommendations of the Brazilian College of Radiology and Diagnostic Imaging, the Brazilian Society of Mastology and the Brazilian Federation of Associations of Gynecology and Obstetrics for breast cancer screening in Brazil. Methods Scientific evidence published in Medline, EMBASE, Cochrane Library, EBSCO, CINAHL and Lilacs databases between January 2012 and July 2022 was searched. Recommendations were based on this evidence by consensus of the expert committee of the three entities. Recommendations Annual mammography screening is recommended for women at usual risk aged 40-74 years. Above 75 years, it should be reserved for those with a life expectancy greater than seven years. Women at higher than usual risk, including those with dense breasts, with a personal history of atypical lobular hyperplasia, classic lobular carcinoma in situ, atypical ductal hyperplasia, treatment for breast cancer or chest irradiation before age 30, or even, carriers of a genetic mutation or with a strong family history, benefit from complementary screening, and should be considered individually. Tomosynthesis is a form of mammography and should be considered in screening whenever accessible and available.

Resumo Objetivo Apresentar a atualização das recomendações do Colégio Brasileiro de Radiologia e Diagnóstico por Imagem da Sociedade Brasileira de Mastologia e da Federação Brasileira das Associações de Ginecologia e Obstetrícia para o rastreamento do câncer de mama no Brasil. Métodos Foram pesquisadas evidências científicas publicadas nas bases de dados Medline EMBASE Biblioteca Cochrane EBSCO CINAHL e Lilacs entre janeiro de 2012 e julho de 2022. As recomendações foram baseadas nessas evidências por consenso do comitê de especialistas das três entidades. Recomendações A mamografia anual é recomendada para mulheres com risco habitual entre 40 e 74 anos. Acima de 75 anos deve ser reservado para aqueles com expectativa de vida superior a sete anos. Mulheres com risco maior do que o normal incluindo aquelas com mamas densas com história pessoal de hiperplasia lobular atípica carcinoma lobular in situ clássico hiperplasia ductal atípica tratamento para câncer de mama ou irradiação de tórax antes dos 30 anos ou ainda portadoras de doença genética mutação ou com forte histórico familiar beneficiam-se de triagem complementar e devem ser considerados individualmente. A tomossíntese é uma forma de mamografia e deve ser considerada na triagem sempre que acessível e disponível.

Mammography Stages Adoption and Health Beliefs in Mexican Women / Etapas de Cambio en el Uso de la Mamografía y Creencias de Salud en Mujeres Mexicanas

Abstract Objective. To identify associations between sociodemographic variables and stages of change and evaluate differences between health belief model variables and these stages. Methods. This cross-sectional descriptive study included 612 women aged 40 years and older admitted to a public hospital in the Northeast of Mexico. The participants answered the health belief model scale and selected the statement that best reflected their experience with mammography screening. The association between sociodemographic and clinical variables and the mammography stages of change was assessed using X2, and the groups of stages of change were compared using one-way ANOVA and Games-Howell post-hoc tests. Results. There was a significant association between age and the stages of action and maintenance. Breast cancer screening methods such as breast self-examination and clinical breast examination were more common among women in the stages of maintenance and relapse. There were differences between pre-contemplation and the more advanced stages in all dimensions except in the perceived seriousness p <.001. Self-efficacy and health motivation were different among women at the stage of contemplation, maintenance, and relapse. Conclusions. Perceived self-efficacy and health motivation may increase adherence to mammography screening.

Resumen El objetivo de la investigación fue identificar la asociación entre las variables sociodemográficas y las etapas de cambio para el uso de la mamografía y evaluar si existen diferencias entre las dimensiones del modelo de creencias en salud y las etapas de cambio. El diseño de este estudio es transversal descriptivo, se realizó de enero de 2017 a enero de 2018, incluyó a 612 mujeres de 40 años en adelante que asistían a un hospital de atención terciaria en el noreste de México. Las participantes firmaron el consentimiento informado y respondieron a la escala del modelo de creencias en salud y seleccionaron la declaración que mejor reflejaba su experiencia con la mamografía. La asociación entre las variables sociodemográficas y clínicas y las etapas de cambio de la mamografía se evaluó mediante X2, y los grupos de etapas de cambio se compararon mediante pruebas post hoc de ANOVA unidireccional y Games-Howell. Se encontró una asociación significativa entre la edad y las etapas de cambio de acción y mantenimiento. Los métodos de detección del cáncer de mama, como la autoexploración de mama y el examen clínico de mama, fueron más comunes entre las mujeres en las etapas de mantenimiento y recaída. Se obtuvieron diferencias significativas entre las etapas de pre-contemplación y las etapas más avanzadas en todas las dimensiones de creencias de salud, excepto en la seriedad percibida p <.001. La autoeficacia y la motivación para la salud fueron diferentes entre las mujeres en la etapa de contemplación, mantenimiento y recaída. La identificación de las etapas de cambio para la adopción de mamografías puede ayudar a desarrollar e implementar estrategias de intervención más efectivas. Además, la autoeficacia percibida y la motivación para la salud pueden aumentar la adherencia a la mamografía como método de detección del cáncer de mama.

Application of artificial intelligence ultrasound in breast cancer screening in Shigatse, Tibet / 中华超声影像学杂志

Objective:To explore the feasibility and clinical value of artificial intelligence-assisted breast ultrasound in screening breast cancer in Tibet.Methods:Two hundred and eighty-six women who participated in breast cancer screening in Shigatse People′s Hospital from August to September in 2021 were selected. The study included four groups. Group 1, ultrasound screening by senior breast ultrasound doctors from Shanghai; Group 2: local ultrasound doctors used intelligent-assisted ultrasound equipment for screening; Group 3: local ultrasound technicians used intelligent-assisted ultrasound equipment for screening; Group 4: ultrasound screening by local ultrasound doctors. The pathological results of screening positive cases and six-month ultrasound follow-up results of negative cases were set as the gold standard.Results:Twenty-seven lesions of 21 persons were screened positive. Pathology showed that 1 case of invasive ductal carcinoma, 1 case of severe atypical hyperplasia, 6 cases of fibroadenoma, 5 cases of breast disease, 14 cases of breast hyperplasia. Two hundred and sixty-five persons were screened negative, and the results of the six-month ultrasound follow-up were still negative. The accuracy, sensitivity, and specificity of group 2 were 0.966, 1, and 0.964 respectively; The accuracy, sensitivity, and specificity of group 3 were 0.935, 0.769, and 0.943 respectively; The accuracy, sensitivity, and specificity of group 4 were 0.860, 0.308 and 0.885 respectively. The accuracy and area under the curve of groups 2 and 3 were significantly different from that of group 4 (all P<0.001), and there was no significant difference from that of group 1 ( P=0.063, P=0.055). Conclusions:Artificial intelligence-assisted breast ultrasound screening technology can effectively improve the screening efficiency of non-breast ultrasound specialists and technicians. It is very suitable to solve the problems faced by grass-roots screening in Tibet and has great social significance and clinical value.

Knowledge of Breast Cancer Among Urban Women in the South of Peninsular Malaysia

@#Introduction: : Breast cancer (BC) is the most commonly diagnosed cancer globally and it is the leading cause of cancer mortality in Malaysian women. Increasing women knowledge of BC and breast self-examination (BSE) leads to increased compliance in early diagnosis and treatment. This study aims to determine the level of knowledge on BC and its association with socio-demographic characteristics among urban women. Methods: A cross-sectional study was conducted among 270 urban women in the South of Peninsular Malaysia using the adapted Breast Cancer Awareness Measure. Data were analyzed through SPSS software version 26.0. Results: Of the participants, 53.7% (n=145) had poor knowledge of BC warning signs, 50.7% (n=137) of BSE and 55.6% (n=150) of risk factors. High education was associated with better BC knowledge on warning signs (p=0.006) and risk factors (p=0.048). Chinese women have poor BC knowledge on warning signs (p=0.005) and BSE (p<0.001) than other ethnicities. Age (p=0.024) and marital status (p=0.028) were statistically significant with BC knowledge on breast self-examination (BSE) while family history of BC (p=0.019) and duration of seeking medical advice (p=0.041) were associated with BC knowledge on the risk factor. Conclusion: The findings of this study may give insight into effective health education strategies for urban women concerning breast cancer awareness.

A systematic review on clinical trials on the different approaches of breast cancer screening uptake in improving screening attendance

Background@#The early stage of cancer can be asymptomatic. Thus, different strategies were utilized to increase breast screening attendance which resulted in better treatment outcomes. Therefore, this review aimed to provide evidence on the effectiveness of the different approaches of breast screening uptake in improving screening attendance.@*Objectives@#The primary objective of this systematic review was to determine the effectiveness of the different approaches to breast screening uptake in improving screening attendance. The secondary objective was to identify the socio-geographic profile that affects the screening uptake.@*Methods@#Online databases, such as PubMed and Cochrane Central Register of Controlled Trials, were searched for studies published between January 2010 to December 2020. This review only included comparative randomized clinical trials involving humans as the research participants. In addition, reference lists of included studies were reviewed to identify additional relevant papers.@*Results@#The study included the review of 12 randomized controlled trials. Seven studies were conducted in a European setting, two in the United States of America, another two studies in Asia, and one study conducted in Canada. The intervention strategy to increase screening uptake were diverse in different studies. Ten of these studies used multiple strategies, while the remaining two studies utilized individualized strategies. Most of the studies were individual-based interventions. One study was a group-based intervention. The results showed that these interventions increase the uptake of breast cancer screening than no intervention at all.@*Conclusions@#The review confirmed that any interventions to increase breast screening uptake showed favorable outcomes in increasing breast screening attendance. However, the effectiveness of any one specific intervention cannot be made as these interventional studies greatly varied in terms of their intervention, study population, and geographical area.

Sparse-view Cone-beam Breast CT Reconstruction via cGAN Constrained by Image Edges / 中国医疗器械杂志

Clinical applications of cone-beam breast CT(CBBCT) are hindered by relatively higher radiation dose and longer scan time. This study proposes sparse-view CBBCT, i.e. with a small number of projections, to overcome the above bottlenecks. A deep learning method - conditional generative adversarial network constrained by image edges (ECGAN) - is proposed to suppress artifacts on sparse-view CBBCT images reconstructed by filtered backprojection (FBP). The discriminator of the ECGAN is the combination of patchGAN and LSGAN for preserving high frequency information, with a modified U-net as the generator. To further preserve subtle structures and micro calcifications which are particularly important for breast cancer screening and diagnosis, edge images of CBBCT are added to both the generator and the discriminator to guide the learning. The proposed algorithm has been evaluated on 20 clinical raw datasets of CBBCT. ECGAN substantially improves the image qualities of sparse-view CBBCT, with a performance superior to those of total variation (TV) based iterative reconstruction and FBPConvNet based post-processing. On one CBBCT case with the projection number reduced from 300 to 100, ECGAN enhances peak-signal-to-noise ratio (PSNR) and structural similarity (SSIM) on FBP reconstruction from 24.26 and 0.812 to 37.78 and 0.963, respectively. These results indicate that ECGAN successfully reduces radiation dose and scan time of CBBCT by 1/3 with only small image degradations.

Design and implementation for portable ultrasound-aided breast cancer screening system / 生物医学工程学杂志

Early screening is an important means to reduce breast cancer mortality. In order to solve the problem of low breast cancer screening rates caused by limited medical resources in remote and impoverished areas, this paper designs a breast cancer screening system aided with portable ultrasound Clarius. The system automatically segments the tumor area of the B-ultrasound image on the mobile terminal and uses the ultrasound radio frequency data on the cloud server to automatically classify the benign and malignant tumors. Experimental results in this study show that the accuracy of breast tumor segmentation reaches 98%, and the accuracy of benign and malignant classification reaches 82%, and the system is accurate and reliable. The system is easy to set up and operate, which is convenient for patients in remote and poor areas to carry out early breast cancer screening. It is beneficial to objectively diagnose disease, and it is the first time for the domestic breast cancer auxiliary screening system on the mobile terminal.

Perfil clínico-epidemiológico das pacientes octogenárias com câncer da mama atendidas em uma unidade oncológica no Sul de Santa Catarina entre os anos de 2010 a 2018 / Clinical epidemiological profile of octogenarian patients with breast cancer treated at an oncology unit in southern Santa Catarina from 2010 to 2018

Introdução: Avaliar o perfil clínico e epidemiológico das pacientes octogenárias diagnosticadas com câncer de mama em um serviço oncológico de referência do Sul de Santa Catarina entre os anos de 2010 a 2018. Métodos: Realizou-se um estudo transversal, retrospectivo, descritivo com coleta de dados secundária e abordagem quantitativa, a partir de prontuários de pacientes octogenárias com câncer de mama. Foram avaliados 50 prontuários; desses, 18 preencheram critérios de inclusão e compuseram a amostra final. Os dados foram classificados de acordo com as características epidemiológicas e clínicas. Resultados: As variáveis epidemiológicas mostraram que a média de idade foi 84,11 anos. 12 das 17 mulheres eram ex-tabagistas, 11 já haviam gestado, 6 não continham histórico familiar de câncer de mama. Entre as características clínicas, o estágio mais encontrado foi o estágio II (4 pacientes), seguido dos estágios I e III e 8 não trouxeram esse dado. O tipo histológico mais comum foi o carcinoma invasivo sem outra especificação. Na imuno-histoquímica, o subtipo mais comum foi o Luminal A (6), seguido pelo Luminal B (3), Triplo negativo (3), Superexpressão HER2 (2) e Luminal HER 2(1). Em relação ao tratamento, 9 das pacientes realizaram cirurgia conservadora e 14 fizeram uso de terapia hormonal. Conclusão: Os resultados encontrados são concordantes com os descritos na literatura, quando analisados tipo histológico e imuno-histoquímico. Em relação ao tratamento, ainda não há consenso de qual conduta aplicar nestas pacientes devido à individualidade das mesmas. O tratamento hormonal mostrou-se favorável a estas pacientes, mas ainda são necessários mais estudos.

Introduction: To evaluate the clinical and epidemiological profile of octogenarian patients diagnosed with breast cancer in a referral oncology service in southern Santa Catarina between 2010 and 2018. Methods: A cross-sectional, retrospective, descriptive study was carried out with secondary data collection and a quantitative approach, from medical records of octogenarian patients with breast cancer. Fifty medical records were evaluated, of which 18 met the inclusion criteria and formed the final sample. Data were classified according to epidemiological and clinical characteristics. Results: The epidemiological variables showed that the mean age was 84.11 years. Twelve of the 17 women were former smokers, 11 had already been pregnant, 6 had no family history of breast cancer. Among clinical characteristics, the most common stage was stage II (4 patients), followed by stages I and III, and in 8 this information was missing. The most common histological type was invasive carcinoma not otherwise specified. In immunohistochemistry, the most common subtype was Luminal A (6), followed by Luminal B (3), Triple negative (3), HER2 Overexpression (2) and Luminal HER 2(1). Regarding treatment, 9 of the patients under-went conservative surgery and 14 used hormone therapy. Conclusion: The findings are in agreement with those described in the literature, when analyzed histologically and immunohistochemically. Regarding treatment, there is still no consensus on which conduct to apply in these patients due to their individuality. Hormonal treatment appeared to be favorable to these patients, but further studies are still needed.

The delay of breast cancer diagnosis during the COVID-19 pandemic in São Paulo, Brazil / O atraso no diagnóstico do câncer de mama durante a pandemia da COVID-19 em São Paulo, Brasil

ABSTRACT Objective To evaluate the impact of COVID-19 pandemic on breast cancer diagnosis in a breast imaging center. Methods This was a retrospective cohort study that included women submitted to breast exams and procedures in a private hospital in São Paulo, SP, Brazil, as from the period of most strict social isolation measures, in 2020 (separated in first period of social isolation, March 24 to June 21, 2020, and second period, June 22 to December 31, 2020), as compared to the same period in 2019. The number of exams, cancer detection rates, pathologic findings and risk factors were analyzed. Results A total of 32,144 patients were included in the study. Breast imaging exams and procedures decreased by 78.9% in the first period, and 2.7% in the second period, in 2020. By the end of 2020, the number of breast cancer lesions detected was just six cases less than in 2019, although the number of patients submitted to mammograms was 35% lower. Conclusion There was a drop in number of breast exams and cancer diagnoses in the first 90 days of the pandemic. The decrease in diagnosis of cancer was partially compensated in the second period, but the number of patients submitted to mammograms by the end of 2020 was lower, still considering a large number of patients with delayed exams.

RESUMO Objetivo Avaliar o impacto da pandemia da COVID-19 no diagnóstico de câncer de mama em um centro de imagem de mama. Métodos Estudo de coorte retrospectivo que incluiu mulheres submetidas a exames e procedimentos de mama em um hospital privado em São Paulo, SP, Brasil, no período de medidas mais rigorosas de isolamento social em 2020 (dividido em primeiro período, de 24 de março a 21 de junho de 2020, e em segundo período, de 22 de junho a 31 de dezembro de 2020), comparado com o mesmo período de 2019. Foram analisados o número de exames, as taxas de detecção de câncer, os achados patológicos e os fatores de risco. Resultados Foram incluídas 32.144 pacientes. Os exames e os procedimentos de imagem da mama em 2020 tiveram redução de 78,9% no primeiro período e 2,7% no segundo período. Ao final de 2020, foram diagnosticadas com câncer de mama seis pacientes a menos do que em 2019, embora o número de pacientes submetidas à mamografia tenha sido 35% menor. Conclusão Houve queda no número de exames de mama e de diagnósticos de câncer nos primeiros 90 dias da pandemia. A redução dos diagnósticos de câncer foi parcialmente compensada no segundo período, mas o número de pacientes submetidas a exames de mamografia até o final do ano foi menor, considerando ainda um grande número de pacientes com exames atrasados.

Theory-based training to promote breast cancer screening among women with breast cancer worries: randomized controlled trial

ABSTRACT BACKGROUND: Breast cancer worries are important determinants in relation to behavior favoring breast cancer screening. OBJECTIVE: To determine the effect of theory-based training to promote breast cancer screening among women with high and low levels of breast cancer worries. DESIGN AND SETTING: Randomized controlled trial, conducted in two family health centers. METHODS: In total, 285 women were recruited. Women with low levels of breast cancer worries were included in the first intervention group (112 women) and the first control group (112 women), while women with high levels of breast cancer worries were included in the second intervention group (37 women) and the second control group (43 women). Theory-based training to promote breast cancer screening was given to intervention groups. The women's willingness to undergo breast cancer screening and breast cancer worry scores were evaluated at 1, 3 and 6 months. RESULTS: The women in the low cancer-worry intervention group performed breast self-examination more in months 1 and 6 following the training, and the women in the high cancer-worry control group performed breast self-examination more in month 3 (P < 0.05). No difference between the women who had low or high levels of breast cancer worries were observed in relation to breast self-examination, clinical breast examination or mammography (P > 0.05). CONCLUSION: The level of worry did not affect the success of theory-based training, and the training was partially effective with regard to willingness to undergo breast cancer screening.

Economic evaluation of breast cancer screening for Chinese urban women / 中国肿瘤临床

Objective: To explore the effectiveness and cost of breast cancer screening strategy that is suitable for the current econom-ic conditions in China. Methods: We collected clinical and cost information of breast cancer screening for Chinese women based on previous screening programs conducted from February 2008 to December 2011 and collected the same information about breast can-cer cases diagnosed in hospitals at the same time. Markov models were developed to analyze the incremental cost-effectiveness ratios (ICER) for 132 breast cancer screening strategies compared to no screening for Chinese women. Results: In 2010, as compared to no screening, the most cost-effective breast cancer screening strategy was biennial screening with clinical breast examination (CBE) and breast ultrasound, in parallel, for women aged between 40 to 64. This screening strategy could save 1,394 quality-adjusted life years (QALY) per 100,000 women, and the cost of saving breast-cancer related QALY would be 91,944 RMB. Sensitivity analysis indicated that in 2016, the most cost-effective breast cancer screening strategy was biennial screening with CBE and mammography (MAM), in parallel, for women aged 40 to 64, with ICER of 159,637 RMB per QALY. Conclusions: Population-based breast cancer screening would be acceptable in the current conditions in China. As the Chinese economy and level of medical care improve, breast cancer screening would be more cost-effective.

Reliability of breast density estimation based on cone beam breast CT / 中国肿瘤临床

Objective:To investigate the accuracy of a threshold-based segmentation method based on cone beam breast CT(CBBCT) images in breast density measurement,and its value for breast-type classification and breast cancer screening.Methods:A retrospec-tive analysis of 195 patients who had undergone CBBCT examination at Tianjin Medical University Cancer Institute and Hospital be-tween May 2012 and August 2014 was performed.A total of 64 breasts were analyzed.On the basis of the classification criteria for breast density in BI-RADS,they were classified into four types and the majority report was reported.Breast density was measured by the threshold-based segmentation method based on CBBCT images and corrected manually to obtain the corrected breast density.A month later,the procedure was repeated.Intra-class correlation coefficients(ICCs)were used to compare the intra-observer and inter-observer consistencies of threshold-based segmentation and manually corrected breast density measurement results for non-dense and dense breasts.Results:For threshold-based segmentation measurements the intra-observer and inter-observer ICC values were 0.0.9624(95% CI:0.9388~0.9770)and 0.9666(95% CI:0.9500~0.9785).For manually corrected measurements,the intra-observer and inter-observer ICC values were 0.9750 (95% CI: 0.9592~0.9847) and 0.9775 (95% CI: 0.9661~0.9855). The ICC between the threshold-based segmentation method and manual correction was 0.9962 (95% CI: 0.9983~0.9977). The ICC values of threshold-based and manually corrected measurement in non-dense and dense breasts were 0.9497(95% CI:0.7072-0.9914)and 0.9983(95% CI:0.9971-0.9990),respectively.Conclusions:The threshold-based segmentation method based on CBBCT is a reliable and accurate com-puter-aided method of measuring breast density.It is expected to be applied in large-scale screening of breast cancer and to provide more information for predicting the risk of breast cancer.

Breast cancer screening: updated recommendations of the Brazilian College of Radiology and Diagnostic Imaging, Brazilian Breast Disease Society, and Brazilian Federation of Gynecological and Obstetrical Associations / Recomendações do Colégio Brasileiro de Radiologia e Diagnóstico por Imagem, da Sociedade Brasileira de Mastologia e da Federação Brasileira das Associações de Ginecologia e Obstetrícia para o rastreamento do câncer de mama

Abstract Objective: To present the current recommendations for breast cancer screening in Brazil, as devised by the Brazilian College of Radiology and Diagnostic Imaging, the Brazilian Breast Disease Society, and the Brazilian Federation of Gynecological and Obstetrical Associations. Materials and methods: We analyzed scientific studies available in the Medline and Lilacs databases. In the absence of evidence, the recommendations reflected the consensus of a panel of experts. Recommendations: Annual mammography screening is recommended for women 40-74 years of age. Among women ≥ 75 years of age, annual mammography screening should be reserved for those with an expected survival > 7 years. Complementary ultrasound should be considered for women with dense breasts. Complementary magnetic resonance imaging is recommended for women at high risk. When available, an advanced form of mammography known as tomosynthesis can be considered as a means of screening for breast cancer.

Resumo Objetivo: Apresentar as recomendações do Colégio Brasileiro de Radiologia e Diagnóstico por Imagem, da Sociedade Brasileira de Mastologia e da Federação Brasileira das Associações de Ginecologia e Obstetrícia para o rastreamento por imagem do câncer de mama no Brasil. Materiais e métodos: Foram analisados os estudos científicos disponíveis nas bases científicas Medline e Lilacs. Na ausência de dados probatórios, as recomendações refletiram o consenso da comissão de especialistas. Recomendações: O rastreamento mamográfico anual é recomendado para as mulheres entre 40 e 74 anos. Acima de 75 anos deve ser reservado para as mulheres que tenham expectativa de vida maior que 7 anos. O rastreamento complementar com ultrassonografia deve ser considerado para as mulheres com mamas densas. O rastreamento complementar com ressonância magnética é recomendado para as mulheres com alto risco. A tomossíntese é uma forma de mamografia que pode ser considerada para o rastreamento do câncer de mama, quando disponível.

BREAST CANCER SCREENING: UPDATED RECOMMENDATIONS OF THE BRAZILIAN COLLEGE OF RADIOLOGY AND DIAGNOSTIC IMAGING, BRAZILIAN BREAST DISEASE SOCIETY, AND BRAZILIAN FEDERATION OF GYNECOLOGICAL AND OBSTETRICAL ASSOCIATIONS / Recomendações do Colégio Brasileiro de Radiologia e Diagnóstico por Imagem, da Sociedade Brasileira de Mastologia e da Federação Brasileira das Associações de Ginecologia e Obstetrícia para o rastreamento do câncer de mama

Objective: To present the current breast cancer screening guidelines in Brazil, as devised by the Brazilian College of Radiology and Diagnostic Imaging (CBR), the Brazilian Society for Breast Disease (SBM) and the Brazilian Federation of Gynecological and Obstetrical Associations (FEBRASGO). Methods: We analyzed scientific studies available in Medline and Lilacs databases. In the absence of evidence, the guidelines reflected the consensus opinion of an expert panel. Guidelines: Annual mammography screening is recommended for women aged 40­74 years. Among women aged 75 years or older, annual mammography screening should be reserved for those with an expected survival of 7 years or more. Complementary ultrasound should be considered for women with dense breasts. Complementary magnetic resonance imaging is recommended for women at high risk. When available, an advanced form of mammography known as tomosynthesis can be considered as a means of screening for breast cancer.

Objetivo: Apresentar as recomendações do Colégio Brasileiro de Radiologia e Diagnóstico por Imagem (CBR), da Sociedade Brasileira de Mastologia (SBM) e da Federação Brasileira das Associações de Ginecologia e Obstetrícia (FEBRASGO) para o rastreamento por imagem do câncer de mama no Brasil. Métodos: Foram analisados os estudos disponíveis nas bases científicas Medline e Lilacs. Na ausência de dados probatórios, as recomendações refletiram o consenso da comissão de especialistas. Recomendações: O rastreamento mamográfico anual é recomendado para as mulheres entre 40 e 74 anos. Acima de 75 anos deve ser reservado para as mulheres que tenham expectativa de vida maior que 7 anos. O rastreamento complementar com ultrassonografia deve ser considerado para as mulheres com mamas densas. O rastreamento complementar com ressonância magnética é recomendado para as mulheres com alto risco. A tomossíntese é uma forma de mamografia que pode ser considerada para o rastreamento do câncer de mama, quando disponível.

Economic evaluation of ultrasonography and mammography for breast cancer screening among women in China / 中国卫生政策研究

Objective: This study aims to analyze the cost-effectiveness and cost-utility of ultrasonography screening, mammography screening and no screening for breast cancer among Chinese women.Methods: A Markov model was developed from a societal perspective among asymptomatic Chinese women over 40 years who are at risk for breast cancer over a lifetime horizon.The decision model was populated with data derived from China, discounted at 3%.After getting the incremental cost-utility ratio (ICUR), this paper explores the parameter uncertainty using one-way sensitivity analysis and probabilistic sensitivity analysis.Subgrouping analysis was conducted based on different city levels and geographical areas in China.Results: Compared to no screening, the incremental cost-utility ratio of ultrasonography screening is ￥102653/QALY and the ICUR of mammography screening is ￥201309/QALY.In probabilistic sensitivity analyses, the probabilities of the ICUR being a threshold of ￥140000/QALY are 54.5% for annual ultrasonography and 26.2% for annual mammography.The subgrouping analysis shows that compared with no screening the ultrasonography screening for breast cancer has high cost-utility in all levels of cities and all geographic areas in China.The ICUR of mammography screening compared with no screening is very close to the threshold in eastern China.Conclusions: Ultrasonography screening could be used as the primary method for breast cancer screening in China, while mammography screening could only be used in economically developed areas in eastern China.

Relationship between Cancer Worries and Breast Cancer Screening with and without Family History among Korean Women / 보건행정학회지

BACKGROUND: Women with family history of breast cancer are more likely to be worried about having cancer and participate in breast cancer screening. However, few studies have examined relationship between family history, cancer worries, and participating in breast cancer screening in Korea. This study is to identify relationship between family history, cancer worries, and participating in breast cancer screening among women with and without family history of cancer. METHODS: Respondents were 2,364 women who based on the 2013 Korean National Cancer Screening Survey which is done by National Cancer Center in Korea. Chi-square tests were performed to determine differences of cancer worries, undergoing of breast cancer screening and methods such as mammogram and ultrasonogram with and without cancer family history. Univariate and multiple logistic regression were performed to identify if family history and cancer worries are related factors on participating in breast cancer screening and methods. Stratified analysis was performed to confirm the effect of ultrasonogram on the dense breast by age. RESULTS: Women with cancer family history frequently checked condition for conscious of having cancer (p=0.0299) and had highly perception of risk about having cancer in the future (p≤0.0001). Women aged 30–49 did not perform significantly more ultrasonogram than women aged over 50 years old. Checking condition (moderate odds ratio [OR], 1.38; 95% confidence interval [CI], 1.20–2.08; frequently OR, 1.58; 95% CI, 1.08–1.76) and perception of risk (moderate OR, 3.12; 95% CI, 1.06–7.06; high OR, 2.74; 95% CI, 1.20–8.08) were related to participate in mammogram and ultrasonogram. A positive family history was related to 1.35 higher odds of performing only breast ultrasonogram (95% CI, 1.04–1.75). CONCLUSION: This study requires national education and publicity to reduce the unnecessary cost of screening, to be possible cost effective screening and to encourage women to receive more mammogram, especially women aged over 50 years old and with socioeconomic factors related to opportunistic screening.

Assessment of Breast Cancer Screening Practices among Women of Reproductive Age in Benin City, Edo State.

Breast cancer is becoming very prevalent in developing countries including Nigeria which is now being bedeviled by the twin public health challenge of both communicable and non-communicable diseases. Aims: This study was conducted to assess breast cancer knowledge and screening practices among women of reproductive age in Benin City, with a view to improving breast cancer screening practices and minimize late presentation and attendant consequences. Study Design: A descriptive cross sectional study design was utilized for this study. Place and Duration of Study: This study was carried out in Central Hospital in Benin City, Edo State between September and December, 2013. Methodology: This study was health facility based involving researcher administration of semistructured questionnaires to 235 consenting women of reproductive age (15-49years) attending immunization clinics in Benin City. The data collected were analyzed using IBM Statistical Package for Sciences (SPSS) version 22.0 with statistical significance set at p< 0.05 and 95% Confidence Interval. Results: The mean age and parity of respondents studied were 28.8±7.4 years and 2.19±1.85 children respectively. Two hundred and seventeen (92.3%) of the women studied, were aware of breast cancer with majority 201(92.6%) having poor knowledge of breast cancer. Furthermore, the practice of breast examination was 143 (65.9%) among respondents studied with self-breast examination accounting for 106(74.1%). In relation to breast cancer screening practice, primary level of education (OR=0.323; 95% CI=0.141 – 0.742) was the only significant predictor identified that less likely influenced the practice. Conclusion: This study identified a high awareness with poor level of knowledge on breast cancer among women of reproductive age. The practice of breast examination was high with level of education identified as a significant predictor for breast cancer screening practice. There is need to create and strengthen breast cancer awareness campaign through all available media platforms and in schools not only for improved breast cancer screening practices but very importantly to improve knowledge on its presentation, risk factors and benefits of early detection and treatment for better health outcome.

An Application Evaluation on Different Screening Methods of Breast Cancer / 预防医学

Objective To evaluate the values of different methods in breast cancer screening using receiver operating characteristic (ROC)curve analysis,and to suggest a appropriate model for female breast cancer screening in rural areas. Methods After questionnaire investigation and clinical examination,breast ultrasound and X -ray mammography were performed in the high risk group.Sensitivity and specificity of clinical examination, breast ultrasound, X -ray mammography and comprehensive examination were evaluated by ROC curves.Results There were 31 pathologically diagnosed cases among the 23,910 screening women.The detection rate of breast cancer was 129.65 /100,000.The sensitivity,specificity and the area under the ROC curves was 90.323,94.604 and 0.954 respectively for comprehensive examination,and 70.968,90.288 and 0.814 respectively for ultrasound examination,and 74.194,91.727 and 0.850 respectively for mammography examination,and 41.935,82.734 and 0.676 respectively for clinical examination.After Z test,comprehensive examination was better than other methods (P <0.05)and there was no significant difference between breast ultrasound and X -ray mammography (P >0.05).Conclusion Both ultrasound and X -ray mammography are the effective methods in breast cancer screening.The comprehensive examination could significantly improve the diagnostic capabilities of breast cancer.

Breast cancer screening: How knowledgeable are female staff of a public university?

Breast cancer is the most common cancer among women worldwide and in Malaysia. It has better cure rate if detected early. However, the practice of breast cancer screening in Malaysia is still low. The objective of this study is to determine the knowledge and its associated factors as well as sources of information on breast cancer and breast cancer screening among female staff in a public university in Malaysia. Materials and Methods: This was a cross sectional study conducted in 2005 involving 394 female staff including academic and non-academic staff, which was selected by cluster sampling. A self-administered questionnaire on socioeconomic characteristics and family history of breast cancer was used for data collection. Chi-square Test and Fisher’s Exact Test was used for testing an association using SPSS 12.0. Results: The response rate was 84.3%. Only 50.9% had high knowledge on breast cancer and breast cancer screening and this was significantly associated with occupational status, monthly family income and educational level (p<0.05). The usual source of information was mass media (92.2%) while the most preferred source is the health team (71.4%). Conclusion: As mass media was a major source of information, all types of mass media could efficiently be utilized to disseminate knowledge by presenting specific programmes associated with breast cancer and breast cancer screening.