Determination of the dissolution of Breviscapinun Dispersive Tablet by HPLC / 中成药

AIM: To establish a method for determing the dissolution of Breviscapin Dispersive Tablet. METHODS: Breviscapin release was investigated in phosphate BS(pH7.4) by the third method for the release determination (Chinese Pharmacopoeia 2005 edition).Breviscapin content was assayed by HPLC and the release percentage was then calculated. RESULTS: The average recovery of scutellarin was 101.93%,RSD=(1.09)%.Good linear relationship was shown in the concentration range of 0.007-0.18 mg/mL,r=0.999 9.The dissolution was almost unaffected by rotation rate,but greatly affected by the type of solvent. CONCLUSION: The method is sensitive,accurate and quick for the quality control of Breviscapin Dispersive Tablet.