Progress on the relationship between BPTF and development of tumors in children / 国际儿科学杂志

The gene of bromodomain PHD finger transcription factor (BPTF) is expressed in all tissues and its protein regulate the transcription process.Overexpression and mutations of BPTF are found in a variety of tumors,which demonstrate poor prognosis.It is also reported that BPTF plays an important role in the development of childhood malignancy.The study aims to summarize the latest studies of tumors in children associated with BPTF.