ABSTRACT
Background: Burns remain a major public health issue all over the world, especially in developing countries. Pseudomonas aeruginosa is a major cause of infection and death in patients with severe burns. So, there is a need to develop drugs which will decrease complications and prevent infections more effectively than the presently used drugs.Methods: Ocimum sanctum, ointment silver sulfadiazine and 24 Rabbits were used in this study. Animals were acclimatized and divided randomly into 04 groups of 06 animals each. After producing partial thickness burn wound ointment silver sulfadiazine was applied daily on the burn wound and Ocimum sanctum was administered orally once daily. Healing was assessed by wound contraction and Oxidative stress and Antioxidant Activity were measured by Malondialdehyde and Superoxide dismutase respectively. Results were analysed by student’s ‘t’ test, one way ANOVA followed by Dennett’s test. P values <0.05 were considered statistically significant.Results: At the end of treatment (After 28th Day) Group treated with ointment silver sulfadiazine+Ocimum sanctum showed maximum Percentage of wound contraction (93.17±4.34), maximum decrease of MDA percentage (0.30±0.02 nmol/ml) and maximum increase of SOD percentage (0.0045±0.0002 IU/gm of Hb).Conclusions: Most effective treatment for burn wound healing in this study was ointment silver sulfadiazine+Ocimum sanctum.
ABSTRACT
Malva sylvestris, Punica granatum, Amygdalus communis, Arnebia euchroma and Scrophularia deserti are important medicinal plants in Iranian traditional medicine (Unani) whose have been used as remedy against edema, burn, and wound and for their carminative, antimicrobial and anti-inflammatory activities. The ethanol extracts of M. sylvestris and P. granatum flowers, A. communis leaves, A. euchroma roots and S. deserti stems were used to evaluate the burn healing activity in alloxan-induced diabetic rats. Burns were induced in Wistar rats divided into nine groups as following; Group-I: normal rats were treated with simple ointment base (control), Group-II: diabetic rats were treated with simple ointment base (control), Groups-III and -VII: diabetic rats were treated with simple ointment base containing of extracts (diabetic animals), Groups VIII: diabetic rats were treated with simple ointment base containing of mixed extracts, Group-IX: diabetic rats received the standard drug (Silver Sulfadiazine). The efficacy of treatments was evaluated based on wound area, epithelialization time and histopathological characteristics. Wound contraction showed that there is high significant difference between the different groups (p<0.001). At the 18th day, A. euchroma, S. deserti, A. communis and mixed extract ointment treated groups healed 80-90%. At the 9th and 18th days the experiment, the best results were obtained with A. communis and standard drug, when compared to the other groups as well as to the controls. It may be concluded that almond leaves (sweet and bitter) formulated in the simple ointment base is effective in the treatment of burns and thus supports its traditional use.
ABSTRACT
PURPOSE: Arteriovenous fistula (AV fistula) and immune suppressive drug have a different effect on wound healing. AV fistula supposed to have a positive role of wound healing by the increased blood flow around the wound. But immunosuppressive drug has a well known effect of delayed wound healing. METHODS: We experienced 55 years old female patient who suffered from 9% burn of TBSA, 2nd to 3rd degree burn of arm and chest wall with arteriovenous fistula in the burned arm. She also take immunosuppressive drugs for 13 years due to kidney transplantation. RESULTS: She takes two consecutive skin graft operations on post admission day 14 and 42. Bleeding from the surface of eschar excised arm was profuse so it makes us unable to finish in the first operation. But graft skins were well taken except partial take-off in chest wall area. Episode of shock make 2nd skin graft postponed for a month but the skin uptake of arm was very successful. CONCLUSION: The arteriovenous fistula has the positive effect in the case of burn wound healing including the skin graft, exceed the negative role of immunosuppressive drugs in the wound healing.