ABSTRACT
Objective: To study the chemical constituents of the herbs of Patrina scabiosaefolia. Methods: Many column chromatographies such as silica gel, Sephadex LH-20, ODS column chromatography and preparative high-performance liquid chromatography were used to separate and purify the chemical constituents of P. scabiosaefolia. The structures of these compounds were identified by physical-chemical data and spectroscopic techniques. Results: Eighteen compounds were isolated and purified from the ethanol extract of P. scabiosaefolia, and their structures were identified as follows: 6-methoxy-7-(1’-henicosacyloxy- 3’-hydroxy-2’-propoxy) coumarin (1), oleanolic acid (2), ursolic acid (3), palmitic acid (4), dodecanoic acid (5), α-tocopherolquinone (6), maslinic acid (7), 4-hydroxy-3-methoxybenzaldehyde (8), 2,6-dimethoxy benzoquinone (9), 3β-acetyloxy-12-en-28-ursolic acid (10), α-tocospiro B (11), 22E-3β-hydroxy-5α,6α-epoxyergosta-22-en-7-one (12), 2α-hydroxy ursolic acid (13), linoleic acid (14), β- sitosterol palmitate (15), 3-hydroxy-1-(4-hydroxy-3-methoxy-phenyl)-1-propanone (16), burselignan (17), and hederagenin (18). Conclusion: Compound 1 is a new compound named scabiosaelactone and compounds 6, 8, 9, 11, 12, 16, and 17 are isolated from the genus Patrina for the first time.
ABSTRACT
Objective To investigate the chemical constituents of the aerial part of Rubia cordifolia. Methods All compounds were isolated and purified by silica gel, Sephadex LH-20, and MCI column chromatography. Their structures were determined by physicochemical properties and spectral data. Results Eleven compounds were isolated and identified as: (-)-episyringaresinol (1), (-)-secoisolariciresinol (2), (-)-3,4-divanillyl tetrahydrofuran (3), lignans (+)-demethoxypinoresinol (4), (+)-syringaresinol (5), (+)-isolariciresinol (6), burselignan (7), (7S,8R)-dihydrodehydroconiferyl alcohol (8), 4,5'-dimethoxy-lariciresinol (9), (+)-7R,8S-5- methoxydihydrodehydroconifery alcohol (10), and 5,5'-dimethoxy-7-oxolariciresinol (11). Conclusion All compounds are isolated from this plant for the first time.